GENOMICS; BIOL-5381/4341 Spring 2006 Genomics is a graduate level biology elective in which the fundamentals of how

the human genome sequence was acquired and the impact of the human genome era on biomedical research, medical care and genetic testing will be explored. We will also cover new tools such as DNA microarray, realtime PCR, mass spectrometry and data mining using bioinformatics. The class will be a mixture of didactic lectures and paper presentations representing applied genomic approaches. Undergraduates are not required to present a paper and exams will be modified. PREREQUISITES TIME AND LOCATION INSTRUCTOR OFFICE HOURS REQUIRED TEXT Biology 3301 with a Grade of C or better MW 5:30 – 6:45 PM FO 3.616 Betty Pace, MD (bpace@utdallas.edu) BE3. 204; Ext. 6240 T 10-11 AM and by appointment How the Human Genome Works Edwin H McConkey Jones and Barlett Publishers Sudbury, MA 01776 Reserve Book: Fundamental Concepts of Bioinformatics Dan E. Krane & Michael L. Raymer Benjamín Cummings, San Francisco CA Four Exams (25% each), Essay Style Students are required to abide by UT-Dallas policies concerning academic integrity (for details, see http://www.utdallas.edu/student /slife/scholastic.html). Failure to comply with these terms will be subject to appropriate disciplinary action If you have a disability that required accommodation, you must notify the instructor and file a request through Disability Services (SU 1.610, ext 2098) on or before the first day of class. By doing so, you can be assured of full cooperation in making appropriate arrangements

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CLASS SCHEDULE Date January 9 11 16 18 23 25 30 February 1 6 8 13 15 20 22 27 March 1 12 13 15 20 22 27 29 April 3 5 10 12 17 19 24 26 Class # 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 Lecture Topic The Human Genome Project DNA/RNA Structure and Function Martin Luther King Holiday Human Mutations Gene Expression Molecular Biology Tools EXAM #1 (25%) *Paper Presentation I Genetic Diseases The Human Genome and Medicine Bioinformatics I (Dr. BU) Database Searches (DR. BU) Evolution/Phylogenetic (DR. ZEIN) *Paper Presentation II EXAM #2 (25%) *Paper Presentation III SPRING BREAK *Paper Presentation IV Gene Profiling & Microarray Disease Modifiers, SNP *Paper Presentation V Protein Structure Proteomics (Dr. ZEIN) Assigned Reading Pages Lecture 1: 1-18 Lecture 2: 19-34 NO CLASS Lecture 2: 19-34 Reserve text, p1-12 Reserve text, p19-30

Lecture 3: 35-52 Lecture 4: 53-68 Reserve text, p33-55 Reserve text, p57-96

NO CLASS Handout #1 Handout #2 Reserve text, p 155-178 Reserve text, p 180-191 Lecture 5: 69-78 Lecture 6: 79-94 Handout #3 Lecture 7: 95-106

EXAM # 3 (25%) The Mitochondrial Genome Genetic Basis of Cancer (DR. ZEIN) *Paper Presentation VI Molecular Diagnostic/ Pharmocogenomics Human Genome & Development *Paper Presentation VII FINAL EXAM (25%) 5:00 PM

* Graduate Students Only **Final grades will be assigned using a curve based on the overall class performance

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