Dr.

Vargas Soriano, Arturo

Farmacologa- V ciclo / USPJB

AUTONOMIC DRUGS
31. How does botulinum toxin work? _____________________________________________
32. Identify the G-protein class for each receptor. (Numbers may be used more than once.)

33. What are the major effects of 1-receptor activation? ______________________________

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34. What are the major functions of 2-receptor activation? ___________________________
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35. What are the major functions of 1-receptor activation? ____________________________
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36. What is the major effect of 2-receptor activation on the body's vasculature? What is the effect on
the respiratory system? _____________________________________________________
37. How does 2-receptor activation affect glucagon release? __________________________

Dr. Vargas Soriano, Arturo

Farmacologa- V ciclo / USPJB
38. In the images below, identify which autonomic drugs work at which site of action.

39. Name five indirect cholinergic agonists. ________________________________________

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40. What symptoms are likely in patients taking cholinomimetic agents? __________________
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41. Which pharmacologic agent is used to treat atropine overdose? _____________________
42. What is a methacholine challenge test? ________________________________________
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43. A farmer presents with diarrhea, abdominal pain, wheezing, pinpoint pupils, copious tears, and
salivation. What medications should be prescribed? ______________________________
44. Why is pyridostigmine used to treat myasthenia gravis? ___________________________
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45. A patient recently began taking haloperidol to treat schizophrenia, but visits his physician because of
new-onset Parkinson's-like motor symptoms. What drug could be used to treat these symptoms?
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46. What are the two effects of atropine on the eye? _________________________________
47. True or False: Diarrhea is a sign of atropine toxicity. ______________________________

Dr. Vargas Soriano, Arturo

Farmacologa- V ciclo / USPJB
48. Low doses of epinephrine are selective for _______ (1, 2, 1, 2) adrenergic receptors.
49. Isoproterenol is an agonist for which receptors? _________________________________
50. Dopamine __________ (is/is not) ionotropic and __________ (is/is not) chronotropic, whereas
dobutamine __________ (is/is not) ionotropic and __________ (is/is not) chronotropic.
51. What are the clinical applications of epinephrine? ________________________________
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52. What role does dopamine have in treating shock? ________________________________
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53. What are the clinical applications of phenylephrine? ______________________________
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54. What is the clinical application for albuterol? ____________________________________
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55. Which sympathomimetics can reduce premature uterine contractions? _______________
56. What effect does isoproterenol have on pulse pressure and heart rate? _______________
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57. What is the effect of clonidine on central adrenergic outflow? On which receptor does it act?
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58. What is the clinical application and mechanism of action of phentolamine? _____________
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59. What is the net effect of epinephrine on blood pressure before and after nonselective -blockade?
Why? ___________________________________________________________________
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60. A 63-year-old man is referred long-term care after his first myocardial infarction. Is a -blocker
suggested or contraindicated for this patient? Why? ______________________________
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61. How do -blockers work in the setting of angina pectoris? __________________________
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62. Which -blockers have partial agonist activity? __________________________________
63. Name two nonselective - and -antagonists. ___________________________________

Dr. Vargas Soriano, Arturo

Farmacologa- V ciclo / USPJB