Ampicillin/ sulbactam

Generic Name: ampicillin/sulbactam (AM-pi-SIL-in/sul-BAK-tam)

Brand Name: Unasyn
Ampicillin/ sulbactam is used for:
Treating infections caused by certain bacteria.
Ampicillin/sulbactam is a penicillin antibiotic. It works by blocking the bacteria's cell wall growth, which kills the
bacteria.
Do NOT use ampicillin/ sulbactam if:

you are allergic to any ingredient in ampicillin/sulbactam or to any other penicillin antibiotic (eg, amoxicillin)

you are taking a tetracycline antibiotic (eg, doxycycline)

you have mononucleosis ("mono")

you have recently received or will be receiving live oral typhoid vaccine

Contact your doctor or health care provider right away if any of these apply to you.
Before using ampicillin/ sulbactam:
Some medical conditions may interact with ampicillin/sulbactam. Tell your doctor or pharmacist if you have any
medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding

if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement

if you have allergies to medicines, foods, or other substances

if you have had a severe allergic reaction (eg, severe rash, hives, difficulty breathing, dizziness) to a
cephalosporin (eg, cephalexin) or other beta-lactam antibiotic (eg, imipenem)

if you have mononucleosis ("mono") or kidney problems

Some MEDICINES MAY INTERACT with ampicillin/sulbactam. Tell your health care provider if you are taking any
other medicines, especially any of the following:

Tetracyclines (eg, doxycycline) because they may decrease ampicillin/sulbactam's effectiveness

Probenecid because it may increase the risk of ampicillin/sulbactam's side effects

Allopurinol because the risk of skin rash may be increased

Heparin because the risk of bleeding may be increased

Methotrexate because the risk of its side effects may be increased by ampicillin/sulbactam

Anticoagulants (eg, warfarin) because their effectiveness may be decreased or the risk of their side effects may
be increased by ampicillin/sulbactam

Aminoglycosides (eg, gentamicin), birth control pills, or live oral typhoid vaccine because their effectiveness may
be decreased by ampicillin/sulbactam

This may not be a complete list of all interactions that may occur. Ask your health care provider if ampicillin/sulbactam
may interact with other medicines that you take. Check with your health care provider before you start, stop, or
change the dose of any medicine.
How to use ampicillin/ sulbactam:
Use ampicillin/sulbactam as directed by your doctor. Check the label on the medicine for exact dosing instructions.

Do not mix ampicillin/sulbactam in the same intravenous (IV) container as aminoglycosides (eg, gentamicin).

Do not take ampicillin/sulbactam at the same time as khat.

Ampicillin/sulbactam is usually given as an injection at your doctor's office, hospital, or clinic. If you will be using
ampicillin/sulbactam at home, a health care provider will teach you how to use it. Be sure you understand how to
use ampicillin/sulbactam. Follow the procedures you are taught when you use a dose. Contact your health care
provider if you have any questions.

Do not use ampicillin/sulbactam if it contains particles, is cloudy or discolored, or if the vial is cracked or
damaged.

To clear up your infection completely, use ampicillin/sulbactam for the full course of treatment. Keep using it
even if you feel better in a few days.

Keep this product, as well as syringes and needles, out of the reach of children and pets. Do not reuse needles,
syringes, or other materials. Ask your health care provider how to dispose of these materials after use. Follow all
local rules for disposal.

If you miss a dose of ampicillin/sulbactam, use it as soon as possible. If it is almost time for your next dose, skip
the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.

Ask your health care provider any questions you may have about how to use ampicillin/sulbactam.
Important safety information:

Ampicillin/sulbactam only works against bacteria; it does not treat viral infections (eg, the common cold).

Be sure to use ampicillin/sulbactam for the full course of treatment. If you do not, the medicine may not clear up
your infection completely. The bacteria could also become less sensitive to this or other medicines. This could
make the infection harder to treat in the future.

Long-term or repeated use of ampicillin/sulbactam may cause a second infection. Your doctor may want to
change your medicine to treat the second infection. Contact your doctor if signs of a second infection occur.

If vomiting or diarrhea occurs, you will need to take care not to become dehydrated. Contact your doctor for
instructions.

Mild diarrhea is common with antibiotic use. However, a more serious form of diarrhea (pseudomembranous
colitis) may rarely occur. This may develop while you use the antibiotic or within several months after you stop
using it. Contact your doctor right away if stomach pain or cramps, severe diarrhea, or bloody stools occur. Do
not treat diarrhea without first checking with your doctor.

Hormonal birth control (eg, birth control pills) may not work as well while you are using ampicillin/sulbactam. To
prevent pregnancy, use an extra form of birth control (eg, condoms).

Ampicillin/sulbactam may interfere with certain lab tests. Be sure your doctor and lab personnel know you are
using ampicillin/sulbactam.

Diabetes patients - Ampicillin/sulbactam may cause the results of some tests for urine glucose to be wrong. Ask
your doctor before you change your diet or the dose of your diabetes medicine.

Ampicillin/sulbactam should be used with extreme caution in CHILDREN younger than 1 year old; safety and
effectiveness in these children have not been confirmed.

Use ampicillin/sulbactam with extreme caution in CHILDREN younger than 10 years old who have diarrhea or an
infection of the stomach or bowel.

PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss
the benefits and risks of using ampicillin/sulbactam while you are pregnant. Ampicillin/sulbactam is found in
breast milk. If you are or will be breast-feeding while you use ampicillin/sulbactam, check with your doctor.
Discuss any possible risks to your baby.

Possible side effects of ampicillin/ sulbactam:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any
of these most COMMON side effects persist or become bothersome:
Mild diarrhea; pain, swelling, or redness at injection site.
Seek medical attention right away if any of these SEVERE side effects occur:
Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face,
lips, or tongue); bloody stools or severe diarrhea; chest pain; chills; fever; severe nausea or vomiting; stomach pain
or cramps; unusual bruising or bleeding; vaginal irritation or discharge; vein inflammation or tenderness; white
patches in mouth.

Generic Name: doxycycline (DOX i SYE kleen)

Brand Names: Adoxa, Alodox, Avidoxy, Doryx, Monodox, Morgidox, NicAzel Doxy 30, Ocudox Convenience Kit,
Oracea, Oraxyl, Vibramycin
What is doxycycline?

Doxycycline is a tetracycline antibiotic. It fights bacteria in the body.

Doxycycline is used to treat many different bacterial infections, such as urinary tract infections, acne, gonorrhea,
and chlamydia, periodontitis (gum disease), and others.
Doxycycline is also used to treat blemishes, bumps, and acne-like lesions caused by rosacea. It will not treat facial
redness caused by rosacea.
Important information
Do not use doxycycline if you are pregnant. It could harm the unborn baby or cause permanent tooth discoloration
later in life.
You should not take doxycycline if you are allergic to any tetracycline antibiotic.
Children should not use doxycycline. It can cause permanent yellowing or graying of the teeth in children younger
than 8 years old.
Doxycycline can make birth control pills less effective. Ask your doctor about using a non hormone method of birth
control (such as a condom, diaphragm, spermicide) to prevent pregnancy while using this medicine.
Take this medication for the full prescribed length of time. Your symptoms may improve before the infection is
completely cleared. Skipping doses may also increase your risk of further infection that is resistant to antibiotics.
Before taking this medicine
You should not take this medicine if you are allergic to doxycycline or to other tetracycline antibiotics such as
demeclocycline, minocycline, tetracycline, or tigecycline.
To make sure doxycycline is safe for you, tell your doctor if you have:

liver disease;
kidney disease;
asthma or sulfite allergy;
a history of increased pressure inside your skull; or
if you take isotretinoin (Amnesteem, Claravis, Sotret).

If you are using doxycycline to treat gonorrhea, your doctor may test you to make sure you do not also have syphilis,
another sexually transmitted disease.
FDA pregnancy category D. Do not use doxycycline if you are pregnant. It could harm the unborn baby or cause
permanent tooth discoloration later in life. Tell your doctor right away if you become pregnant during treatment.
See also: Pregnancy and breastfeeding warnings (in more detail)
Doxycycline can make birth control pills less effective. Ask your doctor about using a non hormone method of birth
control (such as a condom, diaphragm, spermicide) to prevent pregnancy while using doxycycline.
Doxycycline passes into breast milk and may affect bone and tooth development in a nursing baby. You should not
breast-feed while you are taking doxycycline.
Children should not use doxycycline. This medicine can cause permanent yellowing or graying of the teeth in children
younger than 8 years old.
What is gentamicin?
Gentamicin is an antibiotic. It fights bacteria in the body.
Gentamicin is used to treat severe or serious bacterial infections.
Gentamicin may also be used for purposes other than those listed in this medication guide.
What is the most important information I should know about gentamicin?
If you are injecting gentamicin at home, your healthcare provider will give you detailed instructions on how and where
to inject the medication. If you do not understand these directions, do not attempt to inject the medication. Contact
your healthcare provider for further instructions.
Gentamicin may cause damage to the kidneys and/or nerves. Kidney function and drug levels in the blood may be
monitored with blood tests during treatment. Tell your doctor if you experience hearing loss, dizziness, numbness,
skin tingling, muscle twitching, or seizures which may be signs of nerve damage.
What should I discuss with my healthcare provider before using gentamicin?

Do not use gentamicin without first talking to your doctor if you have

sulfite sensitivity;
kidney disease;
hearing loss or loss of balance due to ear problems;
Parkinson's disease; or
a neuromuscular disorder such as myasthenia gravis.

You may not be able to use gentamicin, or you may require a dosage adjustment or special monitoring during
treatment if you have any of the conditions listed above.
Do not use gentamicin without first talking to your doctor if you are pregnant or could become pregnant during
treatment.
Do not use gentamicin without first talking to your doctor if you are breast-feeding a baby.
How should I take gentamicin?
If you are injecting gentamicin at home, your healthcare provider will give you detailed instructions on how and where
to inject the medication. If you do not understand these directions, do not attempt to inject the medication. Contact
your healthcare provider for further instructions.
Do not use any gentamicin that is discolored, has particles in it, or looks different from your previous doses. Throw
away any unused gentamicin after the amount of time determined by your pharmacist or doctor.
Adequate hydration is important during treatment with gentamicin. Fluids may be administered intravenously during
treatment.
It is important that the medication be given on a regular schedule and for the entire amount of time prescribed by your
doctor.
Gentamicin may cause damage to the kidneys and/or nerves. Kidney function and drug levels in the blood may be
monitored with blood tests during treatment. Tell your doctor if you experience hearing loss, dizziness, numbness,
skin tingling, muscle twitching, or seizures which may be signs of nerve damage.
Dispose of used needles and syringes in a puncture resistant container out of the reach of children.
Your healthcare provider will store gentamicin as directed by the manufacturer or give you detailed storage
instructions if you are storing the medication at home.
What happens if I miss a dose?
Contact your doctor if a dose is missed.
What happens if I overdose?
Contact your doctor or seek emergency medical attention if an overdose is suspected. An overdose of the medication
may result in damage to the kidneys or hearing loss, dizziness, numbness, skin tingling, muscle twitching, or seizures
(which may be signs of nerve damage).
What should I avoid while taking gentamicin?
There are no restrictions on food, beverages, or activity while taking gentamicin unless otherwise directed by your
doctor.
Gentamicin side effects
If you experience any of the following serious side effects, stop taking gentamicin and seek emergency medical
attention:

an allergic reaction (shortness of breath; closing of the throat; hives; swelling of the lips, face, or tongue; rash; or
fainting);
little or no urine;
decreased hearing or ringing in the ears;
dizziness, clumsiness, or unsteadiness;
numbness, skin tingling, muscle twitching, or seizures; or
severe watery diarrhea and abdominal cramps.

Other, less serious side effects may be more likely to occur. Continue to take gentamicin and talk to your doctor if you
experience

increased thirst;

loss of appetite;
nausea or vomiting;
a rash.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual
or that is especially bothersome. You may report side effects to FDA at 1-800-FDA-1088.
Gentamicin dosing information
Usual Adult Dose for Bacteremia:
1.5 to 2 mg/kg loading dose, followed by 1 to 1.7 mg/kg IV or IM every 8 hours or 5 to 7 mg/kg IV every 24 hours
Duration of therapy: 14 days, depending on the site, nature, and severity of the bacteremia
Comments: Limiting the duration of gentamicin therapy may help limit toxicity. Once the patient is stable for at least
48 hours, less toxic IV or oral antibiotic therapy may be considered according to microbiology sensitivity data.
Usual Adult Dose for Bacterial Endocarditis Prophylaxis:
1.5 mg/kg (maximum 120 mg) IV or IM once within 30 minutes of starting the procedure
Comments: For high risk patients, in addition to gentamicin, ampicillin 2 g is given IV or IM 30 minutes prior to the
procedure, followed by ampicillin 1 g IV/IM or amoxicillin 1 g orally 6 hours later. In penicillin-allergic patients,
vancomycin 1 g is infused IV 1 to 2 hours prior to the procedure.
Usual Adult Dose for Bacterial Infection:
1.5 to 2 mg/kg loading dose, followed by 1 to 1.7 mg/kg IV or IM every 8 hours, or 5 to 7 mg/kg IV every 24 hours
Duration of therapy: 7 to 21 days, depending on the nature and severity of the infection
Comments: Limiting the duration of gentamicin therapy may help limit toxicity. Once the patient is stable for at least
48 hours, less toxic IV or oral antibiotic therapy may be considered according to microbiology sensitivity data.
Usual Adult Dose for Brucellosis:
2 mg/kg loading dose, followed by 1.7 mg/kg IV or IM every 8 hours or 5 mg/kg IV every 24 hours
Duration of therapy: For the first 2 to 3 weeks of antibiotic therapy
Comments: Oral doxycycline or sulfamethoxazole/trimethoprim should be continued for at least 6 weeks.
Usual Adult Dose for Burns - External:
2 to 2.5 mg/kg loading dose, followed by 1.7 to 2 mg/kg IV every 8 hours
Duration of therapy: 10 to 14 days, depending on the nature and severity of the infection
Usual Adult Dose for Cystic Fibrosis:
5 to 10 mg/kg/day in 2 to 4 divided doses
Duration of therapy: Parenteral therapy should be continued for about 14 to 21 days, depending on the nature and
severity of the infection and improvement of pulmonary function.
Usual Adult Dose for Endocarditis:
American Heart Association (AHA) recommendations:
Native valve infections due to highly penicillin-susceptible viridans Group streptococci and S bovis (MIC <=0.12
mcg/mL): 3 mg/kg IV or IM once every 24 hours in combination with aqueous penicillin G sodium or ceftriaxone
Duration of therapy: 2 weeks; continue other antibiotic for 4 weeks
Native valve infections due to relatively penicillin-resistant S viridans and S bovis (MIC >0.12 mcg/mL and <=0.5
mcg/mL): 3 mg/kg IV or IM once every 24 hours in combination with aqueous penicillin G sodium or ceftriaxone
Duration of therapy: 2 weeks; continue other antibiotic for 4 weeks
Prosthetic valve infections due to S viridans and S bovis: 3 mg/kg IV or IM once every 24 hours in combination with
aqueous penicillin G sodium or ceftriaxone
Duration of therapy: 2 weeks; continue other antibiotic for 6 weeks
Native valve infections due to staphylococci: 1.5 mg/kg IV or IM every 12 hours or 1 mg/kg every 8 hours, in
combination with nafcillin, oxacillin, or cefazolin
Duration of therapy: 3 to 5 days; continue other antibiotic for 6 weeks
Prosthetic valve infections due to staphylococci: 1.5 mg/kg IV or IM every 12 hours or 1 mg/kg every 8 hours, in
combination with nafcillin or oxacillin, plus rifampin, or vancomycin plus rifampin
Duration of therapy: 2 weeks; continue other antibiotics for at least 6 weeks
Native valve or prosthetic valve infections due to susceptible enterococci: 1 mg/kg IV or IM every 8 hours, in
combination with ampicillin, aqueous penicillin G sodium, or vancomycin

Duration of therapy: 4 to 6 weeks; continue other antibiotic for 6 weeks

Native valve or prosthetic valve infections due to penicillin-resistant enterococci: 1 mg/kg IV or IM every 8 hours, in
combination with ampicillin-sulbactam or vancomycin
Duration of therapy: 6 weeks
Comments: Refer to current published guidelines for detailed recommendations.
Usual Adult Dose for Endometritis:
2 mg/kg loading dose, followed by 1.5 mg/kg IV or IM every 8 hours
Duration of therapy: Parenteral therapy should be continued for at least 24 hours after the patient has remained
afebrile, pain free, and the leukocyte count has normalized.
Usual Adult Dose for Febrile Neutropenia:
2 mg/kg loading dose, followed by 1.7 mg/kg IV every 8 hours
Duration of therapy: Once the patient is stable, afebrile for 24 hours, and the absolute neutrophil count is greater than
500/mm3, oral antibiotics may be substituted if antibiotic therapy is to be continued.
Usual Adult Dose for Intraabdominal Infection:
2 mg/kg loading dose, followed by 1.7 mg/kg IV every 8 hours or 5 mg/kg IV every 24 hours
Duration of therapy: 14 days, depending on the nature and severity of the infection
Comments: Less toxic antibiotics may be substituted once the patient is stable for at least 48 hours.
Usual Adult Dose for Meningitis:
2 mg/kg loading dose, followed by 1.7 mg/kg IV or IM every 8 hours
Duration of therapy: Parenteral therapy should be continued for at least 1 week after the patient becomes afebrile and
cerebrospinal fluid normalizes.
Usual Adult Dose for Osteomyelitis:
1.5 to 2 mg/kg loading dose, followed by 1 to 1.7 mg/kg IV or IM every 8 hours or 5 to 7 mg/kg IV every 24 hours
Duration of therapy: 4 to 6 weeks, depending on the nature and severity of the infection; chronic osteomyelitis may
require an additional 1 to 2 months of oral antibiotics
Comments: Limiting the duration of gentamicin therapy may help limit toxicity. Once the patient is stable for at least
48 hours, less toxic IV or oral antibiotic therapy may be considered according to microbiology sensitivity data.
Usual Adult Dose for Pelvic Inflammatory Disease:
2 mg/kg loading dose, followed by 1.5 mg/kg IV or IM every 8 hours or 5 mg/kg IV every 24 hours
Duration of therapy: Parenteral therapy should be continued for at least 24 hours after clinical improvement and
should be followed by oral doxycycline or clindamycin for a total 14 day course.
Usual Adult Dose for Peritonitis:
IV: 2 mg/kg loading dose, followed by 1.7 mg/kg IV every 8 hours or 5 mg/kg IV every 24 hours
Duration of therapy: Therapy should be continued for about 14 days, depending on the nature and severity of the
infection.
Comments: Limiting the duration of gentamicin therapy may help limit toxicity. Once the patient is stable for at least
48 hours, less toxic IV or oral antibiotic therapy may be considered according to microbiology sensitivity data.
Intraperitoneally in CAPD patients: 0.6 to 0.75 mg/kg intraperitoneally once a day or 16 to 20 mg per every 2 L
dialysate
Usual Adult Dose for Plague:
2 mg/kg loading dose, followed by 1.7 mg/kg IV or IM every 8 hours or 5 mg/kg IV every 24 hours
Duration of therapy: Therapy should be continued for about 10 to 14 days, depending on the nature and severity of
the infection.
Comments: Limiting the duration of gentamicin therapy may help limit toxicity. Once the patient's condition improves,
less toxic IV or oral antibiotic therapy may be considered according to microbiology sensitivity data.
Usual Adult Dose for Pneumonia:
2 mg/kg loading dose, followed by 1.7 mg/kg IV or IM every 8 hours or 5 mg/kg IV every 24 hours
Duration of therapy: Therapy should be continued for 14 to 21 days, depending on the nature and severity of the
infection.
Comments: Limiting the duration of gentamicin therapy may help limit toxicity. Once the patient is stable for at least
48 hours, less toxic IV or oral antibiotic therapy may be considered according to microbiology sensitivity data.

Usual Adult Dose for Pyelonephritis:

2 mg/kg loading dose, followed by 1.7 mg/kg IV every 8 hours or 5 mg/kg IV every 24 hours
Duration of therapy: Therapy should be continued for about 7 to 14 days, depending on the nature and severity of the
infection.
Comments: Limiting the duration of gentamicin therapy may help limit toxicity. Once the patient is stable for at least
48 hours, less toxic IV or oral antibiotic therapy may be considered according to microbiology sensitivity data.
Usual Adult Dose for Skin or Soft Tissue Infection:
1.5 to 2 mg/kg loading dose, followed by 1 to 1.7 mg/kg IV or IM every 8 hours or 5 to 7 mg/kg IV every 24 hours
Duration of therapy: Therapy should be continued for at least 10 to 14 days, or until 3 days postacute inflammation,
depending on the nature and severity of the infection; for severe infections, such as diabetic soft tissue infections, 14
to 21 days of therapy may be required
Comments: Limiting the duration of gentamicin therapy may help limit toxicity. Once the patient is stable for at least
48 hours, less toxic IV or oral antibiotic therapy may be considered according to microbiology sensitivity data.
Usual Adult Dose for Surgical Prophylaxis:
1.5 to 2 mg/kg (maximum 120 mg) IV or IM once at induction of anesthesia
Usual Adult Dose for Tularemia:
1.5 to 2 mg/kg loading dose, followed by 1 to 1.7 mg/kg IV or IM every 8 hours or 5 to 7 mg/kg IV every 24 hours
Duration of therapy: Therapy should be continued for about 10 to 14 days, depending on the nature and severity of
the infection.
Comments: Once the patient's condition improves, less toxic IV or oral antibiotic therapy may be considered
according to microbiology sensitivity data.
Usual Pediatric Dose for Bacterial Infection:
0 to 4 weeks, birthweight <1200 g: 2.5 mg/kg IV or IM every 18 to 24 hours
0 to 1 week, birthweight >=1200 g: 2.5 mg/kg IV or IM every 12 hours
1 to 4 weeks, birthweight 1200 to 2000 g: 2.5 mg/kg IV or IM every 8 to 12 hours
1 to 4 weeks, birthweight >=2000 g: 2.5 mg/kg IV or IM every 8 hours
>1 month: 1 to 2.5 mg/kg IV or IM every 8 hours
Usual Pediatric Dose for Bacterial Endocarditis Prophylaxis:
1.5 mg/kg IV or IM once within 30 minutes of starting the procedure
Comments: For high risk patients, in addition to gentamicin, ampicillin 50 mg/kg (maximum 2 g) is given IV or IM 30
minutes prior to the procedure, followed by ampicillin 25 mg/kg IV/IM or amoxicillin 25 mg/kg orally 6 hours later. In
penicillin-allergic patients, vancomycin 20 mg/kg IV is infused over 1 to 2 hours instead of ampicillin/amoxicillin.
Usual Pediatric Dose for Endocarditis:
AHA recommendations:
Native valve infections due to highly penicillin-susceptible viridans Group streptococci and S bovis (MIC <=0.12
mcg/mL): 3 mg/kg IV or IM once every 24 hours or 1 mg/kg every 8 hours in combination with aqueous penicillin G
sodium or ceftriaxone
Duration of therapy: 2 weeks; continue other antibiotic for 4 weeks
Native valve infections due to relatively penicillin-resistant S viridans and S bovis (MIC >0.12 mcg/mL and <=0.5
mcg/mL): 3 mg/kg IV or IM once every 24 hours or 1 mg/kg every 8 hours in combination with aqueous penicillin G
sodium or ceftriaxone
Duration of therapy: 2 weeks; continue other antibiotic for 4 weeks
Prosthetic valve infections due to S viridans and S bovis: 3 mg/kg IV or IM once every 24 hours or 1 mg/kg every 8
hours in combination with aqueous penicillin G sodium or ceftriaxone
Duration of therapy: 2 weeks; continue other antibiotic for 6 weeks
Native valve infections due to staphylococci: 1 mg/kg IV or IM every 8 hours, in combination with nafcillin, oxacillin, or
cefazolin
Duration of therapy: 3 to 5 days; continue other antibiotic for 6 weeks
Prosthetic valve infections due to staphylococci: 1 mg/kg every 8 hours, in combination with nafcillin or oxacillin, plus
rifampin, or vancomycin plus rifampin
Duration of therapy: 2 weeks; continue other antibiotics for at least 6 weeks
Native valve or prosthetic valve infections due to susceptible enterococci: 1 mg/kg IV or IM every 8 hours, in
combination with ampicillin, aqueous penicillin G sodium, or vancomycin
Duration of therapy: 4 to 6 weeks; continue other antibiotic for 6 weeks

Native valve or prosthetic valve infections due to penicillin-resistant enterococci: 1 mg/kg IV or IM every 8 hours, in
combination with ampicillin-sulbactam or vancomycin
Duration of therapy: 6 weeks
Comments: Refer to current published guidelines for detailed recommendations.
Usual Pediatric Dose for Surgical Prophylaxis:
2 mg/kg IV once at induction of anesthesia
What other drugs will affect gentamicin?
Other drugs, especially those that affect the kidneys, can interact with gentamicin resulting in dangerous side effects
and/or decreased effectiveness. Do not take any other prescription or over-the-counter medicines, including vitamins,
minerals, and herbal products, without first talking to your doctor during treatment with gentamicin.