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Genome composition
Organization of the genome,
Coding and non-coding sequences,
Regulatory elements, repeat sequences, transposons, organelle genomes
DNA replication
DNA polymerases, mechanism of replication,
Replication of damaged DNA, termination
DNA Repair
DNA damage response, Mismatch repair, Base Excision repair,
Nucleotide Excision repair, Double strand break repair
DNA Recombination
Recombination models, Recombination proteins, Gene conversion,
Homologous Recombination, DNA recombination and chromosome segregation
Suggested Reading:
C value paradox
C value- The total amount of DNA in the haploid genome
- Excess DNA compared to the number of proteins the genome codes for
- No correlation between C value and morphological complexity
Double stranded DNA has higher affinity for a crystalline form of Calcium Phosphate
Hydroxyapatite. Both ssDNA and dsDNA can be washed off and estimated separately
http://www.learnerstv.com/animation
Highly repetitive, moderately repetitive and Nonrepetitive DNA comprise the Eukaryotic genome
45%
30%
25%