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Aarkstore - Complete 2013-14 Induced Pluripotent

Stem Cell (iPSC) Industry Report

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Published: Feb 2014 | Pages: 127

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Summary
Stem cell research and experimentation has been in process for well over five decades, as stem cells
have the unique ability to divide and replicate repeatedly. In addition, their unspecialized nature
allows them to differentiate into a wide variety of specialized cell types. The possibilities arising
from these characteristics have caused great commercial interest, with potential applications
ranging from the use of stem cells in reversal or treatment of disease, to targeted cell therapy, tissue

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regeneration, pharmacological testing on cell-specific tissues, and more. Diseases such as
Huntingtons Chorea, Parkinsons Disease, and spinal cord injuries are examples of clinical
applications in which stem cells could offer benefits in halting or even reversing damage.
Traditionally, scientists have worked with both embryonic and adult stem cells as research tools.
While the appeal of embryonic cells has been their ability to differentiate into any type of cell, there
has been significant ethical, moral and spiritual controversy surrounding their use for research
purposes. Although some adult stem cells do have differentiation capacity, it is often limited in
nature, which creates narrow options for use. Thus, induced pluripotent stem cells represent a
promising combination of adult and embryonic stem cell characteristics.
Discovery:
Groundbreaking experimentation in 2006 led to the introduction of induced pluripotent stem cells
(iPSC). These are adult cells which are isolated and then transformed into embryonic-like stem
cells through the manipulation of gene expression, as well as other methods. Research and
experimentation using mouse cells at Kyoto University in Japan was the first instance in which
there was successful generation of the iPSC. In 2007, a series of follow-up experiments were done
at Kyoto University in which human adult cells were transformed into iPSC cells.
While there has been continued excitement at the prospect of what such artificially re-manufactured
cells could contribute to medical advances, there have also been issues along the way. By 2010,
there were a number of private companies that were ready to capitalize on the breakthrough
technology that iPSCs represent. One such company, Advanced Cell Technology in Worcester,
Massachusetts, discovered several problematic issues while conducting experiments for the purpose
of applying for U.S. Food and Drug Administration approval to use iPSCs in therapeutic
applications. Concerns such as premature cell death, mutation into cancer cells, and low
proliferation rates were some of the problems that surfaced.
Furthermore, the past twelve months have been a time of massive change for the industry. 2013 was
the first year in which clinical research involving transplant of iPSCs into humans was initiated,
with Masayo Takahashi of the RIKEN Center in Japan investigating the safety of iPSC-derived cell
sheets in patients with macular degeneration. In another landmark event, Cellular Dynamics
International (CDI) went public in July 2013 with a offering that raised $43 million dollars for the
company, securing the companys position as the global leader in producing high-quality human
iPSCs and differentiated cells in industrial quantities. In March of 2013, Celullar Dynamics

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International and the Coriell Institute for Medical Research announced receiving multi-million
dollars grants from the California Institute for Regenerative Medicine (CIRM) for the creation of
iPSC lines from 3,000 healthy and diseased donors, a result that will create the worlds largest
human iPSC bank.
2013 represents a major year for advances in clinical research applications, production and
differentiation technologies, and biobanking of iPSCs. It is clear that iPSCs are a vital research
trend within the scientific community.
Research Advances:
Continued research and experimentation has resulted in numerous advances over the last few years.
In one example, the University of Michigan announced in Circulation Research (2012) that they
had developed innovative methods for use of induced pluripotent stem cells derived from skin
biopsies to create cardiac muscle cells. This accomplishment quickly fueled other research into the
use of iPSCs for the reversal and repair of diseased heart tissue.
Similar advances will continue to be perfected for use of reprogrammed adult cells in the treatment
of other diseases and disorders. Original techniques for iPSC production, such as viral induced
transcription processes, are being replaced with newer technologies as private industries join with
the scientific community to develop safe and efficient methods of iPSC production. With sustained
research and experimentation, established guidelines for effective production of iPSCs will be
commonplace.
In summary, induced pluripotent stem cells represent a promising tool for use in the reversal and
repair of many previously incurable diseases.
Market Metrics - iPSC Research Products:
For this reason a large and thriving research products market has grown into existence for the cell
type. The number of iPSC research products sold worldwide has been growing at an annual rate of
14.7% for the past five years. In addition, 22% of all stem cell researchers now self-report as
having used induced pluripotent stem cells within a research project. It is clear that iPSCs are a
vital research trend within the scientific community.

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A distinctive feature of this report is an end-user survey of 274 researchers (131 U.S. / 143
International) that identify as having induced pluripotent stem cells as their core research focus.
These survey findings reveal iPSC researcher needs, technical preferences, key factors influencing
buying decisions, and more. They can be used to make effective product development decisions,
create targeted marketing messages, and produce higher prospect-to-client conversion rates.
Remember, to benefit from this lucrative product market, you need to anticipate and serve the needs
of your clients, or your competitors will.
Key Findings Include:
Charts, Timelines, and Financials for the iPSC Research Product Market
Trends for iPSC Grants, Scientific Publications, and Patents
5-Year Market Size Projections (2014-2018)
Competitive Environment Analysis, including Market Share by Competitor
Preferred Species for iPSC Research
iPSC Product Categories (Breakdown of Market Share by Each)
Consumer Behavioral Patterns and Preferred Providers
Crucial Trends and Unmet Market Needs
Tested Sentences for Selling to iPSC Scientists
Breakdown of the Marketing Methods Used by Industry Participants
End-User Survey of iPSC Researchers (131 U.S. / 143 International)
In summary, this is a must-read industry report for research supply companies to optimally position
themselves to sell iPSC products. To profit from this lucrative and rapidly expanding market, you
need to understand your key strengths relative to the competition, intelligently position your
products to fill gaps in the marketplace, and take advantage of crucial iPSC trends. Claim this
report now to profit from this expanding market - or your competition will.
Browse complete Report on:

http://www.aarkstore.com/healthcare/51108/Complete-2013-14-Induced-PluripotentStem-Cell-iPSC-Industry-Report

Table of Contents:
I. ABSTRACT

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II. BACKGROUND
A. Definition
B. Discovery
C. Advantages & Disadvantages
III. TIMELINE
A. Production of iPSCs (Key Events)
B. Full Timeline of Events
IV. RESEARCH APPLICATIONS
A. Pharmaco-Toxicological Screening
B. Disease Modeling
C. Autologous Cell Transplantation
D. Breakdown of iPSC Research, By Applied Research Application
V. CHARACTERIZATION OF iPSC RESEARCH ADVANCES
A. Methods of Making iPSCs Comparison of Methods by Downstream Application
B. Summary of iPSC Derivation Methods, by Cell Type
C. Diseases in Which iSPCs Have Been Derived from Patients
VI. COMPANIES SELLING iPSC RESEARCH PRODUCTS
A. Complete List of Companies
B. Rate of Entrants by Year
VII. TYPES OF iPSC RESEARCH PRODUCTS
A. Stem Cell Product Categories
B. iPSC Market Share Breakdown, By Product Area

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VIII. COMPANIES DEVELOPING iPSC THERAPIES
A. Commerical Entities
1. Cellular Dynamics International (CDI)
2. Fate Therapeutic
3. iPerian
4. ViaCyte
5. Advanced Cell Technology (ACT)
B. Non-Commercial Organizations Developing iPSC Therapies
IX. STRATEGIC COLLABORATIONS FOR DEVELOPMENT OF iPSC PRODUCTS
A. Life Technologies (Recently Acquired by Thermo Fisher Scientific)
B. Lonza Group AG
C. EMD Millipore
D. Sigma Aldrich
E. Roslin Cells, Ltd.
F. ArunA Biomedical
G. CeeTox and Cellular Dynamics
X. MARKET TREND ANALYSIS
A. Clinical Trials
B. Grant Analysis
1. Historical Analysis
2. Future 5-Year Projection
C. Patent Analysis

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D. Scientific Publication Analysis
1. Historical Data
2. Future 5-Year Projections
3. Comparison of iPSC Research Frequency, Relative to Other Cell Types
E. Search Phrase Analysis
1. Google News Search Results for iPSC Terms
2. iPSC Product Launches, by Year
F. Geographical Analysis: Domestic vs. International Status
1. Number of iPSC Labs, by Region of World
2. Percent of Total iPSC-Specific Research Funding, by Region of World
G. Additional Sources of iPSC Research Funding
XI. MARKET SIZE
A. Definition: iPSC Research Products
B. Experimental Approach
C. iPSC Research Products, Market Size
D. iPSC Research Products, 5-Year Market Projections
XII. SCIENTIST PANEL: DETAILED END-USER SURVEY
A. Survey Overview
B. Characterization of Market Survey Respondents
1. Geographic Distribution of Respondents
2. Respondent Breakdown by Industry Affiliation
3. Breakdown of Respondents by Duration of iPSC Research Activity

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C. Survey Findings
1. General Scope
2. Comparison of Providers / Brand Preferences
3. Marketing Assessment
D. Terms Used in Online Product Search
XIII. STRATEGIES FOR ACCESSING THE MARKETPLACE
A. Top Research Institutions Performing Stem Cell Research
1. University of Wisconsin, including WARF, WiCell, and the WISC Bank
2. US National Institutes of Health (NIH)
3. Johns Hopkins University
4. California Institute for Regenerative Medicine
5. University of Connecticut Induced Pluripotent Stem Cell Core (iPSCC)
B. Events of Interest (2013-14)
XIV. CONCLUSIONS
APPENDIX

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