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879
The
n e w e ng l a n d j o u r na l
of
m e dic i n e
A
Norepinephrine
and dopamine
300,000
Platelet Count/mm3
Heparin
Death
200,000
Continuous renal-replacement therapy
Ischemic limb necrosis
100,000
Heparin
103
102
Procoagulant
Thrombinantithrombin
complex
Fibrin monomer
Fibrin D-dimer
101
Protein C
concentrate
Normal
100
101
Anticoagulant
Antithrombin
Protein C
102
4.00
4.25
4.50
4.75
5.00
5.25
5.50
5.75
6.00
1.0
0.8
Factor XII
Prekallikrein
Factor IX
Factor XIII
Factor XI
0.4
Factor VII
0.2
0.0
High-molecular-weight
kininogen
Protein S
0.6
Factor II
Protein C
Factor V
0
20
40
r2 =0.62
Antithrombin
Factor X
60
80
100
120
140
160
arising from the combination of greatly in- tors (protein C and antithrombin) can explain
creased thrombin generation with impaired he- ischemic limb necrosis despite palpable pulses
patic synthesis of key natural anticoagulant fac- in patients with acute hepatic necrosis.
880
notices
corrections
McMaster University
Hamilton, ON, Canada
University of Waterloo
Waterloo, ON, Canada
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Electronic Health and Medicine: Advances
and Challenges
The seminar will be held in Warsaw, Poland, on Sept. 27. It
is presented by the Polish Academy of Sciences.
Contact Ms. R. Kuskowska, Polish Academy of Sciences,
PKiN, 00901 Warsaw, Poland; or call 4822 6566371; or fax 4822
6203374; or e-mail renata.kuskowska@pan.pl; or see http://
www.english.pan.pl.
881