Name of Patient

G. V.

Age

43 y.o

Height

52

Diagnosis

T/C PID vs acute AP

Sex

Female

Weight

66 kg

Author

M. M. Olmillo

Website

milkv.co.vu

A/N

youre welcome

DRUG DATA
Generic name:
Ampicillin

CLASSIFICATION
Pharmacologic:
Penicillin

Trade name/s:
Principen
Patients dose:
2g q6o

MECHANISM OF
ACTION

Bactericidal action
against sensitive
organisms; inhibits
synthesis of bacterial
cell wall, causing
death

Therapeutic:
Antibiotic

Maximum dose:
14g/day
Minimum dose:
2g/day
Availability:
Capsules 250,
500 mg; powder
for oral
suspension 125
mg/5mL,
250mg/5mL;
powder for
injection 250,
500mg, 1, 2 g
Route:
IVTT

Pregnancy Category
Risk: B

Onset:
Immediate
Peak:
5 min
Duration:
6-8 hr
Metabolism:
1-2 hr
Distribution:
Crosses placenta,
enters breast milk
Excretion:
Urine, unchanged

INDICATIONS

General:
> treatment of
infections caused
by susceptible
strains of
Shigella,
Salmonella, S.
Typhosa, E.Coli,
Haemophilus
Influenzae,
Proteus mirabilis,
Neisseria
gonorrhoeae
> meningitis
caused by
Neisseria
meningitidis
> prevention of
bacterial
endocarditis
following dental,
oral, or respiratory
procedures in
very high-risk
patients
> prohylaxis in
caesarean section
in certain high-risk
patients
Patients actual
indication:
treatment of
infections caused
by those
mentioned above

CONTRAINDICATI
ON

Contraindicated with
allergies to penicillins,
cephalosporins, or other
allergens

ADVERSE
EFFECTS

CNS: lethargy,
hallucinations,
seizures
CV: heart failure

Precaution:
Use cautiously with renal
disorders.
Interactions:
> drug-drug: increased
effect with probenecid;
increased risk of rash
with allopurinol;
increased bleeding effect
withheparin, oral
anticoagulants;
decreased effectiveness
with tetracyclines,
chloramphenicol,
decreased efficacy of
hormonal contraceptives,
atenolol with ampicillin
> drug-food: oral
ampicillin may be less
effective with food; take
on an empty stomach
> drug-lab test: falsepositive Coombs test if
given IV; decrease in
plasma estrogen
concentrations in
pregnant women; Falsepositive urine glucose
test if Clinitest,
Benedicts solution, or
Fehlings solution is
used.

GI: glossitis,
stomatitis, gastritis,
sore mouth, furry
tongue, black
hairy tongue,
nausea, vomiting,
diarrhea
GU: nephritis
Hematologic:
anemia,
thrombocytopenia
Hypersensitivity:
rash, fever,
wheezing,
anaphylaxis
Local: pain,
phlebitis,
thrombosis at
injection site
(parenteral)
Other:
superinfections
oral & rectal
moniliasis, vaginitis

NURSING
RESPONSIBILITIE
S

Before:
> check doctors order
> assess for allergies to penicillins,
cephalosporins, or other allergens
> assess for renal disorders, lactation
> culture infected area; skin color,
lesion; adventitious sounds
> monitor renal function tests
During:
> administer the right drug in the right
route and dosage at the right time
> check the patency of the IV site and
IV line
> explain the purpose and
importance of the drug to the patient
> administer oral drug on an empty
stomach, 1 hr before or 2 hr after
meals with a full glass of water
> avoid fruit juice and soft drinks
After:
> take this drug around-the-clock
> take the full course of therapy; do
not stop taking the drug if you feel
better
> Check IV site carefully for signs of
thrombosis or drug reaction
> report pain or discomfort at sites,
unusual bleeding or bruising, mouth
sores, rash, hives, fever, itching,
severe diarrhea, difficulty breathing
> document and record.

Source: 2011
Lippincotts NDG

Source: 2011
Lippincotts NDG

Source: 2011
Lippincotts NDG

Source: 2011
Lippincotts NDG

Source: 2011
Lippincotts NDG

Source: 2011
Lippincotts NDG

Source: 2011 Lippincotts Nursing

Drug Guide