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June 2011
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Table of Contents
1.
INTRODUCTION................................................................................................................... 1
1.1
1.2
1.3
1.4
1.5
1.6
1.7
2.
3.
FIRST AID............................................................................................................................. 6
3.1 INHALATION ........................................................................................................................ 6
3.2 CONTACT WITH SKIN .......................................................................................................... 9
3.3 CONTACT WITH THE EYES .................................................................................................. 9
6.
7.
8.
9.
REFERENCES.................................................................................................................... 15
9.1 CHLORINE INSTITUTE REFERENCES ................................................................................... 15
9.2 OTHER REFERENCES ........................................................................................................ 15
9.3 ADDITIONAL OUTSIDE REFERENCES: ................................................................................. 16
1.
INTRODUCTION
1.1
This eighth edition presents information updated from the previous edition and also
includes information pertaining to medical surveillance, chlorine exposure assessment
and occupational hygiene monitoring practices. The information contained in this
pamphlet is intended to provide guidance to anyone who produces, uses, or otherwise
handles chlorine.
This pamphlet provides information for the administration of first aid and medical
treatment for anyone who has been exposed to gaseous or liquid chlorine. In addition,
this pamphlet provides information pertaining to the administration of medical
surveillance programs, exposure assessment programs, and industrial hygiene practices
for persons who may be potentially exposed to chlorine.
In addition to chlorine, other chemical and physical agents may be encountered in
chlorine production, use, or handling facilities. These may include sodium hydroxide,
potassium hydroxide, sulfuric acid, hydrochloric acid, asbestos, mercury, electromagnetic fields, and possibly other materials. Control of exposure to these chemicals
and physical agents should be considered in any overall program of medical surveillance
and hygiene monitoring.
Information on first aid and medical management of chlorine exposure cases is also
provided in the Institutes H-DVD First Response to Chlorine Exposure (9.1).
1.2
2
1.3
PAMPHLET 63
ASR
Breathing Air
Ceiling
CI
CPR
Cardiopulmonary Resuscitation
EPA
FEV1
FVC
Humidified Air
Medical Oxygen
Humidified Oxygen
mg/m3
MSDS
NIOSH
Normal Saline
OSHA
Oxygen Therapy
PEL
PPE
ppm
RADS
REL
SCBA
STEL
1.4
PAMPHLET 63
TLV
TWA
DISCLAIMER
The information in this pamphlet is drawn from sources believed to be reliable. The
Institute and its members, jointly and severally, make no guarantee, and assume no
liability, in connection with any of this information. Moreover, it should not be assumed
that every acceptable procedure is included, or that special circumstances may not
warrant modified or additional procedures. The user should be aware that changing
technology or regulations may require a change in the recommendations herein.
Appropriate steps should be taken to insure that the information is current when used.
These suggestions should not be confused with federal, state, provincial, municipal or
insurance requirements, or with national safety codes.
1.5
APPROVAL
The Institutes Health, Environment, Safety and Security issue team approved Edition 8
of this pamphlet on June 17, 2011.
1.6
REVISIONS
Suggestions for revisions should be directed to the Secretary of The Chlorine Institute.
1.6.1
1.7
REPRODUCTION
The contents of this pamphlet are not to be copied, in whole or in part, without prior
Institute permission. Additional copies of this pamphlet can be obtained from the
Institute.
2.
HAZARDS TO HEALTH
2.1
GENERAL
Chlorine gas is primarily a respiratory irritant. At low concentrations chlorine gas has an
odor similar to household beach. As the concentrations increase from the level of
detection by smell, so does symptomatology in the exposed individual. At chlorine
concentrations above 5 ppm the gas is very irritating, and it is unlikely that any person
would remain in such an exposure for more than a very brief time unless the person is
trapped or unconscious. If the symptoms persist for more than a few hours, the effects
of exposure to chlorine may become more severe for several days after the incident. In
such cases, observation of exposed individuals should be a part of the medical response
program.
The following list is a compilation of chlorine exposure thresholds and reported
responses in humans (with considerable variation among subjects):
0.2 - 0.4 ppm - Odor threshold (decrease in odor perception occurs over time)
1 - 3 ppm - Mild, mucous membrane irritation, tolerated up to 1 hour
5 - 15 ppm - Moderate irritation of the respiratory tract
30 ppm - Immediate chest pain, vomiting, dyspnea, cough
40 - 60 ppm - Toxic pneumonitis and pulmonary edema
430 ppm - Lethal over 30 minutes
1000 ppm - Fatal within a few minutes
References in 9.1 and 9.2 provide additional information.
2.2
ACUTE TOXICITY
2.2.1
Respiratory/Cardiovascular
The toxic effects of chlorine are due to its corrosive properties. Chlorine is water soluble
and primarily removed by the upper airways. As indicated above, exposure to low
concentrations of chlorine gas may cause nasal irritation as well as irritation of the
mucous membranes of the respiratory tract. As concentrations increase, there is an
increase in the irritating effect on the upper and lower respiratory tract manifested as
coughing with eventual difficulty in breathing. Inhalation of chlorine gas (>15 ppm) may
lead to respiratory distress associated with airway constriction and accumulation of fluid
in the lungs (pulmonary edema). As the duration of exposure and/or the concentration
increase, the affected individual may develop the immediate onset of rapid breathing,
wheezing, rales, or hemoptysis. In extreme cases difficulty in breathing can progress to
the point of death through cardiovascular collapse from respiratory failure. An exposed
person with a pre-existing respiratory condition can have an exaggerated response.
Cases of Reactive Airways Dysfunction Syndrome (RADS), a chemical irritant-induced
type of asthma, have been reported.
2.2.2
Dermal
Liquid chlorine in contact with the skin will cause local chemical or thermal (frostbite)
burns. Gaseous chlorine in contact with the skin can dissolve in body moisture (i.e.,
perspiration) to form hypochlorous and hydrochloric acids. At 3,500 ppm chlorine in air,
the pH of moisture on the skin would be approximately 4. A pH of 4 is comparable to
carbonated water. While a burning sensation and skin irritation can occur due to such
PAMPHLET 63
exposure, a review of the literature has provided no specific human data to determine
the concentration of chlorine required to produce such effects.
2.2.3
Eyes
Low concentrations of chlorine in the air can result in eye irritation, associated burning
discomfort, spasmodic blinking, redness, conjunctivitis and tearing. Exposure to higher
concentrations of gaseous chlorine may result in more serious injuries. Liquid chlorine in
contact with the eyes will result in serious thermal and/or chemical burns.
2.3
CHRONIC TOXICITY
Most studies indicate no significant connection between adverse health effects and
chronic exposure to low concentrations of chlorine. However, a 1983 Finnish study
(9.2.1) did show an increase in chronic coughs and a tendency for hypersecretion of
mucous among workers. These workers showed no abnormal pulmonary function in
tests or chest x-rays. There have been indirect references in the literature (e.g., in some
MSDSs) indicating that chronic exposure to chlorine may cause corrosion of the teeth.
However, the Institute has not been able to verify the accuracy of such a statement
through its own review.
In December 1993, the Chemical Industry Institute of Toxicology issued its report on a
study on the chronic inhalation of chlorine in rats and mice (9.2.2). Rats and mice were
exposed to chlorine gas at 0.4, 1.0 or 2.5 ppm for up to six hours a day and three to five
days/week for up to two years. There was no evidence of cancer. Exposure to chlorine
at all levels produced nasal lesions. Because rodents are obligatory nasal breathers,
how these results should be interpreted for humans is not clear.
3.
FIRST AID
First aid is the immediate temporary treatment given to an exposed individual. Prompt
action is essential. Reassurance to the individual will help to alleviate anxiety. When
indicated, medical assistance must be obtained as soon as possible. Never give
anything by mouth to an unconscious or convulsing person. If chlorine has saturated an
exposed individuals clothes and/or skin, decontamination should be done by removing
affected clothing and showering as appropriate.
Responders should take the necessary precautions to protect themselves from any
exposure to chlorine while administering first aid and should move the victim from any
contaminated area as quickly as possible.
3.1
INHALATION
An individual with chlorine inhalation exposure should be evaluated for adequate airway,
breathing and circulation after the inhalation. If breathing has apparently ceased, the
victim should be given cardiopulmonary resuscitation (CPR) immediately. If breathing
has not ceased, the exposed individual should be placed in a comfortable position. The
person should sit in an upright position with the head and trunk elevated to a 45-60
position (unless there is a medical contraindication). Slow, deep breathing should be
encouraged. Vital signs (respiratory rate, pulse, and blood pressure) and oxygen
saturation should be obtained if trained personnel and equipment are available. Suitable
Administration of Oxygen
Oxygen should be administered by first aid providers trained in the use of the specific
oxygen equipment under the guidance of a licensed health care professional.
If a pulse oximeter is not available, oxygen therapy is recommended for any individual
who has inhaled chlorine and continues to be symptomatic after leaving the area of
exposure.
If a pulse oximeter is available, the following findings comprise a base list of situations
in which oxygen therapy is generally indicated to be given by first aid providers after a
chlorine inhalation. Other criteria may be added to this list if specifically recommended
by a physician:
I.
II.
III.
PAMPHLET 63
3.1.3
Symptomatic care
Other symptomatic care measures, such as cool compresses to the face and over-thecounter medications, may help to minimize symptoms. Over-the-counter medications
which may be helpful include:
3.2
3.3
4.
4.1
GENERAL PRINCIPLES
10
PAMPHLET 63
Position the patient with the head and trunk elevated to a 45-60o position
(assuming there are no medical contraindications.)
4.2
4.2.1
Pulmonary Edema
Once pulmonary edema has developed from acute chlorine inhalation, the treatment is
basically that of acute respiratory failure. This individual should be under the care of a
health care professional familiar with this disease process in an intensive care setting. It
should be noted that there is inconclusive evidence regarding the use of corticosteroids
to prevent or alleviate pulmonary edema after an acute chlorine inhalation.
4.2.2
Bronchospasm (Wheezing)
Bronchodilators administered either by nebulization, or subcutaneously, may be
beneficial if patient is having bronchospasm (wheezing).
4.2.3
Acute Anxiety
Acute anxiety (fear and/or apprehension) by an employee exposed to chlorine may
occur. Reassurance is best accomplished without the use of sedatives. Use of
sedatives should only be considered by qualified medical personnel following medical
assessment and only employed under close supervision of respiratory function to
monitor progress.
4.2.4
Delayed Effects
After an acute exposure to chlorine, pulmonary function usually returns to pre-exposure
levels in 7 to 14 days, and complete recovery usually occurs. Post-incident spirograms
may be used for clinical follow-up. Cases of Reactive Airways Dysfunction Syndrome
(RADS), a chemical irritant-induced asthma, have been reported after significant chlorine
inhalation.
The inhalation of any irritating gas may lead to delayed reactions such as pulmonary
edema. Since physical exercise appears to have some relation with the incidence of
delayed reaction, it is recommended that any patient who has had severe inhalation
exposure should be kept at rest for a period of observation. During the period of
observation, the avoidance of irritants (e.g., cigarette smoke, dust, etc.) is
recommended. The length of observation will depend on the clinical assessment of the
exposed individual. Observation may be required up to several days after exposure.
Excitement, apprehension and/or emotional distress may persist for some period of time
following a severe exposure.
5.
11
MEDICAL SURVEILLANCE
The Chlorine Institute recommends a medical surveillance program which would include
baseline and periodic examinations be implemented for personnel working in chlorine
production, use, or handling facilities who are potentially exposed to chlorine, at or
above the ACGIH guideline (9.2.) of 0.5 ppm TWA or 1 ppm STEL during normal
operations (6.3).
5.1
BASELINE EXAMINATION
A baseline medical examination consisting of the following components should be
considered for the above personnel:
5.1.1
Contraindications
Any physical or health condition which precludes an individual's use of prescribed
respiratory equipment should be addressed prior to the individual performing tasks with
the potential for exposure to chlorine.
5.2
PERIODIC EXAMINATION
Medical examinations should be performed on a periodic basis as indicated by an
exposure assessment. The frequency of these examinations should be based on actual
exposure data and/or the potential exposure for specific operations, as determined by
knowledgeable occupational health personnel and in accordance with applicable
regulatory requirements.
Periodic medical examinations may include the following components:
Interval medical and work history including details of first-aid treatment and
details of any chlorine overexposure.
12
PAMPHLET 63
6.
6.1
OCCUPATIONAL HYGIENE
High standards of individual worker cleanliness and hygiene should be followed by all
individuals working with or around chlorine. Company policies and regulatory standards
should be reviewed regarding the storage/consumption of food or drink, the
presence/use of tobacco products, the application of cosmetics/personal hygiene
products, or the taking of medications in work areas where chlorine is handled.
6.2
EXPOSURE ASSESSMENT
Airborne contaminant monitoring (specifically, personal monitoring) is recommended to
evaluate employee exposure to chlorine. Results can indicate where improved controls
are needed and assist in selection of appropriate respiratory equipment. Area
monitoring may be useful in evaluating work areas where chlorine is produced or
handled. Equipment and media used for personal sampling can also be used for area
monitoring/surveys.
6.2.1
Sampling
Airborne contaminant samples should be obtained for those employees that have a
potential for exposure during routine operations. This determination should be made by
someone familiar with the process and associated tasks. If there are work situations in
which the exposures in a job assignment vary because of either the mobility of the
employee or the nature of the production pattern, the most severe situations (maximum
exposure assessment) should be selected for initial sampling. Sample collection should
be as random as practical and of sufficient numbers to be considered representative
(9.2.3). When there is a group of workers having similar risk and type of exposure,
these employees can be grouped and results of sampling applied to the group as a
whole. Sampling typically falls into two basic types: short term and full shift. For
activities that have been identified as having exposure potential that are 15 minutes or
less in duration, short-term exposure sampling should be conducted. Full shift sampling
gives a picture of average exposure for the entire work shift. To be classified as full shift
sampling, the sample must cover 80% of the shift (9.2.3). Good industrial hygiene
judgment should be used to decide how to account for exposure during any shift period
not sampled.
Sampling should be conducted periodically and when there has been a change in
equipment, process, or work practices the exposure risk could change.
6.2.2
Sampling Methods
The following sampling methods may be used to evaluate worker exposure to chlorine.
This list is not exhaustive. Other methods may be available. Chlor-alkali manufacturers
should select the sampling method(s) that best suit their operation and resource
capabilities. When using a sample method that requires a laboratory to perform an
analysis, only AIHA accredited laboratories should be used. When performing shortterm sampling, ensure that the media/method being considered can detect 0.25 ppm or
less for the period of time sampled.
13
6.3
Value
Type
3
7.
7.1
GENERAL
Ceiling
TWA
STEL (15 minutes)
Ceiling
Worker health and safety depend upon proper training and adequate supervision. The
health hazards associated with the chemical and physical agents encountered should be
thoroughly discussed with workers. It is necessary to insure that they are familiar with
and understand these hazards and the precautionary measures that must be followed to
protect themselves and their co-workers.
Periodic refresher sessions are
recommended.
Information provided to employees should include the following:
The readily accessible locations of the material safety data sheets (or
equivalent)
Hazard warnings
14
PAMPHLET 63
RESPIRATORY PROTECTION
A complete Respirator Protection Program meeting all legal requirements should be
established. In the United States these requirements are listed in 29 CFR 1910.134
(9.2.9). Such a program should provide for respirator fit testing, and the training of
employees in the proper use and limitations of each type of respirator, along with
medical clearance to wear assigned respirator.
Employees required to work in chlorine-contaminated atmospheres must use
appropriate respiratory protection certified by NIOSH (9.2.11) for the air concentrations
likely to be encountered.
A NIOSH certified self-contained breathing apparatus (SCBA) or full face air supply
respirator (ASR) with a self-contained air supply (escape air provision) must be used for
protection during upset conditions, emergency response, or maintenance operations
where appropriate. There should be a sufficient number of appropriately located SCBAs
or ASRs to assure their availability when needed.
The proper selection of respirators and their placement should be determined by a
qualified respiratory protection program administrator in accordance with applicable
standards.
7.3
8.
15
FACILITY DESIGN
The design of a facility is a preferred method to minimize worker exposures to chlorine
and other air contaminants (9.2.9).
9.
REFERENCES
The following sections provide detailed bibliographic information on the Chlorine Institute
publications and other documents.
9.1
9.2
Title
Chlorine Institute: First Response to Chlorine Exposure, Video, The
Chlorine Institute: Arlington, VA, 2006.
64
65
73
OTHER REFERENCES
The following documents are specifically referenced in Pamphlet 63:
9.2.1
9.2.2
9.2.3
9.2.4
16
PAMPHLET 63
9.2.5
9.2.6
9.2.7
9.2.8
9.2.9
9.2.10 Pocket Guide to Chemical Hazards, DHHS (NIOSH) Publication No., 2005-149, National
Institute for Safety and Health, Cincinnati, OH, 2007.
9.2.11 NIOSH Certified Equipment List as of periodically published, National Institute for
Occupational Safety and Health, Cincinnati, Ohio.
9.3
9.3.1
Noe, J.D., Therapy for Chlorine Gas Inhalation, Industrial Medicine and Surgery,
32:411 (October, 1963), Excerpta Med. (Section 27): 1664, (1964).
9.3.2
Gay, H.H., Exposure to Chlorine Gas, Journal of the American Medical Association,
183: 806 (March, 1963).
9.3.3
9.3.4
Chester, Edward H. et. al., Pulmonary Injury Following Exposure to Chlorine Gas,
Chest., 72:2, (August, 1977).
9.3.5
Kowitz, T. et. al., Effects of Chlorine Gas upon Respiratory Function, Archives of
Environmental Health, 14, 545-558, (1967).
9.3.6
Weil, H. et. al., Late Evaluation of Pulmonary Function after Acute Exposure to Chlorine
Gas, American Review of Respiratory Diseases, 99, 374-379, (1969).
9.3.7
Jones, R.N. et. al., Longitudinal Changes in Pulmonary Function Following Single
Exposure to Chlorine Gas, American Review of Respiratory Diseases, 123 (suppl.),
125, (1981).
9.3.8
Jones, R.N. et. al., Lung Function After Acute Chlorine Exposure, American Review of
Respiratory Diseases, 134, 1190-1195 (1986).
9.3.9
Morgan & Seaton, Occupational Lung Diseases, Saunders & Company, (1984).
17
9.3.11 Plunkett, E.R., Handbook of Industrial Toxicology, Chemical Publishing Company, New
York (1987).
9.3.12 Burton et. al, Respiratory Care, A Guide to Clinical Practice 4th Edition, Lippincott,
(1997).
9.3.13 Medical Management Guideline for Chlorine. Agency for Toxic Substances and Disease
Registry (ATSDR). (2001) Atlanta, GA; U.S. Department of Health and Human Services,
Public Health Service.
9.3.14 LaDou, J. Occupational and Environmental Medicine. Appleton & Lange, (1997).
9.3.15 Brooks, SM, Weiss MA, Bernstein IL. Reactive airways dysfunction syndrome:
Persistent asthma syndrome after high level irritant exposure. Chest, 88, 376-384
(1985).
9.3.16 Hendrick et al. Occupational Lung Disorders, WB Saunders, (2002).
9.3.17 Rom, W. Environmental and Occupational Medicine 2nd Edition, Little, Brown and
Company, (1992).
9.3.18 Horton, D. et. al. The Public Health Consequences From Acute Chlorine Releases,
1993-2000. Journal of Occupational and Environmental Medicine, 44, 906-914 (2002).
9.3.19 Das R, Blanc PD. Chlorine gas exposure and the lung: a review. Toxicol Indust Health 9,
439-455 (1993).
9.3.20 Schwartz DA. Acute Inhalational Injury. Occup Med 2, 297-318 (1987).
9.3.21 Effects of Exposure to Toxic Gases - First Aid & Medical Treatment, Edition 3; Stopford,
W. and Bumm, W.D., Matheson Gas Products, Inc. Secaucus, N.J., (1988).
9.3.22 Pattys Industrial Hygiene, 6th edition, John Wiley & Sons, (2010).
18
PAMPHLET 63
No
N/A
{3.1}
{3.1.2}
{4.1}
{4.2.4}
{5}
{6.2}
{7.1}
Yes
No
N/A
19
{7.2}
{7.3}
REMINDER:
Users of this checklist should document exceptions
to the recommendations contained in this pamphlet.