M

S. Vol. XX, No. 1-2, (1999) pp. 83-88

t'VJJ
7*
' C M l C A L S T U D Y tin Mi BRINGARAJA
KARPAM IN VELUPPU NOI
m-
K. Ganapathiraman
1
, J. Annathai
2
and K. Sivaprakasam
3
(Received on 2-11-99)
clinical study on Ay a Bringaraja
im in the treatment ofVeluppu Noi
inducted in I.P.D. level. A total
Her of 321 Veluppu Noi patients were
ted with the trial drug Ay a Bringaraja
m at a dose of260mgs. three times a
to evolve its therapeutic efficacy.
Periodical assessment and routine
oratory investigations such as Hb%,
PCV, MCV, urine and motion
inations were also carriedout. It has
observed that the Ranjaka Pitham
pihala Pitham have been mainly
I in Veluppu Noi patients. The trial
|gives a significant effect in the
ition of Veluppu Noi (A condition
or less similar in the hypochronic
icrocytic anaemia).
IK; *
i p:
Introduction
Veluppu Noi (anaemia) is one among
tbe common diseases, which predominently
seai in most of the people. Though the
Veluppu Noi (anaemia) is a symptom of a
disease as per modern aspect, the ancient
Siddhars included it as a disease in their
texts. In which, explains that this disease
also occurs due to Karma and it is also
called as Karma Noi.
In this clinical study it has been
observed that the Ranjaka Pitham and
Anala Pitham have been mainly affected
due to extrinsic and intrinsic factors. A
total number of 321 cases in both sexes
were studied in I.P.D. level. In a sequential
study Aya Bringaraja Karpam was taken
up for the clinical trial to evolve the efficacy
of the drug in Veluppu Noi.
Materials and Methods
A total number of 321 Veluppu Noi
patients were studied in I.P.D. level. Both
male and female patients having low
I. Research Officer
|L Asst. Research Officer
Assistant Director
begional Research Institute (Siddha), Central Council for Research in Ayurveda and Siddha, Govt.
barmacy (Ups) Indira Nagar, Pondicheny-6
83
K. GANAPATHERAMAN, et al.,
percentage of heamoglobin between 40%
and 60 % were admitted for the study,
laboratory findings were recorded before
and after treatment.
The patients were kept for observation
on the first day and they were given
Meganatha Mathirai was administred and
in the next day morning with hot water at
empty stomach according to the patient's
condition as a purgative. The patients who
were suffering from worms infestation were
given Murukkan Vithai Mathirai.
The trial drug Ay a Bringaraja Karpam
260 mgs. was administred three times a
day with honey. During the course of
treatment patients were carefully examined
and symptomatic treatment were also given.
Ordinary Indian diet was given containing
egg, meat, green vegetables and fruits.
Clinical progress was assesed by the
periodical laboratory investigation.
Results and observation :
In this clinical study it has been
observed that the various aspect such as
sex, age, Prakruthi, symptom wise
distribution, etc. The details of studies
given below in (Tables 1 to 7).
Table 1
Sex distribution in 321 cases of
Vellupu Noi
Sex Number of patients
Male
Female
119
202
Table 2
Distribution of 321 case of Vellupu Nc
in different age groups 1
Age group Number of
(age in years) patients ^
10-20
-ii
106
21-30 63
31-40 53 1
i-i
41-50

56
51-60 42
60 and above 1 J
Table 3

Classification of Prakruthi in 321 cases
of Vellupu Noi J
Prakruthi Number of ' "
patient v
Valha Udal
Pitha Udal
Kaba Udal
Thontha Udal
80
102
78
41
{
4
Table 4
Duration of illness in 321
Vellupu Noi case
i* .w;
4
Duration
(in months)
Number of
patient
T!
0- 1
1-4
5-8
9-12
More than 1 year
8
49
96
80
88
m

j j
iU
<1
84
CLINICAL STUDY Obi AYA BRINGARAJA KARPAM W VALUPPU NOI
3 * Table 5
wise classification of 321 cases
1
of VellupuNoi
Liii
Number of
patient
57
111
110
42
1
Table 6
W&M J..'
if Duration of treatment in 321
V n ; Vellupu Noi cases
it,
Number of
cases
'{'I <:.'*
29
56
87
80
54
12
3
Hi #
hi the present study, the incidence is
fli female patients than male patients.
bUgjhthis disease affects patients of
gfoup of people, but the incidence
iff the age group between 21-30
f
On observation of Prakruthi, it was
that more number of Pitha Udal
lehts were affected in this study. More
iber of patients had the illness in the
one year and above and the
Table 7
Signs and symptoms before treatment
of 321 Vellupu Noi cases
Signs and symptoms Number of patients
Pallor of the skin 315
Palpitation 286
Loss of appetite 301
Dyspnoea on exertion 136
Giddiness 280
Lassitude 226
Glossitis 102
Koilonychia
Enlargement of spleen
28
5
Table 8
Results of treatment in Vellupu Noi
j. . cases
Relief Number of cases
Complete ^ v 122
Moderate V 125
Mild 11
Lama 63
Total 321
maximum duration of treatment was given
for 7 weeks. The cordinal signs and
symptoms of the disease have been noted
in respect of all patients.
Results
The results of treatment were noted
accordingly to the effect of improvement
and the patients who had continued the
treatment for 3-4 weeks and a remarkable
85
K. GANAPATHIRAMAN, et al.,
improvement was noted in the patients.
The results are given at (Table-8).
Discussion
An attempt has been made in the present
study about the various aspects of the
Veluppu Noi from the view point of Siddha
concept. The trial drug Ay a Bringaraja
Karpam has been taken up to evolve its
efficacy in the treatment of Veluppu Noi,
which was prepared by IMPCOPS, Adayar-
Chennai, having the combination of herbs
and minerals. It was also noticed, that there
were more number of Pitha Udal patients,
in present study. The efficacy of the
treatment shows significantly well in
conformity with clinical observation of
signs and symptoms. Out of 321 patients
122 complete relief, 125 moderate relief,
11 mild relief and 63 patients had left
against medical advice. In this study the
mean haemoglobin value was 48.7% before
treatment and 72.6% after treatment.
It was observed that more number of
patients had pallor of the skin due to
derangement of Pirasaka Pitham and
Ranjaka Pitham. These two factors are
mainly responsible for the colour of the
skin and blood. Since the Ranjaka Pitham
is in the stomach it gives red colour to the
absorbed food material such as Rasa by the
intestine. Pirasaka and Ranjaka Pitham
have also been found affected in this
condition.
301 patients had loss of appetite due to
impairment of Analapitham, which, helps
in the digestion of food.
120 cases had dyspnoea on exerticjj
due to derangement of Pram V ^ f ^
oxygen. All the 131 patients had kg
number of red blood corpuscles who.ag
responsible to carry oxygen to van.
parts of the body. As the R.B.C. are less
Veluppu Noi patients, the transportation
oxygen is considerably reduced which
inturn leads to dyspnoea.
On observation of Seven UdalDhathus,
that all patients were subjected to
defficieney of Rasa Dhathu and Raktha
Dhathu. The deficiency of Raktha Dhathu
was found out through the signs pallor of
the skin, eye and nail beds. It was also
confirmed by the laboratory findings
th
the all patients showed low percentage,
HB and RBC.
When the digestion is impaired,
is less possibility for the formation of Rasa
Dhathu. Rasa Dhathu and Raktha Dhathu
are the basic factors for the formation of
other Dhathu. The Raktha Dhathu takes
place a vital role in Veluppu Noi.
Conclusion
In this study it is observed the
malnutrition is the main cause for Veluppn\
Noi. Poor socio economic conditions and
f-
excess bleeding during the menstrual cycle,
frequent delivery and worm infestation are,-
seen to be the main causative factors of this??
disease. The clinical study was made in-
various aspects with relevant factors. Thg
/S:
characteristic of Raktha Dhathu and Rasa,
Dhathu aiid- its formation have been
[CLINICAL STUDY ON AYA BRINGARAJA KARPAM IN VALUPPU NOI
plained in Siddha aspects. In this study
found that more female patients
|affected than males. The efficacy of
i treatment is well in conformity with the
ion of clinical signs and symptoms.
therapeutic value of Aya Bringaraja
irpam was also assessed. The results are
at (Table 8).
Acknowledgement
.
The authors are very grateful to the
Director, Central Council for Research in
Ayurveda and Siddha, New Delhi for his
encouragement & financial assistance.
Authors also thanks to Sh. V. Rajendran,
UDC and Sh. George J oseph, GDA for
their secretarial assistance.
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87
K. GANAPATHTRAMAN, et al.,
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