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Community acquired!
widespread in environment
carried on skin/feces
nml flora & opportunistic flora in hospital
Trans: sinks, fomites, plants, fruits, hands, etc
PATHOLOGY/DISEASE of PSEUDOMONAS AEROGINOSA:
Not super virulent
Needs significant break in host defense
Compromised hosts only
INFXNS (non-pneumonia):
UTI. pneumonia, eye, ear, skin
2nd leading cause infection in bum patients
common cause of death in CF
RESPIRATORY INFXNS due to PSEUDOMONAS AEROGINOSA:
Primary
o Inhalation therapy with nebulization
Secondary
o Immunosuppression/ host compromise o
Associated with bacteremia (IV drug use)
Clinically:
o Nml Pts: toxicity, cyanosis, empyema o CF: chronic/recurrent.
confined to respiratory tract, bilateral w/residual damage
DX:
Need to isolate & ID in lab!
Grow in lots of different media
Blue-green water soluble pigment highly characteristic
IX:
MDR common; need susceptibility tests!
Hard to clear, relapse common
Systemic inxn needs combos for synergism
NO broad spectrum Ab (suppress nml flora)