SYLLABUS REVISION

I - M.PHARM
PHARMACEUTICAL TECHNOLOGY
GOAL: To produce a competent Pharmaceutical technologist.
OBJECTIVE: Upon completion of the course, the candidate shall have:
An understanding of the concept and design of various pharmaceutical dosage forms
The ability to formulate and evaluate various dosage forms
The ability to work independently and as a member of the team
The ability to plan his / her work for efficient use of time and resources
The ability to identify the cause and to solve the problem
The ability to think and evaluate scientifically and critically
TEACHING/ LEARNING ACTIVITIES
. Journal Club: weekly, !ournal club meetings to be held to discuss the recent
development in the sub"ect published in the national and international "ournals.
#. S!"nar#: $eminars %&'( in a year) shall be arranged from e*perts in the field.
+. In$u#%r"al &"#"%#: ,isits to pharmaceutical industries to understand shop floor
activities.
-. Con'rn(# an$ !%"n)#: $taff and students are to be encouraged to
participate in seminars, workshops and conferences in the area of this sub"ect.
TITLE O* PAPERS
Pa+r I: Mo$rn P,ar!a(u%"(al Anal-#"#
Pa+r II: A$&an($ P,ar!a(u%"(al T(,nolo)-
Pa+r III: B"o+,ar!a(u%"(# an$ P,ar!a(o."n%"(#
Pa+r IV: A$&an(# "n /ru) /l"&r- S-#%!#
A++n$"0 I: L"#% o' R1u"r$ E1u"+!n%#/In#%ru!n%#:
The following common and speciali.ed e/uipments/instruments, and charts are to be
provided by the course conducting department/institution.
Co!!on E1u"+!n%#:
$ingle pan balances %analytical): 0#
$ingle pan balances %electronic/digital): 0#
1ot air oven: 0#
2agnetic stirrers: 03
2echanical stirrers %,#,& ltrs): 0-
4ouble pan balances %analytical): 0
Thermostatic digital water baths: 0#
4istillation assembly: & ltrs. capacity
1ot plates: 0-
5efrigerator: 0
T67 8it and plates
$ieves of different mesh si.es %0, #, (, ##, --, (0, 30, #0): # each
S+("al E1u"+!n%#:
2onsanto 9 Pfi.er hardness testers: 0# each
4isintegration test apparatus: 0#
4issolution test apparatus %single "ar): 0-
4issolution test apparatus %(/3 !ars):0
U,',isible spectrophotometer %4ouble beam): 0
Tablet compression machine single station: 0
5otary tablet compression machine %&'0 station): 0
:ath sonicator: 0
Table top centrifuge: 0
7apsule filling machine: 0
$tability chamber: 0
7oating 9 Polishing pan: 0
,acuum pump with accessories: 0
Pocket / pen p1 meters: 0#
,acuum filtration units: 0
5otary evaporator: 0
5otary shaker: 0
;iltration sets: 0#
:rookefield ,iscometer : 0
/#"rabl
1igh performance 6i/uid 7hromatography %1P67): 0
7omputers with UP$ and a printer: 0-
;ree.e dryer: 0
Gla##2ar
7ommon laboratory glassware for regular e*periments: :eakers, measuring cylinders,
conical flasks, 5: 9 ;: ;lasks %9 # lt. capacity), filtration unit, distillation unit,
thermometers 0 9 +(0 degree 7elsius etc..
C,!"(al# an$ Ra)n%#
7ommon pharma grade pure drug samples, polymers and other ad"uvants, solvents
etc. for the purpose of formulation re/uired for the regular practicals.
PAPER II -A/VANCE/ PHARMACEUTICAL TECHNOLOGY
THEORY 34 Hour# 56 Hr#/ 7.8
9. PRE*ORMULATION STU/IES
5Mar.# allo%!n% : 93 8 5: Hr#.8
<ntroduction, 7onsideration of physicochemical properties of new drug molecules for
different dosage forms. A/ueous solubility, organic solubility, intrinsic solubility,
methods of enhancement of solubility'surfactants, p1, co'solvency, solid dispersion,
comple*ation. Techni/ues for the study of crystal properties and polymorphism ' 4$7,
T=A, P>54, ?ptical microscopy, hot stage microscopy. @*cipient compatibility studies,
Preformulation stability studies.
6. PHARMACEUTICAL E;CIPIENTS < POLYMERS
5Mar.# allo%!n% : 93 8 5: Hr#.8
Factors afecting the selection of excipients, drug-excipient interactions,
Study of cyclodextrins, ion exchange resins, flm coating materials, super-
disintegrants, directly compressible vehicles, surfactants and thickeners. Co-
processed excipients.
Polymer classification, application of polymers in drug delivery, biodegradable, synthetic,
semi'synthetic and natural polymers. 1ydrogels and their applications.
=. TABLETING TECHNOLOGY
5Mar.# allo%!n% : 93 8 5 3 Hr#.8
7ompression, consolidation, decompression, compaction at high loads, forces distribution
during compression, compaction profiles, measurement of forces during compression,
energy involved in compaction, properties of granules of compression, properties related
to machinery for compression, influence of compression force on the properties of tablets.
>. CAPSULE TECHNOLOGY
5Mar.# allo%!n% : 94 8 5> Hr#.8
2anufacturing e/uipment and machinery used in capsule technology. ;ormulation and
evaluation of hard gelatin capsules and soft gelatin capsules.
3. PARENTERALS TECHNOLOGY
5Mar.# allo%!n% : 94 8 5 3 Hr#.8
2anufacturing of 6,P, $,P, $terili.ation and sterility testing of parenterals, =2P 9
c =2P regulations of parenteral technology.
:. STABILITY TESTING - /RUGS AN/ /OSAGE *ORMS
5Mar.# allo%!n% : 94 8 5> Hr#.8
$olid state drug stability, dosage form stability, accelerated stability testing, shelf life
calculations, strategies for prolonging shelf life. @ffect of packaging materials on dosage
form stability. :asic principles of <71, stability testing of new drug substance and
formulations, photostability testing and o*idative stability, role of containers in stability
testing. A1? stability guidelines.
?. PHARMACEUTICAL PAC@AGING TECHNOLOGY
5Mar.# allo%!n% : 64 8 5: Hr#.8
$election and evaluation of pharmaceutical packaging materials, 7ontainers and closures,
7ontainer'product interactions, Pharmacopoeial specifications, Tests and standards for packaging
materials. 6abels and labeling'Types of labels, adhesives, in"ect and bar'coding, ;le*ible
packaging'Types of films, 7o'e*truded films, foils, coating and laminates, shrink and stretch
films, 7orrugated and solid fiber boards and bo*es'Types of corrugation methods and types of
bo* design and Buality control. Packaging 2achinery'<ncluding strip packaging, form, fill and
seal machines, li/uid and semisolid filling machines, capping machines. 2odern packaging
techni/ues.
A. BUALITY BY /ESIGNC /ESIGN O* E;PERIMENTSC *ORMULATION BY
/ESIGN 5Mar.# allo%!n%: 94 8 5> Hr#8
U$;4ACs view of Bb4, @lements of Bb4, Bb4 tools, 4esign of e*periments D2ethods
and applications ?ptimi.ation techni/ues: 7oncept of optimi.ation, optimi.ation
parameters, classical optimi.ation. $tatistical design %$imple* and factorial design)
D. IPR# an$ REGULATORY GUI/ELINE
5Mar.# allo%!n% : 93 8 5 ? Hr#.8
4efinition, Eeed for patenting, Types of Patents, 7onditions to be satisfied by an invention
to be patentable, <ntroduction to patent search. Parts of patents. ;iling of patents. The
essential elements of patentF =uidelines for preparation of laboratory note book, Eon'
obviousness in Patent. :rief introduction to Trademark protection and A1? Patents. <P5Cs
and its types, 2a"or bodies regulating <ndian Pharmaceutical sector, 74$7?, A1?,
U$;4A, @2@A, T=A, 215A, 277, AE,<$A regulatory re/uirements for contract
research organi.ation. 5egulations for :iosimilars. 5ole of =ATT, T5<P$, and A<P?.
0. TOTAL BUALITY MANAGEMENT
5Mar.# allo%!n% : 94 8 = Hr#.8
Principles of TB2, elements of TB2, 7ontinuous improvement and learning,
management tools of /uality, tools and techni/ues of /uality, new /uality tools and
techni/ues.
PRACTICALS
(6 hours/week)
) @ffect of surfactants on the solubility of drugs.
#) @ffect of co'solvents on the solubility of drugs.
+) Preparation and evaluation of solid dispersion.
-) Preparation and evaluation of inclusion comple*.
&) To study the effect of glidants and lubricants on flowability and compressibility of
granules.
() @ffect of different granulating agents and disintegrants on the properties of tablets.
G) Preparation and evaluation of aspirin effervescent tablets.
3) Preparation and evaluation of chewable antacid tablets.
H) Preparation and evaluation of coated tablets by pan coating.
0) ;ormulation and evaluation of capsules.
) ;ormulation and evaluation of small volume parentarals.
#) ;ormulation and evaluation of large volume parentarals.
+) @valuation of glass as a pharmaceutical packaging material.
-) @valuation of plastic as a pharmaceutical packaging material.
&) Accelerated stability testing, shelf'life determination and e*piration dating of
pharmaceuticals.
SCHEME OF EXAMINATION
. $ynopsis ' #0 marks
#. @*periment
2a"or @*periment ' +& marks
2inor @*periment ' #& marks
+. ,iva'voce ' #0 marks
To%al: 944 !ar.#
REFERENCE BOOKS
! "ieberman #$ and "achman ". %harmaceutical &osage Forms' (ablets. )ol. *, **
and ***, +arcel &ekker, ,e- .ork. "atest /dition.
0!. $vis 1/, "achman " and "ieberman #$, %harmaceutical &osage Forms'
%arenterals. )olume * and **, +arcel &ekker, ,e- .ork. "atest /dition.
2! 3obinson and "ee, Controlled drug delivery' Fundamentals and applications,
+arcel &ekker.
4! Carstensen, %harmaceutical principles of solid dosage forms, C3C.
5! 3ay and 6eller, #andbook of %harmaceutical /xcipients, %harmaceutical %ress.
7! %harmaceutical dosage forms' %arenteral, "achman, "ibermann, and $vis, )ol.
* 8 **
+arcel &ekker.
9! ,icholas %. Che:erision , %roduct design and testing polymeric materials.
;! %olymers in Controlled &rug &elivery 7 /d. "isbeth *lerm, Stanley &avis.
<! =ood manufacturing practices for %harmaceuticals' $ plan for total >uality
control, Second
edition? @y Sidney #. 6illig.
A. &rug formulation manual? @y &.%.S. 1ohli and &.#.Shah. /astern publishers,
,e- &elhi.
! %harmaceutical %re-formulations? @y B.B. 6ells.
0! %ackaging of %harmaceuticals, @y C.F. 3oss.
2! 6ileyCs /ncyclopedia of %ackaging (echnology.
4! Duality $ssurance =uide? @y Ergani:ation of %harmaceutical producers of
*ndia.
5! #o- to practice =+%s? @y %. %. Sharma. )andhana %ublications, $gra.
7! %harmaceutical %rocess )alidation? @y Fra. 3. @erry and 3obert $. ,ash. )ol.
59,
Second /dition. 3evised and /xpanded.
9! $pplied production and operations management? @y /vans, $nderson,
S-eeney and
6illiams.
JOURNALS
. 4rug 4evelopment and <ndustrial pharmacy
#. <ndian !ournal of Pharmaceutical sciences
+. !ournal of Pharmaceutical $ciences
-. <ndian 4rugs
URLE#
. www.cdsco.nic.in
#. www."ournals.elsevier.com
+. www. fda .gov/
-. www. mhra .gov.uk
&. www. anvisa .gov.br/eng/legis/inde*.htm
(. www.pharma guide line.com/#00/0/ mcc .html
G. www. biosimilar news.com/european' biosimilars ' guidelines.
PAPER III - BIOPHARMACEUTICS AN/ PHARMACO@INETICS
Goal: To train the students in the area of biopharmaceutics and pharmacokinetics to work
efficiently in the 594 4ept of industry, to take part in clinical research %clinical trials)
ObF(%"&#: Upon completion of the course, the candidate shall have the ability to:
7alculate Pharmacokinetics parameters from the given data.
Apply the principle of Pharmacokinetics in new drug development as well as in the
design of new formulations.
COURSE /ESCRIPTION
THEORY 34 Hour# 5 T:6Hour#/7.8
9. ABSORPTION O* /RUGS 5A Hr#.8
5Mar.# allo%!n% : 64 8
$tructure of cell membrane, =astro'intestinal absorption of drugs, mechanisms of
drug absorption, ;actors affecting drug absorption: :iological, Physiological,
Physico'chemical and Pharmaceutical. Absorption of drugs from non'per oral routes,
2ethods of determining absorption: In-vitro, in-situ and in-vivo methods.
6. BIOAVAILABILITY 5? Hr#.8
5Mar.# allo%!n% : 93 8
?b"ectives and consideration in bioavailability studies, 7oncept of e/uivalence,
2easurement of bioavailability, 4etermination of the rate of absorption,
:ioe/uivalence protocol and its importance, :ioe/uivalence studies.

=. /ISSOLUTION 5= Hr#.8
5Mar.# allo%!n% : 94 8
:7$ 7lassification, Eoyes'AhitneyCs dissolutions rate law, $tudy of various
approaches to improve dissolution of poorly soluble drug, In-vitro dissolution testing
models, In-vitro release kinetic models, similarity and dissimilarity factors,
biowaivers, In-vitro- In vivo correlation.


>. PHARMACO@INETICS 594 Hr#.8
5Mar.# allo%!n% : 638
:asic considerations, Pharmacokinetic models, 7ompartment modeling: ?ne
compartment model ' <, bolus, <, infusion, @*travascularF 2ulti 7ompartment
modelsF Two compartment model ' <, bolus, <, infusion, @*travascular, Three
7ompartment model in brief, Application of Pharmacokinetics in new drug
development and designing of dosage forms and Eovel drug delivery systems.


3. NON-LINEAR PHARMACO@INETICS 5= Hr#.8
5Mar.# allo%!n% : 94 8
7auses of non'linearity, 4etection of non D linearity, 2ichaelis'2enten e/uation,
@stimation of 8
m
and ,
ma*
with respect to individuali.ation of a drug therapy.

:. NON-COMPARTMENT PHARMACO@INETICS 5= Hr#.8
5Mar.# allo%!n% : 94 8
$tatistical moment theory, 25T for various compartment models, Physiological
pharmacokinetic models.
?. /RUG /ISTRIBUTION 5= Hr#.8
5Mar.# allo%!n% : 94 8
;actors affecting drug distribution, ,olume of distribution, Protein binding' factors
affecting, significance and kinetics of protein binding and drug displacement
interactions.
A. BIOTRANS*ORMATION 5= Hr#.8
5Mar.# allo%!n% : 3 8
Phase < %o*idative, reductive and hydrolytic reactions) and Phase << reactions
%con"ugation), factors affecting biotransformation.


D. E;CRETION O* /RUGS 5=Hr#.8
5Mar.# allo%!n%: 38
5enal and non'renal e*cretion. 7oncept of clearance' renal clearance, organ clearance
and hepatic clearance.
94. /OSAGE REGIMEN 5? Hr#.8
5Mar.# allo%!n% : 64 8
2ultiple dosing with respect to <., and oral route, concept of loading dose,
maintenance dose, accumulation inde*, ad"ustment of dosage in renal and hepatic
impairment, individuali.ation of therapy, Therapeutic 4rug 2onitoring.
PRACTICALS 5T:: Hour#/7.8
. <mprovement of dissolution characteristics of slightly soluble drugs by $olid
4ispersion.
#. <mprovement of dissolution characteristics of slightly soluble drugs by $olvent
deposition.
+. <mprovement of dissolution characteristics of slightly soluble drugs by
comple*ation.
-. <mprovement of dissolution characteristics of slightly soluble drugs by solvent
evaporation.
&. 7omparison of dissolution studies of two different conventional marketed
products of same drug. ' # e*periments
(. <nfluence of polymorphism on solubility.
G. <nfluence of polymorphism on dissolution.
3. Protein binding studies of a highly protein bound drug.
H. Protein binding studies of a poorly protein bound drug.
0. Permeation study of drug through biological membrane.
. 7alculation of 8a, 8e, t
/#
, 7
ma*
, and T
ma*
for two sets of data. '# e*periments
#. 7alculation of bioavailability from urinary e*cretion data for two drugs. '#
e*periments
+. 7alculation of AU7 and bioe/uivalence from the given data for two drugs. '#
e*periments
SCHEME O* E;AMINATION
9. S-no+#"# - 64 Mar.#
6. E0+r"!n% - >4 Mar.#
=. Cal(ula%"on - 64 Mar.#
>. V"&a-&o( - 64 Mar.#
To%al - 944 Mar.#
RE*ERENCE BOO@S
. :iopharmaceutics and 7linical Pharmacokinetics by 2ilo =ibaldi, -
th
edition,
Philadephia, 6ea and ;ebiger, HH.
#. :io pharmaceutics and Pharmacokinetics'A Treatise, :y 4. 2. :rahmankar and $unil
:.!aiswal, ,allabh Prakashan Pitampura, 4elhi
+. Applied :iopharmaceutics and Pharmacokinetics by $hargel. 6 and Iu A:7, #
nd
edition, 7onnecticut, Appleton 7entury 7rofts, H3&.
-. Te*tbook of :iopharmaceutics and Pharmacokinetics, 4r. $hobha 5ani 5. 1iremath,
Prism :ooks Pvt 6td, :angalore, #000
&. :iopharmaceutics and 7linical Pharmacokinetics by 2ilo =ibaldi, #
nd
edition, 2arcel
4ekker <nc., Eew Iork,H3#.
(. 7urrent 7oncepts in Pharmaceutical $ciences: :iopharmaceutics, $warbrick. !, 6ea
and ;ebiger, Philadelphia,HG0.
G. 7ilincal Pharmacokinetics, 7oncepts and Applications: :y 2alcolm 5owland and
Thomas, E. To.en, 6ea and ;ebrger, Philadelphia, HH&.
3. 4issolution, :ioavailability and :ioe/uivalence, :y Abdou 1.2, 2ack, Publishing
7ompany, Pennsylvania H3H.
H. :iopharmaceutics and 7linical Pharmacokinetics'An introduction -
th
edition 5evised
and e*panded by 5ebort ; Eotari 2arcel 4ekker <nc, Eew Iork and :asel, H3G.
0. :iopharmaceutics and 5elevant Pharmacokinetics by !ohn. =. Aagner and 2.
Pernarowski,
st
edition, 4rug <ntelligence Publications, 1amilton, <llinois,HG.
. @ncyclopedia of Pharmaceutical Technology, ,ol +, !ames $warbrick, !ames, 7.
5oylan, 2arcel 4ekker <nc, Eew Iork HH(.
URLE#
. @uropean !ournal of :io pharmaceutics and Pharmacokinetics, Publisher' @lsevier $cience,
www.elsevier.com.
#. <ndian 4rugs.
+. <ndian !ournal of Pharmaceutical $ciences.
-. http://www.columbia.edu/itc/gsas/gH(00/#00-/=ra.iano5eadings/4rugabs.pdf
&. http://www.google.co.in/urlJsaKt9rctK"9/KabsorptionL#0of
L#0drugs9sourceKweb9cdKH9s/iK#9vedK07=-B;"A<9urlKhttpL+AL#;
L#;daactarbhatti.weebly.comL#;uploads
L#;+L#;&L#;L#;(L#;+&(#0GL#;absorptionMofMdrugsMbyMdr.Msoban.ppt9eiK+0AiU<
'E3'srAfM<7w:g9usgKA;B"7E;0,"'*dw?p*8T.hk8hP1lm"s18g
(. http://www.iuphar.org/pdf/humM&&.pdf
G. http://www.synchronresearch.com/pdfMfiles/ba'be'trials.pdf
3. http://fip.org/files/fip/:P$/4issolution/;<PMAAP$M=uidelinesL#0forL#04issolution.pdf
H. http://www.dissolutiontech.com/4Tresour/#00G0#Articles/4T#00G0#MA0#.pdf
0. http://www.pharmpress.com/files/docs/clinicalMpharmacokineticsMsamplechapter.pdf
.http://rmipharmacokinetics.com/uploads/PublicM4ocuments/<ntroductionL#0To
L#0Pharmacokinetics.pdf
#. http://www.pharmpress.com/files/docs/clinicalMpharmacokineticsMsamplechapter.pdf
+. http://archive.a"pe.org/legacy/pdfs/a"(&0##.pdf
-. http://www#.courses.vcu.edu/pt*ed/m#/powerpoint/download/6ambL#04rug
L#04istribution.pdf
&. http://physiologie.envt.fr/spip/<2=/pdf/,olumesMofMdistribution.pdf
(. http://books.mcgraw'hill.com/medical/goodmanandgilman/pdfs/71APT@5+.pdf
G. http://el.trc.gov.om:-000/htmlroot/2@4<7A6/tcolon/pharmacology/=eneral/@'
:ooks/2etabolismL#0@*cretion.pdf
3. https://apps.who.int/chd/publications/referralMcare/referencepdf/&app#.pdf
PAPER IV- A/VANCES IN /RUG /ELIVERY SYSTEMS
GOAL
To train the students in the area of novel drug delivery systems.
OBJECTIVE
Upon the completion of the course, the student shall have an understanding of the need,
concept, design and evaluation of various sustained and controlled release dosage forms.
COURSE /ESCRIPTION
THEORY 34 Hour# 5 T:6Hour#/7.8
1 CONCEPTS O* CONTROLLE/ RELEASE /RUG /ELIVERY SYSTEMS
5Mar.# allo%!n% :648 5? Hr#.8
<ntroduction, concept, advantages 9 disadvantages. ;actors to be considered for designing
controlled release dosage forms. 4issolution, 4iffusion, 7ombination of dissolution and
diffusion controlled drug delivery systems. @valuation of 754;.
6. POLYMER SCIENCE 5 = Hr#.8
5Mar.# allo%!n% : 3 8
Polymer: <ntroduction, classification, general synthesis and evaluation techni/ues.
Appplication of polymers in drug delivery.
+. APPROACHES TO CONTROLLE/ /RUG /ELIVERY SYSTEM 5A Hr#.8
5Mar.# allo%!n% : 64 8
7lassification of rate'controlled drug delivery systems. 5ate'programmed release, activation'
modulated and feedback regulated drug delivery systems. @ffect of system parameters on
controlled drug delivery. 1ydrodynamically balanced systems, ?smotic pressure controlled,
p1 controlled, ion e*change controlled systems.
>. MUCO A/HESIVE /RUG /ELIVERY SYSTEMS 5 A Hr#. 8
5Mar.# allo%!n% : 93 8
7oncepts, advantages and disadvantages, structure of oral mucosa, transmucosal
permeability, theories of muco adhesion and muco adhesive polymers, mucosal membrane
models, permeability enhancers. 4evelopment and evaluation of buccal, nasal, pulmonary,
rectal, vaginal and ocular drug delivery systems and their applications.
3.TRANS/ERMAL /RUG /ELIVERY SYSTEMS 5? Hr#.8
5Mar.# allo%!n% : 93 8

5ationale behind transdermal drug delivery, Permeation through skin, factors affecting
permeation, basic components of T44$, formulation approaches used in development of
T44$ and their evaluation, permeation enhancers. <ontophoresis, sonophoresis and
magnetophoresis.
(. PARENTERAL CONTROLLE/ RELEASE /RUG /ELIVERY SYSTEMS
5Mar.# allo%!n%: 93 8 5 3 Hr#. 8
Approaches for in"ectable controlled release formulations. 4evelopment and evaluation of
<mplantable drug delivery systems, subcutaneous, intramuscular and intrauterine implants.
G. NANO /RUG /ELIVERY SYSTEMS 5 ? Hr#.8
5Mar.# allo%!n% : 63 8
;ormulation, development and evaluation of Eanoparticles' Polymeric nano particles, Eano
crystals, $olid 6ipid Eanoparticles %$6E), 2etal Eanoparticles. ,esicular $ystems'
6iposomes, Transferosomes, @thosomes, Eiosomes, ,irosomes. 7arbon Eano Tubes %7ET)
and 4endrimers. $afety issues related to nano drug delivery systems.
A. TARGETE/ /RUG /ELIVERY 53 Hr#.8
5Mar.# allo%!n% : 93 8
7oncept, advantages and disadvantages, types of targeting and applications. 2onoclonal
antibodies' hybridoma cell production, diagnostic and therapeutic applications D cancer and
autoimmune diseases. Problems related to monoclonal antibodies.
PRACTICALS 5T::Hour#/7.8
. 7omparative evaluation of marketed sustained release tablets and data treatment.
#. Preparation and evaluation of matri* tablets using natural polymers.
+. Preparation and evaluation of matri* tablets using synthetic polymers.
-. Preparation and evaluation of microspheres by solvent evaporation.
&. Preparation and evaluation of muco' adhesive microspheres by ionic gelation method.
(. Preparation and evaluation of microspheres by temperature change method.
G. Preparation and evaluation of microcapsules by wa* embedded method.
3. Preparation and evaluation of buccal patches.
H. Preparation and evaluation of buccal tablets.
0. Preparation and evaluation of transdermal films.
. @valuation of the effect of various permeation enhancers on transdermal drug delivery.
#. Preparation and evaluation of hydrodynamically balanced tablets.
+. Preparation and evaluation of ocular insitu gel.
SCHEME O* E;AMINATION
. $ynopsis ' #0 marks
#. @*periment
a) ;ormulation ' +& marks
b) @valuation ' #& marks
+. ,iva'voce ' #0 marks
To%al: 944 !ar.#
RE*ERENCES
. 7hien IA., Eovel drug delivery systems, #nd edition, revised and e*panded, 2arcel
4ecker, <nc., Eew Iork, HH#.
#. 5obinson !5., 6ee ,16. 7ontrolled drug delivery systems, 2arcel 4ecker, <nc., Eew
Iork,HH#.
+. !ohn Ailey and sons, <nc, @ncyclopedia of controlled delivery, @ditor'@dith 2athiowit.,
Published by Ailey <nterscience Publication, Eew Iork/7hichester/Aeinheim
-. !ain E8., 7ontrolled and novel drug delivery, 7:$ Publishers 9 4istributors, Eew
delhi,;irst edition HHG %reprint in #00)
&. ,yas $P., 8har 58., 7ontrolled drug delivery'concepts and advances, ,allabh Prakashan,
Eew 4elhi, first edition #00#.
(. <ndian Pharmacopoeia #00. ,olume'<, << 9 <<<, <ndian Pharmacopoeia 7ommission. Eew
4elhi.
G. United $tates Pharmacopoeia, U$ Publications, U$
3. :ritish pharmacopoeia
H. 1oward 7. Ansel, Eicholas =., Popovid loyd, Allen "unior :<. Pharmaceutical dosage
forms 9 drug delivery systems. Aaverly pvt, 6td, Eew 4elhi, $i*th edition
0. 6eon 6achman, 6ieberman, 8anig !6., Theory and Practice of <ndustrial Pharmacy,
,arghese Publishing 1ouse, :ombay, +
rd
@dition, H3G.
. :anker and 5hodes, 2odern Pharmaceutics, 2arcel 4ecker <nc., Eew Iork, #
nd
@dition,
HH0.
#. Ansel 17., <ntroduction to Pharmaceutical 4osage ;orms and 4rug 4elivery $ystems,
6ippincott Ailliams and Ailkins, Eew Iork, G
th
@dition, #000.
+. 5emington, the $cience and Practice of Pharmacy, 6ippincott Ailliams, #
st
@dition,
#000.
-. Patrick !. $inko. 6ippincott Ailliams and Ailkins. 2artinCs physical pharmacy and
pharmaceutical sciences. ;ifth edition.
&. Ailium Alfred 2artin P, :ustamante A1., 7hun. Physical Pharmacy, :. <. Aaverly Pvt
6td, new 4elhi, -
th
edition HH&
(. $.:harath. Pharmaceutical Technology'7oncepts and Applications, Pearson @ducation in
$outh Asia, ;irst edition, #0+.
JOURNALS
. <ndian !ournal of Pharmaceutical $ciences %<PA)
#. <ndian drugs %<42A)
+. !ournal of Pharmaceutical @ducation and 5esearch
-. 4issolution Technologies
&. !ournal of 7ontrolled 5elease %@lsevier $ciences), desirable
(. 4rug 4evelopment and <ndustrial Pharmacy %;rancis and Taylor) desirable
G. @uropean "ournal of Pharmaceutical sciences
3. @uropean !ournal of :iopharmaceutics
H. <nternational !ournal of Pharmaceutics
0. !ournal of Pharmaceutical $ciences
. 4A5U: !ournal of Pharmaceutical $ciences
#. Asian !ournal of Pharmaceutical $ciences
+. AAP$ Pharma $ci Tech
-. Advances in 4rug 4elivery 5eviews
&. 5a"iv =andhi !ournal of Pharmaceutical sciences
URLE#
http://www.pharmtech.com/
http://www.pharmacytimes.com/
http://pharmacie'globale.info/
http://www.pharmacy.org/
http://www.dissolutiontech.com/
http://onlinelibrary.wiley.com
http://www.uspharmacist.com
http://www.pharmpress.com/
http://www.elsevier.com/