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2 b
Prothrombin
G20210A Het/total
a
P
b
2 b
Total patients 4G/4G 23/114 4/113
4G/5G 40/151 9/146
5G/5G 29/90 0.15 3.9 6/90 0.55 1.2
A. Internal Organ 4G/4G 7/29 2/29
4G/5G 4/34 2/33
5G/5G 4/6 0.01 9.2 1/6 0.65 0.9
1. Portal Vein 4G/4G 1/16 1/16
4G/5G 1/15 1/14
5G/5G 1/2 0.12 4.3 0/2 0.93 0.2
2. Others 4G/4G 6/13 1/13
4G/5G 3/19 1/19
5G/5G 3/4 0.04 6.7 1/4 0.43 1.7
B. Deep vein 4G/4G 10/32 2/31
4G/5G 18/53 6/52
5G/5G 13/33 0.78 0.5 4/33 0.71 0.7
C. Cerebral 4G/4G 5/24 0/24
4G/5G 11/29 0/28
5G/5G 8/27 0.4 1.8 1/27 0.38 2.0
D. Retinal 4G/4G 0/25 0/25
4G/5G 4/26 1/24
5G/5G 2/21 0.14 4.0 0/21 0.39 1.9
E. Purpura fulminas 4G/4G 0/2 0/2
4G/5G 3/8 0/7
5G/5G 1/4 0.57 1.1 0/4
a
The variations in the total number of samples were due to unsuccessful genotyping of some individuals for the mutations
tested.
b
Statistical analysis was performed by
2
test in order to assess the significance of the co-existence of FV-Leiden or
prothrombin G20210A mutations with PAI-1 genotypes in each group.
92 Balta et al.
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4G/5G Polymorphism of PAI-1 Gene and Thrombosis 93