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EMILIO AGUINALDO COLLEGE

School of Nursing and Midwifery


1113-1117 San Marcelino St. Ermita Manila

Name of Drug
Generic Name: Clozapine

Classification
Pharmacologic Class:

Mechanism of Action
Therapeutic: Chemical

Indication
General Indication:

Trade/Brand Name: Clozaril,

tricyclic dibenzodiazepine

effect: binds to dopamine

Schizophrenia unresponsive to

FazaClo

derivative

receptors within limbic system

or intolerant of standard

of the CNS and may interfere

therapy with other

Patients Dose: tab of

Therapeutic: atypical

100mg/tab OD

antipsychotic

with adrenergic, cholinergic,

antipsychotics (treatment

maximum: 50mg OD

Pregnancy Risk Category:

histaminergic and

refractory). To reduce recurrent

minimum: 50mg OD

pregnancy category B

serotoninergic receptors

suicidal behaviour in

Availability: 25 mg, 100 mg

schizophrenic patients.

tablets
Route(s) of Administration:
PO
Source: nurseslabs.com

Source:www.unilab.com

Therapeutic Effects: relieves

Patients Actual Indication:

psychotic signs and symptoms

Relief of psychotic signs and

Pharmacokinetics:

symptoms

Onset: Unknown
Peak: weeks
Duration: 4-12 hours
Drug Half-Life: 8-12 hrs

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Contraindication
Contraindication: Pts taking drugs that

Side Effects
Blurred vision

Before:

suppress bone marrow function and in

confusion

*Assess patients psychotic condition

those with paralytic ileus, uncontrolled

dizziness, faintness, or lightheadedness

*Monitor baseline WBC and differential counts

epilepsy, history of drug-induced

when getting up suddenly from a lying or

*Assess for risk factors of diabetes

agranulocytosis, myelo-suppressive

sitting position

disorders, severe CNS depression or

fainting

coma, WBC count less than 3,500/mm3

fast, pounding, or irregular heartbeat or


pulse

Nursing Responsibilities

*obtain baseline fasting blood glucose level


*obtain laboratory works
During:
*Watch for signs and symptoms of
cardiomyopathy, including exertional

Drug Interactions: Drug-Drug:

shakiness in the legs, arms, hands, or feet

dyspnea, fatigue, orthopnea

Anticholinergics: increase anticholinergic

sleepiness or unusual drowsiness

*Observe patient carefully when

effects

sweating

administering medication to ensure that

Antihypertensives: increase hypotensive

trembling or shaking of the hands or feet

medication is actually taken and not hoarded

effects

unusual tiredness or weakness


Adverse Effect
CNS: agitation, akathisia, anxiety, ataxia,

or cheeked.

confusion, depression, disturbed sleep or

pain, palpitations, other signs and symptoms

nightmares, dizziness, drowsiness,

of heart failure, ECG changes

fatigue, fever, headache, hyperkinesia,

After:

hypokinesia or akinesia, insomnia,

*After stopping drug, monitor WBC counts

myoclonus, rigidity, sedation, seizures,

weekly for at least 4 weeks

slurred speech, syncope, tremor, vertigo,

*Monitor closely for recurrent psychotic

Citalopram: increase clozapine level


Digoxin, warfarin: increase levels
Psychoactive drugs: produce additive
effects

weakness

*Monitor for signs of myocarditis (unexplained


fatigue, dyspnea, tachypnea, fever, chest

symptoms
*Inform patient of possibility of
extrapyramidal symptoms. Instruct patient to

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report these symptoms immediately.

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Drug Study Form

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