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metoprolol
short-acting, used in
surgery or emergency
{*} quinidine
Drugs
esmolol
Drugs
cinchonism
lupus-like syndrome
procainamide
hypotension
Mechanism
Mechanism
decrease contractility
no eect on Phase 3
increase PR interval
atrial flutter/fibrillation
AV block
tachyarrhythmia caused by
increased sympathetic activity
Therapeutic Use
Class IA
atrial arrhythmia
Therapeutic Use
ventricular tachyarrhythmia
hypotension
AV block
torsade de pointes
bronchospasm
SA and AV block
Adverse Eects
asystole
Adverse Eects
precipate angina
attack if abruptly
stopped
gastrointestinal eects:
nausea
vomiting
diarrhea
CNS disturbances:
depression
sleep alterations
sedation
heart > vascular smooth muscle
anticholinergic eects
CNS eects
Class IB
Class IC
verapamil
Drugs
diltiazem
liver metabolism
ibutilide
Adverse Eects
torsades de pointe
torsades de pointe
Adverse Eects
renal elimination
Mechanism
new arrhythmias
Adverse Eects
bretyilum
hypotension
renal elimination
ARRHYTHMIA
decrease automaticity
negative inotrope
favorable kinetics
dronedarone
Therapeutic Use
non-emergency use
Drugs
(mnemonic: k is bad)
coronary vasodilation
increase PR interval
gastrointestinal discomfort
hypotension
hypotension
verapamil
pulmonary fibrosis
constipation
bradycardia
AV block
hepatotoxicity
amiodarone
Adverse Eects
Adverse Eects
corneal microdeposits
skin discoloration (blue-gray)
negative inotrope
hypo/hyperthyroidism
peripheral neuropathy
thrombocytopenia (rare)
liver metabolism
Mechanism
long half-life
slow automaticity
asystole (brief)
adenosine
chest pain
dofetilide
Adverse Eects
K+ channel antagonist
Therapeutic Use
Mechanism
Therapeutic Use
digoxin
Drugs
Torsade de Pointes
increase QT interval
digixin toxicity
ibutilide
dofetilide
amiodarone
Therapeutic Use
Therapeutic Use
treatment/prevent ventricular
tachycardia/fibrilation
treatment/prevent atrial/ventricular
arrhythmia
Adverse Eects
Class IA
respiratory paralysis
Adverse Eects
Class IB
circulatory collapse
Class IC
propranolol
esmolol
METABOLISM/EXCRETION
Renal
Class III: K+ Channel Inhibidor
ibutilide
dofetilide
bretylium
sotalol
mild bradycardia
hypotension
Mechanism
hinder K+ replenishment
Other
liver metabolism
amiodarone
Class IV: Ca2+ Channel Inhibitor
atenolol
bretylium
sotalol
amiodarone