ANTI-ANGINA

Jenis Tindakan Contoh ubat Indication Doses Sign effect Contraindication Caution Interaction
ubat
Nitrates Isorbide  Rxn & I. Adult  Headache  Allergic to  heapatic &  sildenafil
i. Relax otot licin di dinitrate cegah a. angina  Dizziness drug renal disease (Viagra)
salur darah (Isordil) angina → 5-10mg tab SL  Hypotension  Anemia  acute MI  alcohol
ii. ↑saiz lumen B pectoris → 30-120mg/d PO  Weakness  Hypotension  cerebral  beta blockers
arteri  LVF (divided dose)  Flushing hemorrhage  anti-
iii. ↑pengaliran drh b. LVF  Blur vision  hypothyroidism hypertensive
& bkalan O2 → 40-160mg/d PO  pregnancy drugs
(divided dose)  lactation  tryciclic
→ up to 240mg/d PO antidepressan
(divided dose) ts
II. Peads
Safety & efficacy not
established

Isosorbide  Rxn & I. Adult = Isorbide = Isorbide = Isorbide dinitrate = Isorbide dinitrate
mononitrate cegah 50mg/d PO dinitrate dinitrate
(Elantan) angina
A pectoris
 Rxn CAD
jangka
panjang
Isorbide-5-  Rxn & I. Adult = Isorbide  Allergic to = Isorbide dinitrate = Isorbide dinitrate
mononitrate cegah 30-120mg/d PO dinitrate drug
(imdur) angina  Anemia
A pectoris  Hypotension
 Head trauma

Glyceryl  rxn & cegah I. Adult = Isorbide  Allergic to = Isorbide dinitrate  Imipramine
trinitrate angina 0.5-1mg tab SL dinitrate drug (TCA)
(GTN/angis pectoris (repeat as required)  Severa  Atropine
ed tab)  LVF anemia  Nitrates
C  Early MI  Sildenafil
 Increased (Viagra)
intracranial
pressure
 ANTI-ANGINA
Jenis Tindakan Contoh ubat Indication Doses Sign effect Contraindication Caution Interaction
ubat
Calcium Channel Diltiazem HCl I. Adult  Dizziness  Allergic to  10 Heart block  Aspirin
Blockers (Herbesser) → 60mg tid PO  Headache drug  CHF  Beta blockers
i. Halang B (elderly bid)  Peripheral  Impaired  Gastrointestina  Carbamazepine
pergerakan → increase if edema renal/ l hypermotility (Anti-Epileptics)
ion merentasi necessary to  Hypotension hepatic  Hypotension  Cisapride
membrane 360mg/d  Nausea & function  Impaired liver (Gastroesopha
sel. → max: 480mg/d diarrhea  Heart block function geal reflux/
ii. Paras kalsium II. Peads  Constipation  Acute MI sembelit)
bagi transmisi Safety & efficacy not  Flushing  Hypotension
impulse  established  Lactation
iii. Kesan  preagnancy
pengembang Verapamil I. Adult = Diltiazem HCl  Allergic to = Diltiazem HCl  Beta blockers
an ke atas HCL (Isoptin) → 80-120mg tid/d PO drug  Anesthetic
arteri B → do not exceed  Heart block (inhalation)
iv. Maka lebih 480mg/d (in long term  Hypotension  Digoxin
banyak O2 treatment)  Pregnancy
sampai ke → take regularly ½  Lactation
otot kardiak hour before meal
v. ’Cardiac II. Peads
Workload’ → <1 yr: 0.1-
0.2mg/kg
→ 1-15yr: 0.1-
0.3mg/kg
→ do not exceed 5mg
(PO/IV)
Nifedipine I. Adult = Diltiazem HCl  Allergic to = Diltiazem HCl  Beta blockers
(Adalat) → initial 10mg tid PO drug  Digoxin
B (elderly 5mg)  Diltiazem
→ maintenance: 10-  Fluconazole
20mg tid PO  Itraconazole
→ >180mg/d is ot  Ketoconazole
recommended  Oral anti-
II. Peads coagulants
Safety & efficacy not  Phenytoin
established  Rifampin
 Saquinavir
 Vincristine