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Abstract
The use of biochemical engineering in an industrial setting is presented by examples from the authors own field of
expertise: process development for industrial enzymes. Examples given cover the fields bioreactor performance,
measurement and control on fermentation, downstream operations and development and optimization of production
strains. The use of engineering principles is placed in the industrial context of a high focus on development speed, fast
product turnover and competing technologies such as empirical testing, parallel conclusions. Finally the overall
applicability of engineering principles is reviewed in light of the industrial aspects of process development: existing
production equipment, production facilities of varying age, choice of expression system and overall product economy.
1997 Elsevier Science B.V.
Keywords: Bioprocess development; Optimization; Enzyme production; Mass transfer; k1a; Regime analysis; Flux
analysis; Statistical process control; Metabolic engineering; Downstream operations
1. Introduction
It is in itself interesting that the use of biochemical engineering principles in industry is the title
of a plenary lecture at the first European Symposium on Biochemical Engineering Science, and
that a representative from the high-volume, lowcost end of the biotech industry has been asked to
expand on the subject. It reflects the position of
the research in biochemical engineering as an
uncommonly
collaborative
effort
between
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21
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7. Conclusion
There are still huge gaps in our understanding
of the synergies between biology/biochemistry and
stainless steel. All the model work, be it black-box
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