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Efficacy of Rasasindura in Life-Style

Disorders - A brief review

ANKESH KUMAR AGRAWAL


MD (Ayu) Scholar

Dept. of Rasa Shastra & Bhaishajya Kalpana including Drug Research


Institute for Post Graduate Teaching & Research in Ayurveda,
Gujarat Ayurved University, Jamnagar

Introduction

Man has been using metals and minerals in treatment


of many diseases since ages.

They became an integral part of Ayurvedic


therapeutics due to additional advantages like lesser
doses, higher efficacy etc.

Rasasindura (RS) is one among such mercurial


preparations used in Madhumeha (Diabetes
mellitus), Svasa (Dysponea), Uccha Raktachapa
(Hypertension) etc.

Why this topic?

Prevalence of lifestyle diseases are increasing


alarmingly in recent past.

This may be due to sedentary lifestyles being


adopted worldwide.

This infers lifestyle diseases like heart diseases,


cancer and diabetes etc. are now the primary causes
of death.

Considering wide utility of Rasasindura in lifestyle


diseases, present study has been selected to evaluate
its therapeutic efficacy.

Aims and objectives

Aim of the present study is to compile all available


research works done on Rasa sindura in the
department of RS & BK, IPGT&RA, Jamnagar.

MATERIALS AND METHODS

Total thirteen works have been carried-out in the


Department of Rasashastra & Bhaishajya Kalpana,
Institute for Post Graduate Teaching & Research in
Ayurveda, Gujarat Ayurved University, Jamnagar at
PhD and PG levels during 1974 2014.

They were compiled and screened to emphasize their


safety and efficacy at pre-clinical and clinical levels.

Madhumeha (DM)
Sharma NA et al

Hypoglycemic effect of RS alone and along with


Madhumeha hara yoga was evaluated .
Group 1- Madhumeha hara yoga
Group 2- Madhumeha hara yoga

4 gm
(1.78 gm) with RS (222 mg)

They were administered for thrice a day with water.

Cont

The study concluded that the effect of RS was better


on cardinal symptoms, blood sugar and urine sugar.

The experimental study was also done on


madhumeha hara yoga with RS on the rabbits for
effect on fasting blood sugar level for a week.

The experimental study failed to provide


pharmacological basis to the therapeutic findings.

Uccha-Raktachapa (Hypertension)
Gandhi DB et al

Evaluated clinical efficacy of Hypo-tensive formula


(Sarpagandha ghanavati and Chandrakala rasa)
alone and along with RS.

One group was treated with Hypo-tensive formula in


the dose of 1.5 gm tds while other group was treated
by same along with RS in the dose of 1 gm tds with
water for 6 weeks.

The group treated with RS showed better results in


Uccha-Raktachapa.

Svasa (Bronchial asthma)


Dr G Somanand et al

Clinical efficacy of Arkapatri (Tylophora asthmatica)


Swarasa Bhavita RS in fourteen cases of Tamaka
Svasa (Bronchial asthma) was evaluated.

The drug was administered at a dose of two ratti


(250 mg) in first week then increased up to four ratti
(500 mg) tds, along with honey.

Results showed that nine patients were completely


cured, three were relieved symptomatically and two
had no relief.

Khaire G. D. et al

Clinical efficacy of RS in Svasa was evaluated in


twenty patients.

Comparative study done with Arkadala Choorna (leaf


powder of Calotropis procera Linn.), Kajjali and RS.
RS was administered in a dose of 12.5 mg with
Arkadala Choorna .

Study concluded that Arkadala choorna along with RS


showed better results compared to other groups.

Milan Dasondi et al

The chemical analysis, chronic toxicity and


bronchodilatory effect of four different samples of RS
were evaluated

The samples were assessed for their bronchodilatory


effect in the isolated guinea pig tracheal spirals and
found encouraging results.

Vasa Bhavita Samaguna Rasasindura showed mild


and Vasa Bhavita Shadguna Rasasindura moderate
anti-spasmodic effect.

Shvitra (Leucoderma)
Umesh Agraval et al

Clinical efficacy of RS in Svitra was evaluated.

Comparative study done with RS and Shvitraghna


yoga . Shvitraghna hara taila was applied externally.

The group along with RS showed statistically


significant results compared to the other group.

Kshudra Kushtha
K. Swayam Prakash et al

Clinical efficacy of RS in Kshudra Kustha (Vicharchika,


Dadru and Pama) was evaluated.

Comparative study done with two samples of RS


were prepared with different Paka kala. One with
168 hrs and other with 6 hrs.

Cont.

Both samples were subjected to clinical trial in


kshudra kusthas in a dose of 250 mg twice daily along
with milk for 30 days. 10% Rasasindura Malahara
was applied externally in both groups.

Results showed Rasasindura prepared in 168 hrs has


comparatively better efficacy on kandu than the RS
prepared in 6 hrs.

RS showed normal E.S.R. level and mercury level in


hairs even after completion of treatment.

Vandhyatva (Male sexual problems)


Sudha J. Bhatt et al

Clinical efficacy of RS was evaluated in Vandhytva,


Dhwajabhanga and Daurbalya on 16 patients.

Comparative study done with RS and Aatmagupta


Beeja Churna.

Cont.

Group 1- RS 250 mg
Group 2- Aatmagupta beeja churna 2 gm
Group 3- RS with Aatmagupta beeja churna 644 mg

They were administered three times a day with milk


for 40 days.

RS alone and along with Aatmagupta beeja churna


showed better results.

Dhiraj V Vaghasia et al

Study reported encouraging results with the


treatment of RS in cases of Oligospermia.

Improvement in erectile dysfunction and sperm


motility was observed, while Azoospermia cases
were not responded

Sharma PK et al

The augmenting effect of RS prepared by


Ashtasamskarita Parada in vrishya yoga on male
sexual problems was evaluated.

In this study, one group was treated by vrishya yoga


churna in the dose of 2 gm t.d.s. with milk and other
group was treated by vrishya yoga churna mixed with
RS in same dose. Second group showed encouraging
results.

DISCUSSION

Therapeutic efficacy of Rasasindura has been


validated in cases of Svasa, Madhumeha, UcchaRaktachapa (Hypertension), Shvitra, Kshudra Kusthas,
Vandhyatva (Male sexual problems) etc.

In all the studies, Rasasindura was administered


alone or mixing with other herbal powders and
suitable adjuvant.

No adverse Effects were reported in any of the


clinical studies.

CONCLUSION

All the studies with RS proved to be safe and effective


in certain life style disorders like Diabetes Mellitus,
Bronchial Asthma and Hypertension.

The study of Milan et al reported toxic effects after


administration of RS. Here one should notice that the
trial drug is administered along with water as
anupana, while classic advocates the use of other
vehicles such as Honey etc. In absence of specified
anupana toxicities are likely to develop.

Cont.

No clinical studies reported elevated biochemical or serological abnormalities that prove


the safety aspects of Rasasindura.

Though the sample size in these cases is small


and no standard uniform protocols were
followed; the leads thus generated can be
considered in planning well designed clinical
trials in future. The outcome of such studies will
be beneficial to the ailing popular.

Thank You