Assignment No 5

1. According to UK health and safety Executive, Acceptable FAR is 1.0

2. The diffusion of toxicant through skin membrane is called Dermal Absorption
3. CEI (Chemical Exposure Index) gives unit less risk index which is relative to
various safety and environmental characteristics.
4. If the response of interest is death or lethality, the response vs. log dose curve
is called lethal dose curve.
5. What is the acceptable limit for carcinogens according to US EPA criteria?
Ans. E6
6. Entry of toxicants through skin membrane is called Dermal Absorption.
7. If the response to the agent causes an undesirable response that is not lethal
but is irreversible for example, liver damage or lung damage, the response log
dose curve is called Toxic Dose.
8. Concentration that should not be exceeded, even instantaneously is called
TLV-C
9. What are various types of doses?
The different types of doses are
Lethal Dose (LD) - if the response of internet is death or lethality, the
response vs. log dose curve is called lethal dose curve.
Effective Dose (ED) - if the response to the chemical or agent is minor and
reversible (for example, minor eye irritation etc.), the response-log dose curve
is called ED curve
Toxic Dose (TD) -if the response to the agent is toxic (it causes an
undesirable response that is not lethal but irreversible, for example liver
damage or lung damage), the response-log dose curve is called TD curve
For Gases, Lethal concentration (LD) - logarithm of the dose used
10. Define toxic dose.
In a toxic dose then the response to the agent cause an undesirable
response, but the undesirable response is not lethal, but it is irreversible - for
example, it causes a permanent damage to a liver or a lung of human body.
So, if that kind of dosage response to express as log dose curve is what we
called as a TD curve.