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1. The document reports on the synthesis and antimalarial properties of twelve new chlorinated 9H-xanthones carrying an aminoalkyl side chain.
2. The compounds were tested against chloroquine-susceptible and chloroquine-resistant strains of the malaria parasite Plasmodium falciparum. All compounds showed activity against both strains.
3. One compound, 6-chloro-1-{[2-(diethylamino)ethyl]amino}-9H-xanthen-9-one (1k), exhibited significant activity against the resistant strain with an IC50 of 3.9 micrometers.
1. The document reports on the synthesis and antimalarial properties of twelve new chlorinated 9H-xanthones carrying an aminoalkyl side chain.
2. The compounds were tested against chloroqu…