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Absolute neutrophil count

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Absolute neutrophil count (ANC) is a measure of the number of neutrophil granulocytes[1] (also

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known as polymorphonuclear cells, PMN's, polys, granulocytes, segmented neutrophils or segs)

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present in the blood. Neutrophils are a type of white blood cell that fights against infection.

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The ANC is almost always part of a larger blood panel called the complete blood count. The ANC is

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calculated from measurements of the total number of white blood cells (WBC), usually based on

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the combined percentage of mature neutrophils (sometimes called "segs," or segmented cells) and

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bands, which are immature neutrophils.

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1 Clinical significance

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2 Calculation

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3 Ranges

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4 Related tests
5 References

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Clinical significance

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The reference range for ANC in adults varies by study, but 1500 to 8000 cells per microliter is the
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The reference range for ANC in adults varies by study, but 1500 to 8000 cells per microliter is the

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ballpark. An ANC less than 500 cells/L is defined as neutropenia and significantly increases risk

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of infection. Neutropenia is the condition of a low ANC, and the most common condition where an
ANC would be measured is in the setting of chemotherapy for cancer.

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Neutrophilia indicates an elevated count. This is also known as a "left shift" and can be indicative

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of:

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Premature release of myeloid cells from the bone marrow.

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A leukemoid reaction.

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Calculation

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ANC =
or
ANC = (Absolute-Polys + Absolute-Bands)
In the above, we assume that the WBC is given in cells/L (or thousand cells/mL, i.e. K/mL) such
as 8,800 cells/L or 8,800 K/mL; if the WBC were given in K/L (instead of cells/L or K/mL), such
as 8.8 K/L, you would first convert to cells/L by multiplying the WBC by 1000.
The unit of ANC is cells per microliter of blood (abbreviated cells/L; a microliter is equal to one
cubic millimeter because 1,000,000 cubic millimeters are equal to one liter).

Ranges

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NCI Risk Category

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ANC

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Within normal limits

1500 - <2000/mm

1000 - <1500/mm

500 - <1000/mm

< 500/mm

Source: NCI CTC Toxicity scale Version 2.0 [1]

Related tests

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In some cases, a ratio is reported in addition to the sum. This is known as the "I/T ratio".[2][3]

References

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1. ^ Al-Gwaiz LA, Babay HH (2007). "The diagnostic value of absolute neutrophil count, band count and
morphologic changes of neutrophils in predicting bacterial infections"

. Med Princ Pract 16 (5):

3447. doi:10.1159/000104806 . PMID 17709921 .

2. ^ Walliullah SM, Islam MN, Siddika M, Hossain MA, Chowdhury AK (January 2009). "Role of MicroESR and I/T Ratio in the Early Diagnosis of Neonatal Sepsis". Mymensingh Med J 18 (1): 5661.
PMID 19182751 .
3. ^ Russell GA, Smyth A, Cooke RW (July 1992). "Receiver operating characteristic curves for
comparison of serial neutrophil band forms and C reactive protein in neonates at risk of infection"

Arch. Dis. Child. 67 (7 Spec No): 80812. doi:10.1136/adc.67.7_Spec_No.808 . PMC 1590438 .

PMID 1519980 .
V T E

Medical test: Myeloid blood tests (CPT 8500285999)

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CBC (Platelet count) Mean platelet volume vWF:

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Ristocetin-induced platelet aggregation

clotting factors:
Clotting
(megakaryocytes)

Prothrombin time Partial thromboplastin time

Thrombin time Activated clotting time
coagulation Bleeding time animal enzyme

other/general:

(Reptilase time Ecarin clotting time

Dilute Russell's viper venom time)
Thromboelastography (Thrombodynamics test)

MEP

fibrinolysis:

Euglobulin lysis time D-dimer

CBC

RBC count Hematocrit Hemoglobin

Mean corpuscular hemoglobin

Red blood cell indices

(erythrocytes)

ratios:

Other

Other

Mean corpuscular volume

Red blood cell distribution width

Fetal hemoglobin:

CFU-GM

Mean corpuscular hemoglobin concentration

AptDowney test KleihauerBetke test

Reticulocyte index Haptoglobin Mentzer index

Nitro blue tetrazolium chloride test CBC (Absolute neutrophil count)

Blood film Blood viscosity Erythrocyte sedimentation rate
Index of cells from bone marrow

Description
Disease
Treatment

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Immune system Cells Physiology (coagulation proteins granule contents

colony-stimulating)
Red blood cell Monocyte and granulocyte Neoplasms and cancer Histiocytosis
Symptoms and signs (eponymous) Blood tests (findings)
Transfusion Drugs (antithrombotics antihemorrhagics other)

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This page w as last modified on 25 November 2014, at 19:39.

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