Académique Documents
Professionnel Documents
Culture Documents
Key words
Adverse outcome
Morbidity and mortality conference
Neurosurgical complications
Spine complications
Abbreviations and Acronyms
CSF: Cerebrospinal fluid
ICU: Intensive care unit
MMC: Morbidity and mortality conference
Department of Neurosurgery of the Hospital
Italiano de Buenos Aires, Argentina
To whom correspondence should be addressed:
Federico Alfonso Landriel Ibaez, M.D.
[E-mail: fedelandriel@gmail.com]
Citation: World Neurosurg. (2011) 75, 5/6:709-715.
DOI: 10.1016/j.wneu.2010.11.010
Journal homepage: www.WORLDNEUROSURGERY.org
Available online: www.sciencedirect.com
1878-8750/$ - see front matter 2011 Elsevier Inc.
All rights reserved.
INTRODUCTION
The assessment of surgical complications
is an important tool in neurosurgical practice (11) because it can improve safety and
quality of patient treatment (7, 14, 27, 43).
The different views on and denitions of
what is considered a complication (11), coupled with the absence of a widely accepted
classication of postoperative adverse
events, may lead to a subjective interpretation of surgical negative outcomes (17, 41,
42). Comparisons between two distinct
time periods in a single hospital or between
different institutions are almost impossible
because no standard reporting system exists (17, 19, 25).
To illustrate the problem, we focus on
three extensive reports of complications derived from epilepsy surgery (9, 45, 48),
which offer very different criteria for complications. In two of the reports, complication severity was judged minor (transient)
when the complication resolved within 1
year of the surgical procedure and major
(permanent) when the complication lasted
for more than 1 year postoperatively (9, 48).
In the third report, events that resolved
www.WORLDNEUROSURGERY.org
709
PEER-REVIEW REPORTS
FEDERICO ALFONSO LANDRIEL IBAEZ ET AL.
COMPLICATIONS IN NEUROSURGERY
Grade Ia
Grade Ib
Grade II
Grade IIa
Grade IIb
Grade III
Grade IIIa
Grade IIIb
Grade IV
Surgical Complications
Medical Complications
Adverse events that are not directly related to surgery or surgical technique
complications, (ii) neurosurgically complicated courses, and (iii) medical nonsurgical complications. In 2009, Houkin et
al. (29) presented a quantitative analysis
of complications in neurosurgery and
classied adverse events into ve types,
on the basis of adverse event avoidance
predictability and possibility.
In 2010, Lebude (32) conducted a survey
with more than 200 spine surgeons to establish what was considered a complication. Based on the survey results, Lebude
presented a binary denition of complications, by virtue of which they were classied
into minor and major adverse events.
We based our classication on the proposal of Clavien (17) and Dindo (19) and
modied it to conform to neurosurgical and
spine procedures and outcomes more suitably. This classication focuses on general
postoperative morbidity. We used a fourgrade severity scale based on the therapy
administered to treat a postoperative adverse event and considered how it related to
the surgical procedure to come up with a
simple, practical, and easy to reproduce way
to report negative outcomes.
METHODS
Complications were dened as any deviation from the normal postoperative course
occurring within 30 days of surgery. We
used adverse postoperative event and
710
www.SCIENCEDIRECT.com
PEER-REVIEW REPORTS
FEDERICO ALFONSO LANDRIEL IBAEZ ET AL.
COMPLICATIONS IN NEUROSURGERY
Surgical Complications
Medical Complications
Ia
Local phlebitis
Acute urinary retention
Atelectasis requiring physical therapy
Noninfectious diarrhea
Grade 1 or laminar pneumothorax
Ib
IIa
IIb
IIIa
IIIb
Cardiopulmonary insufficiency
Lung distress and renal failure
Systemic inflammatory response syndrome and pneumonia
Renal insufficiency and hemodynamic instability
Death
IV
Death
Suffix T (Transient)
New neurologic deficit improving within 30 days of surgical procedure; can be added to each grade of complication
Suffix P (Persistent)
New neurologic deficit extending beyond 30 days of surgical procedure; can be added to each grade of complication
present in a single patient, the major complication was assessed. Examples of surgical and medical complications are listed in
Table 2. There was a strong and simple
correlation between the grade of complication and the severity of adverse events.
Grade I complications were considered to
be mild complications, whereas grade II
and grade III were regarded as moderate
and severe.
Between January 2008 and December
2009, 1190 patients were operated on in the
Neurosurgical Department of the Hospital
Italiano de Buenos Aires. Demographics,
medical records, radiologic images, laboratory data, and all documented deviations
from the normal postoperative course were
analyzed from the computerized hospital
data system by a senior neurosurgical resident and presented in the monthly morbidity and mortality conference (MMC). Selected cases with neurosurgical and medical
complications were analyzed in depth and
discussed. Data were objectively compared
with previous months, allowing for longterm quantications and trend identication to be made.
RESULTS
A cohort of 1190 patients who had undergone a cranial (72%) or spinal (28%) neurosurgical intervention in our institution was
analyzed. One or more complications occurred in 14% of patients (n 167). Surgical
www.WORLDNEUROSURGERY.org
711
PEER-REVIEW REPORTS
FEDERICO ALFONSO LANDRIEL IBAEZ ET AL.
DISCUSSION
MMCs are a powerful teaching tool, and the
objective analysis of data conducted in these
conferences may help to improve the quality
and safety of patient care through the interpretation and discussion of adverse postoperative events and the development of alternative approaches to medical decision
making (14, 24, 26). A major effort should
be made to avoid criticizing, blaming, or
intimidating an individual person or group
(14, 16, 21, 28, 30). The aim of the MMC is to
create an atmosphere that is productive in
terms of training and education, one where
surgery residents and staff attendees are encouraged to discuss and comment on the
different cases (3, 4, 13, 14, 28, 29, 34, 35,
38, 40, 44, 47, 49). In brief, the MMC represents a unique opportunity to foster professionalism and improve communication
within the neurosurgical group (38).
Neurosurgical practice is considerably
riskier than other surgical specialties. In
this practice, most errors and resulting adverse events are unavoidable and should be
accepted as part of the surgical procedure
(14, 29). To eliminate any individual tendency to downgrade or deny complications
and to avoid the use of nonspecic terms
such as minor or major to characterize
adverse events, systematic and stratied
classied data should be recorded in every
neurosurgical department (10, 14, 15, 18,
29, 31, 38, 41-43); yet, how can we compare
the global morbidity or mortality of two or
more different centers, with different technology, at different times, if we do not use
the same language to characterize complications?
Specialties such as general surgery and
anesthesiology have successfully improved
the quality of the care they provide and the
safety of their patients by systematizing the
complication records and the MMC (2, 17,
19, 30, 38). General, uniform, and multicentric knowledge of complications not
only would improve patient outcomes,
satisfaction, and health care costs, but also
712
www.SCIENCEDIRECT.com
COMPLICATIONS IN NEUROSURGERY
complications of spinal surgical procedures and determined the clinical consequences of these events in the postoperative
period. The classication was based on
treatment requirements, sequelae, and hospital stay. They concluded that intraoperative adverse events can occur with a frequency of 14%; however, most procedures
(76.5%) were not associated with complications.
Houkin et al. (29) published a quantitative analysis of adverse events related to
neurosurgical procedures. They classied
the nature of events as neurologic, local,
and systemic and ascribed the cause of
these events to patient disease, technical
reasons, equipment, and diagnosis. In the
MMC of their Neurosurgical Department,
all adverse events were classied into ve
types on the basis of three factors: (i) relation to the procedure, (ii) predictability of
the event, and (iii) possibility of avoidance.
In their study, the severity of the complication was not invariably correlated with the
event type, and the inclusion of a complication under predictability or possibility of
avoidance was based on the background
and experience of the conference attendees.
Houkin et al. (29) also dened adverse
events as events requiring additional treatment, resulting in transient or permanent
decits, and requiring longer hospital
stays. Following the perspective of Dindo et
al. (19), length of stay does not constitute
for us a valid inclusion criterion or complication score because each site follows a different standard of care.
More recently, Lebude et al. (32) conducted a survey with experienced spinal surgeons in a set of different clinical scenarios
of postoperative complications. The authors provided no preset denitions and
asked the surgeons to classify postoperative
events accordingly as different complications and to stratify them into minor and
major categories or to regard them as a nonevent. Lebude et al. (32) showed that their
surgeon population considered medical
complications to have occurred even when
these were not directly related to a surgical
procedure and should be included in the
assessment of postoperative complications. Based on the survey responses, Lebude et al. (32) dened perioperative spinal
complications as (i) a major complication,
an adverse perioperative event that produces a permanent detrimental effect or re-
PEER-REVIEW REPORTS
FEDERICO ALFONSO LANDRIEL IBAEZ ET AL.
COMPLICATIONS IN NEUROSURGERY
Procedure
Cranial-spinal
Spinal
Cranial-spinal
Spinal
quires reoperation in the perioperative period (30 days from the time of surgery), and
(ii) a minor complication, an adverse perioperative event that produces only a transient detrimental effect in the perioperative
period.
Given the fact that cranial and spinal interventions were performed by the same
physicians in almost all of the Neurosurgical Departments, a general classication of
complications should and could be applied.
To our knowledge, none of these systems
has gained general acceptance. The classication we propose is based on the therapy
used to treat the adverse event and focuses
on the general postoperative morbidity of
the patient. Documentation of treatment of
a complication is often included in detail in
the patients medical record and is easy to
obtain and classify, whereas adverse events
may be missed or overlooked, especially
when they are regarded as minor. Substantial differences arise in terms of complication evolution or severity. For example,
a postoperative intracerebral hematoma may
be followed only by observation, it may be
Complication Types
Definition
Surgical complications
Surgically complicated
Nonsurgical complications
Minor
Moderate
Major
Nature
Cause
Type I
Unrelated to procedure.
Type II
Type III
Type IV
Type V
Medical error.
Minor
Surgical and clinical transient detrimental effect (30 days from surgery).
Major
Surgical and clinical permanent detrimental effect (30 days from surgery).
www.WORLDNEUROSURGERY.org
713
PEER-REVIEW REPORTS
FEDERICO ALFONSO LANDRIEL IBAEZ ET AL.
COMPLICATIONS IN NEUROSURGERY
CONCLUSIONS
7. Barach P, Small SD: Reporting and preventing medical mishaps: lessons from non-medical near miss
reporting systems. BMJ 320:759-763, 2000.
8. Baron EM, Albert TJ: Medical complications of surgical treatment of adult spinal deformity and how to
avoid them. Spine 19S:106-118, 2006.
23. Fujita T, Kostuik JP, Huckell CB, Sieber AN: Complications of spinal fusion in adult patients more
than 60 years of age. Orthop Clin North Am 29:669678, 1998.
ACKNOWLEDGMENTS
The authors thank Peter Black, M.D., Ph.D.,
President of the World Federation of Neurological Societies, for his helpful comments,
suggestions, and assistance in preparing this
article.
REFERENCES
1. Abbott KH, Gay JR, Goodall RJ: Clinical complications of cerebral angiography. J Neurosurg 9:258274, 1952.
2. Annas GJ: The patients right to safetyimproving
the quality of care through litigation against hospitals. N Engl J Med 354:2063-2066, 2006.
3. Antonacci AC, Lam S, Lavarias V, Homel P, Eavey
RD: A morbidity and mortality conference-based
classication system for adverse events: surgical
outcome analysis, part I. J Surg Res 147:172-177,
2008.
5. Apuzzo MLJ: Preface. In: Brain Surgery. Complication Avoidance and Management, Vol 1. New York:
Churchill Livingstone; 1993:xxi.
21. Esselman PC, Dillman Long J: Morbidity and management conference: An approach to quality improvement in brain injury rehabilitation. J Head
Trauma Rehab 17:257-262, 2002.
37. Perez-Cruet MJ, Fessler RG, Perin NI: Review: complications of minimally invasive spinal surgery.
Neurosurgery 51(Suppl 2):26-36, 2002.
6. Balch RE: Wound infections complicating neurosurgical procedures. J Neurosurg 26:(Pt 1):41-45,
1967.
38. Pierlussi E: Discussion of medical errors in morbidity and mortality conference. JAMA 290:2838-2842,
2003.
714
www.SCIENCEDIRECT.com
PEER-REVIEW REPORTS
FEDERICO ALFONSO LANDRIEL IBAEZ ET AL.
COMPLICATIONS IN NEUROSURGERY
www.WORLDNEUROSURGERY.org
715