Académique Documents
Professionnel Documents
Culture Documents
Lecturers
Prof. Heng Pheng Ann.
Introduction to
Medical Image Processing &
Medical Imaging
Biomedical Engineering
dfwang@cuhk.edu.hk
Prof. Shi Lin
Dept of Medicine and Therapeutics
Biomedical Engineering
shilin@cuhk.edu.hk
Course Outline
Course Outline
Content
Activities
Introduction
12 lectures
Visualization
Analysis
4 assignments
1 site visit (Apr 13, 2015)
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louwutao@gmail.com
Grading Scheme
Textbook
Assignment
Mid-term Exam
Final Exam
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1. Building block
2. Grayscale
3. Dimension
4. Quality
2D: Pixels
3D: Voxels
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2. Grayscale
Dynamic range
Say gray values
Dynamic range:
Human eyes cannot distinguish subsequent intensities Ij
and Ij+1 if they differ less than 1%
128
129
128
130
1.5%
0.7%
Integers
if
= 100 n=463;
if
= 1000 n=694
There is no great incentive to display more than 256 shades of gray since
human vision can only resolve about 32 to 64 shades of gray!
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louwutao@gmail.com
Image Quantization
3. Dimensions
4 bpp
2D: X-ray
3D: CT/MRI
Contouring effect
4D: fMRI/Perfusion MRI/etc
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louwutao@gmail.com
4. Image Quality
Resolution (Spatial)
Dots per inch?
Resolution
Contrast
Noise
Artifact
Point Spread
Function (PSF)
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Contrast
difference in intensity of adjacent regions of image
Noise
Imaging is a stochastic process!
signal-to-noise ratio (SNR or S/N)
noise can be estimated by making a flat-field image
The noise amplitude = Fourier transform of the autocorrelation
of a flat-field image
Noise in MR image
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Source of Noise
Artifacts
Ghosting artifact
Motion artifact
(breathing)
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louwutao@gmail.com
Grayscale transformation
32328
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Grayscale transformation
2562562
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Windowing
A popular gray level transformation!
l: window level
w: window size
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Windowing
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Histogram
Start
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Histogram Equalization
Histogram Equalization
Histogram
Histogram Equalization
Histogram
Equalization
Adaptive
Histogram
Equalization
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Spatial Filtering
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Gaussian filter
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Unsharp masking
Unsharp masking
where
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Geometric Transformations
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Inventor of CT
ii.
Anatomy study
iii.
Physiology study
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louwutao@gmail.com
Mathematics
Radon transform
Image registration
ii.
Physics
1) Wng() Observe
2) Wn() Hear
X-ray
Ultrasound
Endoscopy
Magnetic resonance
iii.
3) Wn() Ask
4) Qi () - Touch
Chemistry
Spectroscopy imaging
iv.
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and more1
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1) Wng() Observe
2) Wn() Hear
Modality examples:
Modality examples:
i.
i.
Ultrasound diagnostic
ii.
ii.
Echocardiography
iii.
Endoscopy
iv. Thermography
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3) Wn() Ask
4) Qi () - Touch
Modality examples:
i.
ii.
imaging (MRE)
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louwutao@gmail.com
Pressure distribution
of soft tissues
1917
Invention of
Radon
transform
1895
Discovery of Xray
1953
First successful
measurement in
heart cavity by
ultrasound (US)
1984
US FDA approved
first commercial
magnetic resonance
scanner (MR)
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1934
Discovery of
artificial
radionuclides
1961
Building of first
positron emission
tomography (PET)
1971
First brain scan by
computed
tomography (CT)
1990s
Elastography was
emerged
Now
More and more
techniques are still
developing
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louwutao@gmail.com
louwutao@gmail.com
Biomedical Imaging
X-ray/Radiograph
Different materials have different
absorption rate in x-ray
X-ray/Radiograph
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louwutao@gmail.com
Biomedical Imaging
X-ray/Radiograph
Biomedical Imaging
X-ray/Radiograph
Mammogram
Treatment planning
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Biomedical Imaging
Ultrasound
Locate objects by reflection of
ultrasound
Diagnostic Ultrasound
Radiation free
Inexpensive
Mobile scanner
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Biomedical Imaging
Ultrasound Applications
Diagnose diseases related to:
heart and blood vessels,
abdominal aorta,
liver,
gallbladder,
spleen,
pancreas,
kidneys,
bladder,
uterus,
ovaries,
infants etc.
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louwutao@gmail.com
Biomedical Imaging
CT
Biomedical Imaging
CT Applications
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louwutao@gmail.com
Biomedical Imaging
MRI
Base on magnetic resonance of molecules (Protons)
Strength of magnetic field 1.5T / 3.0T machines in PWH
Advantages:
Excellent anatomical detail and strong grey/white matter contrast
Non-invasive
Non-ionizing radiation
Disadvantages:
Long scanning time
Expensive
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louwutao@gmail.com
Biomedical Imaging
MRI
Application of MR imaging
Internal organs
Spine
Vessel
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Advantages:
neural activity
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Clinical diagnosis
Presurgical mapping
Risk assessment of invasive brain surgery
Assessment of brain injury
Assessment of patients with disorders of consciousness
Research applications
Mapping brain functions
Detect abnormal neural activity for patients with brain disease
E.g., Alzheimer's disease, Parkinson's disease
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Isotropic
Anisotropic
tissue composition
physical properties of tissue
constituents
tissue microstructure, architectural
organization
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Nuclear Imaging
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New Paradigm
PRECLINICAL Alzheimers Disease
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Fusion Imaging
PET
Good molecular
Provide structural
and functional
details
detail
Lack of anatomical
details
CT
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Fused PET/CT
Both structural and
functional information
Resolution
Cost
Radiation safety
PET
CT
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2) Surgical navigation
3) Computer aided diagnosis
4) Remote medical consultation
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