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Instructional Book
Neurobehaviour System:
History Taking
CEREBROVASCULAR DISEASE
MUSCLE WEAKNESS
During first part of this semester, the focus will be on aspects of the medical interview and physical
examination that relate to the neurological system. The course material is designed to link with your studies
in the basic sciences of this body system. You will also have the opportunity to develop your
communication skills. This will involve learning how to identify and respond to emotional issues that arise
during a medical interview and to communicate effectively with patients who have hearing or cognitive
impairment.
The first tutorial in this series focuses specifically on muscle weakness as a presenting problem. It also
provides an introduction to the basic examination of the neurological system, with emphasis on testing
motor strength and co-ordination of the lower limbs.
Muscle weakness
There are three components to gathering information from a patient whose presenting problem is
weakness:
(i) Does the patient have true muscle weakness?
Firstly, it is important to clarify whether the patient has true muscle weakness, or whether they are
describing a loss of physical or emotional energy, or another non-neuromuscular problem such as
joint pain or stiffness. People who have motor weakness are not able to perform specific activities,
such as standing up from a squatting position or moving a limb.
(ii) Where is the weakness?
Secondly, the pattern of the weakness needs to be established, in order to help determine the
likely site of the underlying pathology. Muscle weakness can be due to a primary problem involving
muscles or it can be due to conditions affecting the neuromuscular junction, peripheral nerves,
spinal nerve roots, anterior horn cells or the corticospinal tracts. It is therefore important to find out
whether the weakness affects all muscle groups or is confined to a particular area of the body.
If the weakness is generalised, this may indicate a problem such as myasthenia gravis, which
affects the neuromuscular junction. If the weakness is not generalised, the next step is to find out if
it is symmetric or asymmetric. Asymmetric weakness is usually caused by conditions that affect the
central or peripheral nervous systems. If the weakness is symmetric, it can be classified as
proximal or distal or localised. Proximal weakness is usually caused by primary muscle disorders
affecting the axial muscle groups, that is, the deltoids or the muscles responsible for hip flexion.
Distal weakness, in contrast, mainly affects the hands or feet and may be caused by peripheral
neuropathy or motor neuron disease.
(iii) What is the cause of the muscle weakness?
Thirdly, information needs to be gathered to help find out the underlying cause. There are many
causes of muscle weakness, including immunological conditions, malignancy, vascular events,
1
drugs or metabolic disorders. At this level of your training, you are not expected to be able to
determine the underlying cause of a patients muscle weakness.
Applying the cardinal features framework to muscle weakness
Cardinal
feature
Notes
Cardinal
Sitefeature
Quality
Severity
The severity can be quantified by determining what function the patient has in the affected area. Can
the patient move the affected area against gravity or is it paralysed? What cant the patient do
because of the weakness?
Time course
This is an important feature as it can help to point to the underlying cause. Did the weakness come on
suddenly? Does it fluctuate? Is it worse at the end of the day?
Context
Ask the patient if there was anything in particular they noticed at the time the weakness started.
Aggravating
factors
Is there anything that makes the weakness worse? Is there anything that triggers episodes of
weakness?
Relieving
factors
Associated
features
As you learn more about diseases that cause muscle weakness, you will be able to ask specific
questions that can help point to a diagnosis.
At this stage, you could ask about whether the patient has any pain in their muscles or whether the
weakness is associated with other neurological symptoms, such as sensory changes. You will learn
about sensory symptoms in the next tutorial.
and then yesterday, I had another fall just outside the market I knocked
myself around a bit hurt both knees and scraped my right arm nothing
broken, like but there was a bit of bleedin
NICK:
MR RUSSELL:
PATIENT:
Not really no
STUDENT:
These communication skills may seem quite straightforward but can be difficult to apply when you are also
concentrating on the content of the interview. It is therefore important that you practice these skills as much
as possible when interviewing patients. It is also important that you apply them in a way that reflects your
personal style of communication.
Yes
No
No
N/A
Yes
Site
Location
Radiation
Quality
Severity
Time course
Onset
Offset
Duration
Temporal profile
Periodicity
Context
Relieving factors
Aggravating or precipitating factors
Associated features
Communication Skills
Done Well
Adequate
Done well
Adequate
Needs
improvement
Needs
Improvement
Cardinal
feature
Migraine
Site
Usually bilateral
Quality
Non-throbbing
Pulsating
Moderate to severe
Often begins in the mornings although can occur at any time of the
day
Variable duration
Severity
Time course
Aggravating
factors
Role-play C: Headache
Background
Joe Martinelli, a 40year old engineer, has come to see his doctor with new onset headaches.
Opening statement
Ive started getting bad headaches. Theyve been coming for about four weeks now and they are really
starting to get me down.
Site: They are always on the right side. They usually start around my eye.
If asked if the pain goes anywhere else, say: It seems to go deep behind my eye and it often moves over
here.
Rub over your right temple area.
Quality: Im not sure how to describe it.
If you are offered a menu of choices, say: That it is a throbbing pain.
Severity:
It is excruciating when it is present. I have to get up and walk around to try to distract myself from the pain.
It stops me from doing anything.
If asked to say how bad the pain is on a scale of 0 to 10, say: Its probably about a 9 or 10 at its worst.
Time Course:
The headaches usually come on suddenly. I dont get any warning and then bang, suddenly its there it
gets really bad after only a few minutes. It usually lasts a couple of hours and then it dies away. Ive been
getting them about once every day or so. Usually the same time, late in the evening.
Context:
Ive noticed that they seem to come on more often when Ive had a few glasses of wine, so Ive stopped
drinking it with my evening meal.
Relieving Factors: Ive tried taking paracetamol but that does nothing
Aggravating factors:
I havent noticed anything in particular. Alcohol seems to bring them on but once they are present, they are
really bad whatever I do.
Associated features:
When I get the headaches, I also get a watery eye and my nose feels stuffy. Sometimes I feel sweaty and
sick in the stomach.
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Role-play D: Headache
Background
You are Rebecca/ Rob Damitri, aged 24 years, a PHD student in economics.
Opening statement
Ive been getting a lot of headaches lately and its really getting me down. Ive got a lot going on right now
and I cant afford to be out of action with these headaches.
If asked to elaborate:
They are coming more and more often, I feel like I always have one. Its pretty
wearing.
Site: I feel it right around my head, on both sides, like a tight headband.
Quality: Its like a pressure feeling, right around my head.
If asked: It is not throbbing.
Severity: Its not bad enough to put me to bed - Im still carrying on working on my PHD. But its still pretty
painful.
If asked to rate out of 10: 3-4 out of 10.
Time Course: Ive had a headache from most days for the last month.
If asked about progression over time: They are much the same as they were when they started.
If asked about frequency, say: They come most days, often later in the day.
Context: Ive been working really hard on writing my thesis so Im doing pretty long work hours, more so in
the last month. Im also working on weekends a lot, so dont have much time for relaxation.
Precipitating factors: I sometimes wonder if the headaches are brought on by sitting at my desk, but Im
not sure.
Relieving factors: If I take a couple of Panadol then that usually gives me some relief. But I still feel a dull
ache, even after 2 Panadol tablets.
Associated features: I feel a bit sore around my neck and shoulders, like theres a bit of tension there in
the muscles.
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Yes
No
No
N/A
Yes
Site
Location
Radiation
Quality
Severity
Time course
Onset
Offset
Duration
Temporal profile
Periodicity
Context
Relieving factors
Aggravating or precipitating factors
Associated features
Communication Skills
Done Well
Adequate
Done well
Adequate
Needs
improvement
Needs
Improvement
12
SENSORY DISTURBANCE
During the last tutorial, the focus was on muscle weakness and the motor neurological examination of the
lower limbs. During this tutorial, you will learn how to interview a patient presenting with sensory
disturbance and perform a sensory examination of the lower limbs. You will also have an opportunity to
develop your ability to identify and respond to emotional issues that arise during a medical interview.
Sensory disturbance
Sensation is the process by which stimuli are detected by specialised receptors in the skin, muscles or
joints and transmitted to the brain via the peripheral nervous system. The processing of this information
allows the body to maintain its posture, react to pain and other noxious stimuli, and use senses such as
touch and hearing to provide information about the surrounding environment. Sensation is an important part
of the bodys defence system. It is a continuous and usually subconscious process. Disordered sensation,
by way of contrast, can be quite intrusive and can lead to considerable disability and distress. As with other
symptoms, it is helpful to have a framework when interviewing patients who present with sensory
disturbance. There are three components to gathering information about this symptom:
(i) What symptoms of sensory disturbance does the patient describe?
Sensory symptoms are usually divided into two main categories: positive symptoms, which are
caused by heightened activity in sensory pathways, and negative symptoms, which are caused by
loss of sensory function.
a. Positive sensory symptoms
Patients experiencing this type of sensory disturbance may describe symptoms such as
tingling, pins and needles, pricking, burning, tightness, a band-like sensation around their
body, or an electric shock. They may also report pain, which is often sharp or stabbing in
nature. Patients who have positive sensory symptoms often do not have a sensory deficit on
physical examination. There are a number of specific terms that are used to describe positive
sensory disturbances:
Term
Meaning
Paraesthesia
Hyperaesthesia
Dysaesthesia
All positive sensory changes, whether due to a stimulus or not (this covers both of the above
terms)
Hyperalgesia
Allodynia
Normal stimulus felt as pain, for example, clothing brushing against body being felt as pain
Patients experiencing this type of sensory disturbance may describe symptoms such as
numbness, coldness or loss of feeling in a particular distribution. Patients who report negative
sensory symptoms often have a sensory deficit on physical examination. There are a number
of specific terms that are used to describe negative sensory disturbances:
Term
Meaning
Hypoaesthesia
Anaesthesia
Analgesia
Note: If a patient has a sensory disturbance that involves the receptors in the muscles, tendons
and joints that serve proprioception, then the patient may report imbalance, and unsteady gait
or a lack of precision with movements. The term sensory ataxia is used to describe these
symptoms.
(ii) What is the pattern of the sensory disturbance?
Establishing the pattern of the sensory loss is helpful in determining the likely site of the underlying
problem. Having a sound knowledge of the underlying anatomy and physiology of the neurological
system facilitates this process. Find out if the sensory loss affects one side of the body, a whole
limb or part of a limb. Also find out if it is symmetric or asymmetric.
Some common patterns of sensory loss are:
(i) A glove and stocking distribution due to peripheral neuropathy
(ii) A dermatomal pattern due to a spinal cord or nerve root lesion
(iii) An area supplied by a particular nerve
(iii) A hemisensory loss, due to a lesion of the spinal cord, brain stem, thalamus or cortex
(iv) What is the underlying cause of the sensory disturbance?
Sensory changes may be due to medical conditions affecting either the central nervous system or
the peripheral nervous system. Central nervous system conditions that cause sensory disturbance
include cerebrovascular disease, multiple sclerosis and tumours. A wide range of conditions can
affect the peripheral nervous system, including diabetes mellitus and alcohol excess. Nerve
entrapment syndromes are a common cause of peripheral sensory disturbance. As you learn more
about medical conditions, you will be able to ask patients specific questions in order to establish
the underlying cause. You are not expected to be able to do this at this stage of your training.
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Notes
Site
Quality
Severity
Time course
Context
Aggravating factors
Relieving factors
Associated features
15
16
17
Crying is a common response to emotional distress. If a patient starts to cry while you are interviewing
them, dont ignore it. Acknowledge that he or she is upset, and convey to them that crying is a legitimate
response to a difficult situation. If you have been writing notes during the interview, stop and put your pen
down.
Try to establish why the patient is distressed. Sometimes the reason will not be obvious or what it seems.
Crying, for example, may mask the fact that the patient is angry about something. Encourage the patient to
express their feelings, however if they dont want to talk about what is making them distressed, dont pry. It
is important to respect patients privacy.
Offer practical help. Provide the patient with a box of tissues if possible. Ask what you can do for the
patient. Also ask if they would prefer that you stay or if they would prefer that you left them alone. If the
patient seems significantly distressed, it is best to advise someone such as the nurse who is looking after
the patient on the ward or the doctor who is supervising you.
Use silence effectively. You may feel it is best to keep talking with the patient but often it is appropriate to
give them time to compose themselves.
Dont offer false hope. Dont say, for example, Im sure everything will turn out OK, as this might not be
the case.
Use touch prudently. It may be of comfort to the patient but take care that it is not interpreted the wrong
way. If you judge that touching a patient is appropriate, placing your hand between their wrist and their
elbow is usually acceptable. It is rarely appropriate to hug a patient. The important thing to remember is
that if you dont feel comfortable touching a patient, dont do it.
Finally, it is important to review your own response when a patient cries. Your reaction to the situation may
be influenced by your own emotions at the time or how closely you identify with the patients situation. Dont
project your own feelings on to the patient. If you feel distressed by a situation on the wards, please contact
the appropriate person from your clinical school.
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19
20
Yes
No
No
N/A
Yes
Site
Location
Radiation
Quality
Severity
Time course
Onset
Offset
Duration
Temporal profile
Periodicity
Context
Relieving factors
Aggravating or precipitating factors
Associated features
Communication Skills
Done Well
Adequate
Done well
Adequate
Needs
improvement
Needs
Improvement
21
23
NO
YES
Vertigo
Disequilibrium
Pre-syncope
Non-specific
Dizziness
NO
YES
Coma
Stupor
Syncope
Vasovagal syncope
Seizure
Cardiac syncope
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Faints (vasovagal
syncope)
Usually present,
includes feeling of
light-headedness and
wobbly legs, vision going
dim, noises sounding
distant
Blackouts (cardiac
sycnope )
Usually not present
Seizure
Primary generalised
seizures usually
begin without warning
Complex partial or
secondary generalised
seizures may have a
prodrome (aura), the
nature of which depends
where the seizure
originates in the brain; dj
vu may occur
Site
Not relevant
Not relevant
Not relevant
Quality
Convulsive
movements can occur,
although usually only
a few jerks
Severity
Time course
Usually 1 2 minutes
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Syncope
Cardinal feature
Faints (vasovagal
syncope)
Blackouts (cardiac
sycnope )
Seizure
Context
Precipitating factors
Vasovagal syncope
often has specific
precipitating factors,
such as fasting, pain,
emotional events or
prolonged standing
Relieving factors
Self-limiting
Self-limiting
Associated features
Tongue biting
common Head
turning common
Usually not sweaty
Cyanosis
Cry or moan at onset
Frothing at mouth
Incontinence of urine may
occur
Rapid recovery of
consciousness
Rapid recovery of
consciousness
Rarely confused
afterwards
Rarely confused
afterwards
Slow recovery
Period of confusion >
2 minutes
May feel exhausted
and sleepy Muscle
aches Injury
common
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27
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Role-play A: TLOC
Background
You are Aaron Schukraft, a 36 year old lawyer. You are presenting to your general practitioner after an
episode of collapse.
Opening statement
I gave my girlfriend a bit of a scare last night. I collapsed in the bathroom in the middle of the night and she
was really worried about me. I feel fine now.
If asked to elaborate: Wed had a pretty big day - Id just been out of town for my brothers wedding and
wed gone pretty hard. We got home really late and I was a still pretty tipsy I suppose. I just got up from bed
to go to the toilet about 3am and thats when it happened.
Cardinal features
Site: N/A
Quality: I dont know what I did - no one saw it happening. I was just standing up at the toilet, about to take
a piss, and then the next minute I woke up on the floor.
If asked specifically about prodrome: I felt a bit light-headed when I walked through to the toilet and then
and my vision went a bit funny - like tunnel vision. Thats the last thing I remember.
Severity: N/A
Time Course: Im not sure how long I was out for, but my girlfriend thinks it was only a minute, or less
If asked how long it was until you felt back to normal: Only a few minutes. Then I was fine. My girlfriend was
keen for me to go to the emergency department, but I didnt see what the fuss was about. But she made
me come here today to get checked out.
Context: Wed had a couple of pretty full-on days before the wedding and then on the wedding day itself.
Wed been drinking a fair bit of wine and dancing, and I guess I hadnt really been drinking much water.
Precipitating factors: Well, I guess the big day wed had and the alcohol didnt help. I think I might have
been a bit dehydrated.
Relieving factors: I felt OK after a few minutes of lying on the bathroom floor.
Associated features: My girlfriend said I was a bit pale when I woke up, and a little clammy.
If asked specifically: You had no tongue biting, no moaning/crying/ no frothing at the mouth/ no incontinence
of urine.
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Role-play B: TLOC
Background
You are Jasmine Lee, a 16 year student. You are presenting to your general practitioner for review after an
episode of collapse.
Opening statement
I had a weird black-out thing today when I was at hockey practice. My coach thought I had a fit and called
my Mum to bring me straight here.
If asked to elaborate:
I was just sitting on the ground with the rest of the team and our coach was talking to us and then the next
thing I know is Im lying on my side with everyone crowded around me, looking worried. It was pretty
embarrassing.
Cardinal features
Site: N/A
Quality: My coach said that I went all stiff and rigid and fell backwards onto the ground, arching my back.
Then he said I started shaking, like I was having a fit.
If asked specifically about prodrome:
I didnt get any warning. I felt fine before I blacked out. Im pretty fit and was ready for training.
Severity: N/A
Time Course: My coach was pretty switched on and timed me with his stopwatch. He said I was out of it for
2 minutes.
If asked how long it was until you felt back to normal: I was a bit groggy for about 10 minutes - I just felt
spaced out. But then after 15 minutes I felt pretty good.
Context: I didnt do anything different today.
Precipitating factors: I guess Ive been up late a few nights doing an assignment for school, so Ive been a
bit tired, but thats pretty normal for me.
Relieving factors: Nil
Associated features: Ive got a sore tongue now - maybe I bit it, I dont know.
If asked specifically: You had no moaning/crying/ no frothing at the mouth/ no incontinence of urine.
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Yes
No
No
N/A
Yes
Site
Location
Radiation
Quality
Severity
Time course
Onset
Offset
Duration
Temporal profile
Periodicity
Context
Relieving factors
Aggravating or precipitating factors
Associated features
Communication Skills
Done Well
Adequate
Done well
Adequate
Needs
improvement
Needs
Improvement
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COGNITION
This tutorial focuses on the assessment of the higher level functions of the brain, specifically memory, which
is an important component of cognition. It also covers the principles of interviewing a patient who has
cognitive impairment and introduces an instrument that is widely used in clinical practice to screen for
cognitive impairment.
Cognition
During your studies in the neurosciences, you have learned how the brain, spinal cord and peripheral
nervous system form a complex, integrated processing and control system. In particular you have learned
about the sensory and motor functions of the body and how to make a basic clinical assessment of these
functions.
During this tutorial, the focus will be on the assessment of the higher functions of the brain, specifically
cognition. The term cognition broadly refers to the mental processes involved in knowledge acquisition,
comprehension and application. The major domains of cognition are:
(i) Memory
Memory refers to the ability to store, retain and retrieve information from the brain. A key
component of memory is attention, which is the ability to selectively concentrate on one element of
the surrounding environment to the exclusion of the other elements.
(ii) Language
Language refers to the ability to comprehend and use expressions in order to communicate. It
incorporates the skills of listening, speaking, reading and writing.
(iii) Executive function
Executive or frontal lobe function refers to the ability to think in an abstract fashion. It involves being
able to organise information, plan ahead and use judgement and reasoning.
Memory and memory loss
The medical interview component of this tutorial is focused on history taking with respect to the memory
component of cognition, specifically memory loss. To start with, it is helpful to have an understanding of the
types of memory in order to effectively gather information about this symptom. There are three types of
memory:
(i) Sensory memory
Sensory memory or attention is the reception and processing of information from a persons
surrounding environment. It involves selection and screening of information by the cerebral cortex.
This process relies on the integrity of a number of brain regions from the brain stem arousal
systems, through to the sensory cortex and the frontal lobes, particularly in the right hemisphere.
(ii) Working memory
Information that is filtered by the attentional systems is transmitted to the pre-frontal cortex. Here it
is held in working or short term memory. Information in working memory can be temporarily stored
for short term use, such as remembering a telephone number in order to make a call.
(iii) Long term memory
Information that has been transmitted to working memory undergoes a process called long-term
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potentiation. This is the process by which memories are stored in a more permanent form. It
predominantly takes place in the hippocampus. Information is more readily archived in long term
memory if it is stored with other related information or if it is augmented by practice or by using
mnemonic devices. This passes information through the hippocampus several times and
strengthens associations.
There are two major types of long term memory. The first is episodic memory, which refers to
memory of personally experienced events. The second is semantic memory, which refers to a
persons store of facts and concepts, as well as words and their meanings. An example of a
semantic memory would be your knowledge of the cardinal features framework for gathering
information about a symptom. An episodic memory, by way of contrast, would be your memory of
interviewing a particular patient about the cardinal features of, for example, their memory loss
during a clinical skills tutorial on a particular day.
There are many types of memory disorders that you will encounter in clinical practice. Disorders of
attention or sensory memory lead to problems in filtering out background noise from the
environment. The most common cause of this type of problem is delirium, which can be caused by
a range of medical problems, such as infections or hypoxia, or certain medications.
Conditions which affect the memory areas of the hippocampus can lead to problems with storing
information from working or short term memory into long term memory. This can be caused by
disorders such as Alzheimers disease, which can affect not only memory but other components of
cognition. Alzheimers disease especially affects episodic memory, especially the retention of
information about day-to-day experiences. Long term memory is often intact in the early stages of
this disease but becomes affected as the disease progresses.
Eliciting the cardinal features of memory loss
When interviewing a patient about memory loss, find out about which type of memory is affected. This can
be difficult as many patients will want to cover up their loss of memory, often for fear of losing their
independence. A supplementary history will usually need to be obtained from another person, such as a
family member or other carer. The time course of the memory loss is also very important. In conditions such
as Alzheimers disease, the progression is usually very slow. Memory loss that occurs acutely is almost
always due to other causes.
Asking about associated features of memory loss is important. At this stage of your training, you do not
need to be able to ask specific questions in order to establish the underlying cause of a persons memory
loss, but you should be able to recognise if the person has other related cognitive problems. They may
report problems with language, such as difficulty with word finding ability (nominal aphasia), or impaired
ability to carry out motor activities despite intact muscle and nerve function (apraxia). They may also have
problems recognising or identifying objects despite intact sensory function (agnosia). A family member or
carer may report that the patient has had a change in personality or behaviour, such as disinhibition or
apathy. Changes in executive function such as planning, judgement and organisation may also be
described.
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34
35
Ask:
Can you tell me the name of this hospital/ house number? What ward/
street name are we on?
What suburb are we in? What
city are we in? What state are
we in?
2.
Ball
Flag
Tree
Number of trials
3.
4.
5.
E.g.
93
86
79
72
65
OR
number of correctly
placed letters
Ball
Flag
Tree
Watch
Pencil
Repetition
Writes sentence
Draws Pentagons
* In section 3 score number of correct responses items 14-18, or item 19, not both. Rate subjects level of
consciousness:
(a) coma,(b) stupor,(c) drowsy, (d) alert Comments:
36