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The Alveolararterial gradient (Aa gradient), is a measure of the difference between the
alveolar concentration (A) of oxygen and the arterial (a) concentration of oxygen. It is used
in diagnosing the source of hypoxemia .
The equation for calculating the Aa gradient is:
CHF exacerbation ( look for risk factors as uncrontrolled HTN,smoking, Coronary artery
disease,COPD,...)can cause tchypnea as left ventricular dysfucntion allows fluid to pool in
the lungs,causing a pleural effusion and hypoxemia due to reduced ventialtion.Tachypnea
causes hypocapnia and respiratory alkalosis. Exam typically shows signs of fluid
overload,S3and S4 gallops,cardiomegaly and bibasilar crackles in the lungs(due to pleural
effusions from CHF).More specific testing for CHF would inculde assessment of the B-type
natriuretic peptide(BNP) and the pulmonary capillary wedge pressure.
In COPD exacerbation, examination typically shows widespread bilateral wheezes and
ABG findings include respiratory acidosis and hypoxia.
The most common cause of pulmonary complications in patients with systemic sclerosis is
interstitial fibrosis.
Cor pulomnale is a term of right sided heart failure most commonly due to pulmonary
disease.Signs of right sided heart failure inculde:jugular venous distension,right sided
S3,right ventricular heave,hepatomegaly,ascites and dependant edema.A chest radiograph
may reveal a prominent right ventricle and pulmonary artery,in addition to any lung disease
that can be visualized.
Pulmonary emboli classically presents with sudden onset pleuritic chest pain( pain
worsened on inspiration),cough,dyspnea,and hemoptysis.PE may arise from the right
heart,pelvic veins,or upper extremity veins,the deep veins of the lower extremities are the
most frequent source.Lower extremity deep vein thrombosis is divided into two categories:
proximal vein thrombosis(above the knee and includes iliac/femoral/popliteal veins)-Calf
vein thrombosis.Proximal deep veins account for more than 90% of acute Pes.Patients have
Hypoxemia and respiratory alkalosis(low PaCO2) with a widended A-a gradient.Chest
CT shows wedge-shaped infarction known as Hamptons Hump ( pathognomonic
feature). Lung cancer would show a rounded mass on CT.
Pneumothroax typically presents with acute onset pleuritic chest pain and dyspnea when it
is symptomatic.Physical Examination reveals hyperreasonance to percussion,diminished
tactile and vocal fremitus,and decreased or absent breath sounds in the affected area.
Pulmonary embolism should be suspected in all patients at risk for deep vein
thrombosis(DVT)(prolonged immobility, OCP use, obesity,s moking, recent abdominal or
orthopedic surgery/ trauma, occult malignancy and other hypercoagulable conditions
including sickle cell trait and Factor V Leinden Deficiency-most common
hypercoagulability and thromboses predisposing factor) who present with acute onset
tachypnea,dyspnea,and chest pain(pleuritic in nature).Pulmonary Angiography is Gold
Standard but the most commonly used and the diagnostic chest of choice is Helical CT of
the chest ( V/Q test could be used sometimes when contrast angiography is contraindicated
as in renal failure patients."Mismatched perfusion defect" which means an area of
perfusion defect without ventilation defect,is characteristic but it is found in <50% of the
patients).A negative D-Dimer is very helpful in excluding the diagnosis of pulmoary venous
thromboembolism in low- risk patient; however, a positive D-Dimer is far from diagnostic
and must be followed by more specific studies.Pleural effusions associated with pulmonary
embolism are usually small and almost always exudative.
In order to differentiate the effusion as exudate or transudate, the classic Light Criteria
classify an exudate as having at least one of the following:
1) Pleural fluid protein/serum protein ratio>0.5
2)Pleural fluid LDH/serum LDH ratio>0.6
3)Pleural fluid LDH > 2/3 of the upper limit of normal for serum LDH.( Exudative>200IU/ml
and Transudative<200IU/ml)
Exudates are caused by increased capillary permeability(infections,autoimmune disease and
neoplasm) while transudates are caused by increased hydrostatic(as CHF) or decreased oncotic
pressure( as in liver failure).Exudates has more protein content than transudates.
***Pleural effusion in Congestive Heart Failure are typically bilateral,symmetrical,and caused by increased
intravascular hydrostatic pressure( in hypoalbuminemia effucsion is due to decreased intravascular oncotic
pressure).Effusions are transudative with few RBCs and WBCs and a glucose concentration equal to that of serum.
Malignancy in lungs or pleural space can cause turbid or bloody exudates with lymphocte predominance of the WBC
fraction and many RBCs and variable glucose concentration depending on the tumor burden but approximates serum
value in early effusions. Aspiration pneumonia will initially cause an exudate due to chemical pneumonitis which can
progress into pulmonary abscess and empyema if left untreated.***
Parapneumonic effusion usually occur from pneumonia.The fluid may be sterile in the intial
stages and resolve with antibiotic therapy;however, in few cases the patient will ontinue to
have elevated temperatures,pleuritic chest pain, and dyspnea.CT scan will identify the fluid
collection.The fluid may be aspirated to determine if empyema has set in.The aspirated fluid
should always be analyzed for protein content,gram stain,cell count,cytology(to rule out
malignancy),and glucose levels( low in RA,TB,Empyema,Malignancy, and Esophageal
rupture).When PH of pleural fluid is <7.2 or Glucose Content <60mg/dl or Positive
Gram Stain=>Drain the infected pleural space with a chest tube( in other words
thoracostomy indication).
Low glucose concentration in exudative effusions is due to the high metabolic activity of
leukocytes within the pleural fluid.(<30mg/dl suggest empyema/rheumatic effusion- 3050mg/dl indicates an effusion due to malignancy/lupus/TB/esophageal rupture)
Management of suspected Pulmonary Embolism:
Acute DVT should be treated with a combination of warfarin and heparin for the first 5 days.After 5
days, the heparin may be discontinued if the patient's INR is theraputic.Warfarin should be
continued for at least 6 months in most patients with a first time clot.A progressing clot in a patient
with a sub-theraputic INR requires bridging heparin until the INR is theraputic.
A massive PE can cause RV dilatation and failure that results in
hypotension,tahycardia,syncope,and shortness of breath.Hemodynamic instability is an absolute
indication, and RV strain a relative indication, for thrombolytics in the setting of PE.
Exudative
Heart Failure
Malignancy(lung,breast,lymphoma)
Nephrotic Syndrome
Paraneumonic Effusions(pneumonia)
Liver Disease
Tuberculosis
Pulmonary Embolism
Pulmonary Embolism
Atelectasis
Pancereatitis
A pleural effusion presentswith abscence of lung sounds and dullness to percussion at the involved
lung base(s). Undiagnosed pleural effusion is best evaluated with thoracocentesis,except in patients
with clear-cut evidence of CHF where a trial of diuretics is warranted.
Pulmonary Hypertension:
It is defined as a mean pulmonary arterial pressure>25mmHg at rest or 30mmHg with excercise.It is
seen following the narrowing of the precapillary vessels, the loss of the pulmonary capillary bed,or
passive backpressure from the post capillary vessels from any cause. It can be classified as follows:
1. Pulmonary hypertension asscociated with disorders of the respiratory system,hypoxemia,or
both.
2. Pulomnary hypertension due to pulmonary venous hypertension(Left Vtricular Heart
disease,Mitral valve disease or pulmonary veno-occlusive disease).
3. Pulmonary hypertension following chronic thromboembolic disease.
4. Pulmonary arterial hypertension(1ry pulmonary hypertension,Hypertension associated with
vasculopathy).
5. Pulmonary hypertension due to disorders directly affecting the pulmonary
vasculature(pulmonary capillary hemangiomatosis).
Clinical Features are the same regardless of the underlying cause.It includes Dyspnea,weakness,and
fatigue( early complaints), which may be followed by chest pain,hemoptysis,syncope,or hoarseness(
due to compression of recurrent laryngeal nerve).RVF develops late in the disease and manifests
with RV heave,JVD,tender hepatomegaly,ascites,edema..CXR would show enlargement of the
pulmonary arteries with rapid tapering of the dital vessels(pruning) and enlargement of the right
ventricle.An EKG may show right axis deviation,which is secondary to right ventricular strain and
hypertophy ue to pulmonary hypertension.Untreated pulmonary hypertension would eventually lead
to Cor-pulmonale.
Germ cell tumors typically affect young patients especially males and display aggressive
biologic behavior.Nonseminomatous germ cell tumors typically produce both alpha-feto
protein(AFP) and human chorionic gonadotropin(B-HCG) as tumor markers.
Newer antipneumoccoccal quinolones,like levofloxacin or moxifloxacin, are the drugs of
first choice for inpatient treatment of CAP. For outpatient therapy,either azithromycin or
doxycycline( when macrolide resistance is suspected) can be used.
TMP/SMX is best inital treatment for and prophylaxis against pneumocystis
pneumonia(PCP).If there is toxicity, switch to clindamycin+primaquine or pentamidine.
Vancomycin is used for suspected methicillin resistant staphylococcus infection.This is often
seen in nosocomial pnemonia patients.
Clindamycin is used if there is a suspicion for aspiration pneumonia like in patients who had
a recent stroke,history of unconsciousness(heavy alcohol user),recent sedation for
procedures(endoscopy,..).,etc.
Goodpasture's Disease affects the lungs causing couh,dyspnea,and hemoptysis and the
kidneys causing nephritic range proteinuria(<1.5g/day),acute renal failure,and dysmorphic
red cells/red cell casts on urinalysis. Systemic symptoms are uncommon. Diagnosis is made
by renal biopsy showing linear IgG antibodies to alpha-3 chain of type IV collagen which is
a protein expressed strongly on the glomerular and alveolar basement membrane.DLCO is
increased.
Glucocorticoids cause neutrophilia by increasing the bone marrow release and mobilizing
the marginated neutophil pool.Eosinophils and lymphocytes are decreased.
Recurrent pneumonia in the same anatomic location is a red flag for lung
cancer.Furthermore,smoking is the primary risk factor for bronchogenic carcinoma. When
lung cancer is suspected,CT scan of the chest is warranted. Bronchoscopic or Ct guided
biopsy may then be performed depending on whether the lesion has a peribronchial or
peripheral location.
Patients with HIV have a 10% per year risk of experiencing reactivation of tuberculosis
which manifests wth fever,night sweats,weight loss,fatigue,pleuritic chest pain,chronic
cough and hemoptysis.CXR findings classically include an apical cavitary lesion.
M.tuberculosis preferentially reactivates in the apices of the lungs because it is an aerobic
organism, and the oxygen tension is highest in this segment of the lungs.
A neoplasm in the pulmonary apex at the thoracic inlet can compress the inferior portion of
the brachial plexus(invasion of the 8th cervical and first thoracic nerves) resulting in shoulder
pain radiating in an ulnar distribution.this is known as Pancoast syndrome.
Aortic arch aneurysm would demonstrate a fusiform dilation of the ascending aorta and
arch,which project to the left within the chest.
Legionella pneumophila is an intracellular gram negative organism commonly spread by
cooling towers and water supplies.Travel-associated infection is well
documented.Symtpoms suggestive of legionnaire's disease include cough,fever>39C,GI
symptoma,and confusion.Diagnosis is confirmed by urine antigen testing or culture on
charcoal agar.Treatment with azithromycin or levofloxacin is appropriate.
Aspergilloma can grow in the apex of the lung but does not cause arm pain.The patient may
present with hempotysis,fever,weight loss, and a chronic cough. The mass is usually mobile
and moves with position.The diagnosis is made by finding hyphae in the
specimen.Aspergillosis can also be seen in immunocompromised patients;however,the chest
xray typically shows a solid mass surrounded by a radiolucent crescent(crescent
sign,Monod's Sign).A mobile cavitary mass in the lung, which presents with intermittent
hemoptysis is usually indicative of aspergilloma.
Cryptogenic organizing pneumonia causes dry cough and systemic symptoms that last for
months.Chest radiography demonstrates Bilateral Ground Glass infiltrates.
Gram negative bacilli (GNB)accounts for <2% of CAP,but account for most of the
nosocomial infection and have high mortality rates. Some of the common gram-negative
bacteria(GNB) causing pneumonia are E.coli(non-capsulated),Klebsiella
Pneumoniae(encapsulated),Pseudomonas(encapsulated-seen in cystic
fibrosis,neutropenia,advanced AIDS,bronchiectasis,and ICU
pneumonias),Proteus,Enterobacter,Serratia marcescens and Acinetobacter.GNB pneumonias
are rare in healthy individuals and usually occur in infants,elderly,alcoholics and
immunocompromised host especially with neutropenia. The usual pathophysiological
mechanism is colonization of the oropharynx,followed by micro aspiration of upper airway
secretions.
Friedlander's pneumonia or Klebsiella pneumonia most frequently affect upper lobe and
produce Currant Jelly-like sputum with tissue necrosis and early abscess formation and a
fulminant course.Klebsiella is one of the most common organisms responsible for
pneumonia in alcoholics ( grows as mucoid colonies).
Carcinoid tumors are usually centrally located and easily visible with bronchoscope.They
may present with a cough and recurrent hemoptysis.The tumors are slow growing and have
the best prognosis of all lung cancers.
Chronic Bronchitis is characterized by a chronic productive cough for at least 3 months
over 2 consecutive years and not attributed to other causes.It occurs following prolonged
exposure of the tracheobronchial tree to nonspecific irritants and is characterized by
hypersecretion of mucus and structural changes in the tracheobronchial tree,The prescence
of a chronic productive cough,prominent bronchovascular marking,mild flattening of the
diaphragm and normal DLCO is suggestive of chronic bronchitis rather than emphysema in
this patient.Patients with predominant chronic bronchitis are also called Blue Bloaters as
they generally have a stocky build with a chronic productive cough,recurrent or persistent
signs of right heart failure, and profound oxygen desaturation.
Acute Bronchitis is a common cause of blood tinged sputum and is usually viral in
etiology.In afebrile patient with new onset blood-tinged sputum without significant signs of
more serious disease,observation and close clinical follow up is the best treatment strategy.
Emphysema is a pathologic diagnosis characterized by permenant and destructive
enlargement of airspaces distal to the terminal bronchioles with loss of normal
artitecture.Patients are generally thin with severe dyspnea(Pink Puffers),and have
hyperinflation of the chest,decreased vascuar markings,decreased DLCO( due to destruction
of alveoli),and moderate oxygen desaturation.Panacinar emphysema is typical for alpha-1antitrypsin deficiency, whereas centriacinar emphysema is more characteristic of COPD.
The development of clubbing and sudden onset joint arthropathy in a chronic smoker is
suggestive of Hypertrophic PulmonaryOsteoarthropathy.This condition is often
associated with lung cancer, and therefore a CXR is indicated to rule out malignancy and/or
other lung pathology(TB, bronchiectasis, or emphysema).
The kidney compensates for respiratory alkalosis by preferentially excreting bicarbonate in
the urine( low bicarbonate excretion and high H+ secretion in acidosis).( in ventilated
patients, ventialtion=tidal volumexRR...and according to this equation u evaluate hypo and
hyperventialtion)
Acidosis accompanied by hypercarbia and a normal/elevated serum bicarbonate is
diagnostic of a respiratory acidosis.Hypoventialtion is a major cause of respiratory acidosis
and may occur in post-ictal state( in post ictal state the lactic acidosis from prolonged and
forceful skeletal muscle activity will manifest as metabolic acidosis with decreased HCO3).
Peak Airway Pressure=Resistive Pressure+Elastic Pressure+PEEP
Peak Airway Pressure is the maximum pressure during the respiratory cycle.
Elastic(Plateau)Pressure(calculates Lung Compliance) is the pressure at the end of an
inspiratory hold maneuver.It is the the product of the lung's elastance and the volume of gas
delivered.(Elastic recoil is inverseley proportional to lung compliance,i.e: a decrease in compliance
as in pulmonary fibrosis is accompanied by increase in the elastic pressure)
Resistive (Peak) Pressure measures total airway resistance which takes into account the
resistance of the ventialtor circuit,endotracheal tube,and the patient's airways(in mechanically
ventilated patients).( it's impossible to calculate upper airway resistance when a patient has an
endotracheal tube in place because the tube bypasses the upper airway)
Positive End Expiratory Pressure(PEEP) is calculated with the end expiratory hold maneuver.
(alveolar end-expiratory pressure=atmospheric pressure increases in obstructive lung disease due
to inability of alveoli to empty completely).
Respiratory muscle strength is determined by measuring the patint's negative inspiratory
force(NIF).
Chest CT is indicated in cases of hemoptysis where PE,mass lesions, bronchiectasis or
vascular malformations are suspected.If diagnosis is unclear and in cases of recurrent
hemoptysis, Bonchoscopy is indicated.
An enlarged left atrium in mitral stenosis( look for history of rheumatic fever-immigrant...)
can cause a persistent cough and elevation of the left main stem bronchus(and phrenic
nerve).
Histoplasma capsulatum(Histoplasmosis) is a common and usually asymptomatic
infection in endemic areas like Mississippi and Ohio River valleys and Central America.It is
usually found in soil with a high concentration of bird or bat guano droppings.the infection
is contracted by inhalation of the spores or mycelial fragments.Less than 5% of infected
people develop the symptomatic disease.The extent of disease is determined by the amount
of exposure and immunity of the host.Symptomatic lunginfection is mostlycharaerized by
self-limiting fever,chills,and a non-productive cough.A chest xray may show patchy lobar or
multinodular lobar infiltrates.Chronic cavitary pulmonary histoplasmosis is a progressive
fatal form of histoplasmosis that usually develops in older COPD patients.Disseminated
histoplasmosis is seen in immunocompromised adults and young children.Occasionally,
mediastinal lymph node enlargement occurs as a result of a lymphagenous reaction to
histoplasma.
Postnasal drip of nasal secretions can cause irritation and initiation of the cough reflex.H1
histamine receptor antagonists (like chlorpheniramine) decrease nasal inflammation and post
nasal drip in patients with allergic rhinitis(there would be a background of environmental
allergies and diagnosis is made based on history and physical exam).
New clubbing in patients with COPD often indicates the development of lung cancer.
(Pulmonary HTN and hypoxemia due to congenital heart disease often result in clubbing
but those of COPD are rarely associated with digital clubbing)
Airway disease is the most common cause of both mild and massive hemoptysis.Chronic
Bronchitis is a frequent cause of mild hemoptysis in patients with significant smoking
history.(Note: thrombocytopenia may present with hemoptysis if the platelet count is
markedly decreased-look for signs of bleeding as epistaxis or petechiae)
Allergic Rhinitis
Dark puffy eyelids is called allergic shiners. The red crease over the nose causes constant
rubbing, called allergic salute. Tx is avoidance and decongestants. ****If rhinitis is not clear
if its allergic or infectious, then next step is Nasal cytology. Demonstration of neutrophils in
nasal secretions suggests infectious cause. Predominant of Eosinophils suggest allergic
cause. Other cause of nasal eosinophilia include Nasal Polyposis (Aspirin sensitivity).
Aspirin Sensitivity Syndrome(V.IMP) (clues to diagnosis include aspirin
ingestion,persistent nasal blockage,and episodes of bronchoconstriction)is believed to be
pseudo-allergic reaction.It results from aspirin-induced prostaglandin/leukotriene
misbalance in susceptible individuals which triggers bronchoconstriction and polyp
formation.Treatment includes avoidance of NSAIDs and the use of leukotriene receptor
antagonists(drug of choice).
Recurrent bacterial infections in an adult patient may indicate humoral immunity
defect.Quantitative measurement of serum immunoglobulin levels helps to establish the
diagnosis.
Theophylline toxicity usually manifests as CNS stimulation(headache,insomnia),GIT
disturbances(nausea,vomiting),and cardiac toxicity(arrythmia).The mechanisms responsible
for the toxicity may include phosphodiesterase inhibition,adenosine antagonism,and
stimulation of epinephrine release.
Lung consolidation causes bronchial breath sounds which are loud(assuming patent
In patient presenting with sudden onset of severe shortness of breath-stridor and harsh
respiratory sounds from the trachea, upper airway obstruction should be immediately ruled
out. ( Laryngeal edema is a common cause-look for history of food allergies and urticaria)
Bird Fancier's Lung is a form of hypersensitivity pneumonitis caused by repeated
inhalation of an inciting antigen which leads to alveolar inflammation.Common responsible
antigens inculde aerosolized bird droppings and molds associated with farming(farmer's
lung). A history of antigen exposure is highly suggestive.Acute episodes may present with
cough,breathlessness,fever and malaise that occur 4-6 hours after exposure.With chronic
exposure patients may develop pulmonary fibrosis and a restrictive pattern on lung
spirometry.Classic radiographic findings include ground glass opacity or haziness of the
lower lung fields.Best treatment is avoidance of antigen exposure.Continued exposure risks
disease progression.
Obesity hypoventialtion Syndrome is defined by severe obesity greater than 150% of ideal
bodyweight and alveolar hypoventialtion during wakefulness.ABG will demonstrate
The leading cause of cancer death in the United States. Risk factors include
tobacco smoke (except for bronchoalveolar carcinoma) and radon or asbestos exposure.
Types are as follows:
Small cell lung cancer (SCLC):Highly correlated with cigarette exposure.Has a central
location.Has a neuroendocrine origin; associated with paraneoplastic syndromes.
Metastases are often found on presentation in intrathoracic and extrathoracic
sites such as brain, liver, and bone.
Non-small cell lung cancer (NSCLC ) : Represents a group of cancers,with the most
common types being adenocarcinoma, squamous cell carcinoma(SCC), and large cell
carcinoma. These cancers are less likely than SCLC to metastasize at an early stage.
Adenocarcinoma:The most common lung cancer; has a peripheral location.Includes
bronchoalveolar carcinoma, which is associated with multiple nodules, interstitial
infiltration, and prolific sputum productionbut is not associated with smoking.
SCC: Has a central location; 98% are seen in smokers.
Large cell/neuroendocrine carcinomas: Least common; associated with a poor
prognosis.
HISTORY/PE
Presents with cough, hemoptysis, dyspnea, wheezing, pneumonia, chest pain, weight loss,
and possible abnormalities on respiratory examination (crackles, atelectasis).
Other findings include the following:
Horner's syndrome (miosis, ptosis, anhidrosis)... patients with Pancoast's tumor at the apex
of the lung.
Laryngeal Edema
Flow volume loops diagrams express airflow in different lung diseases and give the relationship
between flow rates compared with lung volumes.On the Vertical(Y) Flow Rate is expressed and On
the Horizontal(X) axis Volume is expressed( it increases to the left).The shape of the loop can
characterize the type and distribution of airway obstruction.
When comparing Normal flow volume loop with one of Restrictive lung disease, the restrictive lung
disease alters the loop by shifting to the right of the x-axis which means a reduction in lung
volumes.
On the other hand,obstructive lung disease alters the shape of the loop by causing a reduction of
airflow( alteration on the y-axis).
Now in case of fixed airway obstruction(tracheal stenosis /laryngeal edema which occurs after
prolonged intubation) the flow of the loop is is flattened on the top and the bottom. In dynamic
extrathoracic airway obstruction( as in vocal cord paralysis), the obstruction occurs mostly with
inspiration while expiration is mostly normal.This effect causes the flow volume loop to be
flattened only on bottom( the inspiration flow curve will be a straight line almost along the
horizontal axis while there is an expiratory curve).