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Espiritu, Walter Aljhon
Silong, Rafaelle
Tumimbang, Glenn Vincent
I. Abstract
Some organic compounds like ketones, carboxylic acids and esters contain a carbonyl group
(C=O). In these compounds, Greek letters are used to approximate each carbon atom to the carbonyl
group (Klein, 2012). The labeling starts after the carbonyl group. Also, hydrogen atoms are named with
the Greek letter of the carbon in which they are attached, for example for a methyl group in alpha
position, there are -hydrogens. In this experiment, one of the most important reactions at the alpha
position is observed, which is aldol condensation.
II. Keywords: -carbon, aldol condensation, nucleophilic addition, base-catalyzed reaction
III. Introduction
Aldol condensations are important
in organic synthesis, providing a good way to
form carboncarbon
bonds.
The Robinson
annulation reaction sequence features an aldol
condensation;
the Wieland-Miescher
ketone product is an important starting material
for
many
organic
syntheses.
Aldol
condensations are also commonly discussed in
university level organic chemistry classes as a
good bond-forming reaction that demonstrates
important reaction mechanisms. In its usual
form, it involves the nucleophilic addition of
a ketone enolate to an aldehyde to form a hydroxy ketone, or "aldol" (aldehyde + alcohol),
a structural unit found in many naturally
occurring molecules and pharmaceuticals.
IV. Methodology
In a 50mL Erlenmeyer flask, combine
0.80 mL (0.83 g, 8mmol) of benzaldehyde, 0.30
mL acetone and 2 mL 95% ethanol. Then add 2
mL of 10& NaOH and swirl for 20 minutes. After
swirling, collect the solid by suction filtration
then break up the solid and remove the suction.
Add the gathered residue to 3 mL water then
apply suction, repeat this process twice. Finally,
recrystallize the solid using 95% ethanol and
determine its melting point and %yield.
b. acid-catalyzed
_____________________
Rafaelle Silong
_____________________
Glenn Vincent Tumimbang