Académique Documents
Professionnel Documents
Culture Documents
BY
Dr.K.PURUSHOTHAM RAO
M.Pharm., Ph.D
1.
2.
3.
M.PHARM
(PHARMACEUTICAL TECHNOLOGY)
4.
12-07-2011
5.
FORMULATION DEVELOPMENT OF
MEDICATED LOZENGES FOR PEDIATRICS
6.
6.1
Review of Literature:
A through literature survey has been carried out on the proposed topic and most
prominent references found are:
Zinc Gluconate lozenges for treating the common cold in children3.
Delivery of antifungal agents to the oral cavity4.
Development of bioadhesive lozenge containing a synergistic
combination of antifungal agents5.
Koflet lozenges in the treatment of sore throat6.
The nicotine lozenge is a safe and effective new treatment for smoking
cessation in low and highdependence smokers7.
To study the effect of acidic candies on saliva in unilaterally irradiated
6.3
To enhance the patient compliance and acceptance and desire to hold the
tablet in the mouth until it is completely dissolved.
7.
7.1
Source of Data:
Internet, www.rguhs.ac.in.
M.R.Medical college library, Gulbarga.
International pharmaceutical abstract.
H.k.e.ss college of pharmacy library, Gulbarga.
7.2
PHASE-IV
The entire prepared tablet Lozenges will be subjected for stability studies for a
period of three months. The drug content estimation will be carried out on the
sample taken at various time intervals for 15 days.
7.3
7.4
Has ethical clearance have been obtained from your institution in case of
7.4?
--------------------Not applicable-----------------------------------
List of References
1. Joel BE, MSD, DMD, Bruce P, MD2. Oropharyngeal Candidiasis: A Review of
Its Clinical Spectrum and Current therapies. Clin Ther. 1998; 20(1):40-57.
2. Glibert S, Banker, Anderson NR. Tablets. In: Lachman L, Lieberman HA, kanig
JL, editors. The Theory and Practice of Industrial Pharmacy. Bombay: Varghese
Publishing House;1987.p.333.
3. George AE, Davis DR, William WH. Reduction in Duration of Common Colds
by Zinc Gluconate Lozenges in a Double-Blind Study. Antimicrob Agents
Chemother. 1984; 25(1):20-4.
4. Samaranayake LP, Ferguson MM. Delivery of Antifungal Agents to the Oral
Cavity. Adv Drug Deliv Rev. 1994; 13:161-79.
5. Codd JE, Deasy PB. Formulation Development and in vivo Evaluation of a
Novel Bioadhesive Lozenge Containing a Synergistic Combination of
Antifungal Agents. Int J Pharm. 1998;173:13-24.
6. Prakash T. Koflet Lozenges in the Treatment of Sore Throat. The Antiseptic.
2001; 98(4):124-7.
7. Shiffman S, Dresler CM, Hajek P, Gilburt SJA, Targett DA, Strahs KR. Efficacy
of a Nicotine Lozenge for Smoking Cessation. Arch Intern Med. 2002;
162:1267-76.
8. Jensdottir T, Nauntofte B, Buchwald C, Hansen HS, Bardow A. Effects of
Sucking Acidic Candies on Saliva in Unilaterally Irradiated Pharyngeal Cancer
Patients. Oral Oncol. 2006; 42:317-22.
9. Ayoub C, Skoury A, Abdul-Baki H, Nasr V, Soweid A. Lidocaine Lollipop as
Single-agent Anesthesia in Upper GI Endoscopy. 2007; 66(4):786-93.
10. Ahuja R, Jain RK, Nandane AS, Lakadawala M, Patel S, Katkoriya M.
Optimization of the Formulation of Bio-active Throat Soothing Lozenges. 2009;
89:12-18.
11. Purushotham RK, Mohanta GP, Krantikumar S, Veerabhadrappa H, Shivanand
B. Design of Candy Based Doxofylline Tablet Lozenges. Recent Trends
Pharmac. Toxic. 2009; 6:43-50.
12. Purushotham RK, Shivappa NN, Zakaullah S, Zainab H, Arshiya S. Studies on
5
Candy based Clotrimazole Pediatric Tablet lozenges. J Chem Pharm Res. 2010;
2(3):640-6.
9.
10.
11.
Signature of candidate
Remarks of Guide
11.1 Guide
PROFESSOR
DEPT.OF PHARMCEUTICAL TECHNOLOGY
H.K.E.Ss COLLEGE OF PHARMACY
GULBARGA 585105
11.2 Signature
11.3 Co-guide
Shantveer.v.salger
M. Pharm.
ASST. PROFESSOR
DEPT.OF PHARMCEUTICAL TECHNOLOGY
H.K.E.Ss COLLEGE OF PHARMACY
GULBARGA 585105
11.6 Signature