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  • Michael J. Welch, Carol S. Redvanly - Handbook of Radiopharmaceuticals

    Transféré par

    Marc Ritz
    424 vues862 pages
    A comprehensive, authoritative and up-to-date reference for the newcomer to radiopharmaceuticals and those already in the field. Radiopharmaceuticals are used to detect and characterise disease processes, or normal biological function, in living cells, animals or humans. Used as tracer molecules, they map the distribution, uptake and metabolism of the molecule in clinical studies, basic research or applied research. The area of radiopharmaceuticals is expanding rapidly. The number of PET centers in the world is increasing at 20% per year, and many drug companies are utilising PET and other forms of radiopharmaceutical imaging to evaluate products. * Readers will find coverage on a number of important topics such as radionuclide production, PET and drug development, and regulations * Explains how to use radiopharmaceuticals for the diagnosis and therapy of cancer and other diseases * The editors and a majority of the contributors are from the United States

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    A comprehensive, authoritative and up-to-date reference for the newcomer to radiopharmaceuticals and those already in the field. Radiopharmaceuticals are used to detect and characterise disease processes, or normal biological function, in living cells, animals or humans. Used as tracer molecules, they map the distribution, uptake and metabolism of the molecule in clinical studies, basic research or applied research. The area of radiopharmaceuticals is expanding rapidly. The number of PET centers in the world is increasing at 20% per year, and many drug companies are utilising PET and other forms of radiopharmaceutical imaging to evaluate products. * Readers will find coverage on a number of important topics such as radionuclide production, PET and drug development, and regulations * Explains how to use radiopharmaceuticals for the diagnosis and therapy of cancer and other diseases * The editors and a majority of the contributors are from the United States

    Droits d'auteur :

    © All Rights Reserved
    Téléchargez comme PDF, TXT ou lisez en ligne sur Scribd
    Signaler comme contenu inapproprié
    424 vues862 pages

    Michael J. Welch, Carol S. Redvanly - Handbook of Radiopharmaceuticals

    Transféré par

    Marc Ritz
    A comprehensive, authoritative and up-to-date reference for the newcomer to radiopharmaceuticals and those already in the field. Radiopharmaceuticals are used to detect and characterise disease processes, or normal biological function, in living cells, animals or humans. Used as tracer molecules, they map the distribution, uptake and metabolism of the molecule in clinical studies, basic research or applied research. The area of radiopharmaceuticals is expanding rapidly. The number of PET centers in the world is increasing at 20% per year, and many drug companies are utilising PET and other forms of radiopharmaceutical imaging to evaluate products. * Readers will find coverage on a number of important topics such as radionuclide production, PET and drug development, and regulations * Explains how to use radiopharmaceuticals for the diagnosis and therapy of cancer and other diseases * The editors and a majority of the contributors are from the United States

    Droits d'auteur :

    © All Rights Reserved
    Téléchargez comme PDF, TXT ou lisez en ligne sur Scribd
    Signaler comme contenu inapproprié
    sur 862

    Handbook of Radiopharmaceuticals: Radiochemistry and Applications. Edited by Michael J.

    Welch
    and Carol S. Redvanly
    Copyright 2003 John Wiley & Sons, Ltd. ISBN: 0-471-49560-3

    Contents
    Contributors
    Preface

    ix
    xiii

    Production of Radionuclides in Accelerators


    David J. Schlyer

    Accelerators Available for Isotope Production


    Thomas J. Ruth

    71

    Reactor Production of Radionuclides


    Leonard F. Mausner and Saed Mirzadeh

    87

    Chemistry of Nitrogen-13 and Oxygen-15


    John C. Clark and Franklin I. Aigbirhio

    119

    Aspects on the Synthesis of 11C-LabelIed Compounds


    Gunnar Antoni, Tor Kihlberg and Bengt Lngstrom

    141

    Chemistry of Fluorine-18 Radiopharmaceuticals


    Scott E. Snyder and Michael R. Kilbourn

    195

    Production and Application of Synthetic Precursors Labeled with


    Carbon-11 and Fluorine-18
    Richard A. Ferrieri

    . , 229

    Automation for the Synthesis and Application of PET Radiopharmaceuticals


    David L. Alexoff

    283

    Design and Synthesis of 2-Deoxy-2-[18F]Fluoro-D-Glucose (18FDG)


    Joanna S. Fowler and Tatsuo Ido

    307

    vi
    10 Technetium Radiopharmaceuticals
    Ashfaq Mahmood and Alun G. Jones

    323

    11

    Chemistry of Gallium and Indium Radiopharmaceuticals


    Ronald E. Weiner and Mathew L. Thakur

    363

    12

    Chemistry of Copper Radionuclides and Radiopharmaceutical Products


    Carolyn J. Anderson, Mark A. Green and Yasuhisa Fujibayashi

    401

    13 Chemistry Applied to Iodine Radionuclides


    Ronald Finn

    423

    14 Radiobromine for Imaging and Therapy


    Douglas J. Rowland, Timothy J. McCarthy and Michael J. Welch

    441

    15

    467

    Development of Radiolabeled Probes to Monitor Gene Therapy


    Chyng- Yann Shiue and Stephen L. Eck

    16 Mechanism of Target Specific Uptake Using Examples of


    Muscarinic Receptor Binding Radiotracers
    William C. Eckelman

    487

    17 Strategies for Quantifying PET Imaging Data from


    Tracer Studies of Brain Receptors and Enzymes
    Jean Logan

    501

    18

    Radiopharmaceuticals for Studying the Heart


    Dah-Ren Hwang and Steven R. Bergmann

    529

    19

    PET Imaging Studies in Drug Abuse Research


    Joanna S. Fowler, Nora D. Volkow, Yu-Shin Ding, Jean Logan and Gene-Jack Wang

    557

    20

    Research and Clinical Application of Neuroreceptor Imaging


    Henry N. Wagner, Jr. and Zsolt Szabo

    581

    21

    Dynamic Neurotransmitter Interactions Measured with PET


    Wynne K. Schiffer and Stephen L. Dewey

    603

    22 Tumor Imaging
    Roland Hustinx and Abass Alavi

    629

    23

    643

    Radiolabeled Peptides for Tumor Imaging


    Linda C. Knight

    CONTENTS

    vii

    24

    Radiolabeled Antibodies for Tumor Imaging and Therapy


    Michael R. Zalutsky and Jason S. Lewis

    685

    25

    Receptor Imaging of Tumors (Non-Peptide)


    John A. Katzenellenbogen

    715

    26

    Pulmonary Function Imaging with PET Radiopharmaceuticals


    P. H. Elsinga and W. Vaalburg

    751

    27

    Considerations in the Selection of Radionuclides for Cancer Therapy


    Amin I. Kassis and S. James Adelstein

    767

    28

    Radiopharmaceuticals for the Study of Liver and Renal Function


    David R. Vera, Carl K. Hoh, Robert C. Stadalnik and Kenneth A. Krohn

    795

    Index

    823

    Handbook of Radiopharmaceuticals: Radiochemistry and Applications. Edited by Michael J. Welch


    and Carol S. Redvanly
    Copyright 2003 John Wiley & Sons, Ltd. ISBN: 0-471-49560-3

    Handbook of Radiopharmaceuticals: Radiochemistry and Applications. Edited by Michael J. Welch


    and Carol S. Redvanly
    Copyright 2003 John Wiley & Sons, Ltd. ISBN: 0-471-49560-3

    Handbook of Radiopharmaceuticals: Radiochemistry and Applications. Edited by Michael J. Welch


    and Carol S. Redvanly
    Copyright 2003 John Wiley & Sons, Ltd. ISBN: 0-471-49560-3

    Handbook of Radiopharmaceuticals: Radiochemistry and Applications. Edited by Michael J. Welch


    and Carol S. Redvanly
    Copyright 2003 John Wiley & Sons, Ltd. ISBN: 0-471-49560-3

    Handbook of Radiopharmaceuticals: Radiochemistry and Applications. Edited by Michael J. Welch


    and Carol S. Redvanly
    Copyright 2003 John Wiley & Sons, Ltd. ISBN: 0-471-49560-3

    Handbook of Radiopharmaceuticals: Radiochemistry and Applications. Edited by Michael J. Welch


    and Carol S. Redvanly
    Copyright 2003 John Wiley & Sons, Ltd. ISBN: 0-471-49560-3

    Handbook of Radiopharmaceuticals: Radiochemistry and Applications. Edited by Michael J. Welch


    and Carol S. Redvanly
    Copyright 2003 John Wiley & Sons, Ltd. ISBN: 0-471-49560-3

    Handbook of Radiopharmaceuticals: Radiochemistry and Applications. Edited by Michael J. Welch


    and Carol S. Redvanly
    Copyright 2003 John Wiley & Sons, Ltd. ISBN: 0-471-49560-3

    Handbook of Radiopharmaceuticals: Radiochemistry and Applications. Edited by Michael J. Welch


    and Carol S. Redvanly
    Copyright 2003 John Wiley & Sons, Ltd. ISBN: 0-471-49560-3

    Handbook of Radiopharmaceuticals: Radiochemistry and Applications. Edited by Michael J. Welch


    and Carol S. Redvanly
    Copyright 2003 John Wiley & Sons, Ltd. ISBN: 0-471-49560-3

    Handbook of Radiopharmaceuticals: Radiochemistry and Applications. Edited by Michael J. Welch


    and Carol S. Redvanly
    Copyright 2003 John Wiley & Sons, Ltd. ISBN: 0-471-49560-3

    Handbook of Radiopharmaceuticals: Radiochemistry and Applications. Edited by Michael J. Welch


    and Carol S. Redvanly
    Copyright 2003 John Wiley & Sons, Ltd. ISBN: 0-471-49560-3

    Handbook of Radiopharmaceuticals: Radiochemistry and Applications. Edited by Michael J. Welch


    and Carol S. Redvanly
    Copyright 2003 John Wiley & Sons, Ltd. ISBN: 0-471-49560-3

    Handbook of Radiopharmaceuticals: Radiochemistry and Applications. Edited by Michael J. Welch


    and Carol S. Redvanly
    Copyright 2003 John Wiley & Sons, Ltd. ISBN: 0-471-49560-3

    Handbook of Radiopharmaceuticals: Radiochemistry and Applications. Edited by Michael J. Welch


    and Carol S. Redvanly
    Copyright 2003 John Wiley & Sons, Ltd. ISBN: 0-471-49560-3

    Handbook of Radiopharmaceuticals: Radiochemistry and Applications. Edited by Michael J. Welch


    and Carol S. Redvanly
    Copyright 2003 John Wiley & Sons, Ltd. ISBN: 0-471-49560-3

    Handbook of Radiopharmaceuticals: Radiochemistry and Applications. Edited by Michael J. Welch


    and Carol S. Redvanly
    Copyright 2003 John Wiley & Sons, Ltd. ISBN: 0-471-49560-3

    Handbook of Radiopharmaceuticals: Radiochemistry and Applications. Edited by Michael J. Welch


    and Carol S. Redvanly
    Copyright 2003 John Wiley & Sons, Ltd. ISBN: 0-471-49560-3

    Handbook of Radiopharmaceuticals: Radiochemistry and Applications. Edited by Michael J. Welch


    and Carol S. Redvanly
    Copyright 2003 John Wiley & Sons, Ltd. ISBN: 0-471-49560-3

    Handbook of Radiopharmaceuticals: Radiochemistry and Applications. Edited by Michael J. Welch


    and Carol S. Redvanly
    Copyright 2003 John Wiley & Sons, Ltd. ISBN: 0-471-49560-3

    Handbook of Radiopharmaceuticals: Radiochemistry and Applications. Edited by Michael J. Welch


    and Carol S. Redvanly
    Copyright 2003 John Wiley & Sons, Ltd. ISBN: 0-471-49560-3

    Handbook of Radiopharmaceuticals: Radiochemistry and Applications. Edited by Michael J. Welch


    and Carol S. Redvanly
    Copyright 2003 John Wiley & Sons, Ltd. ISBN: 0-471-49560-3

    Handbook of Radiopharmaceuticals: Radiochemistry and Applications. Edited by Michael J. Welch


    and Carol S. Redvanly
    Copyright 2003 John Wiley & Sons, Ltd. ISBN: 0-471-49560-3

    Handbook of Radiopharmaceuticals: Radiochemistry and Applications. Edited by Michael J. Welch


    and Carol S. Redvanly
    Copyright 2003 John Wiley & Sons, Ltd. ISBN: 0-471-49560-3

    Handbook of Radiopharmaceuticals: Radiochemistry and Applications. Edited by Michael J. Welch


    and Carol S. Redvanly
    Copyright 2003 John Wiley & Sons, Ltd. ISBN: 0-471-49560-3

    Handbook of Radiopharmaceuticals: Radiochemistry and Applications. Edited by Michael J. Welch


    and Carol S. Redvanly
    Copyright 2003 John Wiley & Sons, Ltd. ISBN: 0-471-49560-3

    Handbook of Radiopharmaceuticals: Radiochemistry and Applications. Edited by Michael J. Welch


    and Carol S. Redvanly
    Copyright 2003 John Wiley & Sons, Ltd. ISBN: 0-471-49560-3

    Handbook of Radiopharmaceuticals: Radiochemistry and Applications. Edited by Michael J. Welch


    and Carol S. Redvanly
    Copyright 2003 John Wiley & Sons, Ltd. ISBN: 0-471-49560-3

    Handbook of Radiopharmaceuticals: Radiochemistry and Applications. Edited by Michael J. Welch


    and Carol S. Redvanly
    Copyright 2003 John Wiley & Sons, Ltd. ISBN: 0-471-49560-3

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