Académique Documents
Professionnel Documents
Culture Documents
Advantages
Components:
Solute
Solvent
Other exipients
Disadvantages
Flexible dosing
administration
No need to shake container
Facilitates swallowing in difficult cases
container breakages
dose on administration
Unsaturated solution
Oral solution
Supersaturated Solution
Otic solution
Ophthalmic solution
Topical solution
8/16/2014
Syrups
% strength
% w/w
%w/v
%v/v
Spirits
Aromatic waters
Ratio strength
Tinctures
Fluid extracts
agitation
CaCO3 + H2O
Simple solution
8/16/2014
astringent
Formulation:
Iodine active
Potassium iodide solubilizing agent
Purified water solvent
Concentrated alcohol
Dehydrated alcohol
Diluted alcohol
Rubbing alcohol
94.9 to 96%
99.5 %
49 %
70 %
Aromatic waters
Aqueous acids
Douche
Enemas
Mouthwashes
Gargles
Juices
Nasal solutions
Otic solutions
Irrigation solutions
8/16/2014
These
are
clear,
saturated
solutions(unless otherwise specified) of
volatile oils or other aromatic or volatile
substances.
Components
Volatile/aromatic substances active
Water vehicle/solvent
Talc clarifying/distributing agent
Methods
Characteristics
of Preparation
By Solution
By Distillation
By Direct Solution
2:1000
A method which saves time and dose not need a
special equipment
Example: Camphor water
By Alternate Method
Solution by intervention
15:1000
Most frequently employed, easiest and fastest method
of preparing aromatic waters
Example: Peppermint water and Cinnamon water
Other Methods
Use of soluble concentrates
Incorporation of solubilizing agents
Use of alcoholic solutions of volatile oils
Uses
Flavored vehicle
Perfumed vehicle
Examples:
Peppermint water USP
Stronger Rose Water USP
8/16/2014
Salting out
Principal problem encountered in
water
Latin name/s: Aqua cinnamoni
Use/s: Vehicle, antiseptic and carminative
Formulation:
Are
Oxyacids
Contain oxygen
Examples: HNO3, H2SO4, H3PO4
Preservation
Preparation
Concentration
of Acids
8/16/2014
Sample problem:
Make 100ml of Diluted Hydrochloric acid USP
Formulation:
8/16/2014
Preparation
Vaginal douches
DOs
in the administration
Are
aqueous,
pleasantly-flavored
solutions employed for their deodorant,
refreshing or antiseptic effect.
Use/s: Gargle
Formulation:
Phenol glycerin active
FDC Red #3 colorant
Purified water solvent
8/16/2014
Uses of mouthwashes
Therapeutic mouthwashes
formulated to reduce plaque, gingivitis, dental
caries, and stomatitis.
Cosmetic mouthwashes
formulated to reduce bad breath through the
use of antimicrobial and/or flavoring agents.
Humectants
Flavors
Flavors are used in conjunction with alcohol
and humectants to overcome disagreeable
tastes, at the same time flavors must be safe
to use.
Common flavorants used:
Components:
Alcohols
Surfactants
Used at a concentration of 0.1 to 0.5%
Functions
Solubilizing agent for flavors
Provides a foaming action
Examples
Polyoxyethyulene / Polyoxypropylene polymers
Sodium lauryl sulfate
Cetylpyridium chloride
Colorants
Used to enhance or to make the product
pleasing to the sight
FD&C colors
Peppermint
Spearmint
Cinnamon
Oil of wintergreen
Menthol
8/16/2014
solution
Latin name/s: Liquor aromaticus alkalinus, Liquor
antisepticus alkalinus
Use/s: Antibacterial mouthwash
Formulation:
8/16/2014
Acetic Irrigation
Use
for relief of internal cystitis
Glycine Irrigation
transurethral prostatic
resection
Ringers Irrigation
general irrigation
washing wounds
Uses
Cefazolin or Gentamicin
Anti-infective irrigation
5-Fluororacil
10