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M.PHIL. CHEMISTRY
SEMESTER-I
CHEM 7105
Credit Hour 3
CHEM 7106
Separation Techniques
Credit Hour 3
CHEM 7107
Credit Hour 3
CHEM 7108
Radiation Chemistry
Credit Hour 3
12
SEMESTER-II
CHEM 7206
Credit Hour 3
CHEM 7210
Credit Hour 3
CHEM 7102
Credit Hour 3
CHEM 7212
Credit Hour 3
12
Credit Hour 12
THESIS
36
OPTIONAL COURSES
1.
2.
3.
4.
Environmental Chemistry
Biosynthesis of Natural Products
Gene Technology
Nano Chemistry
CHEM 7204
CHEM 7207
CHEM 7211
CHEM 7209
Course Code:
Course Title:
Credit hours:
CHEM-7105
Nuclear Magnetic Resonance Spectroscopy
03
COURSE CONTENTS:
Basic principles of 1D and 2D NMR spectroscopy, interpretation of 1H- and 13C-NMR
spectra, factors affecting the chemical shifts and coupling constants. Recent advances in
1D and 2D-NMR spectroscopy including J-resolved, shift correlated multiple quantum
spectra and inverse measurements. Identification of carbon-multiplicity with
Distortionless Enhancement by Polarization Transfer (DEPT) technique. Applications of
Heterocuclear Multiple-Quantum Coherence (HMQC), Heteronuclear Multiple-Bond
Connectivity (HMBC) and Homonuclear Shift-Correlation Spectroscopy (COSY) in
structure elucidation of organic molecules. Nuclear Overhauser Enhancment (NOE) and
its applications in stereochemical dispositions. Introduction, principle and therapeutic
applications of Magnetic Resonance Imaging (MRI).
RECOMMENDED BOOKS:
1. Berger S., Sicker D., Classics in NMR: Understanding Spectra of Natural
Products, Wiley-VCH (2009).
2. Abraham R., Mobli M., Modelling 1H NMR Spectra of Organic Compounds:
Theory Applications and NMR Prediction Software. Wiley, 2008).
3. Bible R.H., A Guide for Selecting NMR Techniques VCH, (2008).
4. De Graaf R., In Vivo NMR Spectroscopy: Principles and Techniques WileyInterscience, (2008).
5. Simpson J.H, Organic Structure Determination Using 2-D NMR Spectroscopy: A
Problem-Based Approach, Academic Press (2008).
6. Jag Mohan., Organic Analytical Chemistry; Theory and Practice; Narosa
Publishing House, New Delhi. (2003).
7. Whittaker.D, Interpreting Organic Spectra, The Royal Society of Chemistry
(2000).
8. Atta-ur-Rahman & M. Iqbal Choudhary., Solving Problems with NMR
Spectroscopy.; Academic Press Inc. USA. (1996).
9. Donald L. Pavia, Gary M. Lampman, George S. Kriz., Inroduction to
Spectroscopy; A Guide for students of Organic Chemistry., 2nd edition, Harcourt
Brace College publishers, Florida. (1996).
10. Kemp.W, Organic Spectroscopy, Macmillan Education Ltd; Third Edition
(1991).
11. Bender.G.T, Principles of Chemical Instrumentation, W.B.Saunders Company
(1987).
12. Macomber.R.S, NMR Spectroscopy Basic Principles and Applications, Books
for Professionals, Inc (1988).
13. Atta-ur-Rahman., Nuclear Magnetic Resonance; Basic Principles., SpringerVerlag New York Inc. (1986).
Course Code:
Course Title:
Credit hours:
CHEM-7106
Separation Techniques
03
COURSE CONTENTS:
Chromatography: Classification, Classic and Kinetic Theory, Solvent Extraction
and Solid Phase Extraction, Gas Chromatography: separation process, sample
injection, detectors, sample preparation, method development. High Performance
Liquid Chromatography: Chromatographic process, columns and stationary
phase, injection and detectors, method development for reversed phase separation,
gradient separations. Fast Protein Liquid Chromatography (FPLC): Principle and
work flow, Cation/ Anion exchange chromatography, hydrophobic interaction
Chromatography. Optimization of conditions and calibration of Instrumentation.
Ion Exchange Chromatography, gel filtration chromatography. CAPILLARY
ELECTROPHORESIS: Basic principle, Zeta potential and the phenomenon of
Electro-osmosis, General instrumentation and applications. CENTRIFUGATION:
Principle of Centrifugation, Working with Normal and Ultracentrifuges. Use of
Density Gradient Differential Centrifugation for Separation of Cellular
Components.
RECOMMENDED BOOKS:
iiiiii-
iv-
Analytical Chemistry
R. Kellner, J-M. Mermet, M. Otto, H.M. Widmer
Quantitative Chemical Analysis
Daniel.C.Harris
Practical Biochemistry
Principles and Techniques
Editors: Keith Wilson and John Walker
4th edition 1997
Cambridge University Press
Fundamental Laboratory Approaches for Biochemistry and Biotechnology
Alaxander J Ninfa & David P Ballou
Fitzgerald Science Press Inc. 1998
Bthesda, Maryland
3
v-
vi-
Course Code:
CHEM-7107
Course Title:
Credit hours:
03
COURSE CONTENTS:
Brief description to symmetry and the concept of lattice, Data collection techniques,
Determination of unit cell constants by single crystal techniques. Symmetry
determination, indexing, reflection intensity determination and its relationship with
structure factor, data reduction and calculations of structure factors, Electron density,
Patterson factor and solving structure examples and refinement of structure by least
square method. Direct methods.
RECOMMENDED BOOKS:
i-
ii-
iii-
Course Code:
CHEM-7108
Course Title:
Radiation Chemistry
Credit Hours:
03
COURSE CONTENTS:
Constitution of nucleus: Nuclear Characteristics, Types of radiations, Physical properties
of radiations, Nuclear stability, Nuclides chart, Decay schemes, Kinetics of radioactive
decay. Measurement of radioactivity: Detectors used for the measurement of Activity,
Geiger Muller Counter, Scintillation counter. Development of Radiation Chemistry.
Introduction, radiation sources. Interaction of radiation with matter: Energy loss by
gamma rays, energy loss by electrons, energy loss of other charged particles, Effect of
LET, Dosimetry. Ions and electrons: Excited states. Radiolysis of gas, liquid and gas.
Production and decay of excited state. Application of Radiation Chemistry: Application
of radiation chemistry in sterilization, polymerization, nitrogen fixation, food
preservation, analytical methods, medicines etc.
RECOMMENDED BOOKS:
iiiiiiivvvi-
SEMESTER II
Course Code:
Course Title:
CHEM-7206
Organic Polymer Chemistry
Credit hours:
03
COURSE CONTENTS:
Introduction to Polymer Chemistry, Polymerization. Step growth and Addition
polymerisation,
Zielger-Natta
Coordination
polymerization,
Co-polymerization.
Course Code:
Course Title:
CHEM-7102
Principles Of Biochemical Processes
Credit hours:
03
COURSE CONTENTS:
A.
Up Stream Processing
a) Microorganisms of Industrial importance
b) Asceptic Techniques
c) Isolation and Purification Maintenance of Microorganisms
d) Fermentation and Fermentors
e) Fermentation MediaFormulation and optimization
f) Fermentation Kinetics
g) Biotechnological productions
B.
i.
ii.
Industrial Enzymes
iii.
iv.
v.
Electricity
vi.
Biofuels
preparation,
solubilization
techniques,
dialysis,
fractionation,
by Stanbury
2.
3.
4.
Fundamentals of Biochemistry
By Donald Voet and Judith G. Voet
5.
6.
Biochemistry
by Albert L. Lehninger
7.
Course Code:
Course Title:
CHEM-7209
Nano Chemistry
Credit hours:
03
COURSE CONTENTS:
Nanotechnology, nanomaterials, mesoporous, microporous and macroporous materials.
Nanoscale, Nanometer, Nanoparticles, Nanotubes, Thin films, Nanocomposites,
Nanostructured bulk materials.
Synthesis of nanoparticles, mesoporous materials and composites (Bottom Up and Top
Down Production). Synthesis by anodization, hydrothermal, convention heating,
deposition-precipiation methods.
Characterization of nanomaterials by X-ray Diffraction (XRD), Scanning Electron
Microscopy (SEM), Transmission Electron Microscopy (TEM), Brunauer, Emmett and
Teller (BET) adsorption method, Thermogravimetric Analysis (TGA), Atomic
Absorption Spectroscopy (AAS), Ultraviolet-Visible Spectroscopy (UV-Vis) and Fourier
Transform Infrared (FTIR) spectroscopy etc.
Course Code:
Course Title:
CHEM-7204
Environmental Chemistry
Credit hours:
03
COURSE CONTENTS:
(A).
COMMONALITEIS IN ENVIRONMENT
The nature and composition of human environment, Relationship between
WATER POLLUTION
Sources of water pollution (industrial, sewage and agriculture), point and non-
10
Course Code:
Course Title:
CHEM-7210
Instrumental Analysis (A practical Course)
Credit hours:
03
COURSE CONTENTS:
1. Crystal structure determination of Organic and Inorganic
compounds by Single Crystal Diffraction Technique
2.
Chromatography
6. Purifications of serum proteins by Fast Protein Liquid
Chromatography
7. Purity determination of active pharmaceuticals drugs by
spectrophotometry
RECOMMENDED BOOKS:
1) Crystal Structure determination By Werner Massa
2) An introduction to X-Ray Crystallography By Michael M Woolfson
3) Analytical Chemistry By Gary D. Christan
4) Fundamentals of Analytical Chemistry By Douglas A Skoog
Course Title:
Gene Technology
11
Course Code:
Chem 7211
Crdit Horus :
03
COURSE CONTENTS:
DNA finger printing: DNA profiling process, RFLP Analysis, PCR Analysis, DNA
family relationship analysis, Y-chromosome analysis, mitochondrial analysis, DNA
database, evidences of genetic relationship. Gene mapping: physical mapping, disease
association, genome mapping, quantitative trait locus. DNA sequencing: Maxam
Gilbert sequencing, chain termination methods, dye terminator sequencing,
challenges, automotion and sample preparation, Large-scale sequencing strategies,
new sequencing methods, in vitro clonal amplification, parallelized sequencing,
sequencing by ligation, microfluidic sanger sequencing, major landmarks in DNA
sequencing. Molecular cloning: recombinase-based cloning, restriction/ligation
cloning, isolation of insert, transformation, transfection, genetic engineering, gene
therapy, cloning cells and animals.Gene chip technology: principle, uses and types,
fabrication, spotted vs. in situ synthesized arrays, two-channel vs. one-channel
detection, microarrays and bioinformatics, experimental design, standardization,
statistical analysis, relation between probe and gene mutagenesis.
RECOMMENDED BOOKS:
Principles Of Fermentation Technology
by Stanbury
Fermentation Microbiology and Biotechnology
by El-Mansi
Biochemistry (Mosby International Edition)
by James M Orten and Otto W. Neuhah
Fundamentals of Biochemistry
By Donald Voet and Judith G. Voet
Modern Protein Chemistry: Practical Aspect
By Gary C Howard and William E.
Biochemistry
by Albert L. Lehninger
Advances In Protein Chemistry
By Christian Anfinsen, John Edsall, Frederic Richards and David Eisenberg,
Course Code:
CHEM-7207
12
Course Title:
Credit hours:
COURSE CONTENTS:
General Classification of Natural Products. Polyketide, Mevalonate and Shikimate metabolic pathways.
Course Code:
Course Title:
CHEM-7212
Advanced Chemical Kinetics
Credit hours:
03
Course Outlines:
13
Temperature effect, pressure effects and the volume of activation on the rate of reaction.
Transition state theory and its applications, solvent effects, salt effects, kinetic isotope
effects. Composite rate constants mechanism, Enzymatic processes involving electron
transfer and their kinetics
Reference Books for Chemical Kinetics
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iiiiiivv-
vi-
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