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32) Explain the role of periportal & perivenous hepatocytes in the
regulation of blood ammonium levels.
Glutamine in the blood circulation is taken up by the periportal
hepatocytes,
Where it is converted to glutamate & NH
3
by glutaminase enzyme.
Glutamate reacts with OAA & produce KG & aspartate.
Produced NH
3
& aspartate enter the urea cycle.
NH
3
in the blood circulation is taken up by the perivenous
hepatocytes,
Glutamate in the perivenous hepatocytes reacts with NH
3
to
produce glutamine, in the presence of glutamine synthase.
Produced glutamine is released to the blood circulation where most
of it is taken up by the periportal hepatocytes.
Some amount of the glutamine produced in the perivenous
hepatocytes is diverted from liver to kidney to be used for
gluconeogenesis.
Amount diverted is more when acidosis occurs.
In the kidney,
glutaminase
Glutamine NH
3
+ Glutamate Glucose + HCO
3
-
+ NH
3