Dokumen Artikel Penelitian ini milik penulis/peneliti yang diserahkan sebagian (judul dan Abstrak) hak ciptanya kepada

Universitas Airlangga untuk

digunakan referensi dalam penulisan artikel ilmiah.

Tim Peneliti : Prof.Dr.Trijoedani Widodo, drg.,MS.,SpKG Prof. Dr. Suhartono Taat Putra, dr., MS

Thomas Kardjito Soetopo

Analisis Perubahan Imunopatologik Pada Pulpitis Reversibel dan

Ireversibel untuk Memperbaiki Diagnosis atas Dasar
Imunopatogenesis Pulpitis
Abstrak :

The aim of this research is to explain about the immunopathogenesis of pulpitis by observing the
immunopathologic changes in the dental pulp tissue of pulpitis. This research was done on three groups of
sample: irreversibel pulpitis, reversible pulpitis and sound teeth, each as a control group. The
immunopathologic changes that were observed were in no way influenced by the observer, so the method of
this research is explanative research by Observational Cross-section Analytic design.
The results of this research were three pulpitis immunopathologic patterns which can be used to explain the
immunopatogenesis of pulpitis. The sound teeth immunopathologic pattern shows that a low immune
response happens to prevent disruption of the pulp after an external injury . The reversible pulpitis pattern
shows that a higher immune respons happens to act as a protective reaction to prevent further disruption at
this stage. There are two possibilities, the first represents the beginning of inflammation, and the second
shows the inflammation has become chronic and in the process of slow repair. The irreversible pulpitis
immunopathologic pattern shows the highest immune response, with regard to the makrofag and the ratio
of subset T4 lymphocyte and T8 lymphocyte. Normally a high level of subset T4 lymphocyte with result in
high level of IgG, IgM and IgA. However, while IgG and IgM increased, but the pulpitis showed an
unusually low level of IgA. This low level of IgA means that irreversibel pulpitis has a low mucosal
immunity.
In addition to the low IgA level, the researcher also took special note of the unusually high level of subset
T4 lymphocyte. The researcher is aware that the subset T4 / T helper lymphocyte consists of Th1 and Th2,
and that when the composition consists of a higher ratio of Th1, the pulpitis will repair itself. The
researcher suggests that since the irreversible pulpitis does not repair, so the subset T4 lymphocyte consists
of a higher ratio of Th2 to Th1. This high level of Th2 will show the higher reaction of Delayed Type
Hypersensitivity (DTH). However, further research is required to prove this suggestion by using cytokine
profile.
Using this new understanding of the immunopathogenesis of pulpitis, the researcher wanted to prove that
immunopathogenesis was a better method of analysis than clinicall diagnostic analysis. By clustering, it
was found that 11 teeth, with clinically diagnosed irreversible pulpitis, could be saparated into 3 groups by
immunopathogenesis : 2 teeth were irreversible pulpitis, 6 teeth were reversible pulpitis and 3 teeth were
actually sound teeth. 13 teeth with clinically diagnosed as reversible pulpitis were divided into two groups
by immunopathogenesis : 5 teeth as reversible pulpitis and 8 teeth as sound teeth. 16 teeth with clinically
diagnosed as sound teeth were proved by immunopathogenesis to be sound.
Keyword :
Dental pulp, pulpitis diagnosis, immunopathology

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