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Original Article
ABSTRA
CT
Background: Periodontal disease is one of the major reasons for tooth loss. Accumulating
evidence suggests that chronic infections, such as periodontitis, are associated with increased
risk for cardiovascular diseases (CVD) possibly through providing a systemic inflammation and
found that 25% to 50% increase in risk of CVD for those with periodontitis when compared to
those with no or minimal periodontitis.
Aim: To evaluate the association between chronic periodontal disease and cardiovascular
risk factor such as hyperlipidemia.
Materials and Methods: A hospital-based study was conducted among the patients who came
to the out-patient department. Fifty subjects including both males and females were selected by
systematic random method, and community periodontal index was recorded on all subjects.
Subjects were divided in to healthy group (controls) and chronic periodontitis group (cases)
based on presence/ absence of loss of attachment. Blood samples were collected from all subjects
for the measurement of lipid profile in the serum.
Results: Mean total cholesterol values in controls and cases were 190.44 and 200.64, which were
not statistically significant between the groups. Mean LDL cholesterol values in controls and cases
were 110.96 and 136.64, which were statistically increased in cases (P = 0.003). Mean HDL
cholesterol values in controls and cases were 61.60 and 49.28, which were statistically higher in
controls (P = 0.041).
Conclusion: Chronic periodontitis patients may have high risk of getting cardiovascular diseases
since cardiovascular risk factors such as total cholesterol and LDL are associated with
periodontitis.
Key words: Chronic periodontitis, cardiovascular diseases,
and cholesterol levels
INTRODUCTION
Periodontitis is a chronic inflammatory disease, which
destroys connective tissue and bone that support the
teeth. Periodontal disease is one of the major reasons
for tooth loss and impaired oral health. Poor oral
Address for correspondence
Dr. Anitha,
Department of Public Health Dentistry, Mamata Dental
College, Khammam - 507001, Andhra Pradesh, India.
E-mail: anithareddy176@gmail.com
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Response
Code:
MATERIALS
METHODS
AND
RESULT
S
A total number of 50 subjects with the age range
between 30 and 60 years participated in the study.
The mean age of the subjects in control was 39.88
+ 8.16 years and cases were 42.92 + 10.11 years
Age group
DISCUSSION
A cross-sectional study was conducted to evaluate the
association between chronic periodontal disease and
cardiovascular risk factor such as hyperlipidemia.
In the present study, total cholesterol, high density
lipoprotein, low density lipoprotein, very low density
lipoprotein, and triglycerides in serum were measured
for subjects with chronic periodontitis and without
chronic periodontitis.
Controls
Cases
30-40
41-50
10
14
40
56
08
15
32
60
51-60
01
02
Total
25
100.0
25
100.0
Controls
Cases
Male
Female
7
18
28
72
5
20
20
80
Total
25
100.0
25
100.0
Controls
P-value
(mean value)
Total cholesterol
190.44
200.64
0.173
HDL cholesterol
61.60
49.28
0.041*
LDL cholesterol
110.96
136.64
0.003*
VLDL cholesterol
15.28
18.32
0.05*
88.76
0.156
Triglyceride cholesterol
77.46
Independent variables
Presence/Absenc
e of Periodontitis
Sex
P-value
0.657
ECG
0.104
Total cholesterol
0.517
LDL
0.474
HDL
0.674
VLDL
0.839
Triglycerides
0.910
251
CONCLUSION
In the present study, there was an association between
chronic periodontitis and cardiovascular risk factors
like hyperlipidemia. LDL-cholesterol was significantly
increased in subjects with chronic periodontitis
than in healthy subjects, which is risk factor for
cardiovascular diseases. HDL-cholesterol levels were
significantly increased in healthy subjects than in
Journal of Dr. NTR University of Health Sciences 2014;3(4)
8.
Suggestions
and
recommendations
There is a need to conduct the longitudinal
studies to know the causal association between
periodontitis and cardiovascular diseases.
Patients with periodontal diseases are advised to
monitor the cardiovascular risk factors like lipid
profile in the blood to prevent the cardiovascular
diseases among them.
16.
17.
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