8/6/2015 HypertonicSaline(3%and5%SodiumChlorideInjection)DrugInformation:Description,UserReviews,DrugSideEffects,InteractionsPrescribingInfo

August6,2015

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HypertonicSaline
3%and5%SodiumChlorideInjection,USP
inVIAFLEXPlasticContainer

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3%and5%SodiumChlorideInjection,USPisasterile,nonpyrogenic,
hypertonicsolutionforfluidandelectrolytereplenishmentinsingledose
containersforintravenousadministration.ThepHmayhavebeenadjusted
withhydrochloricacid.Itcontainsnoantimicrobialagents.Composition,ionic
concentration,osmolarity,andpHareshowninTable1.

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SIZE COMPOSITION
(ML)
(G/L)

IONIC
CONCENTRATION

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(MEQ/L)

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CHLORIDE

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*OSMOLARITY PH
(MOSMOL/L)
(CALC)

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SODIUM CHLORIDE

USP(NACL)
3%
Sodium
Chloride

500

30

513

513

1027

Injection,
USP

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quick,easy,
pillidentification
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5%
Sodium

5.0
(4.5
to
7.0)

500

50

856

856

1711

Chloride
Injection,
USP

5.0
(4.5
to
7.0)

*Normalphysiologicalosmolarityrangeisapproximately280to310mOsmol/L.Administrationof

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substantiallyhypertonicsolutions(600mOsmol/L)maycauseveindamage.

TheVIAFLEXplasticcontainerisfabricatedfromaspeciallyformulated
polyvinylchloride(PL146Plastic).Theamountofwaterthatcanpermeate
frominsidethecontainerintotheoverwrapisinsufficienttoaffectthe

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8/6/2015 HypertonicSaline(3%and5%SodiumChlorideInjection)DrugInformation:Description,UserReviews,DrugSideEffects,InteractionsPrescribingInfo
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solutionsignificantly.Solutionsincontactwiththeplasticcontainercanleach
outcertainofitschemicalcomponentsinverysmallamountswithinthe
expirationperiod,e.g.,di2ethylhexylphthalate(DEHP),upto5partsper
million.However,thesafetyoftheplastichasbeenconfirmedintestsin
animalsaccordingtoUSPbiologicaltestsforplasticcontainersaswellasby
tissueculturetoxicitystudies.

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LastreviewedonRxList:10/3/2008
Thismonographhasbeenmodifiedtoincludethegenericandbrandnameinmany
instances.

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