Important: Read carefully!

TM

pharmacia

Dompy

domperidone
Film Coated Tablets & Oral Suspension

COMPOSITION:
Each OompyT'llftlm coated labia' contain.
: Oomperidonl 10 m;
Each m! of DompyN orl' Iv.penllon contain.:
Domperidone 1 mg.

MODE OF ACTION:
Domperidone i, dopamine antagonitt with anti-emetic propertiea, domperidona do" not readily Cto tn. blood-brain barri.r. In domperidona utrllp.,ramidat ,Id. effect. are very rare.
The antiemetlc effect nil)' be due to combination of peripherlll (guttokineticl -'feet. and antagonl,m of dopamine rKlptOrs in In. c:hemor.ceptor trigger Ion wticl'llie out,1de the bloodbrain
barrierinl . ,...po.trtmL
Stuell in man hi." ,hown on.l domperidOM to inerllillow'f
llOpMg,.1 pt ur lmpro.enterodvodana' motility and acceleratl gulric emptying.

pharmacia

INDICAIONS:
II The dr.peptIc aymptom complex that i, often ,ocrated with delayed gamic emptying, ;a.tro-oelopr.g
t retux and DeIOp!W.gitil:
Epgutric ten" oIluIln lfy Mtiely, ''''ing of abdominal distention, upper abdominal pe.,n.
-Biolling,lruetatlon.t.lul.m:
.
H.ua nd vomillng.
He.rtburn with or without r.gurgitallon. of g.stric cont.nta in lhe Mouth.
tit H.u nd vomiting of lunctlon.~ org.nic, infK1iou' or di.tatlc origin or Induced by radiotherapy or drug Ihtlrapy A. ap.cllc indication
.goni.l u d in Par1UnlOfl'adi t.ucllul-clopa.
and bromoaiptln.).

i. nau

nd vomiling Induc.d

by dopamine

CONTRAINDICATIONS:
Dompy""" ,a cOQlraul!dte.l.c1 In pali.nla with known Into .ruc.
to I dt\lg Dompy""".hould not be und
gUlrelnt llnal lW..mormag. mlCl'Ianleal OOllt\lctlon or pa.rtor.llon.
Oompy"""I. at.o eonu.lltdlclted
In paUlnt. willi I prol.ctlnral sJng pituitary tumour tprolac:tinoma)

wh.n""l(

.timul.tlon

01

guttie

mOlility i. d.ng.rou.,

g. In Ih. pr nc:e of

SIDE EFFECTS:
Side eff.ct r. rlre, c.ptlonally aom. tranaient inteltinal cramp' have bHn repontld.
Ellr.pyr.mld.,
phenomena ara far. In young chlldr.n .nd exc.ptlon.lln &dun.. they rev.rse apon,.necu.,y.nd
compiete'Y" loon the It.llmenll. ItOpped.
AI 11'1I pilultary gl.nd I. loc.led outllde the bloodbraln bamar, Dompy"" may ntue.
In Incr.11I In the pI m. prollctin ,.vel In rart: e Ihi. IIYP&rpfol.clln ml. m.y give rill to
neufo.ndocrlnologic.1 phenom.n uellu g.l.ctorrholl.nd
gyn comuli .
When tM bloodbraln barrlar I. Immatura , In Inf.nt., or impaired, the po"lbI. oce:..mnc. 01 n.urological lid ffecl. c.nnot be tot.lly eluded.
Rare .lIerglc re.ctlon., .uell ,"II.nd unlcari', have .1.0 been rapaned.

WARNINGS AND PRECAUTIONS:

a)Use in infants:
aec.uII the metlbollc .nd bloodbr.ln barrier function. at. nOllully d.v.loped
medlc.1 .upervilion. Sinc. IhllypicaJ .bllnc.
01 neurological lid. ,,"eela
o..c,""
.tfK11 c.nnot be totally ududad in lnIanta unci. 1 y t of~ .

the firll month. of lif., any dNg

are mainly due 10 Itl poor pe

only be given to Inllnl. willi graa' e.ullon .nd under clo.e

tll"ough thl bloodbr.in bam,r, thl po"lbI. occurr.nce 01 .uell

/iverdiscrders:

s.e.. ooapMdona II
:.oua.o
C) Use in kidney disorders:

dill

00rt"OW-.d

ba..ct
1IIII1iI. 0/ dompetidoftl . ~1Hd
ffoI!I 7" to 20.1 houB, but pI.am. drug levell
that the do of IiftgII .art. edllHru.trlbon nlad. 10 be .oju.led in patient. wittI
lor twiC' daily, d.pendltlg 0" tbI 'Iverily of the Imp.lrm.nt. and lhe eese m.y

In pall.ntl with IIv.r. r.n,1 Inlufficl.ney ,lItv ct tinln.8 mg/IOO 11'I1,L 0.8 III ~
w.,. lowlr than in hellthy volunt"rs. Sinca nr)' little unchanged drug II excrlted II the
ren.lln.ull\claney
How,vlr, on rlpe.ted .011'I .trIItlon, the do.ing Iraqulncy InoUkt be
nl.dlob.redueed.OenlraUypatllnllonptOlongedtherapywuldbarev$ewldragl.rty

d) Pregnancy

and lactation:

Oomperidon. giv.n to Inlmall al d011l up 10 180 mglkgld.y did not produell.raloglnlC

IftIdL
Kthi. II lu.llfied by the Intlclpated therapeutic ban.fit. Up 10 now, there has been no rlidenc:e of
ral' (mo.tly II mll.bolit . k concentration 01 -40 .nd 80 mg/ml IIt.t oral and L ad
lower tl'lan corrllpanding pI m&. It II nol known whither Ihil II harmful 10 the nl.bo...,
benlfit.OIJIW.lgh.nypotlntialri.k,

__

_lDIdiein
Dampy"" lhould only be u.ad during thl first lrimall.r of pregnancy
""
of m.Korm.llonl in human . The drug ,. Ilcrll.c1 in br st milk oIl.ctaling
rllpectiv.ly. In wOll'lln Oompetidon. conclntralion in br 1 milk i timl'
_ nOI rlComm.nded lor molhera who arl taking Domp),""",unll" Ihlupectecl

e) Use in post-operative:
NOI

recomm.nded for routine prophylaxl. 01 post-operltive vomiting or lor chronic ad

OVERDOSAGE:

DRUG INTERACTIONS:
Concomitant .dminl.lr.lion
01 .nticholin'r;1C dno;s
dompel1done they lower III or.' blO"'.l.bllity
p.nlcul.rly
tho with IUltlln.d
ral or .'t'.~c.~ad
domperidonl did not Influ.nce 11'1Iblood 'i. 01 thuoI
OompyTVm.y allll be oci.led with; n.urollpbes, 1M acD:In
dllllrd.ra,n.u ndvomltingil.uppr without

. IIBCI
lor""

~..,.
I

GI

)'Ipeptic I"act 01 Dompy""". Ant.cidl and

. glitro-kinllic
.fleet. it m.y intulnce
In p.tlentl
.Irlldy
.t.blllud

,",o ".t,

CA

dopamin.rgic agonlatll~

f)' dt\lg noutd not be gw.n IImultan.oully

wilh
a.=aotpl:!on 01 concomit.ntl,
orally .dminl.l.red
dt\lg.,
or p.r.elt.mol,
contomltant
admini.tratlon
of

Co ;OI1n

~pel.

who unw.nled perip/'llrallflecta

lueh digestive

DOSAGE AND ADMINISTRATION:

I ChronIC.d)'SpepNllTII.lnly oral admlnillr.tion}

Mult. 10 mg tll1btll or 10 ml }3 lim d.ily. 15-30 mmulel cccn mukl5l,
I eec:esaary, onc. mot. balore rlliring.
ChIldren. Ort.l ,u'petillon; 2.5 mt par 10 kg bod)' wtigtt. 3 tmea Co
be!'1)n!mull and tIIe ry, once more in IhI .verting
When rllult
not MtllI.ctory, the lbov. dO,lgl m.y be doab.ed III aduIla and cHJdtln who are above 1 year.
z.A.eut nd lubacltl.conditionl,paniculariy
n.Ullllnd"o
gl
Mutt . Oral 20 mg t2 t.blet . or 20 mi 13411mes d.lly belor. 11'I11" artd before bedtIme

t.

pharmacia

PRESENTATION:
T.bl.I.: P.ckof3bUlllraoll0t.bI.l.llcn
Su.penllon
In 200 ml Imber colour gl."

bottll.

STORAGE CONDITIONS:
StOll

between 15 251 C

THIS IS A MEDICAMENT
Medicament is a product that affects your health, and its consumption contrary to instructions s dangerous
for you.
Follow strictly the doctor's prescription, the method of use and the instructions of the pharmacist who sold the
medicament.
The doctor and the pharmacist are experts in medicine, its beneflls and risks.
Do not by yourself interrupt the period of treatment prescribed.
~t
repeat the same prescription without consultingyour doctor.
Keep medicament out of the reach of children.

Council of Arab Health Ministers & Union of Arab Pharmacists

t1I G . I . T Medicine
pharmacia

Dompy

is a quality product manufactured by :

L... J LiI ,a!J-?-Do-?

jamjoom Pharma
P.O.Box

6267

Jeddah-21442-Saudi

32171098 - Rev. 01/24-04-07

Arabia

pharmacia