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Introduction
Format
All questions are in the A-type multiple-choice format, that is, the single best answer of the five options given.
When visual material has been turned on its side, an arrow on the page indicates the orientation of the visual
material.
Questions do not necessarily appear in the order in which they were first printed.
Answers
Scoring
A correct answer will score one mark and an incorrect answer zero. There is no negative marking in the
FRACP Written Examination.
Queries
Contact the Executive Officer, Examinations’ Section, Department of Training and Assessment via e-mail:
exams@racp.edu.au.
Please note that with changes in medical knowledge, some of the information may no longer be current.
All Written Examination papers are copyright. They may not be reproduced in whole or part without written
permission from The Royal Australasian College of Physicians, 145 Macquarie Street, Sydney, Australia.
2 P100
Question 1
Which one of the following represents the closest approximation to the risk that the baby will develop congenital
varicella syndrome?
A. 0.01%.
B. 2%.
C. 15%.
D. 50%.
E. 80%.
Question 2
Which one of the following would be least appropriate for the assessment of a 36-month-old infant with
suspected neuro-developmental delay?
A. Bailey scale.
B. Griffith’s scale.
C. McCarthy scale.
Question 3
The mean pulmonary artery (capillary) wedge pressure most closely approximates which one of the following
pressures?
A well 14-year-old girl is travelling to Zimbabwe and Malawi on an exchange program for three months. She
leaves in six weeks. She plans to visit villages and attend school.
Which one of the following plans is most appropriate for preventing hepatitis A virus (HAV) infection during her
visit?
C. HAV vaccination now, test for antibody titres before departure and if negative administer
immunoglobulin.
Question 5
The reabsorption of most bicarbonate (HCO3) from the glomerular ultrafiltrate is by:
B. intercellular transport.
C. pinocytosis.
E. transcellular aquapores.
Question 6
Which area of the lung has the highest ventilation/perfusion (V/Q) ratio in the erect position?
A. Anterior.
B. Diaphragmatic.
C. Middle.
D. Posterior.
E. Upper.
Drug X is given intravenously using two different regimens, to the same patient on two different occasions. Both
times there is no measurable amount of the drug in plasma prior to its administration. On both occasions the
volume of distribution of X is 0.85 L/kg and the plasma half-life is six hours.
Using regimen A, the plasma concentration of X after 48 hours was 100 mg/L.
A. 50 mg/L.
B. 75 mg/L.
C. 100 mg/L.
D. 125 mg/L.
E. 150 mg/L.
Question 8
In acute lymphoblastic leukaemia, which cytogenetic feature carries the worst prognosis?
A. Hyperdiploidy.
C. Translocation (1;19).
D. Translocation (9;22).
E. Translocation (12;21).
Question 9
Which one of the following autoantibodies is most specific for coeliac disease?
A. IgA endomysial.
B. IgA gliadin.
C. IgA gluten.
D. IgA reticulin.
E. IgG gluten.
Which one of the following modes of transmission of hepatitis B virus (HBV) resulting in hepatitis B infection,
in the absence of active or passive immunisation, is most likely to result in chronic carrier status in the
recipient?
Question 11
Question 12
A 15-year-old boy dislocated his right shoulder while playing football. This was reduced in the emergency
room and he was discharged after observation. After removal of his sling he had problems in abducting his
arm. Examination showed weakness of abduction at the shoulder and sensory loss on the lateral aspect of
his arm at the insertion of the deltoid muscle.
A. accessory.
B. axillary.
C. musculocutaneous.
D. radial.
E. suprascapular.
Question 13
A. antihistone.
B. antinuclear.
C. anti-ribonucleoprotein.
D. anti-Ro (SS-A).
E. anti-Sm.
I:1 and his wife I:2 take part in a Tay-Sachs carrier screening program and are both shown to be carriers. Their
children have not been tested. The frequency of the heterozygous state is 1 in 30 in the particular population from
which all these individuals in this pedigree are drawn.
The risk that the foetus III:1 will be affected with Tay-Sachs disease is closest to:
A. 1 in 240.
B. 1 in 180.
C. 1 in 120.
D. 1 in 60.
E. 1 in 30.
Question 15
A 12-month-old girl is referred to you for assessment and advice/management of her obesity.
Her birthweight was 3600 g (75th percentile) and her length was 51 cm (75th percentile). Now, her weight is
12.5 kg (1 kg >97th percentile) and her length is 78 cm (90th percentile). Neither parent is obese.
Developmentally she is normal and you can find no pathological reason for her obesity.
What is the approximate likelihood that she will be obese in her 20s?
A. 15%.
B. 30%.
C. 45%.
D. 60%.
E. 75%.
What is the most important mechanism by which the drug omeprazole exerts its effect on the gastric mucosa in
the treatment of peptic ulcer disease?
C. Blocks H1 receptors.
D. Blocks H2 receptors.
Question 17
Which one of the following is not an essential feature for a diagnosis of autism?
A. Communication difficulties.
C. Intellectual deficit.
Question 18
A male infant has pulmonary atresia/ventricular septal defect. After undergoing a systemic to pulmonary
artery shunt his arterial saturation is 90%. Assuming a mixed venous saturation of 70% and a pulmonary
venous saturation of 95%, the pulmonary to systemic flow ratio (Qp:Qs) is:
C. 0.2:1.
D. 1:1.25.
E. 4:1.
Question 19
Your region has a birth rate of about 50,000 babies per year. About 50 preschool children are diagnosed
each year with "crumblitis", a rare gastrointestinal disorder, the cause of which is unknown. You hypothesise
that this condition is related to maternal ingestion of orange rhubarb during pregnancy.
Which one of the following is the most appropriate research design to test your hypothesis?
A. Case-control study.
B. Cohort study.
A. Angiotensin II.
B. Endothelin 1.
C. Prostacyclin.
D. Prostaglandin H2.
E. Thromboxane A2.
Question 21
A drug X has a half-life of four hours and a volume of distribution of 0.8 L/kg.
The drug is administered by continuous intravenous infusion in a dose of Y mg/hr, starting at time zero.
After 24 hours the continuous infusion rate is halved to Y/2 mg/hr. At time 44 hours the plasma concentration
of X is approaching the new steady state concentration, B (within 3%).
If, at time 24 hours, the continuous infusion rate had been reduced to Y/4 mg/hr, instead of Y/2 mg/hr, the time
at which the plasma concentration of X falls to within 3% of the new steady state concentration, C, would be
closest to:
A. 40 hours.
B. 44 hours.
C. 48 hours.
D. 64 hours.
E. 88 hours.
Folinic acid is used to “rescue” cells from the cytotoxic effect of which one of the following chemotherapeutic
agents?
A. Adriamycin.
B. Asparaginase.
C. Cisplatin.
D. Cyclophosphamide.
E. Methotrexate.
Question 23
IgE-mediated hypersensitivity reactions may resolve over years, due to loss of IgE antibodies. For which one
of the following is this least likely to occur?
A. Bee venom.
B. Egg.
C. Peanut.
D. Penicillin.
E. Soybean.
Question 24
A newborn infant with severe hyaline membrane disease is receiving mechanical ventilation. Different
methods of ventilation are used sequentially to achieve the same oxygenation and carbon dioxide removal.
There is no change in lung compliance over this period. The FiO2 is 1.0.
The pressure swings at alveolar level will be smallest during which one of the following methods of
ventilation?
Question 25
Which one of the following target autoantigens is least likely to be associated with type 1 (insulin-dependent)
diabetes mellitus?
A. Double-stranded DNA.
B. Endomysial antigen.
D. Thyroid peroxidase.
E. 21-hydroxylase.
You are asked to consult on the aerial transfer of a sick infant with bronchiolitis. By what amount will you
expect the alveolar oxygen to drop when the plane is pressurised at an altitude of 5000 feet?
(The atmospheric pressure at 5000 feet is 647 mmHg. The carbon dioxide level is 45 mmHg, the respiratory
quotient is 0.8 and the water vapour pressure is 47 mmHg. These values remain constant. The flight will
begin at sea level where the atmospheric pressure is 760 mmHg.)
A. 5-10 mmHg.
B. 11-15 mmHg.
C. 16-20 mmHg.
D. 21-25 mmHg.
E. 26-30 mmHg.
Question 27
B. Hepatitis B.
C. Measles-mumps-rubella.
D. Meningococcal polysaccharide.
E. Oral polio.
Question 28
A one-month-old infant presents with failure to thrive. There is a three-week history of progressive
tachypnoea, sweating and feeding difficulties. The respiratory rate is 60/minute with moderate recession. The
liver is palpable 5 cm below the costal margin. The praecordium is active and a grade 3/6 systolic ejection
murmur and a grade 3/6 apical mid-diastolic rumble are audible. An echocardiogram demonstrates a large,
non-restrictive perimembranous ventricular septal defect.
Which one of the following most accurately reflects the anticipated pulmonary blood flow (PBF), pulmonary
vascular resistance (PVR) and pulmonary artery systolic pressure (PSP)?
Note:
The laboratory telephones you with the following test results of blood taken from a 16-year-old male student
who had requested hepatitis B screening.
C. hepatitis D superinfection.
Question 30
Which one of the following is the most common cause of familial thrombophilia (deep vein thrombosis and
pulmonary emboli)?
C. Protein C deficiency.
D. Protein S deficiency.
Question 31
A four-year-old girl is thought to have Prader-Willi syndrome. To confirm the clinical diagnosis, DNA samples from
the child and her parents have been studied. The results shown below are obtained after probing a Southern blot
with a DNA probe located within the region of chromosome 15 that is commonly deleted in this syndrome. This
probe detects a restriction fragment length polymorphism with two alleles in men and women in the normal
population.
Question 32
Interleukin 1 (IL-1) is primarily produced by which one of the following cell types?
A. B cells.
C. Macrophages.
D. Neutrophils.
E. T cells.
Question 33
The standard deviation of a set of ‘n’ observations, which are normally distributed, is best described as an
estimate of the:
D. interquartile range.
Question 34
When assessing the response of small airways to bronchodilators, the best test is:
C. inspiratory capacity.
E. peak flow.
A patient with pancreatic insufficiency refuses to take enzyme replacement and later presents with renal calculi.
Increased excretion of which one of the following is the most likely cause of calculus formation?
A. Bicarbonate.
B. Cysteine.
C. Oxalate.
D. Phosphate.
E. Urate.
Question 36
10 0
A
% of
m axim u m
effe ct
B
L og [X ]
Curve A represents the log dose-response curve for drug X when given alone.
Curve B represents the log dose-response curve for drug X in the presence of a fixed concentration of another
drug, Y.
A. X is a competitive antagonist of Y.
B. X is a non-competitive antagonist of Y.
C. Y is a competitive antagonist of X.
D. Y is a non-competitive antagonist of X.
E. Y is a partial agonist.
An eight-year-old boy presents with a presumed stroke. He has a profound right hemiparesis involving the
face, arm and leg.
Which one of the following clinical signs would suggest that the cerebral cortex is involved?
A. Aphasia.
C. Dystonic posture.
E. Eye deviation.
Question 38
D. Maternal autoantibodies.
E. Thyroid dysgenesis.
Question 39
In the neonatal syndrome of "persistent foetal circulation" (persistent pulmonary hypertension of the newborn),
which one group of physiological ratios is usually seen?
A. 1 <1 >1
B. >1 1 1
C. 1 <1 1
D. 1 <1 <1
E. 1 1 <1
Note:
Which one of the following diseases is not considered to be mediated by antigens acting as "super-antigens"?
A. Kawasaki disease.
B. Rheumatic fever.
C. Scarlet fever.
Question 41
In which one of the following is an increased ionised serum calcium most likely to occur?
A. Alkalosis.
C. Hypoalbuminaemia.
D. Vitamin D deficiency.
E. Williams syndrome.
Question 42
A. 8 hours.
B. 12 hours.
C. 24 hours.
D. 48 hours.
E. 72 hours.
Question 43
A 34-week gestation infant is diagnosed as having mild hyaline membrane disease. The resident places an
umbilical line to facilitate blood gas analysis.
A sample is taken from this catheter for blood gas measurement. The FiO2 is 0.6. An oximeter placed on the
infant’s foot reads 100%. You have suspicions that the catheter is misplaced.
If the catheter was in the umbilical vein rather than the umbilical artery the catheter blood PO2 measurement
would be closest to:
A. 200 mmHg.
B. 150 mmHg.
C. 100 mmHg.
D. 50 mmHg.
E. 20 mmHg.
A three-year-old boy presents with acute hepatocellular injury secondary to viral hepatitis.
Which one of the following tests most accurately assesses his current liver synthetic function?
A. Alanine aminotransferase.
B. Ammonia.
D. Gamma glutamyltransferase.
Question 45
Which one of the following statements explains the greatest proportion of the 12-13 cm difference in final adult
height between males and females?
Question 46
An eight-year-old has had a cough and rattly respirations for six months. The following respiratory signs are
found:
Which one of the following is the best explanation for these signs?
The pedigree shown below is consistent with several different modes of inheritance.
C. Mitochondrial inheritance.
D. Multifactorial inheritance.
Question 48
interleukin 2 (IL-2)
interleukin 4 (IL-4)
interleukin 5 (IL-5)
interferon gamma (IFNγ)
Which one of the following combinations would best reflect a Th2 type T cell immune response?
A. IL-2, IFNγ.
B. IL-2, IL-4.
C. IL-4, IFNγ.
D. IL-4, IL-5.
E. IL-5, IFNγ.
The anticoagulant effect of the coumarin derivative warfarin is most likely to be enhanced by which one of the
following?
A. Carbamazepine.
B. Erythromycin.
C. Oral contraceptive.
D. Phenytoin.
E. Vitamin K.
Question 50
A new test may be useful as a screening test for Disease A. It is trialed with 100 patients attending a clinic,
10% of whom actually have Disease A, with the following results:
Disease A
Yes No
Test + 9 23 32
Results
– 1 67 68
10 90 100
Based on these results, it is next trialed in a community population in which the prevalence of Disease A is
1%.
A. The sensitivity.
B. The specificity.
Question 51
If the full immunisation schedule has been properly administered to a two-year-old, which one of the following
gives the least effective protection?
A. Diphtheria.
C. Measles.
D. Pertussis.
E. Rubella.
Question 53
The cough associated with the use of angiotensin-converting enzyme (ACE) inhibitors is mediated through
which one of the following?
A. Aldosterone.
B. Angiotensin I.
C. Angiotensin II.
D. Bradykinin.
Question 54
A. Carboplatin.
B. Cyclophosphamide.
C. Doxorubicin.
D. Etoposide (VP-16).
E. Vincristine.
Question 55
A clear preference for using the left hand at 12 months of age is most likely a manifestation of which one of the
following?
B. Cerebral palsy.
D. Normal variation.
E. Osteomyelitis.
A two-year-old boy with Duchenne muscular dystrophy (DMD) has an identified mutation within the DMD gene.
Although his mother does not have this mutation in the blood and there is no clinical or biochemical evidence to
suggest that she is a carrier, there is still a low recurrence risk among his male siblings.
Which one of the following mechanisms is the most likely explanation for these recurrences?
C. Gonadal mosaicism.
D. Incomplete penetrance.
E. Polygenic inheritance.
Question 57
During a phase 1 clinical trial, a drug was administered as single doses to the same patient, on two different
occasions. On the first occasion it was given by rapid intravenous infusion, and on the second occasion the
same dose was given by the oral route. The two plasma concentration versus time curves are shown above.
Both graphs have the same scale. Area A (intravenous) is five times greater than area B (oral).
Which one of the following statements is not consistent with these findings?
Question 58
Which one of the following results in improved unloading of oxygen from oxy-haemoglobin molecules?
C. Decreased temperature.
D. Increased pH.
E. Increased 2,3-diphosphoglycerate.
A previously well eight-year-old boy presents to his paediatrician with recent onset left-sided facial weakness.
Which one of the following would suggest that this is not a Bell's palsy?
A. Frontalis weakness.
B. Hyperacusis.
C. Impaired lacrimation.
Question 60
The following data were obtained at cardiac catheterisation from a patient with a ventricular septal defect.
A. 4 L/minute.
B. 6 L/minute.
C. 8 L/minute.
D. 10 L/minute.
E. incalculable.
Question 61
An eight and a half-year-old girl is referred for assessment of obesity. Her weight is 45 kg, her height is 123
cm and her surface area is 1.1 m².
A. 30.
B. 32.
C. 34.
D. 36.
E. 38.
The principal mode of action of parathyroid hormone with respect to the regulation of serum calcium is to:
Question 63
D. sequence alteration which occurs at or near regulatory sequences in the 5' untranslated region of the
gene.
E. single base change which alters that codon to one which now reads stop.
Question 64
An infant is born at 28 weeks gestation. There is no perinatal asphyxia, but she develops moderate
respiratory distress requiring ventilation and subsequently experiences some problems with feed intolerance
and recurring apnoeic episodes.
Which one of the following neurological problems is most likely to be present on long-term follow-up?
C. Hemiplegia.
D. Spastic diplegia.
E. Spastic quadriplegia.
Question 65
A drug with a narrow therapeutic index is highly protein-bound and cleared by oxidative metabolism followed by
urinary excretion of the inactive metabolite.
The most common mechanism of drug interaction likely to cause toxicity of this type of drug is:
C. inhibition of glucuronyltransferase.
B. creatinine clearance.
C. Schwartz formula.
D. urea clearance.
99
E. Tc MAG-3 clearance.
Question 67
In the given section of a developmental record form following, P means that the child can do this item, F
means that the child cannot do this item. Assuming that this child is developmentally “average”, about how
old is he/she?
A. 1 year 3 months.
B. 2 years.
C. 2 years 9 months.
D. 3 years 6 months.
E. 4 years 3 months.
A. Interstitial disease.
C. Poor effort.
D. Skeletomuscular disease.
Which one of the following common infectious diseases does not warrant exclusion from school or day care
centre?
E. Rubella.
Question 70
Which one of the following primary immunodeficiency disorders is most likely to be associated with anaphylaxis to
blood products?
A. Ataxia-telangiectasia.
E. X-linked agammaglobulinaemia.
Answers
1. B 25. A 49. B
2. E 26. D 50. C
3. A 27. B 51. D
4. B 28. C 52. B
5. A 29. E 53. D
6. E 30. A 54. E
7. C 31. D 55. B
8. D 32. C 56. C
9. A 33. E 57. B
10. E 34. D 58. E
11. D 35. C 59. D
12. B 36. D 60. B
13. E 37. A 61. A
14. B 38. E 62. D
15. A 39. A 63. B
16. B 40. B 64. D
17. C 41. E 65. B
18. E 42. C 66. A
19. A 43. D 67. B
20. C 44. E 68. B
21. B 45. D 69. C
22. E 46. A 70. D
23. C 47. C
24. B 48. D