Siemens Avanto SQ (mr154) Full Description PDF

Operations Office:
11600 96
th
Avenue North
Maple Grove, MN 55369
Phone: 763-315-1947
Fax: 763-425-4709
www.dmsHealthTechnologies.com

Page 1 of 24
Equipment Description

Exhibit A

MR154 - Siemens MagnetomAvanto 1.5T MRI System

MAGNETOM Avanto System - The Siemens 1.5T MAGNETOM Avanto, the first Timsystem, is a revolutionary, high performance
whole body scanner and the optimal choice for highest patient throughput and best image quality through: Tim (Total imaging
matrix) technology, which shifts the spotlight onto a new and tremendously innovative RF systemand matrix coil technology.
AudioComfort for optimal noise reduction during image acquisition with world class gradients syngo, the Siemens unique multi
modality software providing innovative applications and workflow automation features. The system including magnet,
electronics and control roomcan be installed in 30 sqm space. The basic systemincludes for example: - Ultra-short 150 cm long,
whole-body superconductive 1.5T magnet with Zero HeliumBoil-Off technology - Actively Shielded water-cooled Siemens
exclusive gradient system - Digital RF Transmit and Receive System- RF Coils - High performance new host computer and image
processor - syngo MR software including Inline Technology, 1D/2D PACE, iPAT and Phoenix - TimApplication Suite including the
dedicated Neuro Suite, Angio Suite, Cardiac Suite, Body Suite, Onco Suite, Breast Suite, Ortho Suite, Pediatric Suite and
Scientific Suite. For system cooling either the predefined chiller option or the Separator is required. The MAGNETOM Avanto
system features the Tim Application Suite. The Tim Application Suite provides a complete range of clinically optimized
sequences, protocols and workflow functionalities for all clinical indications. Nine dedicated application packages are available:

Neuro Suite
Angio Suite
Cardiac Suite
Body Suite
Onco Suite
Breast Suite
Ortho Suite
Pediatric Suite
Scientific Suite

The high performance host computer and the image processor are ideally suited for even the most demanding applications. 30
m2 (325 ft) of space is sufficient to install the systemincluding magnet, electronics and control room. The system includes:

Magnet: Ultra-short 150 cm(4 11) long, whole-body superconductive 5th generation 1.5T magnet with active shielding (AS)
technology with counter coils, External Interference Shielding (E.I.S.) and excellent homogeneity (based on 24 plane plot, 50 cm
DSV typ. 0.8 ppm). The magnet has a helium capacity of 1,600 liters and a typical Heliumboil-off rate of 0 l/a during typical,
undisturbed clinical operation depending on the sequences used and examination time, and provided the systemis serviced in
regular intervals. It has an integrated magnet cooling system.

Gradient systemand AudioComfort: Prepared for actively shielded water-cooled worldclass gradient systemwith
AudioComfort. MaximumFoV is 50 cm.

RF Transmit/Receive System:

Compact water-cooled solid state RF amplifier with 15 kW peak power
Integrated electronics cabinet water cooling
Integrated circularly polarized Body Coil
The revolutionary Total imaging matrix that allows a huge number of coil elements to be seamlessly integrated into
one examination together with a large number of RF channels, optimized coil positioning and virtually eliminated coil
changing times.

RF Coils:

Head Matrix coil
Operations Office:
11600 96
th
Avenue North
Phone: 763-315-1947
Fax: 763-425-4709

Page 2 of 24
12-element design with 12 integrated preamplifiers, two rings of 6 elements each (i.e. 4 clusters of 3 elements each)
Operated depending on the Matrix Coil Mode as a 4-channel coil (CP Mode), 8- channel coil (Dual Mode) or 12-
channel coil (Triple Mode)
For applications like head examinations, MR Angiography, combined head/neck examinations, TMJ (temporo-
mandibular joints)

Neck Matrix coil
4-element design with 4 integrated preamplifiers, 2 clusters of 2 elements each
Operated depending on the Matrix Coil Mode as a 2-channel coil (CP Mode) or 4- channel coil (Dual Mode, Triple
Mode)
For applications such as Cervical Spine, Neck, Larynx/Esophagus, MR Angiography, Mediastinum, combined head/
neck examinations

Spine Matrix coil
24-element design with 24 integrated preamplifiers, 8 clusters of 3 elements each
Operated depending on the Matrix Coil Mode as an 8-channel coil (CP Mode), 16- channel coil (Dual Mode) or 24-
channel coil (Triple Mode)
For applications such as high resolution imaging of the whole spine, but also for various applications in combination
with additional coils

Workflow and Patient Handling- Tim Total imagingmatrix

Timprovides increased patient comfort and optimized workflow efficiency. Only one patient setup, no repositioning,
no changing of coils
Ultra-light-weight coils
Imaging with optimized surface coil quality
Software-controlled remote table move
Feet-first positioning for almost all examinations

Patient Table
Free-floating table with max. scan range of 154 cm (5 1) and max. patient weight including vertical movement of 250
kg (550 lbs). The tabletop travels approx. 52 cm(20.5) - resp. 103 cm (40.6) with the optional Tim Whole Body Suite
beyond the rear end of the system, for additional patient access.
Two ergonomically designed and positioned Tableside Control Units, integrated left and right into the front covers
The systemhas a large patient friendly 60 cm opening to enhance comfort for the patients. The systemis only 160 cm
long and thus gives a short and open appearance that can significantly help patients with claustrophobia or anxiety
about the MR examination. The cantilevered table design gives the systema light and unimposing appearance while
providing unobstructed foot space for attending staff and better access to the patient.

Patient PositioningAids - Comprehensive set of pads for comfortable and stable patient positioning together with safety
straps.

Patient Comfort facilities, Patient Communication - Ergonomically designed patient intercomsystem. Variable (3 levels)
ventilation and lighting inside the magnet bore.

Application packages:

Tim Application Suite: MRImaging- par excellence - The Tim Application Suite has a complete range of clinically optimized
examinations for all body regions. Excellent head-to-toe imaging can be accomplished with the sequences and features
included in this application suite. To enable comprehensive head-to-toe MR imaging, nine dedicated application packages
Neuro Suite, Angio Suite, Cardiac Suite, Body Suite, Onco Suite, Breast Suite, Ortho Suite, Pediatric Suite and Scientific Suite
have been included as standard applications.

Neuro Suite - Neuro Suite is part of the TimApplication Suite. Comprehensive head and spine examinations can be performed
with dedicated programs that are optimized for clinical examinations. High-resolution protocols and fast protocols for
Operations Office:
11600 96
th
Avenue North
Phone: 763-315-1947
Fax: 763-425-4709

Page 3 of 24
uncooperative patients are provided. Neuro Suite also includes protocols for diffusion imaging, perfusion imaging, and fMRI. It
includes for example:

EPI sequences and protocols for diffusion, perfusion and fMRI for advanced neurological applications.Diffusion
weighted imaging is possible with up to 16 bvalues in the orthogonal directions as well as multiple direction diffusion
weighting in 6 or 12 directions to generate data sets for diffusion tensor imaging.
Dynamic Analysis software (included in standard configuation) enables calculation of:
ADC maps
t-test maps fromthe EPI images for fMRI
Time-to-Peak maps for perfusion analysis.
3D isotropic resolution volume imaging using T1 3D MPRAGE / 3D FLASH, SPACE DarkFluid, T2 SPACE and 3D TSE.
Whole spine protocols acquire in multiple steps via software controlled table movement in a single click.
T2-weighted high-resolution 3D Restore protocols optimized for inner ear examinations.
2D and 3D MEDIC protocols for T2-weighted imaging particularly in C-spine transverse where reproducibility can be
difficult due to CSF pulsations and blood flow.
3D Myelo with 3D HASTE and 3D TrueFISP sequence for anatomical details
Dynamic sacro-iliac joint imaging using fast T1-weighted FLASH 2D sequence
Spine diffusion protocols with PSIF sequence.

Angio Suite - Angio Suite is part of the Tim Application Suite. Excellent MR Angiography can be performed to visualize arteries
and veins with or without contrast agent. This package includes:

Contrast-enhanced MRA
3D contrast-enhanced MRA protocols with or without iPAT for head, neck, thorax, abdomen, and peripheral regions
with the shortest TR and TE. Due to the strong gradients the arterial phase can be separated fromthe venous phase.
The ultrafast ce-MRA protocols avoid venous contamination.
CareBolus functionality for excellent results. It supports accurate determination of the Bolus arrival time and the
Stop and Continue real-time switching to the 3D ce-MRA scan protocol after the 2D bolus observation scan.
Excellent peripheral ce-MRA can be acquired with flexible coil combinations. Non-contrast-MRA and venography
2D and 3D ToF protocols for MRA for Circle of Willis, carotids, neck vessels, and breath-hold protocols for abdominal
vessels
Triggered 2D/3D ToF sequences for non-contrast MRA, particularly of the abdomen and the extremities
2D/3D phase-contrast
MR venography with 2D/3D ToF and phase-contrast
TONE (Tilted Optimized Non-saturation Excitation) and MTC techniques for improved CNR
Water-excitation 3D ToF protocol for better suppression of orbital fat Image processing and workflow features
MIP, MinIP, and 3D SSD (MaximumIntensity Projection, Minimum Intensity Projection, Shaded Surface Display)
Inline Subtraction and MIP for immediate results
Inline standard deviation maps of phase-contrast measurements for differentiating arteries fromveins. Software-
controlled table movements.

Cardiac Suite - The Cardiac Suite covers the complete application range frommorphology, ventricular and valvular function to
tissue characterization. It features the new BEAT tool. The utilization of triggering requires the optional PMU Wireless Physio
Control. This package includes:

Cardiac view creation with BEAT
Cardiac scouting provides a step-by-step procedure for the visualization and planning of typical cardiac views (short
axis, 4 chamber and 2 chamber views), based on e.g.TrueFISP or dark blood TurboFLASH.
Disease-oriented protocols are provided.
Morphology Heart and Vessel structure with BEAT
Various breath-hold techniques for strong contrast between the blood and vascular structures. Dark Blood TSE and
HASTE imaging are available for the structural evaluation of the cardio-thoracic anatomy, including vessels..
Ventricular Function, Valve Function and Wall Motion with BEAT
Tools for rapid evaluation of left or right ventricular function.
Operations Office:
11600 96
th
Avenue North
Phone: 763-315-1947
Fax: 763-425-4709

Page 4 of 24
Automatic adjustment of parameters to the current heart rate.
Use of the Physio Display for graphical triggering setup.
Retrogated Cine Imaging with TrueFISP or FLASH contrast.
iPAT integration for high temporal/spatial resolution.
Standard cine techniques for dynamic display can be used to visualize function of the heart valves (FLASH or
TrueFISP).
Tissue characterization with BEAT
Fast techniques for dynamic imaging with iPAT capabilities for the assessment of coronary heart disease. These
protocols allow the acquisition of multiple slices with high resolution, under stress and rest, with arbitrary slice
orientation for each slice (e.g. 3 short axis slices and 1 long axis slice).
TI scout for the optimization of contrast between tissues.
High contrast and high resolution tissue characterization.
Single Shot or segmented IR TrueFISP/TurboFLASH for tissue characterization with free breathing.
Robust and reproducible contrast between tissues with 2D phase-sensitive inversion recovery, eliminating the need of
TI adjustment (TrueFISP, TurboFLASH).

Body Suite - Body Suite covers your needs for clinical body applications. Ultrafast high-resolution 2D and 3D protocols are
provided for abdomen, pelvis, MR Colonography, MRCP, dynamic kidney, and MR Urography applications. Siemens unique 2D
PACE technique makes body imaging easy allowing for multi-breath-hold examinations as well as free breathing during the
scans. Motion artifacts are greatly reduced with 2D PACE Inline technology. This package includes:

Free breathing 2D PACE applications with 2D/3D HASTE (RESTORE) and 2D/3D TSE (RESTORE)
Optimized fast single shot HASTE protocols and high-resolution 3D RESTORE protocols based on SPACE and TSE for
MRCP and MR Urography examinations - Dedicated fat suppression protocols with Quick FatSat, STIR, SPAIR, FLASH
and HASTE in-phase and opposed-phase protocols as well as multi-echo TSE. DIXON - 2 point Dixon with 3D VIBE, the
following contrasts can be obtained: in-phase, opposed phase, fat and water image.
Dynamic 3D VIBE protocols for best visualization of focal lesions with high spatial and temporal resolution
High-resolution pelvic imaging (prostate, cervix)
Isotropic T2 SPACE 3D protocols for tumor search in the pelvis
Colonography bright lumen with T2-weighted TrueFISP and dark lumen with T1- weighted VIBE
Dynamic volume examinations with 3D VIBE
syngo REVEAL: diffusion imaging for liver and whole body exams (prerequisite: "Inline Diffusion" option)

Onco Suite - MR imaging has an excellent advantage of soft tissue contrast, multi-planar capabilities and the possibility of
selectively suppressing specific tissue e.g. fat or water. This helps visualize pathologies, particularly metastases. The Onco Suite
features a collection of sequences as well as protocols and evaluation tools that guide through a detailed screening of clinical
indications, such as in hepatic neoplasms. This package includes:

STIR TSE and FLASH in-phase and opposed-phase protocols with a high sensitivity to metastases visualization
Dynamic imaging protocols for assessment of the kinetic behavior for lesion visualization and characterization
Quantitative evaluation and fast analysis of the data with colorized Wash-in, Washout, Time-To-Peak, Positive-
Enhancement-Integral, MIPtime and combination maps with Inline technology or for offline calculation
Display and analysis of the temporal behavior in selected regions of interest with the included MeanCurve
postprocessing application. This includes the capability of using additional datasets as a guide for defining regions of
interest even faster and easier than before.
syngo REVEAL: diffusion imaging for liver and whole body exams (prerequisite: "Inline Diffusion" option)

Breast Suite - MR imaging has proven a very high sensitivity for breast lesions and is the gold standard for the examination of
silicone implants. Extremely high spatial and temporal resolution can be achieved in very short measuring times (e.g. 1 min) by
using iPAT with GRAPPA. Excellent soft tissue differentiation, customized protocols (e.g. with fat saturation or water excitation
or silicone excitation), as well as flexible multiplanar visualization allow for fast, simple and reproducible evaluation of MR
breast examinations. This package includes:

High-resolution 2D protocols for morphology evaluation.
High-resolution 3D protocols covering both breasts simultaneously.
Operations Office:
11600 96
th
Avenue North
Phone: 763-315-1947
Fax: 763-425-4709

Page 5 of 24
Protocols to support interventions (fine needle and vacuumbiopsies, wire localization).
Protocols for evaluating breasts with silicone implants.
Automatic and manual frequency adjustment, taking into account the silicone signal
Detection of the silicone signal either to suppress the silicone signal, if the surrounding tissue is to be evaluated, or to
suppress the tissue signal in order to detect an implant leakage.
SPAIR robust fat sat (robust fat suppression using a frequency selective inversion pulse)
DIXON - 2 point Dixon with 3D VIBE, the following contrasts can be obtained: inphase, opposed phase, fat and water
image.
iPAT with GRAPPA for maximum resolution in short time.
Inline subtraction and MIP display.
Offline subtraction, MPR and MIP display.
syngo REVEAL: diffusion imaging for breast exams (prerequisite: "Inline Diffusion"
option).

The Breast Suite also includes:

VIEWS(Volume Imagingwith Enhanced Water Signal)

bilateral both breasts are examined simultaneously
axial the milk ducts are directly displayed
fat-saturated or water-excited fat complicates clinical evaluation and is suppressed
isotropic 3D measurement the same voxel size in all three directions for reconstruction in any slice direction
submillimeter voxel highest resolution for precise evaluation

Ortho Suite - Ortho Suite is a comprehensive collection of protocols for joint and spine imaging. MR imaging is especially
suitable for avascular necrosis and internal derangements. The protocols included in this Suite can also be applied for imaging
of tumors and infections. This package includes:

2D TSE protocols for PD, T1 and T2-weighted contrast with high in-plane resolution and thin slices
3D MEDIC, 3D TrueFISP protocols with water excitation for T2-weighted imaging with high in-plane resolution and
thin slices
High resolution 3D VIBE protocol for MR arthrography (knee, shoulder and hip)
3D MEDIC, 3D TrueFISP, 3D VIBE protocols with water excitation having high isotropic resolution, optimized for 3D
post-processing
PD SPACE with fat saturation and T2 SPACE with high isotropic resolution optimized for 3D post-processing
Whole spine single-step or multi-step protocols
Excellent fat suppression in off-center positions, e.g. in the shoulder due to high magnet homogeneity
Dynamic TMJ and ilio-sacral joint protocol
Susceptibility-insensitive protocols for imaging in the presence of a prosthesis
Multi-Echo SE sequence with up to 32 echoes for the calculation of T2 time maps (calculation included in the Scientific
Suite)

Pediatric Suite - The parameters for pediatric imaging vary significantly in comparison to the parameters for adults. The reasons
are developing tissues, body size, faster heart rates and restricted compliance with breath-hold commands. This suite provides
dedicated protocols for pediatric imaging by age groups, for example, protocols for imaging tumors, malformations and
epilepsy in the brain, cardiac morphology as well as functional imaging and contrast enhanced MR Angiography. This package
includes:

Neuro
Brain protocols divided according to age groups and providing best contrast-to-noise ratio with optimized
parameters, for example, protocols for under 6 months old infants, protocols for infants between 6 months and one
year, protocols for toddlers between one and two years of age.
Excellent T1-weighted contrast with optimized TR, TE and flip angles
Protocols with MTC pulse for post-contrast T1-weighted imaging that provides excellent contrast-to-noise ratio
resulting in improved conspicuity of lesions/pathologies
Operations Office:
11600 96
th
Avenue North
Phone: 763-315-1947
Fax: 763-425-4709

Page 6 of 24
Cardiovascular
Cardiac morphology protocols according to age groups and optimized for a small FoV and faster heart rates in
congenital heart diseases (CHD)
Imaging protocols for ventricular function as well as valvular and septal defects
ce-MRA as an adjuvant in the assessment of congenital heart disease and vasculature

Scientific Suite - Scientific Suite supports the scientifically oriented user with an easy access to application-specific data for
further processing and advanced image computation methods.

Support of USB memory sticks
Access to the file system by means of a secure and convenient browser
Anonymization of patient data
Easy generation of AVIs and screenshots for integration into presentations and training videos
Export function for tables, statistics and signal-time-courses in a communal format (MeandCurve, Spectroscopy, DTI
evaluation)
Advanced image computation methods such as T2 and T1 time calculation, addition, subtraction, multiplication,
division, and integration of images

SPACE - SPACE is a variable 3D TSE sequence method with very long echo trains (>200). Tissue contrast is optimized through a
flip angle amplitude modulation over the course of the echo train adapted to the specific application. This also substantially
reduces SAR. T2, T1, PD conrasts as well as DarkFluid and BrightFluid contrast are possible. Due to the extremely high signal
efficiency of 3D technology, protocols with isotropic submillimeter resolution can be created (resolution within the slice =slice
thickness <1mm). The SPACE package includes 3D protocols for any body region (head, cervical spine, thoracic spine, lumbar
spine, pelvis, abdomen, MRCP, hip, knee) and for any contrast. The sequences, features and techniques for acquisition and
reconstruction included in the TimApplication Suite are described in detail below.

Sequences
Spin Echo (SE): Single Echo, Double Echo and Multi Echo (up to 32 echoes)
Inversion Recovery (IR)
2D/3D FLASH (spoiled GRE)
2D/3D FISP
2D/3D PSIF
PSIF Diffusion
2D/3D TrueFISP
Shared Phases Real-time TrueFISP
2D/3D MEDIC (Multi Echo Data Image Combination)
2D/3D TurboFLASH (MPRAGE)
3D VIBE (Volume Interpolated Breath-hold Examination) with interpolation and quick fat saturation
2D/3D TSE
Echo Sharing technique for dual-contrast TSE enhancing speed by using acquired echoes in both proton density and
T2 images simultaneously.
Speeds up dual-contrast TSE by almost a factor of 2
2D/3D RESTORE TSE
SPACE for 3D imaging with high isotropic resolution with T1, T2, PD, and dark fluid contrast
2D/3D TurboIR (TrueIR, STIR, Dark-Fluid-T1 and T2)
2D/3D HASTE (Half-Fourier Acquisition with Single Shot Turbo Spin Echo)
2D/3D HASTE IR for fat or fluid suppression
2D/3D Single Shot TSE for strong T2-weighting
2D/3D Time-of-Flight (ToF) Angiography, single- and multi-slab
2D/3D Time-of Flight (ToF), triggered and segmented
2D/3D Phase Contrast and multi-venc Phase Contrast Angiography
2D/3D Phase Contrast, triggered
ce-MRA sequences
BEAT Tool
Operations Office:
11600 96
th
Avenue North
Phone: 763-315-1947
Fax: 763-425-4709

Page 7 of 24
TrueFISP segmented
2D/3D FLASH segmented
Magnetization-prepared TrueFISP (IR, SR, FS)
IR TI scout
RetroGating
Single Shot-EPI (SE and FID)
2D/3D segmented EPI (SE and FID)
3D GRE fieldmapping

Tim Application Suite: Acquisition and Reconstruction Techniques

Diffusion-weighted imaging
Perfusion imaging
fMRI BOLD Imaging
1D/2D PACE (Prospective Acquisition CorrEction)
Whisper Mode for scanning with reduced noise; beneficial for children, noncooperative, or anxious patients
LOTA (Long TermData Averaging) technique for motion and flow artifact reduction without increasing scan time
Elliptical scanning reduces scan time for 3D imaging
Selectable centric elliptical phase reordering in the user interface for special applications
Inversion Recovery to suppress the fat or fluid signal and to obtain strongly T1- weighted image contrast
Dark-blood inversion recovery technique that suppresses blood signal
Saturation Recovery for 2D TurboFLASH, gradient echo, and T1-weighted 3D Turbo- FLASH with short scan time (e.g.
MPRAGE)
Presaturation technique: RF saturation pulses to suppress flow and motion artifacts. Up to six saturation bands may
be positioned in any orientation
Tracking SAT Bands maintain constant saturation of venous and/or arterial blood flow, e.g. for 2D/3D sequential MRA
Fat saturation: Additional frequency-selective RF pulses, used to suppress bright signal fromfatty tissue. Two modes
can be selected: weak, strong
Water saturation: All sequences used for fat saturation can be used to suppress the water signal
Quick FatSat
SPAIR robust fat sat (robust fat suppression using a frequency selective inversion pulse)
DIXON - 2 point Dixon with 3D VIBE, the following contrasts can be obtained: inphase, opposed phase, fat and water
image.
Fat excitation: Spectral-selective RF pulses for exclusive fat excitation
Water excitation: Spectral-selective RF pulses for exclusive water excitation
Silicone detection for breast examinations
Magnetization Transfer Contrast (MTC). Off-resonance RF pulses to suppress the signal from certain tissues, thus
enhancing the contrast, e.g. in MRA
TONE (Tilted Optimized Nonsaturating Excitation). Variable excitation flip angle to compensate inflow saturation
effects in 3D MRA. TONE pulses are selectable depending on the desired direction of flow sensitivity
GMR (Gradient Motion Rephasing): Sequences with additional bipolar gradient pulses, permitting effective reduction
of flow artifacts
Freely adjustable receiver bandwidth, permitting studies with increased signal-tonoise ratio
Freely adjustable flip angle: Optimized RF pulses for image contrast enhancement and improved signal-to-noise ratio
Half-fourier technique to further reduce the scan time (by approximately half), while maintaining the same spatial
resolution
Rectangular FoV capability from10%to 100%in steps of 1%, enables reduction in scan time by reducing the number
of phase encoding steps while maintaining the same in-plane resolution
Multi-Slice/Multi-Angle function: Scans in different planes can be acquired simultaneously in a single sequence, such
as for the acquisition of superimposed orthogonal survey images (Scout) or studies in the spinal region, in order to
image several vertebral disks exactly in their transverse orientation.

The MAGNETOM Avanto magnet:

Operations Office:
11600 96
th
Avenue North
Phone: 763-315-1947
Fax: 763-425-4709

Page 8 of 24
The 1.5 T MAGNETOM Avanto magnet utilizes a stainless-steel cryostat with proven structural reliability and excellent
behavior in minimizing artifact-inducing eddy currents.
Magnet length is only 1.50 mwhile the excellent homogeneity allows for 50 cmFoV imaging. This is unique for such a
short magnet and provides excellent image quality over a wide range of applications.
Homogeneity: Guaranteed <1.5 ppm Vrms (typ.: 0.8 ppmVrms, Vrms =Volume rootmean- square) in a spherical
volume diameter (DSV) of 50 cm using the most accurate 24-plane method with 20 sampling points per plane. The 24-
plane plot method measures the largest number of sampling points in the industry and provides accurate values that
are not subject to aliasing (which may occur with other plotting methods; the Vrms technique is more representative
than the older peak-peak methods).
The MAGNETOM Avanto magnet represents the 5th generation of actively shielded magnets with counter coils. The
magnet has patented External Interference Shielding (E.I.S.). E.I.S. protects against external interferences caused by
moving ferromagnetic objects (e.g. elevators, cars) and works continuously (especially also during scanning when you
need it most) to maintain premiumimage quality.
The magnetic 0.5 mT fringe field is 2.5 mradially (x, y) and 4.0 m axially (z) for easy siting, mostly even without
additional shielding.
The systemis equipped with Zero HeliumBoil-Off technology. During typical undisturbed clinical operation the boil
off rate is 0.0 l/a depending on the sequences used and examination time, and provided the system is serviced in
regular intervals. The heliumcapacity is about 1,600 liters.
Magnet weight: approx. 3630 kg. In many cases will allow siting on upper floors or older rooms without special floor
reinforcement.
Hybrid shimsystem: Active (with 3 electric linear shim channels) and passive shims for maintaining extremely high
homogeneity and excellent image quality over a wide range of applications. Online shimming is performed using 3D
shim, a patient and coil specific technique which optimizes the homogeneity for each patient in normally less than 20
seconds.

MAGNETOM Avanto Digital Radio Frequency System:

The digital signal processing system operates at 63 MHz resonance frequency and utilizes digital filtering, digital
quadrature demodulation as well as digital controls for RF amplitude stabilization for superior resolution and image
quality.
The RF transmitter incorporates a compact maintenance-free high-performance solid state 15 kW RF amplifier with
integrated water cooling.
The receiver operates over a very large 1 MHz bandwidth for outstanding sampling speed and high signal-to-noise
ratio. The high bandwidth enables fast imaging techniques including Single Shot EPI.
The transmit amplitude digitization resolution is 50 ns and the receive amplitude digitization resolution is 100 ns; this
ensures highest precision at maximum speed.
Dynamic gain control eliminates the need for receiver adjustments, thus saving up to 30 seconds for every study.
The systemhas built-in bandwidth flexibility which compensates for natural magnetic field drift for a period of up to 5
years, without the need for adjustments.

MAGNETOM Avanto - Table and Systemcontrols - Two ergonomically designed tableside control units (one on each side of the
magnet main face plate) at a comfortable level, control a number of patient table and system functions. Illuminated control
buttons:

Control buttons for vertical and horizontal table movement. Horizontal speed can be accelerated with an additional
Speed button. Transition from horizontal to vertical movement and vice versa takes place without intermediate
stop.
Table Stop button for immediate interruption of table move.
"Light Localizer" button activates and deactivates the laser light localizer for accurate patient positioning .
"Center Position" button for automatic table move of the selected location into the magnet isocenter after the laser
light localizer has been used for positioning. If the laser light localizer has not been used, the system automatically
centers to the center of the Head Matrix coil.
The "Home Position" button drives the table all the way out of the magnet, but not down. This will facilitate
repositioning the patient and will save time at the end of an examination.
Operations Office:
11600 96
th
Avenue North
Phone: 763-315-1947
Fax: 763-425-4709

Page 9 of 24
The "Fan" button controls the ventilation within the patient opening. The fan has 4 settings: off, low, medium, high -
The "Light" button controls the lighting within the patient opening. The light also has 4 settings: off, low, medium,
high
The "Scan Start/Stop" button starts a pre-loaded protocol. This is particulary useful, e.g. for breath-hold, when the
operator is inside the examination room.

MAGNETOM Avanto standard surface coils:

Head Matrix Coil - The Head Matrix Coil is a fully iPAT-compatible no-tune coil. It has a 12-element design with 12 integrated
preamplifiers that are arranged in 4 clusters of 3 coil elements each. The Head Matrix Coil can be operated depending on the
Matrix Coil mode as a 4-channel coil (CP mode), 8-channel coil (Dual mode) or 12-channel coil (Triple mode).

The upper coil part can be removed for better patient handling. The lower coil part, which can stay on the table for most
examinations, can be used without the upper part. The Head Matrix, Neck Matrix and Spine Matrix coils are smoothly
integrated into the patient table, thus enabling high flexibility in imaging and fewer coil changes and easy handling when
switching patients.

The Head Matrix Coil is equipped with two removable cushioned head stabilizers for stable and comfortable positioning of the
patients head. A detachable double mirror for increased patient comfort and reduced claustrophobic feeling is included. It
attaches to the upper part of the Head Matrix Coil and enables the patient to look out of the magnet even when his head is in
the center of the magnet. This double mirror design shows all objects in their correct up/down and left/right orientation. It can
also be used for visual fMRI studies.

The Head Matrix Coil can be used e.g. for head examinations, MR Angiography, combined head/neck examinations (in
combination with the Neck Matrix Coil) or for imaging of the TMJ (temporo mandibular joints).

A combination with the Neck Matrix and Spine Matrix Coil and the optional Body Matrix coils (up to 4) and PA (Peripheral
Angio) Matrix Coil is possible. Additionally, the combination of flexible coils like CP Flex coils is possible. The dimensions of the
Head Matrix Coil are 300 mm x 300 mmx 330 mm (L x W x H). Its weight is about 5 kg (11 lbs).

Neck Matrix Coil - The Neck Matrix Coil is a fully iPAT-compatible no-tune coil. It has a 4-element design with 4 integrated
preamplifiers that are arranged in 2 clusters of 2 coil elements each, and can thus be operated as a 2-channel (CP mode) or 4-
channel (Dual mode, Triple mode) coil. The upper coil part can be removed for better patient handling. The lower coil part can
remain on the table for most examinations. The Head Matrix, Neck Matrix and Spine Matrix coils are smoothly integrated into
the patient table, thus enabling high flexibility in imaging and fewer coil changes and easy handling when switching patients.

The Neck Matrix Coil through its easy combinability with the Head Matrix and Spine Matrix Coil can be used for applications like
neck or cervical spine examinations, imaging of the Larynx/Esophagus and Mediastinum MR Angiography, and combined
head/neck examinations. It thus replaces a neurovascular coil. Besides the typical combination with the Head Matrix and Spine
Matrix Coil, this coil can also be combined with the optional Body Matrix coils (up to 4) and PA (Peripheral Angio) Matrix Coil for
whole body imaging. Additionally, the combination with flexible coils like CP Flex coils is possible. The dimensions of the Neck
Matrix Coil are 190 mmx 330 mmx 332 mm (L x W x H). Its weight is about 2.6 kg (5.7 lbs).

Spine Matrix Coil - The Spine Matrix Coil is a fully iPAT-compatible no-tune coil. It has a 24-element design with 24 integrated
preamplifiers that are arranged in 8 clusters of 3 coil elements each, and is operated as an 8-channel coil (CP Mode), 16-channel
coil (Dual Mode) or 24-channel coil (Triple Mode). The Spine Matrix coil can remain on the table for most examinations. The
Head Matrix, Neck Matrix and Spine Matrix coils are smoothly integrated into the patient table, thus enabling high flexibility in
imaging and fewer coil changes and easy handling when switching patients. The Spine Matrix Coil can be used for high-
resolution imaging of the whole spine as well as for various other applications through its perfect combinability with the Head
Matrix and Neck Matrix Coil and also the optional Body Matrix coils (up to 4) as well as the PA Matrix Coil (Peripheral Angio)
and all flexible coils (e.g. CP Flex coils). The dimensions of the Spine Matrix Coil are 1185 mm x 485 mmx 33 mm (L x W x H). Its
weight is about 11 kg (24 lbs).

MAGNETOM Avanto Computer and Intercomsystem: The PC-based computer system uses the intuitive syngo MR user
interface. The computer and intercom system include the following components:

Operations Office:
11600 96
th
Avenue North
Phone: 763-315-1947
Fax: 763-425-4709

Page 10 of 24
High-performance image processor with dual processor 2 x AMD Opteron CPU generation with 2.6 GHz clock-pulse
rate, 8 GB RAM, one hard disk (36 GB) for systemsoftware and 4 hard discs for raw data storage (each 36 GB), one
CD/DVD ROM drive
1252 recons per second for online Fast Fourier Transformation (FFT) of a 256 matrix full FoV or 8694 recons per
second (256 FFT, 25%recFoV),
High-performance host computer with 2 x Dual Core Intel Xeon CPU with 2.66 GHz clock-pulse rate, 4 GB RAM, one 73
GB systemhard disk, one 73 GB hard disk for the database, one 73 GB hard disk for about 110,000 images (256 or
512 matrix, non-compressed), one CD/DVD-R writer for non-compressed image storage (CD approx. 4,000 images in
matrix 256, DVD approx. 25,000 images in matrix 256) on CD/DVD-R in DICOM standard (ISO 9660 Level 1) or
storage of other data like AVI files, a CD-ROM or DVD-R drive and an electronic mouse.
The combination of host computer and image processor offers a truly powerful imaging system designed for large
matrix sizes of up to 1024 x 1024. The unrestricted multitasking capability allows time-saving parallel scanning and
reconstruction,
High-resolution 19 color LCD flatscreen monitor with 1280 x 1024 pixel display, integrated gamma correction for
optimum display of radiographic grayscale images and automatic backlight control for longtermbrightness stability,
The intercom system includes an ergonomically designed patient communication unit for desktop positioning on the
syngo Acquisition Workplace control board and pneumatic headphones for the patient during examination. It controls
emergency table stop, volume control of speaker and headphones in the examination room, volume control of
speaker in the control room, response to the patient's activation of the assistance-call button and provides a
connection to an external audio system (external audio systemis not included in the basic unit) for music playback.

MAGNETOM Avanto syngo MR Software: MAGNETOM Avanto runs syngo MR software. syngois the unique software
platform for medical applications. It integrates all patient-related information, physiological and imaging data across the entire
clinical workflow. syngos innovative user interface allows the user to know intuitively what to do on every workplace. Its
intelligent automated functions accelerate your examination, enabling smooth, efficient workflow across modalities,
departments and people. Siemens brought intelligence to MR. With Inline technology, Phoenix, Intelligent Coil Control and a
variety of other features the system is geared for high patient throughput and highresolution scans with excellent image
quality.

The syngo-based, graphical user interface offers optimized clinical workflow. Parallel working and one-click exams are
efficiently supported.
Parallel scanning and reconstruction are standard. Images can be loaded and used for graphical slice planning during
reconstruction.
The task card approach enables structured workflow with multiple patients by easy image exchange between tasks.
In addition to the three segments of graphical slice positioning the user interface shows small reference views from
other series. The drag&drop functionality is fully supported. As soon as images are reconstructed they can be used for
slice positioning. Images can be automatically loaded into the User Interface and displayed in Movie mode (Inline
Movie).
Preset exam-oriented scan programs can be customized to meet clinical requirements in daily routine, and stored in a
hierarchical structure.
The unique Phoenix technique is the easiest way to exchange protocol data. It supports intelligent extraction of
sequence parameters fromimages acquired on a MAGNETOM Avanto system.
Software-controlled patient table movement by soft buttons or automatically within the scan protocols. Almost all
table control functions, including ventilation and illumination of the magnet bore, can be controlled fromthe
operator console.
With scan@center the table automatically moves into the magnets isocenter for measurement. This allows for
excellent image quality, especially with fat saturation.
iPAT image reconstruction is performed in minimum time due to high-performance computer hardware and the
optimized GRAPPA algorithm.
Automatic voice commands, e.g. for breath-hold examinations
The context-sensitive "Online Help" function and syngo Scan Assistant offer support and propose solutions to MR-
specific questions and parameter conflicts.
Intelligent Coil Control supports and automates the use and administration of receive coils:
Detection of the position of the fixed-position and flexible-position receive coils
Graphic display of the receive coil position within the images that are used for slice planning
Operations Office:
11600 96
th
Avenue North
Phone: 763-315-1947
Fax: 763-425-4709

Page 11 of 24
Graphic selection of receive coils directly fromthe syngo user interface
Automatic Coil Select: coils in the field of view are selected automatically.
In order to ensure an efficient work and measurement flow, many post-processing steps are performed automatically
via Inline technology during or directly after a measurement, e.g. calculation of subtraction images, MIP, standard
deviation, wash-in and wash-out maps etc.
1D/2D PACE (Prospective Acquisition CorrEction) the motion correction for examinations with breath-hold and free
breathing
iPAT (integrated Parallel Acquisition Techniques) further increase the acquisition speed compared with conventional
standard scan techniques. iPAT is fully compatible with the MAGNTEOM Avanto surface coils. Due to the Matrix coil
technology iPAT provides highest flexibility even for large scan ranges. The TimAssistant helps to make Parallel
Imaging easier by automatically recommending the appropriate PAT factor for the selected application. The Tim
Assistant always knows the selected coil elements and the MR protocol, ensuring the optimal iPAT configuration for
each application. The required calibration data is gained time- efficiently during measurement (Auto Calibration). For
PAT averagings to suppress motion artifacts, self-calibration is used without loss of time.iPAT image reconstruction is
performed in minimumtime due to high-performance computer hardware and the optimized GRAPPA algorithm.
The Image Viewing Card allows simultaneous management, viewing and processing of up to three patients or
comparisons of different studies or patients.
Dynamic Analysis evaluation software allows the calculation of functions such as addition/subtraction,
division/multiplication, ADC maps, T1 and T2, z-Score (t-Test), Time-to-Peak maps (TTP) and standard deviation.
Mean Curve can be used to evaluate dynamic examinations, e.g. employing contrast media.
The 3D Post-Processing Card includes the basic functionalities for manual MPR, MIP, MinIP and SSD image
reconstructions (Multiplanar Reconstruction, Maximum Intensity Projection, Minimum Intensity Projection and
Shaded Surface Display).
Efficient filming is possible directly fromthe different Task Cards and can be controlled by minimum user interaction.
There is a wide range of different film layouts with regular and irregular formats. The Mother and Child function
allows to display the position of the measured slice in a scout showing a small image in the upper right-hand or the
lower left-hand corner of the larger image (image within an image).
With the Patient Browser the images can be freely positioned on the film via drag&drop. Pan&zoomand windowing
of images on the filmsheet is also possible. (Camera is not included)
Supports storing of a viewing tool (DICOM Viewer) together with images on a DICOM CD to be handed out to the
patient.
Argus viewer can be used to display cine studies. Argus Viewer allows users to load a large list of dynamic data sets
and view them comfortably. This is a feature that greatly reduces the reading and review time for MR cardiac studies.
Additionally, an integrated 8 on1 movie provides efficient review of data.
AVI creation of movie loops (up to 4 on1) is possible.
Studies can be easily networked and managed using the standard DICOM 3.0 protocol for efficient support of
workflow. The following standard functions are supported: Send/Receive, Query/Retrieve, Basic Print for DICOM-
compatible laser cameras (camera is not included in the basic unit), DICOM Worklist, DICOM Storage Commitment
(SC).

I-class - I-class is the new generation of Tim-based MRI scanners, which enables innovative applications and workflow
efficiency. The I-class package comprises: - 3D Distortion Correction - MPPS - ImageFilter SW - PhoenixZIP - DICOM Study Split I-
class with the new syngo 64 bit SW architecture allows running new and faster applications. With I-class you can access a broad
variety of new applications covering all your needs, fromclinical routine to high end. I-class systems support your workflow at
the MR scanner. With intelligent functionalities that allows the communication of information from the MR to RISsystems. The
I-class package consists in detail of the following components:

Offline 3D distortion correction filter for high spatial accuracy e.g. for neuro intraoperative imaging, stereotactic
planning or radio therapy planning.
DICOM MPPS(Modality Performed Procedure Steps) for efficient organization of workflow within HIS/RIS systems.
MPPSallows to communicate examination data from the MR system to an information system (e.g. RIS system) and
to provide data for billing, documentation and planning purposes to the information system.
Image filter software for adaptive filtration of MR images. The image filter has three levels that can be changed
individually using the smoothing and edge enhancement parameters. The images can be filtered inline or offline, as a
Operations Office:
11600 96
th
Avenue North
Phone: 763-315-1947
Fax: 763-425-4709

Page 12 of 24
result of the inline filtration the filtered and unfiltered image will be displayed directly after measurement. With
offline filtration, individual or multiple images or series can be filtered. Filtration will be performed in the background.
PhoenixZIP (delivery with SW syngo MR B15) enables easy transfer of complete scan programs. Apart from protocol
data of the measured protocols, PhoenixZIP also includes their links to each other. So with PhoenixZIP it is possible to
precisely reproduce programs measured once and repeated examinations are efficiently facilitated.
DICOM Study Split (delivery with SW syngo MR B15) enables the distribution of an examination to different studies
directly at the MR scanner. With this functionality, different requirements e.g. for different anatomies, can be
measured time-efficiently in one examination and then stored in different studies for reporting.

Tim [76x18] SQ-engine - Tim[76x18] SQ-engine performance level Tim[76x18] is Total imaging matrix with 76 seamlessly
integrated coil elements, combinable to 18 RF channels. It is for demanding high-end applications and optimized throughput.
Tim[76x18] has flexibility in Parallel Imaging. Maximum SNR is ensured through the new matrix coil technology. SQ-engine
Gradient System with AudioComfort Siemens SQ-engine are actively shielded, water cooled strongest gradients with
AudioComfort. The SQengine is designed combining high performance and quietness.

Tim [76x18] performance level has
Up to 76 simultaneously connected coil elements which can be seamlessly integrated into one examination
18 independent RF channels (Analog/Digital Converters, ADCs) Combinations of receiving coils with up to 76 coil
elements in total can be connected simultaneously. They can be seamlessly integrated into the examination without
repositioning the patient or even changing a single coil. Up to 18 coil elements can be used simultaneously within one
scan.

The multi-element Matrix coil technology is an essential part supplementing Total imagingmatrix . The numerous matrix coil
elements enable advanced iPAT capabilities. Full iPAT applied throughout the large FoV without patient repositioning or
changing the coil setup improves throughput. Multi-directional, i.e. three dimensional, high-speed, high-resolution iPAT in the
head-feet, anterior-posterior or left-right directions benefit fromthe multiple coils and Matrix Coil modes. The user selectable
Matrix Coil Modes (CP, Dual and Triple Mode) enable a flexible operation of the Matrix Coils depending on the application
profile. iPAT with acceleration factors up to 4 (one direction) or 12 (in two directions with iPAT, optional) speeds up
acquisitions. The Tim Assistant provides ease-of-use and optimized iPAT settings.

SQ-engine Gradient Systemwith AudioComfort - Innovative integrated measures comprehensively reduce acoustic noise
without compromising strongest gradient performance. With AudioComfort, acoustic noise is reduced by up to 30 dB(A) as
compared to conventional systems. This is a reduction of 97%in sound pressure. Patients will benefit significantly fromthis
feature. All gradient demanding protocols using EPI techniques such as diffusion imaging, perfusion imaging or fMRI
examinations show a significant acoustic noise reduction. AudioComfort makes MR examinations a comfoable experience even
for children. AudioComfort prevents the necessity of implementing noise-absorbing measures to gain a comfortable noise level
for technicians and neighbors. The SQ-engine gradients have - Maximum gradient amplitude of 45 mT/m for longitudinal
direction and 40 mT/mfor horizontal and vertical direction, i.e. 72 mT/mvector summation gradient performance,

max. slew rate 200 T/m/s, i.e. 346 T/m/s vector summation,
minimal rise time 200 s, from 0 to 40 mT/m amplitude,
Max. output voltage for each of the gradient axes 2000 V
Max. output current for each of the gradient axes 625 A
Separate cooling channels that simultaneously cool primary and secondary coils allow the application of extremely
gradient intensive techniques in a new class of performance.
100%duty cycle for fast and demanding techniques such as ultra-short TE MRA in continuous operation, thin slice
single breath-hold liver studies and EPI imaging techniques (all optional in appropriate clinical packages).
Variable Field-of-View selection from0.5 cm to 50 cmfor optimumcoverage and highest resolution in diagnostics.
The minimumslice thickness in 2D and 3D is 0.1 mm and 0.05 mm, respectively.
Acquisition of sagittal, transverse, coronal, oblique and double oblique slices with highest resolution.
The extremely compact water-cooled gradient amplifier features a modular expandable design with excellent linearity
and pulse reproducibility. It is digitally controlled and has very low switching losses due to ultrafast solid state
technology.

Operations Office:
11600 96
th
Avenue North
Phone: 763-315-1947
Fax: 763-425-4709

Page 13 of 24
Label Tim [76x18] - Label on the front cover displaying the Timlevel of the system. The label displays: MAGNETOM Avanto Tim
[76x18]

PC Keyboard USEnglish - Standard PC keyboard with 101 keys. The keys of the numerical key panel are assigned to syngo-
specific functions and labeled with the corresponding syngo icons. The keyboard supports the country specific special
characters.

Standard Patient Matrix Table - The patient table is mounted directly to the magnet assembly. The table can support up to 250
kg (550 lbs) patients with unrestricted vertical and horizontal movement. The cantilevered table design gives the system a light
and unimposing appearance while providing unobstructed foot space for attending staff and better access to the patient. The
patient table can be lowered to a minimum height of 47 cm (18.5") fromthe floor, for easier patient positioning and better
accessibility for geriatric or pediatric patients. The tabletop travels beyond the rear end of the system, enabling additional
patient access. For a seamless integration of multiple surface coils 10 coil connector slots are embedded in the table.

4-channel Flex Coil Pckg- The 4-channel Flex Coil Kit offers a set of flexible coils with the capability for parallel imaging for easy
and quick examinations of a large variety of different anatomies. The following items are included:

4-channel Flex coil, large
Wrap-around coil made of soft and flexible material
Capable of parallel imaging with iPAT factors up to 2 (iPAT up to 4)
For applications such as imaging of large regions, e.g. medium to large shoulders, hip and knee
4-channel Flex coil, small
Wrap-around coil made of soft and flexible material
Capable of parallel imaging with iPAT factors up to 2 (iPAT up to 4)
For applications such as imaging of small regions, e.g. small to medium shoulders, wrist, elbow and ankle
4-channel Flex Coil Interface
For connection of e.g. the large or small 4-channel Flex coil

4-channel Flex Coil, large - Light-weight, very flexible, iPAT compatible, 4-element no-tune receiver coil made of soft and
smooth material. It is used for examinations of extremities (e.g. mediumto large shoulder, hip or knee) and for abdominal
examinations. The coil can be wound around or placed flat on top of the area of interest. This rectangular coil measures approx.
21 cm x 52 cmand connects to the Flex Coil Interface. The optional comfort kit enhances positioning flexibility and helps
minimize involuntary patient motion artifacts.

4-channel Flex Coil, small - Light-weight, very flexible, iPAT compatible, 4-element no-tune receiver coil made of soft and
smooth material. It is used for examinations of the upper and lower extremities (e.g. small to mediumshoulder, wrist, elbow or
ankle). The coil can be wound around or placed flat on top of the area of interest. This rectangular coil measures approx. 17 cm
x 36 cmand connects to the Flex Coil Interface. The optional comfort kit enhances positioning flexibility and helps minimize
involuntary patient motion artifacts.

4-channel Flex Coil Interface - Interface with 4 integrated preamplifiers for the connection of the following coils:
4-channel Flex Coil, large
4-channel Flex Coil, small
Loop Coil, large (optional)
Loop Coil, medium(optional)
Loop Coil, small (optional)

The interface is not permanently mounted and therefore allows free positioning of the flexible coils as required by the
examination procedure. The 4-channel Flex Coils can also be combined with a large variety of further coils, e.g.: All Matrix
coils, All flexible coils, or CP Head Array coil.

PMU Bluetooth Physio Control
Physiological Measurement Unit (PMU)\
Wireless Physio Control for wireless triggering, synchronizes the measurement with the physiological cycles of cardiac
and/or respiratory motion. Wireless technology for all sensors allows fast and easy patient set-up and comfort, and
Operations Office:
11600 96
th
Avenue North
Phone: 763-315-1947
Fax: 763-425-4709

Page 14 of 24
robust cardiac or respiratory signal transmission as it eliminates the need to attach cables to the patient. The
Wireless Physio Control contains wireless VCG, respiration and pulse sensors and a charging station as all sensors are
powered by rechargeable batteries. The physiologic signals are displayed on the console monitor. They can also be
displayed on the optional exam room PMU display.
Cable free signal transmission allows robust triggering and high patient comfort especially in cardiac imaging.
Wireless VCG acquires ECG signal from two projection directions, for easy identification of the R-wave with superior
gradient interference suppression via digital signal processing.
30 ECG - disposable electrodes are provided
Wireless red-light pulse sensor for peripheral pulse signal
Wireless pneumatic cushion to be placed on the chest or abdomen (for respiratory triggering)
Signals can be transmitted to an external MRI compatible patient monitoring system (Option) via a respective receiver
interface in the patient monitoring system
Wireless Physiological Signal Display
ECG (2 channels I and / or aVF)
Pulse
Respiration
External Trigger Input Display

Advanced Cardiac - This package contains BEAT, special sequences and scan protocols for advanced MR examinations of the
heart. It enables comprehensive cardiac MR examinations covering morphology, function, tissue characterization, coronary
imaging and plaque characterization. Combining the unique advantages of Tim and BEAT with iPAT and powerful gradients,
allows performing cardiac MR examinations without compromise in image resolution or acquisition speed.

Morphology Heart and Vessel Structure with BEAT - Dark-blood imaging with free breathing for high resolution
morphological imaging.

Ventricular Function, Valve Function and Wall Motion with BEAT
3D cine TrueFISP imaging for ventricular function assessment .
Arrhythmia rejection for VCG-triggered retrogated cine imaging with TrueFISP, supporting iPAT - no compromise in
image quality for patients with arrhythmia.
Radial imaging - no compromise in high spatial and temporal resolution.
Real-time radial imaging cine studies, e.g. for stress examinations.
Cine TrueFISP radial imaging.
Real-time cine TrueFISP imaging for triggered or non-triggered free breathing acquisitions, supporting iPAT.
Visualization of myocardial contractility using tagging techniques.

Tissue characterization with BEAT - 3D tissue characterization

Coronary Imagingwith BEAT - Dedicated sequences for high resolution 3D coronary artery imaging, providing free breathing
navigator (1D PACE) and breath-hold techniques and Whole-heart coronary imaging with CT-like results in only one
measurement.

Plaque characterization - High resolution techniques for plaque characterization

Flow Quantification - The Flow Quantification Package includes special sequences for quantitative assessment of flow. It
enables the acquisition of flow encoded images and the evaluation of blood as well as of cerebro-spinal fluid (CSF). Sequences
include:

ECG Triggered 2D phase contrast
Segmented 2D FLASH with echo sharing for breath-hold technique
Retrospective reconstruction algorithms for full R-R interval coverage
iPAT support
Maxwell Term Compensation
For quantitative flow analysis the Argus Flow option is required.

Operations Office:
11600 96
th
Avenue North
Phone: 763-315-1947
Fax: 763-425-4709

Page 15 of 24
Argus Flow MRC - Evaluation software for determination of flow properties in the blood vessel and Cerebrospinal Fluid (CSF).
The software has automatic segmentation capabilities for determination of regions. Output parameters include: peak velocity,
mean velocity, mean flow, total flow and more. The results are displayed graphically on the monitor and can be documented
and stored as DICOM images. Prerequisite: Syngo Argus Viewer. When reordering options, it is absolutely necessary that you
specify the following: Dongle ID (Hardware Identifier ), SystemSerial Number, and SystemPart Number.

Argus 4D Ventr.Function syngo - syngo Argus 4D Ventricular Function software processes MR cine images of the heart and
generates quantitative results for physicians in the diagnostic process. This new package includes the previous Argus Function
as well as Argus 4D Ventricular Function as a new Argus protocol. It provides volumetric cardiac data of an examined patient
fast and easily.

Argus Function:
Automatic, semi-automatic, or manual segmentation of the left and right ventricle.
Volumetric analysis and wall thickness analysis.
Output of parametric results, volume-time curves and bulls-eye plots.
DICOM Structured Reporting.

Argus 4D Ventricular Function:
Parametric results and volume-time curves are calculated and displayed online, based on the automatic creation and
adaptation of a 4D model of the left ventricle.
The resulting 4D model of the patients heart can be displayed superimposed on anatomical images as a reference in
a 4D viewer.

Inline Ventricular Function syngo - syngo Inline VF performs volumetric evaluation of cardiac cine data fully automatically right
after image reconstruction. There is no user input necessary. syngo Inline VF, a new member of the Inline family, brings
intelligent image analysis on the fly directly to the scanner. Inline results are displayed and stored to the data base. If desired,
inline calculated segmentation results can be loaded to Argus Ventricular Function for further review or processing.

Native syngo - This package contains sequences and protocols for non-contrast 3D MR angiographic imaging with high spatial
resolution. NATIVE allows imaging especially of abdominal and peripheral vessels and is an alternative to MR angiography
techniques with contrast medium, especially for patients with severe renal insufficiency. NATIVE provides:

MR angiography without contrast medium
Separate imaging of arteries and veins
Display e.g. of the renal arteries or extremity vessels

BLADE - Motion and flow insensitive multi-shot Turbo Spin Echo (TSE) sequence for all body regions with optional inter-shot
motion correction. BLADE supports T2-weighted, dark fluid and STIR contrast imaging as well as inversion recovery T1-
weighted imaging. BLADE uses an acquisition scheme which is less sensitive to motion and flow than the scheme used by
conventional TSE. In the head additionally a 2D (in-plane) motion correction can be used to further reduce artifacts resulting
from patient motion during the scan. Complete protocols for brain studies in uncooperative patients are provided including all
orientations and T2-weighted, dark fluid and STIR contrasts. Dedicated protocols for soft tissue/breast imaging are provided.

Composingsyngo - This application provides dedicated evaluation software for creating full-format images fromoverlapping
MR volume data sets and MIPs (starting from syngo MR B13) acquired at multiple stages. The option features:

Display and storage of full-format images, e.g. of the spine, the central nervous system or the vessel tree (starting
from syngo MR B13), combined from multiple overlapping stages. Dedicated composing algorithms, optimized for
the generation of anatomical or angiographic (starting from syngo MR B13) full-format images. Data sets with
different FoV, resolutuion, matrix and slice thickness can be combined (starting from syngo MR B13).
Generation of full-format images frominline MIPs (starting from syngo MR B13). Original, detail and reconstructed
images can be displayed in different layouts.
Comparison of two reconstructed images for evaluation and diagnosis is thus made possible.
Filming in different layouts is supported.
Measurements of basic functions via reconstructed images is then possible.
Operations Office:
11600 96
th
Avenue North
Phone: 763-315-1947
Fax: 763-425-4709

Page 16 of 24
Measurements of extended orthopedic functions: scoliotic angle, kyphotic angle, vertical distance measurement and
differences in width of the intervertebral spaces.
Prerequisite: SW syngo MR B13.

Inline Diffusion - Automatic real-time calculation of trace-weighted images and ADC maps with Inline technology. Compatible
to single-shot diffusion-weighted EPI.

Inline Technology ProcessingInstead of Post-processing. - Inline Technology helps to streamline the clinical workflow by
automating post-processing steps before image viewing. This facilitates getting clinical results immediately. This package
integrates Inline technology with diffusion imaging. Automatic real-time calculation of traceweighted images and ADC maps
with Inline technology is possible. An optimized EPI sequence for diffusion imaging is included in the standard TimApplication
Suite. In this package there are additionally special 1- and 3-scan Trace EPI with strong diffusion weighting and short echo times
with integrated post-processing for an ADC-Map and trace-weighted images.

Prostate Imaging: TSE, 3D SPACE and VIBE for morphological imaging and VIBE and syngo REVEAL for functional imaging are all
included in the basic package. In order to overlay the morphological information with the functional information, it is
recommended to use the Inline Diffusion and Image Fusion.

Arterial Spin Labeling- ASL is a non contrast enhanced brain perfusion technique. EPI sequence enhanced for PASL (Pulsed
Arterial Spin Labeling) with preparation module (inversion pulse, saturation pulses) and selectable prospective motion
correction. Perfusion-weighted color maps and relative cerebral blood flow (relCBF) color maps are calculated with Inline
technology. In combination with the BOLD licenses, spatial filtering and GLM statistics are applicable. ASL is a non contrast
enhanced brain perfusion technique. The measurement of relative CBF is being done by combination of an ASL preparation
module with the 2D multi-slice EPI sequence with full iPAT compatibility. Technically, the ASL module consists of a spatially
selective inversion pulse combined with different types of saturation pulses (slice presaturation, label slab saturation) and can
be classified under PASL (Pulsed Arterial Spin Labeling). Output quantities are a series of labeled and unlabeled images, a series
of inline calculated perfusion weighted color maps and a series of relative cerebral blood flow (relCBF) color maps. Prospective
motion correction and spatial filtering can be applied for inline calculation to improve the image quality. The technique is
compatible with the BOLD features spatial filtering and GLM statistics for perfusion or functional evaluation (prerequisite: BOLD
evaluation and imaging license).

Single Voxel Spectroscopy - Integrated software package including sequences and protocols for proton spectroscopy to
examine metabolic changes in the brain (e.g. in tumors and degenerative diseases). The Single Voxel Spectroscopy option is
used to measure proton spectra from single voxels. The spectra may show alterations in brain metabolism e.g. in brain tumors,
in degenerative changes of the brain and in metabolic diseases. The possibility of automatic adjustment, measurement and
evaluation permits near automatic spectroscopy measurements. The whole procedure, including the evaluation of the spectra
using the mandatory spectroscopy evaluation option, takes approx. 6 minutes and can be done by doctors or technologists.
The package comprises: - Single voxel measurement with Spin Echo and STEAM techniques:

Echo times down to 30 msec for Spin Echo and 20 msec for STEAM
Voxel size down to 0.5 cm3 (Range 5mm-40mm per direction)
Voxel can be freely angulated
Fully automatic adjustments including localized 3D volume shimming for optimized homogeneity of the volume of
interest
Optimized B1- and T1-insensitive water suppression with variable suppression bandwidth
New with SW syngo MR B15:
Spectral suppression (user definable parameter) to avoid lipid superposition in order to reliably detect e.g.choline in
the breast
Up to 8 regional saturation (RSat) bands for outer volume suppression can be defined by the user.
Physiological triggering (ECG, pulse, respiratory or external trigger) in order to avoid e.g. breathing artefacts.
Variable phase cycling
An online display allows monitoring of scan progress
All adjustments can still be performed manually with real-time guidance.
Optimized protocols for proton spectroscopy of the brain
Quality control using a FID techique is available to the user
Operations Office:
11600 96
th
Avenue North
Phone: 763-315-1947
Fax: 763-425-4709

Page 17 of 24

Spectroscopy Evaluat.syngo - The evaluation software is fully integrated in syngo MR. Evaluation protocols adapted to the scan
protocols carry out a complete and automatic evaluation of the measured data.
The following functions are included:

Subsequent water suppression with optional phase correction
Apodization
Zero filling
Fourier transformation
Base line correction
Automatic or manual phase correction
Curve fitting and peak labeling
Summaries in tabular form of the essential results specifying the metabolites, their position, integrals and signal ratios
in relation to a selectable reference.
Capability of exporting spectroscopy header information and data into a documented external format.
Automated peak normalization to tissue, water or reference
Dedicated evaluation protocols for SVSbreast (for 1.5T only!) For CSI the following functions are included: Spectra of
selected voxels are automatically calculated, corrected for possible B0
deviations and displayed.
Spectral fit is automatically optimized for each voxel
CSI data can be represented as spectral maps and colored metabolite images that can be superposed onto anatomical
images.

Advanced High Order Shim-- The 'Advanced High Order Shim' System includes 5 non-linear 2nd order electric channels for
precise additional fine-tuning of homogeneity once the patient is inside the system.

Chemical Shift Imaging- Integrated software package with sequences and protocols for proton chemical shift imaging (CSI) to
examine metabolic changes in the brain (e.g. in tumors and degenerative diseases) and in the prostate. The Chemical Shift
Imaging option is used to measure 2D and 3D proton spectroscopic data to generate metabolite images e.g. in brain tumors,
metabolic diseases of the brain and degenerative changes in brain metabolism. The whole procedure, including the generation
of metabolite images using the spectroscopy evaluation takes approximately 8 minutes (the evaluation package is required and
the license must be selected for the syngo Acquisition Workplace, syngo MR Workplace or the syngo MultiModality
Workplace). Optimized protocols for 3D CSI in the prostate are also included. The package comprises:

2D and 3D hybrid CSI measurement with Spin Echo and STEAM techniques
Echo times 30-300 msec for Spin Echo and 20-300 msec for STEAM
Repetition times 0,5-10 sec.
voxel size down to 2,5x2,5x5 mm3 in the three spatial directions
Field of View down to 80mm, matrix size between 8x8 and 32x32 voxels
volume can be freely angulated
Fully automatic adjustments including localized 3D volume shimming for optimized homogeneity of large volumes for
2D and 3D hybrid CSI
All adjustments can still be performed manually with real-time guidance (as i.e. interactive shimming).
Optimized B1- and T1-insensitive water suppression with variable suppression bandwidth
Optimized protocols for CSI brain examinations
Quality control using a FID techique is available to the user
Fully excited VoI (Volume of Interest)
Outer Volume Suppression (OVS)
Spectral Suppression

Mapit syngo - Based on the T1, T2 or T2* properties of the cartilage syngo ParametricMap allows the early detection of
osteoarthritic break down of cartilage structures even before morphological changes occur. The method supports therapeutic
decisions in individual patients and can be used to control treatments non-invasively, replacing surgeries or biopsies. The
assessment of T1, T2 and T2* properties of tissues in other body regions is also possible. syngo ParametricMap provides very
Operations Office:
11600 96
th
Avenue North
Phone: 763-315-1947
Fax: 763-425-4709

Page 18 of 24
fast 2D and 3D high resolution imaging sequences and the Inline calculation of parametric maps for the T1, T2 and T2*
properties of the imaged tissue. Features:

3D VIBE sequence for Inline T1 mapping
Multiecho spin echo sequence for Inline T2 mapping
3D Multiecho gradient echo sequence for Inline T2* mapping
iPAT compatibility
Protocols for Inline parametric mapping

Using iPAT the 3D sequences provide isotropic imaging extremely high resolution while maintaining clinical measurement
times. These data sets allow for the multi planar reconstruction of all planes. 3D is necessary to properly visualize the whole
articular cartilage since it typically has a complex shape. In addition the accuracy of isotropic high resolution 3D data sets is
superior because partial volume effects between e.g. synovial fluid and cartilage are minimized. For the visualization of the
parametric maps in the anatomical context the maps can be displayed as a colored overlay onto anatomical images using the
optional package syngo Image Fusion

CISS& DESS- Advanced 3D imaging sequences and protocols which are unique to Siemens: - 3D DESSand - 3D CISS.

3D DESS- for high-resolution 3D studies of joints with excellent T1 and T2 contrast. DESS is a double echo gradient sequence in
which a FISP (transversally rephased gradient echo) and a PSIF (RF-refocused gradient echo) echo are simultaneously acquired
and added, resulting in an increased signal-to-noise ratio.

3D CISS- for excellent very high resolution studies, especially useful in inner-ear examinations.
These Advanced 3D data sets provide very thin contiguous slices with high signal-to-noise ratio which are also well suited to
MPR post-processing along straight (oblique or double oblique) or curved lines. In some cases such as MR Myelography or inner
ear work, the MIP algorithm also provides very useful information.

syngo Expert-I - This software application enables support by remote staff (connected via network only) for planning and
processing. The option is integrated in the syngo user interface thus enables easy access to the user interface of the syngo
Acquisition Workplace for planning and processing support purposes. The access is protected by appropriate security
mechanisms (active enabling prior to every connection through the user present on site, password protection), in order to
prevent unwanted connections. The client software can be operated on any commercial PC with the following specification:
Operating system: Windows NT or XP, 32 bit graphics board, and 850 MHz CPU.

Body Matrix Coil - The new multi-element Matrix coil technology is an essential part supplementing the most innovative Total
imaging matrix. Matrix coils have multiple receive coil elements that can be clustered in groups. Each receive coil element is
equipped with a low noise preamplifier to maximize signal-to-noise ratio. The Body Matrix Coil features:

6-element design with 6 integrated preamplifiers, with 2 clusters of 3 elements each
Operated depending on the Matrix Coil Mode as a 2-channel coil (CP Mode), 4-channel coil (Dual Mode) or 6-channel
coil (Triple Mode)
Operates in an integrated fashion with the Spine Matrix coil (2 rings of 6 elements each =12-element design)
Can be combined with further Body Matrix coils for larger coverage
No coil tuning
iPATcompatible Applications:
Thorax (incl. heart)
Abdomen - Pelvis - Hip Can be combined with:
Head Matrix coil
Neck Matrix coil
Spine Matrix coil
Additional Body Matrix coils (typically 2-3 in total) for additional anatomical coverage
PA Matrix coil (Peripheral Angio Matrix; optional)
All flexible coils (e.g. CP Flex coil, small, CP Flex coil, large)
CP Head Array coil
Endorectal coils
Operations Office:
11600 96
th
Avenue North
Phone: 763-315-1947
Fax: 763-425-4709

Page 19 of 24

The Body Matrix Coil has a 6-element design with 6 integrated preamplifiers that are arranged in 2 clusters of 3 coil elements
each. Depending on the user selectable Matrix Coil Mode it is operated as a 2-channel coil (CP Mode), 4-channel coil (Dual
Mode) or 6-channel coil (Triple Mode). The Body Matrix Coil will be typically used together with the Spine Matrix Coil with
which it operates in an integrated fashion as 12-element design, creating 2 rings of 6 elements each. No tuning of the fully
iPAT-compatible Body Matrix Coil is necessary. For examinations where larger anatomical coverage is required, several Body
Matrix Coils can be used simultaneously. Up to 4 Body Matrix Coils can be used simultaneously, typically 2-3 will be used for
coverage of the entire abdomen or in the case of large patients. The Body Matrix Coil is typically used in combination with the
Spine Matrix Coil for examinations of the thorax, abdomen, pelvis or hip. The Body Matrix Coil can also be used for cardiac
applications. Through its perfect combinability with the Spine Matrix Coil, further Body Matrix Coils, the optional PA Matrix Coil
(Peripheral Angio Matrix), but also the Head Matrix and Neck Matrix Coil as well as all flexible coils (e.g. CP Flex coils, Endorectal
coils) it contributes for all large-Field-of-View applications including whole-body imaging. The dimensions of the Body Matrix
Coil are 322 mmx 520 mmx 4 0 mm(L x W x H). Its weight is about 2 kg (4.5 lbs), whereas the patient feels as little weight as
950 g (2 lbs).

Shoulder Array Coil - This iPAT compatible coil for examinations of the left or right shoulder consists of a base plate and two
receive array coil attachments available in different sizes, these will be attached and can be relocated on the basis plate. The
iPAT compatible receive shoulder array coil is adapted to the shape of the shoulder. To obtain maximum image quality for
different body shapes two different sized coil tops are included. 165 mm (6.5 in) diameter for small and medium sized
shoulders and 200 mm (7.9 in) diameter for large shoulders. The coil top can be used either for left or right shoulders. It
features slidable attachment to the base plate and can easily be adjusted for comfortable positioning. The coil excels in highest
resolution imaging with exceptional signal/noise ratio.

8-channel Knee Coil - The 8-channel Knee Coil is an iPAT compatible no tune receive coil for knee joint examinations. The
anatomically adapted coil is placed on a laterally movable holder and is capable to allow offcenter scanning with comfortable
positioning of both legs. The upper part of the coil can be removed for easy patient positioning. The 8-channel Knee Coil is
suited for iPAT to acquire highest resolution images with excellent SNR. Availability presumably 3rd quarter 2004 for
MAGNETOM Avanto and 2nd quarter 2005 for MAGENTOM Espree.

8-channel Foot/ Ankle Coil - The 8-channel foot-ankle coil is an iPAT-compatible no-tune receiver coil for the examination of
the foot and the ankle joint.

MR Console Tables and Containers

MR Workplace Table 1.2m- Table suited for syngo Acquisition Workplace and syngo MR Workplace based on syngo Hardware.
The table design matches the MED-wide uniform design with silver-finished rim, use of friendly colors matching the Siemens
color pattern for MAGNETOM and SOMATOM.

Width 120 cm
Depth 80 cm
Height 72 cm

MR Workplace Container, 50cm - 50 cmwide extra case for the syngo host computer with sliding front door to allow change of
storage media (CD/DVD/USB). The table design matches the MED-wide uniform design with silver-finished rim, use of friendly
colors matching the Siemens color pattern for MAGNETOM and SOMATOM. Table height 72 cm, matching the syngo
Acquisition Workplace and syngo MR Workplace console table, for installation in the operator roomeither directly to the left or
right of the syngo Acquisition Workplace or syngo MR Workplace console table or separately.

Width 50 cm
Depth 80 cm
Height 72 cm

Alternatively this casing is also suited for the Recon image processor (except for the MR systems with the new Tim generation:
there the Recon image processor is always placed inside the electronics cabinet).

Operations Office:
11600 96
th
Avenue North
Phone: 763-315-1947
Fax: 763-425-4709

Page 20 of 24
Cable Set syngo 11/9 - Cable length inside the cabin 11 m, cable length outside the cabin 9 m. Inclusive Ethernet Twisted Pair
Adapter and 10 m cable.

Armrest - An MR-compatible armrest that supports the patient's arm on the magnet patient table when starting intravenous
lines. The board is removed after the IV is inserted. This product has been tested and verified for compatibility with the
following Siemens' products: MAGNETOM Trio, Espree, Avanto and Symphony. Compatibility with other products cannot be
assured and may void service contracts and/or systemwarranties.

7-channel Breast Coil INVIVO - Avanto and Espree Systems Biopsy Breast Array coil to take advantage of 8 channel system
capabilities including parallel imaging applications. Open apertures provide for both lateral and medial access for MR breast
interventional procedures. Fully Integrated biopsy and immobilization kit, Head Rest and pad, patient comfort pad, phantom,
sample interventional instrument kit and Operators Manual are included. This product has been tested and verified for
compatibility with the following Siemens' products: Avanto and Espree 1.5T MR. Compatibility with other products cannot be
assured and may void service contracts and/or systemwarranties.

Diffusion Tensor Imaging- Single Shot EPI sequence for measuring diffusion-weighted data sets with up to 256 directions of
diffusion weighting. Based on these data sets, the diffusion tensor itself and parametric maps derived fromit (e.g. fractional
anisotropy) are calculated automatically and in real-time. The package supports both the clinical applications (e.g. diseases of
the white matter) and advanced research applications.

Single Shot EPI sequence for measuring diffusion-weighted data sets with diffusion weighting in more than 60 directions. Based
on these data sets, the diffusion tensor and parameter cards derived from it are calculated automatically and in real-time
(fractional anisotropy). The package supports both the clinical applications (e.g. diseases of the white matter) and advanced
research applications.

The Single Shot EPI sequence in the Diffusion Tensor Imaging package has been optimized for the measurement of data sets
allowing the evaluation of diffusion anisotropy in the brain. Efficient diffusion direction patterns are pre-defined to allow for
optimal diffusion direction resolution. Patterns with more than 60 directions can be selected.

Inline technology enables automatic and immediate calculation of the diffusion tensor, including the fractional anisotropy (FA)
of the image derived from it.

In order to further support clinical application, the inline diffusion functionality (mandatory item) has been integrated. Based
on the DTI measurement, trace-weighted and ADC images can also be calculated automatically and immediately. Details:

Measurements with more than 60 different directions
Measurements with up to 16 different b-values
Inline calculation of tensor, FA image, ADC image and trace-weighted image
Support of parallel imaging (iPAT)
Clinical protocols with full coverage of the brain, incl. inline calculation of tensor, FA, ADC and traceweighted images
in 4 minutes.

Diffusion Tensor Imaging allows for a complete description of the diffusion properties of the brain within the scope of the
tensor diffusion model, both for anisotropic and isotropic diffusion. The package is optimized for clinical application regarding
diseases of the white matter (e.g. Encephalopathia Diseminata, brain maturation disorders, displacement of nerve fiber tracts
through masses...). In connection with Tim technology, the package additionally offers the scientific user full flexibility of
measuring highly complex DTI data sets. Prerequisite: Software syngo MR 2006A

DTI Evaluation - Task card for advanced post-processing and visualization of Diffusion Tensor Imaging (DTI) data. DTI Evaluation
enables calculation of different diffusion parameter maps and joint ROI-based evaluation of parameter images and anatomical
images, as well as color-coded display and fused 3D visualization in the anatomical context.

Based on the tensor, in addition to the already inline-calculated parameter maps, further maps characterizing the anisotropy of
diffusion properties can be calculated and stored. The display options include 2D and 3D tensor graphics, color-coded images
and overlay images on the anatomical images.

Operations Office:
11600 96
th
Avenue North
Phone: 763-315-1947
Fax: 763-425-4709

Page 21 of 24
In fusion mode the color-coded diffusion images can be overlaid on an anatomical 3D image data set acquired in the same
examination. The overlaid image volume can be evaluated, displayed and stored in cut planes with any double oblique
angulation.

If the option syngo 3D Offline fMRI or Advanced Functional Neuro is available, the results of an fMRI experiment from
the same examination can also be displayed fused with DTI and anatomy.

Clinical application is supported by a dedicated DTI evaluation mode. Multiple diffusion parameter maps (e.g. Fractional
Anisotropy, ADC, b=0) and an anatomical image are displayed next to each other in the same slice position for comparison. The
images can be evaluated together based on ROI and the results can be documented in a table. The following parameter maps
can be calculated and displayed:

Measures of isotropic diffusion:ADC, trace-weighted, exponential ADC
Eigen vectors of the diffusion tensor:E1, E2, E3
Measures of anisotropic diffusion:
o Fractional Anisotropy (FA), Relative Anisotropy (RA),Volume Ratio (VR), E1-E3, E1-E2, E2-E3
o Shape-descriptive measures of the diffusion tensor:Linear, planar, spherical

Visualization options include:

2D/3D grayscale and color display.
2D/3D display with color coding of one preferred diffusion direction, e.g. Fractional Anisotropy image with color
coding of the direction of the first Eigen vector of the diffusion tensor.
Display of tensor as an overlaid graphic on parameter maps or anatomical images as an ellipsoid orcuboid (colored).
Overlay of parameter maps on anatomical images (if the syngo 3D Offline fMRI option or the Advanced
Functional Neuro option is available: also simultaneous overlay of fMRI results)

Documentation
Storage of parameter maps. Storage of all views. Storage of the result table of the common ROI-based evaluation of
parameter maps
Storage of multi-planar, double oblique reconstructed series fromoverlaid 3D visualizations (anatomy +diffusion
parameters)

The DTI Evaluation package with comparative side by side mode is optimized for clinical application to support diagnostics of
white matter diseases (e.g. multiple sclerosis, brain maturation disorders...).

In addition, the package offers the scientific user full flexibility of 2- and 3-dimensional visualization of the diffusion tensor with
measures of isotropic and anisotropic diffusion, Eigen vectors of the diffusion tensor and shape-descriptive measures of the
diffusion tensor. Prerequisite: Sofware syngo MR B13

DTI Tractography syngo - syngo DTI Tractography allows the visualization of multiple white matter tracts of the human brain
based on diffusion tensor imaging data. DTI Tractography is optimized to support the presurgical planning and to allow for
neuro physiological research with respect to connectivity and white matter pathology. The option syngo DTI Evaluation is a
prerequisite for DTI Tractography. - Advanced 3D visualization of white matter tracts in the context of 2D or 3D anatomical
datasets and DTI datasets (also fMRI results if the option "BOLD 3D Evaluation" is present) - Interactive QuickTracking displays
the tract originating from the mouse pointer position while moving over the DTI data set. -Texture Diffusion, a highly versatile
in-plane visualization of white matter tracts, allows to display and read DTI Tractography results on PACS reading stations and in
the OR. - Seed points for tracking with single ROI and with multiple ROIs to assess connectivity. - Tract and seeding ROI statistics
(mean/max FA value, min/mean/max ADC value, ...).

syngo DTI Tractography is optimized for the clinical use: DTI data sets can be explored fast and intuitively using the interactive
QuickTracking. This also allows identifying good regions to place seeding ROIs. Seeding ROIs can be placed in fused views
displaying the anatomical reference and e.g. the colored FA map simultaneously.

Operations Office:
11600 96
th
Avenue North
Phone: 763-315-1947
Fax: 763-425-4709

Page 22 of 24
At the same time the package provides the scientific user with the flexibility to configure the tracking algorithmand to change
display settings for the tracts.

All views can be exported as DICOM images or bitmaps. Tract and seeding ROI statistics can be exported as html files.

Inline BOLD Imaging- Inline technology enables the automatic real-time calculation and display of statistical (t-value) images
during the measurement of BOLD paradigms (including 3D motion correction and spatial filtration). The mosaic image format is
supported. Clinical protocols are prepared (e.g. motorized, visually). With Inline BOLD Imaging, functional brain mapping can be
optimally integrated into clinical routine, e.g. prior to neurosurgical interventions. This application makes great demand on the
temporal stability and/or B0 homogeneity of the magnetic field. In the mobile environment, ambient conditions may not always
be met, therefore application results may vary.

The advanced BOLD imaging package is based on blood oxygen level dependent (BOLD) contrast-sensitive single-shot EPI
sequences. The sequences allow the user to define protocols which, apart from the measurement, configure automatic
evaluation of the measured data during the scan. With Inline Technology it is thus possible to generate statistical images (t-
value) based on 3D motion corrected and spatially filtered data automatically in real time without any further user interaction.
Features:

Based on single-shot EPI imaging (multi slice)
Inline image reconstruction
MOSAIC image mode for accelerating display, processing and storage of images
Inline retrospective 3D motion detection and correction in 3 rotational and 3 translational directions (Advanced
Retrospective Technique ART, selectable)
Inline spatial filtering (selectable)
Inline t-statistics calculation for variable paradigms and display of t-value images
Starting from syngo MR B13: additionally improved statistical evaluation by means of General Linear Model (GLM):
paradigms can be configured
transitions between passive and active states can be modelled by the hemodynamic response function
correction of low-frequency trends
allows for time delays due to the BOLD-EPI slice order during a measurement
display of GLM design matrix
display of a continuously updated t-value card during measurement
display of activation cards continuously updated during measurement (t-value above configured threshold), overlaid
over the respective BOLD images using Inline technology
Clinical protocols are provided.

With Inline BOLD Imaging the processing steps (motion correction, ART, spatial filtering, t-test or GLM) are calculated
automatically with Inline Technology. With result images being generated without user interaction functional brain mapping
can be easily integrated into the clinical routine e.g. prior to neurosurgical interventions. The Inline display of activation cards
allows the user to decide during the scan whether enough statistical power has built up for his brain mapping task or if the
examination is corrupted by motion. As a result examinations will be shorter with a higher success rate.

3D PACE syngo - 3D PACE (Prospective Acquisition CorrEction) enhances Inline BOLD imaging with motion correction during the
acquisition of a BOLD exam. In contrast to a retrospective motion correction that corrects previously acquired data, the unique
3D PACE tracks the head of the patient, correcting for motion in real time during the acquisition. By tracking the patients head
3D PACE reduces motion resulting in increased data quality beyond what can be achieved with a retrospective motion
correction. As a result the sensitivity and specificity of BOLD experiments are increased. Features:

Real time prospective motion correction: Highest accuracy real time motion detection algorithm feeding a real time
feed back loop to the acquisition system with updated positioning information
3D motion correction for 6 degrees of freedom (3 translation and 3 rotation)
Motion related artifacts are avoided in first place instead of correcting for them retrospectively
Significant reduction of motion-related artifacts in statistical evaluations
Increased sensitivity and specificity of BOLD experiments

Operations Office:
11600 96
th
Avenue North
Phone: 763-315-1947
Fax: 763-425-4709

Page 23 of 24
BOLD 3D Evaluation syngo - BOLD 3D Evaluation syngo is the comprehensive processing and visualization package for BOLD
fMRI. It provides a full set of features for clinical fMRI, as well as advanced features for more research oriented applications.
This package provides statistical map calculations from BOLD datasets and enables the visualization of task-related areas of
activation with 2D or 3D anatomical data, allowing the spatial relation of eloquent cortices with cortical landmarks or brain
lesions. The unique inline function of BOLD 3D Evaluation merges, in real time, the results of ongoing BOLD imaging
measurements with 3D anatomical data. Additionally, evolving signal time courses in taskrelated areas of activation can be
displayed and monitored. Functional and anatomical image data can be exported for surgical planning as DICOM datasets
(syngo MR B13), additionally all color fused images and results can be stored or printed. Inline BOLD Imaging is a prerequisite
for BOLD 3D Evaluation. - Statistical map generation: paradigmdefinition, calculation of t-value (General Linear Model (syngo
MR B13) or t-test) - 3D Visualization: fused display of fMRI results, color tvalue maps on anatomical datasets - Inline 3D real
time monitoring of the fMRI acquisition - On-the- Fly Adjustment for t-value thresholding, 3D clustering, and opacity control -
Data export to neurosurgical planning software (syngo MR B13) - Analysis of Signal Time Courses - Data Quality Monitoring: B0
field map, Cine display of the BOLD time series (syngo MR B13). All tasks fromstatistical evaluation of the fMRI datasets to
reading and exporting results are supported by BOLD 3D Evaluation syngo:

Generation of statistical maps: In cases an inline calculated statistical map is not available a statistical map can be generated
easily using processing protocols. An intuitive editor UI allows the paradigmdefinition and offers the selection of head motion
correction, image filters and statistical evaluation. Predefined processing protocols and paradigms are available. They can be
edited and saved to create a user specific database of processing protocols and paradigms. The paradigmused for statistical
evaluation is saved with the statistical map.

General Linear Model - Starting from syngo MR B13: additionally improved statistical evaluation using a
General Linear Model (GLM) approach:

Transitions between passive and active states can be modeled by the hemodynamic response function.
Correction of low-frequency trends.
Allows for time delays due to the BOLD-EPI slice order during a measurement.
Output of a t-value map and the GLM design matrix used.

3D Visualization of fMRI Results

Overlay of color t-value maps on anatomical 2D and 3D datasets.
Visualization with 3D volume rendering.
Superimposing on cut planes through the volume.
If the DTI Evaluation option is available, the results froma Diffusion Tensor Imaging measurement from the same
examination can also be displayed together with fMRI results and anatomy.

Inline monitoringof the fMRI exam

During an ongoing BOLD imaging exam results are calculated (by Inline BOLD imaging) and displayed in real time.
The results are displayed and continuously updated as an overlay on online adjustable, free angulated cut planes
through the anatomical 3D data set.
The evolving signal time courses in task-related areas of activation can be displayed and monitored.

Tool for Pre-surgical Planning- The 3D display of functional brain mapping results allows a better understanding of the spatial
relationship between eloquent cortices, cortical landmarks and brain lesions like tumors. syngo BOLD 3D Evaluation helps to
present the fMRI results to the referring surgeon. If the DTI Evaluation option is available, DTI parameter images can also be
integrated in the fused display in order to be able to assess the tract shifts of white matter. SW version syngo MR B13 includes
dedicated multi planar reformatting and data export functions to neurosurgical planning software.

On-the-Fly Adjustment of the View

Instantaneous update of activation view after adjustment of the t-value threshold
Various activation color palettes.
Operations Office:
11600 96
th
Avenue North
Phone: 763-315-1947
Fax: 763-425-4709

Page 24 of 24
Online-adjustable 3D clustering: allows definition of the minimumdisplay size of clusters of activated voxels, thus
single voxels of activation, most likely not representing functional activation but noise, are suppressed.
Change of the degree to which anatomical structures shine through the overlaid activation.

Fly Through the Volume - Zoom, pan and rotate in 3D without noticeable delay. Free double oblique angulation of up to 6 cut
planes.

Analysis of Signal Time Courses

Interactive specification of volumes of interest (VOIs) on sectional images.
Calculation of the mean signal time course of all voxels in the VOI, the calculation may be restricted to activated
voxels.
Time courses are displayed instantaneously.
Individual signal time courses from up to ten VOIs can be displayed simultaneously.

Cine display of the BOLD time series (as of software version syngo MR B13)

Visualization of correction parameters used for inline motion correction or for subsequent motion correction with
Advanced Retrospective Technique (ART).
Cine display of EPI volumes in 3 orthogonal cuts for evaluation of non-corrected head motion.
Display of signal time courses of individual pixels.

Data Quality Monitoring- Based on the B0 field map, loaded automatically with the fMRI data, areas with less reliable results
are indicated.

Archiving& Distribution

Views in all view-ports can be saved, archived, and exported as DICOM images.
All DICOM images can be printed on film or paper printers, color printers are supported.
Views can be exported as bitmaps for, e.g., presentation purposes.
SW version syngo MR B13 includes dedicated multi planar reformatting and data export functions to neurosurgical
planning software.

Every attempt has been made to assure complete and accurate system specifications to the best of our ability. DMS Interim Solutions assumes
no responsibility for any unintentional errors or omissions.

Siemens Avanto SQ (mr154) Full Description PDF

Transféré par

Informations du document

Description originale:

Titre original

Copyright

Formats disponibles

Partager ce document

Partager ou intégrer le document

Options de partage

Avez-vous trouvé ce document utile ?

Ce contenu est-il inapproprié ?

Droits d'auteur :

Formats disponibles

Siemens Avanto SQ (mr154) Full Description PDF

Transféré par

Droits d'auteur :

Formats disponibles

Operations Office:

Vous aimerez peut-être aussi