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Aisling Ahlstrm
Learning objectives
To describe the basic structure of a eukaryotic
cell
To understand the cellular processes occurring
within the cell
Cell membrane
The cell membrane is made up of a phospholipid bilayer.
Fluid mosaic model (1972, Singer)
hydrophillic
Barrier
Transporter
Maintains
Membrane potential
Cell volume
Homeostasis
hydrophobic
Permeability
The most important property of the cell membrane is its selective permeability,
Small and nonpolar (hydrophobic) molecules can freely pass through the membrane,
but charged ions and large molecules such as proteins and sugars are barred passage.
Cell junctions
Tight junction
Adherent junction
Desmosomes
Gap junctions
Chatterjea, BluSci
The nucleus
Cytoskeleton
Protein structure, organization and transport
Shape change and movement, resist stress
Connects cell to external environment
Cytoskeleton
Microtubules, form tracks that
can span the length of the entire
cell, like highways for
intracellular traffic, can
reorganize rapidly.
Centrosome
Division centre segregating chromosomes
Nucleus
The genome
Chromatin consists of DNA, RNA
and proteins
Chromatin
Chromosome
Sperm DNA
During spermiogenesis, histones
are replaced by protamines,
condensing the DNA into tightly
packaged toroids
High state of supercoiling inhibits
transcription
DNA structure
ehinger.nu
Cell cycle
labmonsters.com
Mitosis
Diploid parent cell
2n:2c
DNA replication
Prophase
2n:4c
Metaphase
2n:4c
SAC
Anaphase
4n:4c
Telophase
4n:4c
Cytokinesis
2n:2c
Meiosis I
&
Meiosis II
4c
Crossing over
Spindle assembly checkpoint
2c
1c
Gametogenesis
Spermatogenesis
Oogenesis
Metabolic pathways
Energy/ATP
Mitochondria
Mitochondria
Imbalance of ATP supply/demand
associated with
MII
D3
D4
D5
Sperm
Defects in structure, genome, membrane
potential or O2 consumption associated to
loss of sperm function
Critical for fertilization
Sperm mtDNA is then degraded inside the
zygote
DNA (blue)
Protein synthesis
Ribosomal
RNA
Transfer RNA
classes.kumc.edu
Messenger RNA
Universal code
en.wikipedia.org
sciencephoto.com
brittocellproj.weebly.com
Golgi Apparatus
Lysosomes
Summary
The eukaryotic cell is a highly functional unit
Is able to take care of household functions
with specialised organelles, to replicate,
manufacture and dispose.