THE KICK OF MEETING

Chief Executive Officer (CEO)

Project Manager

Name of product

: Curcuma Mangga Cure (CMC)

Type of product

: Herba Medicine

Dosage forms

: Capsule

Departement:
1. Research and Development
Research
(1) Composition : - Curcuma Mangga Extract :
mg
- Lactose
:
mg
(2) Content
: For the major component of essential oil monoterpenes
gathering mangoes are a class of hydrocarbons, the main component mirsen
(78.6%), -osimen (5.1%), -pinene (3.7%) and -pinene (2.9 %) and
compound that gives flavor like mango is -3-karen and (Z)-osimen -.
Curcuminoid content in mango retrieval of 0:18 to 0:47%. Meeting of rich
mango chemical constituents such as tannins, curcumin , sugar, essential oils,
resins, flavonoids, and the toxic protein that can inhibit the proliferation of
cancer cells.
(3) Dosage
:
1. For healing: 2 capsules a day, after meals
2. For prevention: 1 capsule a day, after meals
(4) Effectivity and Useful
: reduce sinus, anti-oxidant, anti-inflammatory,
anti-toxic, cancer prevention, reduce abdominal fat, itchy skin problems,
asthma, bronchitis, stop the bleeding.
(5) Side effect
: found no adverse side effects for humans
Defelopment ;
Antioxidants in turmeric prevents damage to deoxyribonucleic acid
(compounds that make up a gene), is because of the damage to genes is one of the
causes of cancer. While curcumin with feruloyl and 4-hydroxy-cinnamoyl are
anti-inflammatory compound found in turmeric. In conclusion, both the content of
curcumin was instrumental in the fight against cancer, the genes that Prevent
Damage and Prevent the inflammation, Because The cancer always Occurs
inflammation. Curcuma mango contains "toxic protein". Similar ribosome in
activating protein (RIP). This is a protein that is Able to deactivate the ribosome,
so that protein synthesis in cells disrupted. The protein is Easier to penetrate into
the cancer cells than healthy cells. As a result, the cancer cells can not proliferate.
Because cancer cells have an age limit, then over time will run out by it self.

2. Clinical Affairs ;
Cancer cells grown in the laboratory and after being given a certain
concentration of white turmeric. The cytotoxic activities observed for curcuma
mangga rhizomes are ascribable to the presence of the active compound 1 in the
hexane fraction, and compound 3 and the curcuminoids in the ethyl acetate fraction.
Even though these compounds are not as effective as doxorubicin against cancer cell
lines, in comparison they have low toxicity against human normal cell lines. The
present study provides important preliminary data of extracts or isolated compounds
with potential anti-neoplastic properties for future work. Since curcuma mangga is
widely used in traditional medicine for the treatment of cancer, the current findings
provide scientific validation in the use of the rhizomes for this purpose. As the
rhizomes are also widely consumed as salad in food without any known undesirable
side effect, it can be assumed that the plant is safe for consumption at the normal dose
as food. Curcuma mangga, is therefore a promising dietary agent that holds great
potential for use in chemopreventive and chemotherapeutic strategies. Nevertheless,
further investigations are necessary to validate its use and to determine its mode of
action.
White Turmeric (Curcuma Mangga) including natural ingredients, then use the
long term though, remains safe for humans. Although it has benefits for a normal
person, but preferably should not be used during pregnancy can lead to miscarriage
his deep.
3. Produksi ;
White turmeric dry extract which choice is made then mixed with other
additives in a mixer and mix eventually will be automatically entered into the capsule
by capsule filling machine. drugs so that was prepared in guinea fowl enter the bottle
and packaged in boxes of medication containing 60 capsules per bottle. all stages in
the production process to follow existing standard operating procedures so that they
can more easily follow GxP. goal in order to maintain performance and results.
4. Quality Assurance (QA)
Quality assurance is a wide-ranging concept covering all matters that
individually or collectively influence the quality of a product. With regard to
pharmaceuticals, quality assurance can be divided into major areas: development,
quality control, production, distribution, and inspections.
The Medicines Quality Assurance Programme, which is part of Quality and
Safety: Medicines of the Essential Medicines and Pharmaceutical Policies
Department, contributes to public health by enabling quality medicines to reach
patients through:
- Developing norms, standards and guidelines for quality assurance
- Developing The International Pharmacopoeia
- Establishing International Chemical Reference Substances (ICRS)
- Collaborating with numerous stakeholders
- Providing country support

5. Regulatory Affairs
The entire documentation of the drug be send to the Directorate of Traditional
Drug Control was established under the Directorate General of Drugs and Food
Control of the Ministry of Health. the government would gave guidance on all
aspects of traditional drugs development. the government has set many
requirements for traditional drugs and crude drugs:
- Production, distribution and labelling of traditional drugs;
- Procedure for registration of traditional drugs and imported crude drugs;
- Licensing of traditional drugs and imported traditional drugs; and
- Control requirements, such as for a production code, labelling and
advertisement
6. Marketing and Sales
Marketing plan for a local advance in order to obtain the label fitofarmaka.
sales plan will be distributed to pharmacies, hospitals and licensed drug stores. This
drug is a drug that can be purchased without a prescription. So the drug include over
the counter drug although the drug is a drug to suppress the growth of cancer cells.
because it does not contain chemicals beside the effect was minimal.