Tylenol (Acetaminophen) Questions and Drug Interactions from BJC HealthCare - BJC Help For Your Health - BJC

HealthCare

Font Size: S M

Home >> Prevention >> Ask the Pharmacist >>

Tylenol (Acetaminophen) Questions and Drug
Interactions

Recent Articles
Heart Disease Risk Assessment for Men
Heart Disease Risk Assessment for Women
How Many Calories Do You Need?
Exercise: Ways to Get Moving
Low-Fat Eating Tips
Low-Salt Eating Tips
Herb Guide

Related Links

Multivitamin Quiz
Herbal Supplement Quiz

The Prevention Institute

Centers for Disease Control
and Prevention
National Library of Medicine
Physical Activity and Health:
Surgeon General Report
American Academy of
Family Physicians: The
Exercise Habit
Diet, Nutrition and Eating
Right
Wellness/Healthy Lifestyle
U.S. Department of
Agriculture Food and
Nutrition
Missouri Department of
Health and Senior Services
Dental and Oral Health
Health at the American
Association of Retired
Persons
Health Effects of Common
Household Products

Tylenol (Acetaminophen) Questions and Drug Interactions

CAUTION:Limit your daily intake of acetaminophen to 3000mg to avoid liver
problems. Make sure all your health care providers have a complete list of your
medications, including over-the-counter medications, herbals and vitamins.
Can you take Aleve in the morning and Tylenol in the afternoon?
Yes. They may actually be taken together if needed.
Can I take Tylenol PM with methylprednisolone?
Yes. Take the steroid as instructed on the package, until finished. Normally this is taken
with food or milk to prevent stomach upset.
Can I take a cold medication like Tylenol Cold while taking nifedipine and HCTZ?
Yes. There are several formulations of Tylenol Cold. If you are
taking the nifedipine or
HCTZ for high blood pressure, and the Tylenol Cold product has a decongestant
(pseudoephedrine or phenylephrine), please contact your physician.
CanI take Tylenol with oxycodone?
Tylenol (acetaminophen) is already combined with oxycodone in a
Percocet tablet. So as
long as you are not allergic to either of these,
yes you may take them together.
Can I take Panadol Cold and Flu while on NeoClarityn?
Although a minor interaction is possible, these drugs are often
used together. You may feel
drowsy or more tired when taking these drugs together. Do not drive or operate
machinery until you know how these drugs affect you. Panadol Cold is the UK brand of
Tylenol Cold. NeoClarityn is the UK brand of Clarinex.

http://www.bjchealth.org/Tylenol[11/3/2014 7:06:03 PM]

Tylenol (Acetaminophen) Questions and Drug Interactions from BJC HealthCare - BJC Help For Your Health - BJC HealthCare
Can I take Tylenol Cold Nighttime with methylprednisolone?
There are no direct drug interactions between Tylenol Cold Nighttime (acetaminophen,
diphenhydramine) and methylprednisolone (Medrol).
Can I take Tylenol with codeine and fluconazole together?
Yes.
Can I take Allegra and Tylenol Sinus together?
Tylenol Sinus (acetaminophen, pseudoephedrine) may have several
different formulations.
If you have the pain/decongestant combination,

there are no direct drug interactions with Allegra (fexofenadine).

Can I take Tylenol PM while taking Xarelto, Cardizem anddigoxin for afib?
The Tylenol PM (acetaminophen w/diphenhydramine) has no direct drug interactions with
Xarelto (rivaroxaban), Cardizem (diltiazem) or digoxin (Lanoxin). Take these three
medications exactly as prescribed by
your physician.
Is it OK to mix acetaminophen and 10mg of Adderall?
There are no direct drug interactions between acetaminophen (Tylenol) and Adderall
(mixed amphetamine salts).
Can I take Tylenol Severe Cold and Flu after benzonatate?
There are two Tylenol Cold and Flu Severe products (Daytime and Nighttime). Neither of
these will interact with benzonatate.
Can I take Tylenol if I took phentermine in the morning?
There are no direct drug interactions between Tylenol (acetaminophen) and phentermine
(Adipex).
What is the difference between Tylenol extra-strength and Panadol?
Panadol and Tylenol are both brand names of acetaminophen.Panadol is usually found in
UK countries.Tylenol is found in the US.
I'm taking guaifenesin/codeine100 5ML. Isit OK to take Tylenol cold multisymptom?
There are several formulations of Tylenol Cold Multi-symptom Severe. Some have
antihistamines, some do not but all have dextromethorphan. There may be an interaction
with guaifenesin/codeine (Cheratussin AC). The interaction is due to increasing the chance
or severity of the side effects. The formulas with antihistamines can make this even
worse. You may feel drowsy or more tired when taking these drugs together.
CanI use Advil or Tylenol with Paxil, Klonopin and atenolol?
The Tylenol (acetaminophen) does not have any direct interactions with any of the other
medications. The Klonopin (clonazepam) does not have any direct interactions with any of
the other
medications. The Advil (ibuprofen) though, can interact with both the atenolol
(Tenormin) and the Paxil (paroxetine), although in a minor way.
The Advil, or any NSAID,
taken for long periods of time, can decrease the ability of the atenolol (or any blood
pressure medication) to control the blood pressure. If you check your own blood pressure
at home
and notice an increase in your blood pressure, contact your health care
provider.
Many people can use these medications together without any issues. Please be aware
there is a chance for unwanted problems. Continue to take your regular medications as
prescribed. Always keep your medication list current, including OTC products. Make sure
all of your health care providers have a current copy.
Can you take Tylenol Cold Multi Symptom Night Time Formula if you have taken
CheratussinAC?
There is a chance for an interaction between these two medications. You may feel drowsy
or more tired when taking codeine cough
syrups and antihistamines, like
chlorpheniramine, together. Although an
interaction is possible, these drugs are often
used together. If you have high blood pressure or heart disease, please speak to your

physician before taking any oral decongestant like phenylephrine.

http://www.bjchealth.org/Tylenol[11/3/2014 7:06:03 PM]

Tylenol (Acetaminophen) Questions and Drug Interactions from BJC HealthCare - BJC Help For Your Health - BJC HealthCare

I take Cymbalta 60mg. Can I take Tylenol or any type of cold medication?
Cymbalta (duloxetine) does not interact with Tylenol Cold: (acetaminophen,
chlorpheniramine, dextromethorphan, pseudoephedrine). The Tylenol product has the
fever/pain, antihistamine, anti cough, and sinus decongestant products all in one.
Can a person take Amoxil and Tylenol Cold Head Congestion together?
There are no direct drug interactions between Amoxil (amoxicillin) and Tylenol Cold Head
Congestion (acetaminophen, chlorpheniramine, dextromethorphan, phenylephrine). They
may be taken together if needed.
I took Claritin last night. Can I take Tylenol Cold Multi-Symptom Daytime the next
morning?
Tylenol Cold Multi-Symptom Daytime

(acetaminophen,dextromethorphan,pseudoephedrine) products do not contain

antihistamines. There would not be any interaction with the Claritin (loratadine) from the
night before.
Can I take Tylenol and Zoloft and then extra strength Reactine about 4 hours
later?
There are no direct drug interactions between Tylenol (acetaminophen), Zoloft (sertraline)
and Reactine (cetirizine).
Can you take TylenolPM with levofloxacin?
There are no direct drug interactions between Tylenol PM (acetaminophen
w/diphenhydramine) and levofloxacin (Levaquin).
Can I take Tylenol with daytime multi symptom daytime non drowsy tabs?
There are no direct drug interactions between Tylenol and the daytime multi symptom
products. If you have high blood pressure or heart
disease, many cold products contain an
oral decongestant (pseudoephedrine or phenylephrine). These products can constrict the

blood vessels and make your heart work harder and/or your blood pressure
to go up.
Can you take CheratussinAC with Tylenol PM?
There is an interaction between Cheratussin AC (guaifenesin w/codeine) and Tylenol PM
(acetaminophen w/diphenhydramine), but it is along the lines of duplication and
increasing the likelihood of side effects of these two medications. You may feel drowsy or
more tired when
taking these drugs together.
Can you take Tylenol Cold and Flu Severe and Midol Complete at the same time?
Both Tylenol Cold and Flu Severe (acetaminophen, pseudoephedrine, dextromethorphan)
and Midol Complete (acetaminophen, pamabrom, pyrilamine), as well as many other cold
products; contain acetaminophen (Tylenol). It is important to keep track of the total daily
amount of acetaminophen that you take. The next possible issue is if you have high blood
pressure or heart disease. Do not take cough, cold, flu and allergy products containing
pseudoephedrine with your blood pressure or heart medications without talking to your
health care provider.
CanI take Tylenol Cold and Sinus when I'm on metoprolol?
There is a drug interaction between Tylenol Cold and Sinus (acetaminophen,
dextromethorphan and pseudoephedrine) with metoprolol (Toprol or Lopressor). Do not
take these together without first speaking
to your physician.
I am taking benzonatate. Can I take Tylenol extra strength?
They may be taken together if needed.
CanI take Tylenol Sinus Congestion and Pain and Zyrtec together?
Zyrtec (cetirizine) and most forms of Tylenol Sinus Congestion and Pain both have
antihistamines. Do not take Zyrtec with other antihistamines without speaking to your
doctor.

http://www.bjchealth.org/Tylenol[11/3/2014 7:06:03 PM]

Tylenol (Acetaminophen) Questions and Drug Interactions from BJC HealthCare - BJC Help For Your Health - BJC HealthCare
Can I take Cipro 500mg and Tylenol Cold or Tylenol Sinus together ?
Some of the Tylenol Cold products have oral decongestants. If you have high blood
pressure or heart disease, please speak to your doctor before taking this type of product.
In theory, these drugs may interact in a beneficial manner. Generally, acetaminophen,

pseudoephedrine products, antihistamines and Cipro (ciprofloxacin) may be used together

with no adverse effects.
Can I take Tylenol and levofloxacin together?
Yes. Take the antibiotic levofloxacin until finished.
It has been 8 hours sinceI took a Tylenol #3. Is it safe to take a Lortab now?
Eight hours between doses is perfectly fine when alternating these two medicines. Both can
cause drowsiness.
Can you take Suprax 400mg with Tylenol Sinus Congestion/Pain?
Yes. There are no direct drug interactions between Suprax (cefixime) and Tylenol Sinus
Congestion/Pain (acetaminophen,chlorpheniramine,phenylephrine).
CanI take Ativan and Tylenol?
Yes. There are no direct drug interactions between Ativan (lorazepam) and Tylenol
(acetaminophen).
Can you take fluconazole with Tylenol extra strength or Midol?
There is a slight chance of an interaction between fluconazole (Diflucan) and some forms of
Midol that include ibuprofen (Motrin). The fluconazole may lead to increased blood levels
of ibuprofen. Side effects from ibuprofen may get worse if you take fluconazole. If you
notice new or worsening side effects such as stomach
pain or heartburn, bleeding,
difficulty passing urine or decreased urination, notify your health care provider. You may
want to just stick to the Tylenol while taking the fluconazole.
Can I take Tylenol Cold Multi-Symptom with Afrin?
Even though the Afrin (oxymetazoline) is a nasal spray/drop, there can be a severe
interaction with Tylenol Cold Severe Multi-symptom (acetaminophen, dextromethorphan,
guaifenesin, phenylephrine). Taking phenylephrine containing products with the

oxymetazoline can increase the risk of high blood pressure, nervousness,

palpitations,
problems with sleep or other serious side effects. You could try using saline nasal spray
(Ocean) to help open the nasal passages
What Tylenol, aspirin or Bayer product contains Dramamine and promethazine?
Tylenol (acetaminophen) and aspirin are each mixed with many different products but
neither are combined with promethazine (Phenergan) or either formulation of Dramamine
(dimenhydrinate or meclizine).
Can I take digoxin and Tylenol PM together?
Yes. The Tylenol product should be taken just prior to bedtime. Digoxin is normally taken
in the morning.

I'm taking ciprofloxacin 500mg. Can I take Tylenol with Codeine for pain?
Yes. Take the ciprofloxacin until finished, and the Tylenol with Codeine only as needed.
Would it hurt to take Tylenol with codeine just two hours after you took Tylenol
extra strength?
Tylenol (acetaminophen) is recommended to be taken no sooner than
everyfour hours,
but the major concern is keeping the daily amount of acetaminophen to be under
3000mg. If you are still having pain
and can take ibuprofen (Motrin), I would suggest
using a different pain
reliever.
Can I take acetaminophen and trazodone together?
Yes. Take the acetaminophen only as needed.

http://www.bjchealth.org/Tylenol[11/3/2014 7:06:03 PM]

Tylenol (Acetaminophen) Questions and Drug Interactions from BJC HealthCare - BJC Help For Your Health - BJC HealthCare
Can I take Tylenol 650mg twice a day and takeAleve, regular Tylenol and
Tramadolthree times a day?
Yes. In fact, there is a product that contains both Tylenol and tramadol.
CanI take Flexeril with Tylenol Sinus and Pain?
Yes. If you have high blood pressure or heart disease, speak to your doctor before taking
any oral decongestant like pseudoephedrine.
Itook Robitussin with codeine.I still have a headache. CanI take Tylenol?
Yes. They may be taken together if needed. Only take these as necessary.
Can I take Tylenol with Zantac?
Yes. They may be taken together if needed.
I am taking Zoloft. Can I take Tylenol?
There are no direct drug interactions between Zoloft (sertraline) and Tylenol
(acetaminophen). They may be taken together, if
needed. Limit the total daily amount of
Tylenol to 3000mg.
Can I take Tylenol Arthritis while I am taking colchicine for gout?
There are no direct drug interactions between Tylenol Arthritis (acetaminophen) and
colchicine. They may be taken together if needed.
Can I take Tylenol with milk?
Milk will not affect the absorption of Tylenol (acetaminophen) in any form.
Can I take Tylenol and a codeine cough syrup?

The most common side effect involves Central Nervous System depression:reduced
breath volume, drowsiness, sedation, confusion,
dizziness and even hallucinations.Next
would be GI disturbances: nausea, vomiting, stomach pain, heartburn and constipation.
Then you need to worry about liver function with the Tylenol.Limit the total daily amount
of Tylenol (acetaminophen) to 3000mg. If you have specific questions, talk to your
pharmacist or doctor.
I'm taking Flexeril 10mg. Afterfour hourscanI take Tylenol Extra-Strength?
Yes. They may be taken together.Flexeril (cyclobenzaprine) can cause drowsiness. Be
careful if you must be alert.
Limit Tylenol to no more than 3000mg in 24 hours.
CanI take acetaminophen while taking Flagyl 500mg?
Yes. They may be taken together if needed. Limit Tylenol
to no more than 3000mg in 24
hours, and take the Flagyl until finished with food or milk to prevent the bad taste that
this drug causes.
Can you take Tylenol Cold Multi-Symptom Nighttime if you took extra-strength
acetaminophenthree hours earlier?
Only take medications that treat symptoms you have.Limit your intakeof Tylenol
(acetaminophen) to 3000mg per 24 hours. The recommended dosing for Tylenol is no
more frequently than every 4 hours. Take only the drug you need, and keep 4 hours

between doses of any Tylenol product.

Can I take TylenolPM and Ambien if I'm having trouble sleeping?
Tylenol PM (acetaminophen with diphenhydramine) and Ambien (zolpidem) are both to
help you sleep. Do not take both the same day.You can alternate days -- MondayWednesday-Friday with one and
Sunday-Tuesday-Thursday-Saturday with the other.Take
both only asneeded, and take the prescribed amount. If you still have trouble, talk to
your doctor. There are several other things one can do to facilitate sleep.A lifestyle coach
may be helpful.
Can I take Tylenol with 500mg tablets of ciprofloxacin (Cipro)?
Yes. They may be taken together if needed. Ciprofloxacin
is normally taken on an empty
stomach. Take the antibiotic until completed and the Tylenol only when needed. Limit the

http://www.bjchealth.org/Tylenol[11/3/2014 7:06:03 PM]

Tylenol (Acetaminophen) Questions and Drug Interactions from BJC HealthCare - BJC Help For Your Health - BJC HealthCare
Tylenol to 3000mg per 24 hours.
What are apap-codeine drug interactions?
Generally speaking, apap with codeine (Tylenol with codeine) can interact with any
medication that may cause drowsiness or constipation. The codeine would increase both
of these problems.If you take any medication that can irritate the stomach or GI tract,
again the codeine can increase these effects. The recommended daily limit for Tylenol
(acetaminophen or APAP) is 3000mg.
Can Tramadol, Tylenol #3 and Benadryl be taken together?
There are interactions between all of these medications.
Tramadol (Ultram), Tylenol #3
(acetaminophen with codeine) and Benadryl
(diphenhydramine) all cause drowsiness. You
may feel drowsy or more tired when taking these drugs together. Do not drive or operate

machinery until you know how these drugs affect you. If you notice slurred speech,
confusion, severe weakness, seizures, difficulty breathing, decreased pain relief, increased
nausea, vomiting, dizziness,
constipation, tremor or other unusual effects, contact your
physician immediately. Limit your daily intake of all Tylenol products to 3000mg.
CanI take a Tylenol with clarithromycin 500mg?
There are no direct drug interactions between Tylenol and clarithromycin (Biaxin). They
may be taken together. Take clarithromycin until finished. Take it with food if your
stomach becomes
upset. Limit the Tylenol to not more than 3000mg per day.
Can I take Tylenol Sinus and Phenergan?
Yes. They may be taken together. Take only as needed. Phenergan can cause drowsiness.
If you have high blood pressure or heart
problems, talk to your doctor before taking any
oral decongestant like pseudoephedrine.
Can I take Tylenol PM and vitamins at the same time (vitamins: joint soother,
omega 3 fish oil, c-100mg, beta-carotene, and E-400iu)?
There are no direct drug interactions between Tylenol PM
(acetaminophen with
diphenhydramine), and these vitamins and supplements. Take Tylenol PM only as needed
andwhen you are ready for sleep. Limit the daily amount of Tylenol to no more than
3000mg.
CanI take Tylenol with metoprolol?
Yes. They may be taken together. Take no more than 3000mg Tylenol per day.
Can you mix Tylenol Body Pain, Crestor and aspirin 81mg daily low-dose
together?
Although an interaction is possible, these drugs are sometimes used together. While the
combination of Tylenol and aspirin (or any salicylate) is helpful to treat pain, kidney side
effects are possible with high doses or long-term use. Limit the daily intake of Tylenol to
3000mg. Crestor (rosuvastatin) can be taken with either of these. One side note: Tylenol
Body Pain is nothing more than 650mg of acetaminophen (2 regular strength Tylenol or
generic).
Does acetaminophen affect sinus function?
No.Acetaminophen (Tylenol) is a pain- and fever-reducing medication. It does not affect
any sinus function.
Does Tylenol elevate blood sugar?
Tylenol does not affect blood sugar readings. You may take Tylenol if you are diabetic.
Take no more than 3000mg Tylenol per 24 hours.
Can I take Tylenol Flu and cephalexin?
Yes. They may be taken together. Take the cephalexin until complete and the Tylenol
product only as needed.
Can I take Tylenol Cold PM with melatonin, Flexeril and mefloquine?

http://www.bjchealth.org/Tylenol[11/3/2014 7:06:03 PM]

Tylenol (Acetaminophen) Questions and Drug Interactions from BJC HealthCare - BJC Help For Your Health - BJC HealthCare
Flexeril (cyclobenzaprine) is a problem with both Tylenol Cold PM (acetaminophen,
chlorpheniramine, dextromethorphan, phenylephrine) and mefloquine (Lariam). The
interaction with the Tylenol
product can cause more drowsiness, dry mouth and difficulty
with urination. The problem with the antimalarial is possible heart problems.
Taking these
drugs together can increase the risk of a dangerous change
in heartbeat or heart rhythm.
Talk to your doctors regarding your medications. They may already be monitoring your
heart functions.
Can you take Tylenol Extra-Strength when you are on phentermine?
Yes.
Is it okay to take Tylenol when I have taken Aleve?
You may take them together, but I would suggest alternating the doses with at least 2
hours between the drugs. Take Aleve with food or milk and limit Tylenol to no more than
3000mg per day.
Can I take Tylenol Sinus Congestion and Pain with Loratadine Severe Allergy and
Head Cold?
The issue with taking both Tylenol Sinus Congestion and Pain (acetaminophen,
chlorpheniramine, phenylephrine) with loratadine (Claritin) is the duplication of
antihistamines. Chlorpheniramine is a short-acting, possibly sedating antihistamine, and
loratadine is a long-acting nonsedating antihistamine. You may feel excessive dry mouth

and possibly increased drowsiness taking both. If you only have allergy symptoms, stick
with loratadine. If you have pain, fever or congestion, just take the Tylenol product. Take
both only as needed.
Can Itake Tylenol PM with tizanidine?
You could feel drowsy or more tired when taking these drugs together, because of the
diphenhydramine in Tylenol PM (acetaminophen with diphenhydramine).Do not drive or
operate machinery until you know how these drugs affect you.If you take plain Tylenol,
there are no problems.
CanI take Tylenol Extra-Strength Rapid Release Gels with Paxil and Klonopin?
Yes. They may be taken together if needed.Klonopin can cause drowsiness.
Can I take Tylenol #3 with Extra-Strength Tylenol?
Yes. Thereare no interactions between plain Tylenol (acetaminophen) and Tylenol #3
(acetaminophen with codeine).Limit your dailyconsumption of acetaminophen to 3000mg
or less.
Ihave a sulfa allergy. Is it safe to take RobitussinDM with Tylenol?
Yes. They may be taken together with plenty of water.The sulfa allergy poses no problem
with either.Limit the Tylenol to no more than 3000mg/day, and drink plenty of water with
the Robitussin.
Can I take Tylenol PM and a CVS brand Cold and Sinus Relief medicine together?
If the ingredients of the CVS Cold and Sinus product are
ibuprofen and pseudoephedrine,
there are no direct interactions with Tylenol PM (acetaminophen with
diphenhydramine).Take any NSAID like ibuprofen with food or milk to avoid stomach
upset.If you have high blood pressure or heart problems, you should avoid oral nasal

decongestants, like pseudoephedrine. Limit the daily amount of acetaminophen to

3000mg.Take both of these only as needed.
Can I take Tylenol #3 with Sudafed?
There
are no direct drug interactions between Tylenol #3 (acetaminophen with codeine)
and Sudafed (pseudoephedrine).They may be taken together.
CanI take TylenolPM if I'm taking atenolol 100mg?
Yes. There are no direct drug interactions between Tylenol PM (acetaminophen with
diphenhydramine) and atenolol (Tenormin).They may be taken together at bedtime.

http://www.bjchealth.org/Tylenol[11/3/2014 7:06:03 PM]

Tylenol (Acetaminophen) Questions and Drug Interactions from BJC HealthCare - BJC Help For Your Health - BJC HealthCare

I'm taking chlorpheniramine/hydrocodone. CanI take Tylenol for fever?

Yes. There are no direct drug interactions between chlorpheniramine/hydrocodone
(Tussionex) and Tylenol.They may be taken together. Limit Tylenol to no more than
3000mg per day. Takethe cough syrupno more than twice daily.This may cause extreme
drowsiness, so be careful if you must be alert.
Can I take Tylenol Cold with amphetamine salts?
No. Tylenol Cold (acetaminophen, chlorpheniramine, dextromethorphan, pseudoephedrine)
has a severe interaction potential with amphetamine salts and any related drug.
Itook Tylenol Sinus at 10 am. It is now
6 p.m., andI have fever. CanI take
Tylenol Extra-Strength Rapid Release Gels?
Yes. You may take the Extra-Strength Tylenol (acetaminophen) within 6 hours of the
Tylenol Sinus (acetaminophen with pseudoephedrine).
Can I take Tylenol and doxycycline at the same time?
Yes. There are no direct drug interactions between Tylenol and doxycycline
(Vibramycin).They may be taken together.Take doxycycline on an empty stomach,
without vitamins/minerals/calcium or milk productsforthree hours or so.Take until
finished or as otherwise prescribed by the doctor.
Can I take Micardis with Equate, acetaminophen and metformin?
Yes. There are no direct drug interactions between Micardis (telmisartan), Equate
(dextrose), acetaminophen and metformin (Glucophage).Take metformin before meals,
without alcohol.Limitacetaminophen to no more than 3000mg per day.
I'm takingciprofloxacinand methylprednisolone. Can I take Tylenol PM timed
release capsuleswhen I can't fall asleep?
There are no direct drug interactions between ciprofloxacin (Cipro), methylprednisolone
(Medrol) and Tylenol PM (acetaminophen with diphenhydramine). Take the ciprofloxacin
and methylprednisolone until finished.Take Medrol with food to prevent
stomach upset.
Tylenol PM should only be used if you can devote at least six hours for sleep.Taking the
steroid late in the day could keep you awake.If this is the case, take all the daily doses
by
at least four hours prior to bedtime.Limit your total daily intake of Tylenol to no more
than 3000mg.

If you do not have pain or fever, you could take plain Benadryl for sleep.
Can I take Tylenol Cold Multi-Symptom with penicillin if I am a diabetic?
Yes. There are no direct drug interactions between any type of penicillin and Tylenol Cold
Multi-Symptom medication, unless you
are allergic to penicillin, or if you have high blood
pressure or heart
problems. Talk to your physician if you have heart problems before

taking any oral decongestant.

CanI take Tylenol PM with Phenergan?
Tylenol PM (acetaminophen with diphenhydramine) can interact with Phenergan
(promethazine) by causing Central Nervous Systemdepression and additive drowsiness.I
would suggest taking plain Tylenol with the Phenergan at bedtime or only take the

Phenergan early in the day if you can.It is the diphenhydramine (Benadryl) part of the
Tylenol PM that interacts with the Phenergan.
Does acetaminophen make your heart race?
Tylenol (acetaminophen) does not increase the heart rate
by itself.There are several
pain/cold combinations that have acetaminophen with decongestants which can increase
the heart rate (race).When taking acetaminophen, limit the daily amount to 3000mg
or
less.If you have any type of heart condition or high blood pressure, contact your
physician before taking any oral decongestant.
Can I take Claritin and Tylenol together?
Yes. They may be taken together.Limit the Tylenol to no more than 3000mg per day.

http://www.bjchealth.org/Tylenol[11/3/2014 7:06:03 PM]

Tylenol (Acetaminophen) Questions and Drug Interactions from BJC HealthCare - BJC Help For Your Health - BJC HealthCare
Can I take Tylenol PM with chlorpheniramine maleate?
No. Take one or the other, but not both. There is a duplication of antihistamines if you take
the Tylenol PM and chlorpheniramine together. Tylenol PM (acetaminophen with

diphenhydramine) contains a very sedating antihistamine, and technically

the
chlorpheniramine is considered mildly sedating.Due to the duplicative pharmacology and
potential for additive side effects, combining diphenhydramine with other antihistamines is
not generally recommended.
Can I takeLovenox with Tylenol?
Yes. Don't take aspirin or NSAIDs without talking to your physician. Rotate the
Lovenox(enoxaparin) injection site.

Can I take TylenolPM and Paxil at the same time?

Yes.They may be taken together at bedtime.The PM part (diphenhydramine) can cause
drowsiness.
Can I take Tylenol or other pain reliever with amoxicillin and Cheratussin AC? I
have bronchitis and a sinus infection.
Yes. There are no direct drug interactions between Tylenol, amoxicillin and Cheratussin AC
(guaifenesin with codeine). I cannot answer about "other pain reliever" withoutknowing

specifically which you mean.Take amoxicillin until finished, and Tylenol or Cheratussin as
needed. The codeine part of the cough syrup can cause drowsiness.

I take 20mg of Benicar, and started Z-pak today. Can I take Tylenol for a
headache?
Yes. There are no direct drug interactions between Benicar (olmesartan), Z-pak (Zithromax
or azithromycin) and Tylenol (acetaminophen). Take the Z-pak each day until finished.
Take the Benicar at the same time daily. Take the Tylenol only as needed and limit the
Tylenol to 3000mg or less per day to protect your liver.

Can I mix Pamprin and Tylenol Cold MS?

Take one or the other, but not both at the same time.Both have acetaminophen and an
antihistamine.You could alternate doses, keeping in mind the drowsiness possibility, and
limit your daily intake of acetaminophen to no more than 3000mg.

CanI take phentermine 37.5 (Adipex) in morning and take Tylenol Cold Multisymptom Nighttime at night?
Yes. But if you have high blood pressure or heart problems, talk to your physician before
taking either of these drugs.They both canraise blood pressure.

Can Tylenol PM be taken with Benicar (olmesartan)?

Yes. Only take Tylenol PM at bedtime, if you are having pain and cannot sleep. If you take
the Benicar at bedtime, you may take it with Tylenol PM.

CanI take Tylenol with cephalexin (Keflex)?

Yes. Take the cephalexin until finished or as directed by your physician.Do not take more
than 3000mg of Tylenol per day --6 extra-strength tablets.

CanI take TylenolPM while I'm taking Celebrex (celecoxib)?

Yes but if Celebrex is controlling the pain, there is no
reason to take the combination drug
Tylenol PM at bedtime. Simply take Benadryl (diphenhydramine), which will make you
sleepy.This could save you cost and keep you from taking an unnecessary added

drug.Take Celebrex with food to avoid stomach upset.

CanI take Tylenol Sinus Severe while taking albuterol and Paxil?
While there are no direct drug interactions between Tylenol Sinus Severe Congestion
(acetaminophen,guaifenesin and pseudoephedrine), albuterol (Ventolin/Proventil/ProAir)
and Paxil (paroxetine), there can be additive side effects between the Tylenol product and
albuterol.The decongestant (pseudoephedrine) in the Tylenol and albuterol both can
cause jittery nervousness and problems for peoplewith high blood pressure or heart
disease.Talk to your physician if you have either of these issues.

http://www.bjchealth.org/Tylenol[11/3/2014 7:06:03 PM]

Tylenol (Acetaminophen) Questions and Drug Interactions from BJC HealthCare - BJC Help For Your Health - BJC HealthCare

Can I take Tylenol PM with cold medicine?

Not knowing what "cold medicine" you mean, I would suggest NO.Tylenol PM has
acetaminophen and diphenhydramine, a fever/pain reducer and an antihistamine. Talk to
your pharmacist when you need to select an over-the-counter medication.
CanI take Tylenol Cold with Zyrtec and Delsym?
There are no direct drug interactions between Tylenol Cold (acetaminophen
w/diphenhydramine), Zyrtec (cetirizine) and Delsym (dextromethorphan),but there is a
duplication of therapy. Tylenol Cold contains an antihistamine.Zyrtec is an

antihistamine.Check the label of your Tylenol, as there are several formulations with the
name Tylenol Cold.If yours has an antihistamine, only take it at bedtime. If you take the
Zyrtec for allergies, take it in the morning.This is a long-lasting nonsedating
antihistamine.Drink plenty of water, and take Delsym and Tylenol as needed.
Can I take Robitussin and Tylenol Cold Nighttime in the same day?

It's important to know the complete ingredients in medications, because of the multiple
formulas of Robitussin and Tylenol Cold products. Ifit's plain Robitussin (guaifenesin) and
regular Tylenol Cold (acetaminophen, chlorpheniramine, dextromethorphan,
pseudoephedrine), theyare fine together.Duplication of ingredients can easily happen,
however, when mixing Tylenol and Robitussin products.Have your pharmacist help choose
the proper over-the-counter medication.
Can I take acetaminophen for headaches if I am taking colchicine for a gout
attack?
Yes. Drink plenty of water with the colchicine, and follow your physician's instruction on
the proper amount and length of time to take this drug. Never take more than 3000mg
acetaminophen per day. Ask your doctor for a list of foods to avoid, as some foods may

trigger gout attacks or make you more likely to have an attack.

Is it OK to take 0.5 Mirapex and 800mg ibuprofen at the same time?
Yes. Always take the ibuprofen with food or milk to protect the stomach and take only as
needed. Mirapex has several indications and depending on the diagnosis could be taken 1
to 3 times daily. The dose is usually started low and tapered upward until the expected
result is found. Mirapexcan cause sleepiness, dizziness, confusion and unusual dreams.
Be careful if you must be alert. Do not stop or change the dose of Mirapex without the
doctor's advice.
Can Tylenol Cold and Sinus be taken with Zyrtec?
The names of the Tylenol products change quite frequently, and currently there is not a
Tylenol product with the name Tylenol Cold and Sinus. Most Tylenol cold products have
some combination of antitussive, decongestant, antihistamine and acetaminophen. Check
your container for the ingredients. If there is an antihistamine (usually chlorpheniramine

or diphenhydramine), then do not take Zyrtec (cetirizine), which is an antihistamine. If

you have high blood pressure or heart problems, do not
take the Tylenol product if there
is a decongestant (usually pseudoephedrine or phenylephrine). The decongestant could
increase blood
pressure or put a strain on your heart.For over-the-counter medications,
ask the pharmacistto help in making the right selection. Always carry a list of your
medications with you. Always read
the packages and heed the warnings if they apply to
you.
My father is on MS Contin 30 mg every 12 hours. Can he take Tylenol #3 in
between his 12 hour doses of the MS Contin?
MS Contin is a long-acting morphine pain reliever. Frequently, there is "breakthrough"
pain. Many physicians order an immediate-release pain reliever to help. Only give the
Tylenol #3 (acetaminophen with codeine) if this is prescribed for your father. The added
codeine can cause additional drowsiness. Limit acetaminophen to 3000mg in 24 hours. If
both medications were not prescribed by the same physician, contact the prescriber of the
MS Contin before giving any Tylenol #3.
Can I take Tylenol PM while I am taking ciprofloxacin and metronidazole?

Yes. Take the metronidazole with food or milk. This drug will leave an unusual taste in

http://www.bjchealth.org/Tylenol[11/3/2014 7:06:03 PM]

Tylenol (Acetaminophen) Questions and Drug Interactions from BJC HealthCare - BJC Help For Your Health - BJC HealthCare
your mouth. If you are taking Tylenol PM just to help sleep, consider taking plain
diphenhydramine (Benadryl). This is the only part of this combination drug that will make
you sleepy. Taking Tylenol (or any drug) without a reason is not a good idea. Take the

ciprofloxacin and metronidazole until finished.

Can I take phentermine with Tylenol Sinus?
Yes. If you have high blood pressure or heart problems, talk to
your doctor before taking
either of these medications. Limit daily Tylenol intake to less than 3000mg to avoid liver
problems.
Can I take Motrin 800 and Tylenol #3 together?

Yes. Avoid alcohol. Taking these together may increase stomach irritation. Take the Motrin
with food or milk. Tylenol #3 can cause drowsiness. Take these only as needed and limit
the total amount of Tylenol to 3000mg per 24 hours.
Can I take Tylenol PM while taking methylprednisolone?
Yes. Tylenol PM is only indicated for use at bedtime for people
who cannot sleep due to
pain. Methylprednisolone is normally used for an allergy reaction or rash. Take itwith food
or milk. If you have
severe itching, taking plain diphenhydramine can help relieve the

histamine response and reduce the itch. Take with caution if you must be
alert, as this will
cause drowsiness. Limit daily amount of Tylenol to no more than 3000mg. Take
methylprednisolone as directed until finished.
Can I take Tylenol for a headache while taking Lipitor?
Yes. One concern would be regarding liver enzymes and function. Have you been taking
the Lipitor a long time? Does your prescribing physician take regular blood tests for liver
function? Both of these drugs may affect the liver. With Tylenol, it is more dose related
(over 3000mg per day) but with Lipitor, it may happen at any dose. If you must take
Tylenol (aspirin would be a better choice if you can take it), take the least amount you can
to stop the headache. If you
have to take multiple doses of Tylenol, I would suggestcall
your doctor.
Can I take Flexeril and Tylenol Cold Multi-Symptom Night Time at the same time?

Yes. Only take the Tylenol Night Time when you go to bed, as the diphenhydramine in this
product will cause drowsiness, added to the Flexeril will increase this side effect. Only take
these when needed.
Can I take Adderall with Tylenol PM and Aleve?
There are no direct drug interactions between Adderall (amphetamine salts), Tylenol PM
(acetaminophen with diphenhydramine) and
Aleve (naproxen). Take the Adderall in the
morning as directed by your doctor. Take the Aleve as needed with food. Tylenol PM
should only be taken at bedtime as needed. Always let your health care providers know of
all your medications.
Can I take Tylenol and Advil at the same time or should I alternate them? If I
alternate, what does that mean?

Tylenol (acetaminophen) and Advil (ibuprofen) could be taken together, but I have found
that alternating is a better therapy. By alternating, I
mean take the proper dose for you of
each every six to eight hours.If you follow the six-hour frequency, that would be take a

Tylenol dose, 3 hours later an Advil dose, then 3 hours later another Tylenol dose on and
on as needed. Every eight hours would be a Tylenol dose followed by an Advil dose 4
hours later, then another Tylenol dose in 4 more hours and so on. Take the Advil with food
or milk to avoid stomach upset. Limit Tylenol to 3000mg every 24 hours.
Is it safe to take Tylenol PM, while taking levothyroxine?
Yes. Take levothyroxine every day before breakfast and Tylenol PM just before bedtime, as
needed.
Can you take Tylenol PM with phentermine (Adipex)?

Yes. Normally phentermine is taken in the morning daily and Tylenol PM is taken just
before bedtime when needed. If you take Tylenol for pain/fever/headaches or multisymptom cold medications (that usually include acetaminophen), limit daily intake of

http://www.bjchealth.org/Tylenol[11/3/2014 7:06:03 PM]

Tylenol (Acetaminophen) Questions and Drug Interactions from BJC HealthCare - BJC Help For Your Health - BJC HealthCare
acetaminophen to 3000mg.
Can I take erythromycin and Tylenol Arthritis together?

Yes.Take erythromycin until finished. Take with food, if it upsets

your stomach. Take
Tylenol as needed, but no more than 3000mg daily.
Can you take Tylenol PM with metoprolol ER?
There is a drug interaction between Tylenol PM (acetaminophen with diphenhydramine)
and metoprolol ER (Toprol XL). Diphenhydramine in Tylenol PM affects the metoprolol
such that there can be an increase in the plasma concentration of the beta blocker. This
can cause the heart rate to fall to a very low level. Avoid antihistamines with beta

blockers. If you take metoprolol in the morning and only use Tylenol PM at bedtime,12 or
more hours later, the likelihood of the interaction causing a problem is greatly reduced.
The Tylenol part is not the problem, so if you are having difficulty sleeping due to pain, try
taking plain Tylenol and see if this helps.
Can I take Tylenol and atenolol (Tenormin) together?
Yes. Take Tylenol only as needed and limit it to 3000mg daily. Take the atenolol at the
times prescribed, every day.
Is it safe to take Tylenol PM and 3mg melatonin together?
Yes. There is a chance of dizziness and increase in falls, especially if you take high blood
pressure medications. Be careful if you get up in the night, or beforeeight full hours of
sleep. Take these only as needed, and avoid alcohol before bedtime.
Can I take acetaminophen for headaches if I am taking colchicine for a gout
attack?
There are no direct drug interactions between acetaminophen (Tylenol) and colchicine.
Drink plenty of water with the colchicine and follow your physician's instruction on the
proper amount and length of time to take this drug after an acute gout attack. Never take
more than 3000mg acetaminophen per day. Those with gout, should ask your doctor for a
list of foods to avoid. Certain foods may trigger gout attacks or may you more likely to
experience an attack.
Can I take Tylenol Sinus Daytime with Ambien?
There are no direct drug interactions between Ambien (zolpidem) and Tylenol Sinus
Daytime formula. Remember to allow for 8 hours sleep before taking the Ambien. The
drowsiness may continue to the next day, so be careful if you must be alert. Drink plenty
of water with the Tylenol product and limit the amount of acetaminophen to 3000mg per
day.
Can you take Tylenol #3 with atenolol?
There are no direct drug interactions between Tylenol #3
(acetaminophen with codeine)
and atenolol (Tenormin). Taking both together may slow you down somewhat. Keep track
of the number of Tylenol
you take any given day. Taking both Tylenol and the beta blocker
may slow your heart rate lower than the doctor expects. Check your pressure often. If you
notice a severe drop in blood pressure or pulse, contact the doctor.
Can I take Tylenol #3 with Aleve?
There are no direct drug interactions between Tylenol #3
(acetaminophen with codeine)
and Aleve (naproxen). The codeine and Aleve can both irritate the stomach, so take with
food or milk. The codeine can also cause constipation and drowsiness. Be careful if you

must be alert. Take these only as needed.

Can I combine Benadryl and Tylenol?
Yes, these are safe to take together. Do not give Benadryl (diphenhydramine) to children
without the advice of a physician.
Can I take any antibioticswith Tylenol Cold and Sinus?
Tylenol Cold and Sinus may be taken with any appropriate antibiotic.
I have a sore throat and feel a cold in my chest. My thyroid has been removed
due to cancer. Can I take Tylenol Cough?

http://www.bjchealth.org/Tylenol[11/3/2014 7:06:03 PM]

Tylenol (Acetaminophen) Questions and Drug Interactions from BJC HealthCare - BJC Help For Your Health - BJC HealthCare
Not having a thyroid does not keep one from taking Tylenol, but with the symptoms you
describe, why would you need Tylenol Cough? The sore throat could be soothed with an
anesthetic throat lozenge (Cepastat) and an expectorant (such as guaifenesin) would help

clear your lungs. Drink plenty of fluids, and take plain Tylenol (acetaminophen) if you
have a fever or pain.
CanI take Tylenol Sinus Congestion and Pain with promethazine that contains
codeine syrup?
Yes. Limit the amount of acetaminophen to 3000mg per day, take both of these
medications only as needed. If you have high blood pressure or heart problems, talk to
your doctor before taking the Tylenol Sinus product. Promethazine with codeine cancause
drowsiness.
Can I take Ativan (lorazepam) with Tylenol PM?
There are no direct drug interactions, but there is a duplication of action or indications with
these drugs. Tylenol PM is to help you go to sleep, as well as relieve pain or fever. The
Ativan may also be used to help you relax to fall asleep.Be very careful if you take these
and must be alert. Talk with your doctorabout taking these both at night.
CanI take Tylenoland Plaquenil?
Yes. You may take them together. Take no more than 3000mg of Tylenol per day, and
always take the Plaquenil with food at the prescribed times. Keep this and all medications
out of the reach of children.
Can I take Tylenol PM when I'm on warfarin?
Yes. These may be taken together at bedtime. Take Tylenol PM as needed and when you
can devote 8 hours for sleep. Be sure to have your blood checked regularly while on
warfarin, to ensure the dosing is correct.
Can I take Tylenol #3 with Mucinex D?
Yes. Take both only as needed.Limit the amount of Tylenol to 3000mg per day. Codeine
can cause drowsiness, upset the stomach and cause constipation.Drink plenty of water
with the Mucinex and if you have high blood pressure or heart problems, you should only
take plain Mucinex.
CanI take Tylenol with diclofenac and tramadol?
Yes. Limit Tylenol to no more than 3000mg per day. Take diclofenac with food or milk to
prevent stomach upset. Tramadol may cause drowsiness, so be careful if you must be
alert. Always let all your health care providers know of all medications you take.
Can you take Tylenol #3 and loratadine together?
Yes. Take these only as needed and remember that the codeine will possibly make you
drowsy.Even though loratadine is advertised as non-drowsy, one of the main side effects
is drowsiness. Be
careful if you must be alert. Drink plenty of water and if the Tylenol #3
upsets the stomach, take it with food.
CanI take Lipitor and Tylenol together?
Yes. If you are just beginning the Lipitor, make sure that your doctor has you get a blood
test for your liver in a few weeks.
Both Tylenol and Lipitor may affect your liver
function.Do not take more than 3000mg of Tylenol per day. If you develop leg pains or

cramps after starting Lipitor, notify your doctor.

I have a cold and cough. I am taking Robitussin Cough and Cold but I also have a
headache. Can I take Tylenol?
Yes.Robitussin Cough and Cold can cause blood pressure to go up.
Will it hurt to take Tylenol with Hydrochlorot?
If you are referring to hydrochlorothiazide, a diuretic;
there are no drug interactions with
Tylenol (acetaminophen). You would normally take hydrochlorothiazide (HCTZ) in the
morning, with juice.
I takeone Celebrex in the a.m. Can I take Tylenol for a headache later in the day?
Yes.

http://www.bjchealth.org/Tylenol[11/3/2014 7:06:03 PM]

Tylenol (Acetaminophen) Questions and Drug Interactions from BJC HealthCare - BJC Help For Your Health - BJC HealthCare
Is it OK to take Tylenol PM with Mucinex D?I want to get the same effects as
NyQuil without having to buy it and without having the lousy feeling the next
morning. I have a cold and need to get some sleep.
Yes.You cantake Tylenol PM (acetaminophen with diphenhydramine) and Mucinex D
(guaifenesin with pseudoephedrine).But if you do not have pain, fever or headache, why
not take plain diphenhydramine before bedtime to help sleep? Only take medications that
are required (or prescribed).Don't take things you do not need.
Can I take Tylenol Cold medicine with Claritin?
There are many formulations of Tylenol cold medicine. Several have antihistamines
(chlorpheniramine or diphenhydramine). Claritin (loratadine) is an antihistamine. Read the
label carefully.If there is an antihistamine listed, for runny nose anditchy watery eyes,
then do not take the Claritin with the Tylenol Cold. You will be duplicating the
antihistamine and perhaps cause drowsiness.
Can I take Tylenol Sinus with paroxetine 20mg?
There are no direct drug interactions between the many types of Tylenol (acetaminophen)
Sinus and paroxetine (Paxil).Please check your box of Tylenol and read the ingredients.If
there is an antihistamine (diphenhydramine) listed,
this can increase the chance of
drowsiness that the Paxil may also cause. Be careful if you must be alert. Drink plenty of
water while taking the Tylenol Sinus and only take as long as needed.
Can I take Tylenol while on Glucophage, Glucotrol and warfarin?
There are a couple of worries with this group of medications. The Glucophage (metformin)
and warfarin (Coumadin) are fine
together.The problems begin with the addition of
Tylenol (acetaminophen).Concurrent use of acetaminophen and warfarin may result in an
increased risk of bleeding. Unfortunately, Tylenol is the safest nonprescription pain and
fever drug with warfarin. Watch for unusual bruising or bleeding. Glucotrol (glipizide) and
warfarin may result in an increased risk of hypoglycemia. You are most likelyOK
with
these as you have been taking these already.Hopefully you check your blood sugar
regularly and your body has adjusted to this drug
combination.Discuss this with your
physicians.
Can Tylenol PM and Mirapex be taken together?
Yes.Drink plenty of water during the day, as both of these medications can cause dry
mouth. Do not take them unless you can devote at least 6 hours for sleep.
Is there a drug interaction between acetaminophen and zolpidem?
There is no direct drug interaction between acetaminophen (Tylenol) and zolpidem
(Ambien).Avoid alcohol while taking these drugs, particularly if you have any liver
function problems. Limit acetaminophen to 3000mg per 24 hours and only take zolpidem
if needed.
I'm taking Wellbutrin XL 150mg. Can I take Tylenol Extra-Strength or Midol?
Wellbutrin XL (bupropion extended release) may be taken with either Tylenol
(acetaminophen) or Midol (pyrilamine with acetaminophen). I would not take the Tylenol
and Midol together as both contain acetaminophen.Another alternative would be to use

ibuprofen with Midol for added relief. This will be fine with the Wellbutrin also. Always limit
acetaminophen to 3000mg per day and if you
take NSAIDs (nonsteroidal antiinflammatory drugs), like ibuprofen, take them with food or milk.
I have dry cough and cold. Is it okay to take Tylenol Extra-Strength 500mg with
Robitussin cough syrup cough suppressant and expectorant?
You do not say why you want to take the Tylenol (acetaminophen). I assume the Tylenol is
for fever or aches and pains. Robitussin DM (guaifenesin with dextromethorphan) is fine to
take with Tylenol. Drink plenty of water with the Robitussin and limit yourself to
no more
than 3000mg Tylenol in 24 hours. Take each product only as long
as needed. If you have
a fever for more than 24-48 hours while on Tylenol, call your doctor.
Can Tylenol PM and benzonatate be used together?
Tylenol PM (acetaminophen with diphenhydramine) should only be taken prior to bedtime,
when you have at least six to eight hours to devote for sleep. The cough suppressant

http://www.bjchealth.org/Tylenol[11/3/2014 7:06:03 PM]

Tylenol (Acetaminophen) Questions and Drug Interactions from BJC HealthCare - BJC Help For Your Health - BJC HealthCare
benzonatate (Tessalon) can also cause drowsiness. There are no direct drug interactions
between the two.
Be careful taking the benzonatate if you must be alert. Take no more

than 3000mg of acetaminophen per day.

Can you take two 500mg tablets of acetaminophen with 5mg zolpidem?
Yes. There are no drug interactions between Tylenol (acetaminophen) and zolpidem
(Ambien). Be sure to limit yourself to no more than 3000mg of Tylenol in 24 hours and
remember to be able to devote at least 7-8 hours for sleep when taking zolpidem.
Is it safe to take Tylenol Cold Severe (to alleviate cold symptoms) with Keflex?
Keflex (cephalexin) is a first generation cephalosporin antibiotic that may be taken with
any cough/cold/fever remedy.Tylenol Cold Severe has dextromethorphan, guaifenesin,

pseudoephedrine and acetaminophen, so take this with plenty of water and

only as long
as needed.Take Keflex until complete.
CanI take TylenolPM with Medrol?
Yes. Medrol (methylprednisolone) and Tylenol PM (acetaminophen with diphenhydramine)
may be taken together. Take Medrol in the morning with food and Tylenol PM when you go
to bed.
CanI safely take TylenolPM with prednisone?
Yes. Normally you would take prednisone early in the day
with food and Tylenol PM just at
bedtime.Both are fairly short-acting drugs.
Can I take Tylenol Cold with Cymbalta?
Yes. Drink plenty of water with Tylenol Cold. The main side effects of Cymbalta include GI
problems and drowsiness or a decrease in alertness, dizziness and fatigue.
Can I take Tylenol with sulfamethoxazole?
Yes, as long as you are not allergic to sulfa products, you may take Tylenol
(acetaminophen) along with sulfamethoxazole. Take the antibiotic until complete and
drink plenty of water while on this medication. Limit Tylenol to 3000mg in 24 hours and
take as needed only.
Can I take paracetamol while taking prednisolone?
Paracetamol is another name for acetaminophen (Tylenol) used in other countries. Yes,
prednisolone may be taken with acetaminophen. Do not take more than 3000mg of
acetaminophen per day.
Can I take Tylenol Sinus Congestion and pain with clarithromycin 500mg?
Yes. Normally you would want to take clarithromycin (Biaxin) twice a day with food, as this
antibiotic can upset the stomach.This should be taken until gone. Tylenol Sinus
Congestion should be avoided near bedtime as it may keep you awake.Drink plenty of
water.
Can I take Tylenol with prednisone and Keflex?
Yes. Take prednisone with food or milk.
Can I mix apap drops 80mg with gas drops?
Yes, apap (acetaminophen, Tylenol) may be given with simethicone (gas) drops.
Can I take Tylenol, Zithromax and Robitussin together?
Yes, if the times for the various doses are close, it is
alright to take these together.
Zithromax (azithromycin) is normally taken in the morning, once daily, until finished. Take
no more than 3000mg of Tylenol (acetaminophen) per day, and drink plenty of fluids

(water) with the Robitussin (guaifenesin).

Is it safe to take naproxen and acetaminophen (Tylenol) at same time?
Naproxen (Naprosyn, Aleve) may be taken with acetaminophen. You may take any NSAID
with acetaminophen (Tylenol). Take
naproxen with food or milk.
Can I take prednisone with Tylenol PM?
Yes, prednisone is a steroid that may be taken with Tylenol PM (acetaminophen with
diphenhydramine). Normally you should take the prednisone early in the day with food or

http://www.bjchealth.org/Tylenol[11/3/2014 7:06:03 PM]

Tylenol (Acetaminophen) Questions and Drug Interactions from BJC HealthCare - BJC Help For Your Health - BJC HealthCare
milk. Tylenol PM should only be taken at bedtime.
Can I take Tylenol PM with lidocaine?
Lidocaine is a topical anesthetic. You may use lidocaine with Tylenol PM (acetaminophen
with diphenhydramine).
Can Itake Tylenol with methylprednisolone? Or what would be the best headache
reliever to take while on steroids?
Tylenol (acetaminophen) is the only headache reliever that I would recommend to take
with methylprednisolone, or any steroid product. Remember to limit Tylenol use to
3000mg per day, or less.
CanI take acetaminophen with a nasal decongestant?
Yes, acetaminophen (Tylenol) may be taken with decongestants. Limit the amount of
Tylenol to 3000mg per day and if you have high blood pressure or heart problems, be sure
to talk to your doctor before using any nasal decongestant.
I took Tylenol and Xanax almost at the same time while pregnant. Problems?
Tylenol (acetaminophen) is fine to take if you are pregnant. It still must be limited to
3000mg per day. Using Xanax (alprazolam), there is positive evidence of human fetal risk,
but the benefits from use in pregnant women may be acceptable despite the risk; if the
drug is needed in a life-threatening situation or for a serious disease for which safer drugs
cannot be used or are ineffective. I always recommend avoiding Xanax while pregnant.
How long can a person take Tylenol #3? I have been taking it every day for about
10 years. Sometimes two a day. Sometimes six-eight a day.
There are two issues with long-term ingestion of Tylenol
#3 (acetaminophen with codeine).
The first is liver problems. The way to check is a liver function test. The other issue is
dependence to the narcotic, codeine. Talk to your doctor regarding your worries, the

direction of therapy and order tests if needed.

Can I take Zoloft 50mg and Tylenol PM Extra-Strength together?
Yes, the Zoloft (sertraline) is compatible with the Tylenol PM (acetaminophen with
diphenhydramine). Take Tylenol PM at bedtime. There will be increased drowsiness after
taking Zoloft.
Can I take Tylenol after a promethazine injection?
Yes, you can take Tylenol (acetaminophen) before, with or just after promethazine
(Phenergan).
Can I take Tylenol with Paxil?
Yes, Tylenol (acetaminophen) can be taken with Paxil (paroxetine). Avoid alcohol while
taking these. Tylenol can cause liver problems that alcohol could make worse. Paxil and
alcohol can cause extreme drowsiness.
Can I take 500mg of naproxen if I have already taken 400mg of Tylenol?
Yes, naproxen (Naprosyn, Aleve, Anaprox) may be taken with Tylenol (acetaminophen).
Take the naproxen with food and do not take more than 3000mg of Tylenol per day.
Can I take Coumadin and Tylenol PM?
There is an interaction between Coumadin (warfarin) and Tylenol (acetaminophen) wherein
concurrent use may result in an increased risk of bleeding.The PM part of the Tylenol,

diphenhydramine, is not a problem.So, if you are taking the Tylenol PM to help go to

sleep, just take a generic Benadryl (diphenhydramine).Tylenol is still the safest pain
reliever/fever reducer to take with Coumadin.
Can I take acetaminophen with cephalexin?
Acetaminophen (Tylenol) may be taken with cephalexin (Keflex), an antibiotic.Take the
cephalexin until gone. You do not have to avoid food with either medication.
Can I take Tylenol Cold for night if I have taken ibuprofen 5 hours earlier?
As long as you are taking plain ibuprofen, you may take them right with the Tylenol Cold.
Take ibuprofen with food or milk, and limit
Tylenol (acetaminophen) to no more than

http://www.bjchealth.org/Tylenol[11/3/2014 7:06:03 PM]

Tylenol (Acetaminophen) Questions and Drug Interactions from BJC HealthCare - BJC Help For Your Health - BJC HealthCare
3000mg daily.
I take 25mg hydrochlorothiazide for hypertension. After running a fever (100
degrees) for 4 days with a constant backache, (flu-like symptoms), my doctor
prescribed azithromycin and methylprednisolone. Can I take Tylenol as well?
Yes. Take the azithromycin until complete and the methylprednisolone with food or milk.
Can I take Celebrex 200mg twice a day along with Ultram and Tylenol?
Yes. Celebrex (celecoxib) for arthritis, may be taken with Ultram (tramadol) and Tylenol
(acetaminophen) for pain. Always take the Celebrex with meals, the Ultram can cause
drowsiness, and limit
the Tylenol to 3000mg or less per 24 hours. Do not take more

Ultram than prescribed.

Can I take Tylenol PM and atenolol 25mg together?
Atenolol (Tenormin) is a beta blocker that lowers blood pressure and can reduce heart
rate. As such, it can slow you down to the
point of drowsiness. You may take them both
together at bedtime. Be careful if you get up during the night. I would suggest taking the

atenolol in the morning and taking only Tylenol PM prior to bedtime.

Can Tylenol PM be taken several hours after taking Aleve?
Yes. You could actually take them together, if you take them at bedtime.Take Aleve with
food or milk.
Can I take Aleve and Tylenol within a few hours of each other?
Yes. You may take Tylenol (acetaminophen) with Aleve (naproxyn) or any NSAID.Take no
more than 3000mg of Tylenol in 24 hours. Take Aleve with food or milk.
Can I take Tylenol #3 and azithromycin together?
Yes, Tylenol with codeine (acetaminophen with codeine) may be taken with azithromycin
(Zithromycin).Both may upset the stomach, so take them with food.Take the antibiotic
until finished, and remember the Tylenol #3 can cause drowsiness.
Can I take Extra-Strength Tylenol for a headache while on 500mg Glucophage XR
and 12.5mg Zoloft daily? Or ibuprofen?

Tylenol (acetaminophen) is fine and actually less prone to interactions than ibuprofen.Do
not take more than 3000mg acetaminophen per 24 hours.
Can I take Extra-Strength Tylenol, Sudafed, ibuprofen and a Z-pak?
Yes. These medications are compatible.If the timing of doses is such that you must take
some of them together, you may. Tylenol Extra-Strength is 500mg per tablet, and the
daily limit is 3000mg (6 tablets).Sudafed may cause your blood pressure to increase, and
ibuprofen should be taken with food or milk.Take the
whole prescription of the Z-pak.
Can I take Tylenol #3 and Xanax?
Yes. Tylenol #3 ( acetaminophen with codeine) has 30mg of codeine (opiod analgesic) per
tablet.This may cause sedation and loss of alertness. Xanax (alprazolam) is an
antianxiety product (benzodiazepine) that also may cause extreme drowsiness and loss of

alertness.The two together will have additive effects.If you

have any respiratory
problems, consult your physician first before taking these together.Concurrent use of
opiod analgesics and benzodiazepines may cause additive respiratory depression.Limit

your daily amount of Tylenol, in all forms, to no more than 3000mg.

Can I take 12-Hour Afrin and Tylenol and Sudafed?
Yes. Afrin (oxymetazoline) and Sudafed (pseudoephedrine)
are decongestants.These can
cause an increase in blood pressure and heart rate.If you have coronary or vascular
medical conditions, consult your physician first before taking either of these.Use the Afrin
for only three days in a row -- at the most --or you will run the risk of acquiring
acondition called rebound congestion, which makes it difficult to stop using this product.
Do not take more than 3000mg of Tylenol (acetaminophen) in 24 hours.
If I am taking Pentasa, can I also take Tylenol for pain?
Yes. Pentasa (mesalamine)may be taken with Tylenol (acetaminophen).The daily limit of
Tylenol is 3000mg.

http://www.bjchealth.org/Tylenol[11/3/2014 7:06:03 PM]

Tylenol (Acetaminophen) Questions and Drug Interactions from BJC HealthCare - BJC Help For Your Health - BJC HealthCare
Can I take Xanax while I am taking Sudafed PE and Benicar 20-12.5?
Yes. There are no interactions between this group of medications.Xanax (alprazolam) may
cause drowsiness, Sudafed PE (phenylephrine) may make your blood pressure or heart
rate increase.Both your internist and your cardiologist should be aware
of your taking
Sudafed.
Can I take Tylenol and Celebrex together?
Yes. Limit your Tylenol to no more than 3000mg per day and take the Celebrex with food
to protect the stomach.
Can I take Extra-Strength Tylenol with Zyrtec 10mg?What's the dosage?
Yes. Tylenol (acetaminophen) extra strength (500mg) may be taken with Zyrtec (cetirizine
hydrochloride).The normal dose for Zyrtec is one 10mg tablet in 24 hours.The total daily
dose of Tylenol should be 3000mg or less --6 extra-strength pills in 24 hours.
CanI take Tylenol with Mucinex and Zyrtec?
Yes. Acetaminophen (Tylenol) may be taken with Mucinex (guaifenesin) and Zyrtec
(cetirizine).Drink plenty of fluids with both Mucinex and Zyrtec.Do not take more than
3000mg of Tylenol in
24 hours.
Can I take Mucinex Dand Tylenol?
Yes.
Can I take Tylenol while taking azithromycin?
Yes. Limit the Tylenol to 3000mg per 24-hour period.
Can I take Celebrex and Tylenol together?
Yes. You may take Tylenol (acetaminophen) with Celebrex (celecoxib), an antiinflammatory anti-arthritis drug.Take no more
than 3000mg Tylenol per 24-hour
period,and take the Celebrex as directed with food.
Can I take Tylenol with Mucinex?
Yes. You may take Tylenol (acetaminophen) with Mucinex (guaifenesin).Do not take more
than 3000mg of acetaminophen per 24-hour period, and drink plenty of fluids with the
guaifenesin.
I took a Tylenol #3 and it did not stop the pain in my lower back.Can I take a
hydrocodone 5/acetaminophen
500mg now? I am a diabetic.
Yes. Tylenol #3 (Tylenol with codeine) has 325mg of acetaminophen, and generic Vicodin
has 500mg.As long as you are an
adult andnot allergic to narcotics, you could take the

hydrocodone/acetaminophen if it has been longer than 4 hours. Do not take more than
3000mg acetaminophen in any 24-hour period. Be careful if you must be alert. These
products can make you drowsy.
Can I take Extra-Strength Tylenol with Mucinex DM?
Yes. Extra-Strength Tylenol (acetaminophen 500mg) can be
taken with Mucinex DM
(guaifenesin and dextromethorphan). Remember the daily limit of acetaminophen is
3000mg. That is6 extra-strength tablets. Also, drink plenty of fluids with the Mucinex.
Can I take the Z-pak and Aleve or Tylenol together?
Yes. Z-pak (azithromycin), Aleve (naproxen) and Tylenol (acetaminophen) may all be
taken together. They all may be taken with food.Take the azithromycin until it is finished,
and don't take more than 3000mg acetaminophen per 24-hour period.
Is is safe to take Motrin or Tylenol with Zithromax?
Yes, as long as there are no other reasons to avoid the Motrin or Tylenol. Zithromax
(azithromycin) is an antibiotic normally given for
a five-day course of therapy.Motrin
(ibuprofen) is an NSAID for pain, fever or inflammation. Tylenol (acetaminophen) is for
pain and fever. If the Zithromax upsets your stomach, the Motrin could aggravate the
problem.Take with food or milk.
Can I take Claritin 12-Hour and then take Tylenol? How about Mucinex DM,
Claritin 24-hour and Tylenol?

http://www.bjchealth.org/Tylenol[11/3/2014 7:06:03 PM]

Tylenol (Acetaminophen) Questions and Drug Interactions from BJC HealthCare - BJC Help For Your Health - BJC HealthCare
Yes, but you cannot take Claritin at all if you have prostate issues. Claritin (loratadine) is
an antihistamine.Tylenol (acetaminophen) is a pain- and fever-reducer.Mucinex DM is

guaifenesin with dextromethorphan. Follow dosing directions on the labels. Drink extra
liquids.Limit Tylenol to 3000mg per day or less to avoid changes in liver function.
Can I take Tylenol Cold Multi-Symptom Nighttime with Mucinex?
There are a couple Tylenol multi-symptom nighttime products.None of them that I found
have an expectorant included.If you have the plain Mucinex (guaifenesin) then yes, you
may take the two together. Drink extra fluids to help thin the secretions.
After surgery, instead of taking 2 hc-ibuprofen at once, can I take one and then a
couple of hours later take a Tylenol #3?
I assume you mean hydrocodone/ibuprofen and Tylenol with codeine.Talk with your
physician about taking the Tylenol with codeine.Some doctors suggest alternating various
pain relievers for added affect or if the patient has stomach issues that would be affected
by ibuprofen (NSAID).
Can I take acetaminophen with codeine and prochlorperazine 5mg together?
As with many drugs such as these, a narcotic pain reliever and an anti-nausea/anti-anxiety
product, there are no specific drug interactions. But taking them together you may find an
increased central
nervous system depression, sedation or loss of alertness. Be careful if
you must drive or operate any machinery.

Can I take Tylenol Cold Multi-Symptom Nighttime with Mucinex?

There are a couple Tylenol multi-symptom nighttime products. None of them that I found
have an expectorant included. If you have plain Mucinex (guaifenesin) then yes, you may
take the two together. Drink extra fluids to help thin the secretions.
Copyright 1997-2014, BJC HealthCare.
All Rights Reserved.

http://www.bjchealth.org/Tylenol[11/3/2014 7:06:03 PM]

Search | Organ Donation | Site Map | HIPAA

Print This Page | E-Mail This Page | Our Policies | BJC HealthCare