PESANTE, KATHLEEN KAYE V.

MT 1238 Assignment 1 on Biochemistry

FOOD POLLUTANTS
Benzene

Butylated Hydroxy-Toluene

EXAMPLES OF FOOD
Soft drinks, flavoured mineral
water, fruit juice and drinks,
energy drinks, sports water,
cooked foods
Cereals, fats, meats, potatoes

Chlorine

Chlorinated water

Chlorobenzene Pesticide
Dioxins

Mothers milk, fruits, vegetables,

meat, fish, poultry,
Meat, fish

Ethanol

Alcoholic beverages

Hydrazine

Food additive

Nitrosamines

Food, food containers

Polychlorinated Biphenyls

Animal fats and harvested fishes

contaminated by PCB

Phenols

Mercury

Citrus varieties, peached, plums,

pears, grapes, cherries, berry
family, yellow onion. potatoes
fishes

Ricin

Castor

01/06/15

EFFECT ON DNA
Display independent activity
against topoisomerase II alpha

Induce morphological changes

and DNA double-strand breaks
Inducing structural aberrations,
also
appears
to
affects
chromosome
morphology
producing short, overcondensed
chromosomes
Alteration of bases or disruption
of the sugar-phosphate backbone
Exposure to dioxin caused
changes in the DNA methylation
patterns of sperm that were
transmitted across generations
Production of endogenous DNAdamaging molecules as a result
of alcohol consumption and
metabolism
DNA damage in
uiuo
alters gene expression and causes
DNA damage
strong
and
monotonically
increasing DNA fragmentation
index with increasing serum
levels of CB-153
induced DNA mutations in MLL
gene
M e r c u r y d a ma g e s D N A i n
a n o t h e r w a y: l i k e c a n c e r
cells,
Mercury
creates
intracellular acidity by
r e d u c i n g o x yg e n a t i o n o f
t h e h u ma n c e l l
induces generation of reactive
species, lipidperoxidation, DNA
fragmentation and depletion of

Benzo(a)pyrene

Charbroiled food

Saccharin

Soda and sweet beverages

Aspartame

Low-calorie drinks, ice cream,

frozen fruit pops, chewing gum

GSH
can interfere with or alter DNA
replication (formation of DNA
copies during cell division), and
may be associated with an
increased risk
of several forms of cancer
could interact with DNA and
cause mutations
Reported that ASP was not
mutagenic and clastogenim but
have a genotoxic risk

References
Books.google/com.ph
http://www.rowatworks.com/ Science/To_Do_No_Harm/Invisible_Cripples.html
www.ncbi.nlm.nih.gov/pubmed/15833037
scholarship.clarement.edu
http://www.niehs.nih.gov/news/newsletter/2012/11/science-dioxin/
http://www.ncbi.nlm.nih.gov/pubmed/9309320
http://www.jbc.org/content/266/3/1509.full.pdf
http://www.sciencedaily.com/releases/2009/07/090705215239.htm
http://www.livestrong.com/article/389334-a-list-of-foods-containing-aspartame/
http://www.epa.gov/teach/chem_summ/BaP_summary.pdf
http://www.hindawi.com/journals/ijg/2010/605921/