RFA-MD-15-014 - NIMHD Transdisciplinary Collaborative Centers For Health Disparities Research On Chronic Disease Prevention (U54)

Department of Health and Human Services
Part 1. Overview Information

Participating Organization(s)
National Institutes of Health (NIH (http://www.nih.gov))
Components of Participating Organizations

National Institute on Minority Health and Health Disparities (NIMHD (http://www.nimhd.nih.gov/))
Funding Opportunity Title
NIMHD Transdisciplinary Collaborative Centers for Health Disparities

Research on Chronic Disease Prevention (U54)
Activity Code
U54 (http://grants.nih.gov/grants/funding/ac_search_results.htm?
text_curr=u54&Search.x=0&Search.y=0&Search_Type=Activity) Specialized Center- Cooperative
Agreements
Announcement Type
New
Related Notices
None
Funding Opportunity Announcement (FOA) Number
RFA-MD-15-014
Companion Funding Opportunity
None
Number of Applications
Only one application per institution is allowed, as defined in Section III. 3. Additional Information on
Eligibility.
Catalog of Federal Domestic Assistance (CFDA) Number(s)

93.307
Funding Opportunity Purpose

This Funding Opportunity Announcement (FOA) invites applications to establish specialized
Transdisciplinary Collaborative Centers (TCCs) for health disparities research focused on chronic
disease prevention, with an emphasis on developing, implementing and disseminating communitybased multilevel interventions.
Key Dates
Posted Date
August 4, 2015
Open Date (Earliest Submission Date)

November 16, 2015
Letter of Intent Due Date(s)

November 16, 2015
Application Due Date(s)

December 16, 2015, by 5:00 PM local time of applicant organization. All types of non-AIDS applications
allowed for this funding opportunity announcement are due on this date.
Applicants are encouraged to apply early to allow adequate time to make any corrections to errors
found in the application during the submission process by the due date.
AIDS Application Due Date(s)

December 16, 2015 by 5:00 PM local time of applicant organization.
All types of AIDS and AIDS-related applications allowed for this funding opportunity announcement are
due on this date.
Applicants are encouraged to apply early to allow adequate time to make any corrections to errors
found in the application during the submission process by the due date.
Scientific Merit Review

March 2016
Advisory Council Review

May 2016
Earliest Start Date

July 1, 2016
Expiration Date
December 17, 2015
Due Dates for E.O. 12372

Not Applicable
** ELECTRONIC APPLICATION SUBMISSION REQUIRED**

NIHs new Application Submission System & Interface for Submission Tracking (ASSIST) is available for the
electronic preparation and submission of multi-project applications through Grants.gov to NIH.
Applications to this FOA must be submitted electronically; paper applications will not be accepted. ASSIST
replaces the Grants.gov downloadable forms currently used with most NIH opportunities and provides
many features to enable electronic multi-project application submission and improve data quality,
including: pre-population of organization and PD/PI data, pre-submission validation of many agency
business rules and the generation of data summaries in the application image used for review.
Required Application Instructions

It is critical that applicants follow the instructions in the SF424 (R&R) Application Guide
(http://grants.nih.gov/grants/guide/url_redirect.htm?id=12000), except where instructed to do otherwise (in
this FOA or in a Notice from the NIH Guide for Grants and Contracts (http://grants.nih.gov/grants/guide/))
and where instructions in the Application Guide are directly related to the Grants.gov downloadable forms
currently used with most NIH opportunities. Conformance toall requirements (both in the Application
Guide and the FOA) is required and strictly enforced. Applicants must read and follow all application
instructions in the Application Guide as well as any program-specific instructions noted in Section IV.
When the program-specific instructions deviate from those in the Application Guide, follow the programspecific instructions. Applicationsthat do not comply with these instructions may be delayed or not
accepted for review.
There are several options to submit your application to the agency through Grants.gov. You can use the
ASSIST system to prepare, submit and track your application online. You can download an application
package from Grants.gov, complete the forms offline, submit the completed forms to Grants.gov and track
your application in eRA Commons. Or, you can use other institutional system-to-system solutions to
prepare and submit your application to Grants.gov and track your application in eRA Commons. Learn
more (http://grants.nih.gov/grants/ElectronicReceipt/preparing.htm#2).
Apply Online Using ASSIST Problems accessing or using ASSIST should be directed to the eRA
Commons Help Desk (/grants/ElectronicReceipt/support.htm#desk).
Table of Contents
Part 1. Overview Information
Part 2. Full Text of the Announcement
Section I. Funding Opportunity Description
Section II. Award Information
Section III. Eligibility Information
Section IV. Application and Submission Information
Section V. Application Review Information
Section VI. Award Administration Information
Section VII. Agency Contacts
Section VIII. Other Information
Part 2. Full Text of Announcement

Section I. Funding Opportunity Description
Background
Although scientific and technological advances have improved the health of the U.S. population overall,
racial/ethnic minority populations, socioeconomically disadvantaged populations and rural populations
continue to experience a disproportionate share of many chronic diseases and adverse health conditions.
As the Nations steward of biomedical and behavioral research, NIH has devoted considerable resources
to characterize the root causes of health disparities, uncovering complex webs of interconnected factors
(e.g., biological, behavioral, social and environmental factors) acting at multiple levels across the life
course. As an important next step, research is needed that capitalizes on this knowledge to develop
interventions that reduce and eventually eliminate health disparities.
Tackling the complex drivers of health disparities requires a transdisciplinary framework that cuts across
scientific and organizational silos to integrate multiple disciplines biology, behavioral and social sciences,
epidemiology, data science, public health, health care delivery, economics, environmental science, public
policy, etc. It also requires strong collaborations between researchers, community organizations, health
service providers, public health agencies, policymakers and other stakeholders to ensure that relevant,
contextually appropriate research is conducted and, more importantly, that findings can be translated into
sustainable community and system-level changes that promote health equity.
To pursue these objectives, NIMHD Transdisciplinary Collaborative Centers (TCCs) for health disparities
research comprise regional coalitions of research institutions and consortium partners focused on priority
research areas in minority health and health disparities. The TCC program's overarching goal is to develop
and disseminate effective interventions that can be implemented in real-world settings.
Chronic diseases and conditions are among the most common, costly, and preventable of all health
problems. Seven of the top 10 causes of death in 2010 were chronic diseases. By investing in prevention
and early diagnosis and treatment of the most common chronic diseases, the U.S. could decrease
treatment costs by $218 billion per year and reduce the economic impact of disease by $1.1 trillion
annually. Reducing disparities in chronic diseases should start with health disparity populations at high risk
for chronic diseases such as cardiovascular diseases, diabetes, cancer, chronic pulmonary disease,
arthritis etc. For example, many health risks are associated with obesity. However, the prevalence of
obesity among non-Hispanic black and Hispanic adults is significantly higher than among non-Hispanic
white adults. Cigarette smoking is the leading cause of preventable death in the United States. Yet, more
adults who live below the poverty level are current cigarette smokers compared to those who live at or
above the poverty level. Also, hypertension, a precursor to cardiovascular disease, is more prevalent and
not as well controlled in non-Hispanic blacks, versus non-Hispanic whites. Non-Hispanic blacks have a
much higher prevalence of uncontrolled blood pressure when compared with non-Hispanic whites. Women
from poor, low-income, and middle-income households are less likely to receive a mammogram compared
with women from high-income households.
Research Objectives
Chronic diseases/conditions are defined broadly as conditions that last one year or more and require
ongoing medical attention or limit activities of daily living or both. For the purposes of this FOA, chronic
diseases/conditions that disproportionately affect health disparity populations include but are not limited to
diabetes, cancer, cardiovascular diseases, kidney disease, HIV/AIDS, asthma, depression and other mental
illnesses, substance abuse and addiction disorders.
Current science advances in developmental biology, life-course science and environmental epigenetics
expand our understanding of the possible etiologies and mechanisms of many chronic diseases and
conditions. The advances also build a persuasive case for reframing public health research efforts to
emphasize health promotion and chronic disease prevention.
This initiative encourages investigators using a transdisciplinary, collaborative and systems approach to
address disparities in chronic disease prevention. Priorities will be given to primary and secondary
prevention activities that aim to prevent disease from occurring or aim to find and treat disease early. No
treatment costs will be covered. Multilevel approaches are encouraged in order to better understand and
appropriately intervene to eliminate health disparities. Multilevel interventions are interventions with
multiple components designed to affect factors in two or more levels of the local ecology that contribute to
wellness and illness, with the goal to effect changes within and between different levels. Dynamic
interventions involving individual, family/team/group, community, state, or national levels may account for
multidimensional influences on individual risk factors and population level macro-social factors. For
example, evidence suggests that population-level behavior changes can best be achieved by changing
physical and social environments for four key risk factors: tobacco use, unhealthy diet, lack of physical
activity, and harmful use of alcohol. Increasingly, there is recognition that single-level interventions are not
adequate to reduce health inequalities. Multilevel interventions that take into account complex interactions
at multiple ecological levels can better address social determinants of health.
This FOA encourages working extensively with community partners to implement community-based
multilevel interventions. For the purposes of this FOA, community is defined as a group of people with
diverse characteristics who are linked by social ties, shared common perspectives, and engage in joint
action in geographical locations. Each TCC will identify a community with existing evidence of a high
prevalence or incidence of chronic diseases or conditions and lack of prevention and health promotion
interventions or resources. In the projects first year, each TCC is expected to carry out a comprehensive
needs assessment in that community (including social stratification, community ecological context, cultural
factors, environmental factors, health-related policies, etc.), identify barriers to access and utilization of
health promotion or preventive care services, build extensive partnership within the community, and
acquire baseline data on multiple chronic diseases including clinical data, biomarkers, or other
measureable outcomes as necessary. Multimodal methods should be used to triangulate findings and
identify the underlying mechanisms of disparities. Based on that information and collaboration with local
community partners, in years 2-5 each TCC will initiate and implement multilevel interventions at individual,
family/team/group, community, or higher levels (at least three or more levels) to improve chronic disease
prevention and promote health equity.
Given that TCCs for health disparities research are focused on regional approaches and collective impact,
priority will be given to multilevel interventions that target 500 or more participants within the selected
community(ies), and to projects targeting communities without previous government-sponsored
community-wide interventions.
Each TCC must consist of multidisciplinary teams of personnel from community organizations and
academic institutions, health service providers and systems, and state and local public health agencies to
address disparities through a multilevel approach that utilizes community, academic, and governmental
resources. Each TCC must include the following components: Administrative Core, Consortium Core,
Methodology Core, Intervention Projects, and Dissemination Core.
The Administrative Core will oversee activities providing overall project evaluation; ensuring that
component plans are implemented according to proposed timelines; submitting annual progress
reports; monitoring progress on intervention projects, and ensuring that TCC-supported research is
carried out in compliance with applicable federal regulations and policies.
The Consortium Core will serve as a focal point for organizing and nurturing productive working
relationships with consortium partners. Consortium Core leadership is expected to include members
of all consortium partner organizations including NIMHD scientific staff. Research shows that
diverse teams working together to capitalize on innovative ideas and distinct perspectives
outperform homogenous teams. Moreover, involving community stakeholders in needs assessment,
project planning and design, implementation, and dissemination of results enhances their
participation in research and facilitates development of workable multilevel interventions.
The Methodology Core will formulate appropriate theoretical framework, study design, data analysis
plan, and assessment of community-based multilevel interventions. Investigators must carefully
determine the unit of intervention and the unit of analysis according to their research questions. The
systematic appraisal of costs and benefits of community-based multilevel intervention is needed.
Intervention Projects will promote prevention research and related activities aimed at initiating and
implementing multilevel interventions in community settings, working in close collaboration with
community partners, health service providers, public health agencies, policymakers and other
consortium partners as appropriate. Each TCC is required to have at least two projects with different
interventions. Multiple chronic disease/conditions are encouraged.
The Dissemination Core will identify, develop effective methods, systems, infrastructures, and
strategies to disseminate research findings and to overcome barriers to the adoption, adaptation,
integration of evidence-based multilevel interventions.
NOTE: TCC awards will not support cores that duplicate institutional resources or cores supported by
other federal funding if those resources are already available for use by TCC participants.
To promote optimal use of TCC resources, TCC investigators are strongly encouraged to collaborate with
other federally-funded investigators who have expertise and/or interest in multilevel chronic disease
prevention and health disparities or other resources that can be leveraged to help achieve TCC objectives.
Although delineation of the region and populations(s) under study is determined by the applicant,
applications must specify in which of the 10 established HHS regions the proposed work will occur
(http://www.hhs.gov/about/regions/). Applicant-defined regions may fall within a single HHS region or

across multiple regions.
REGION I: CT, ME, MA, NH, RI, VT
REGION II: NJ, NY, PR, VI
REGION III: DE, D.C., MD, PA, VA, WV
REGION IV: KY, MS NC, TN, AL, FL, GA, SC
REGION V: IL, IN, MI, MN, OH, WI
REGION VI: AR, LA, NM, OK, TX
REGION VII: IA, KS, MO, NE
REGION VIII: CO, MT, ND, SD, UT, WY
REGION IX: AZ, CA, HI, NV, and the six U.S. Associated Pacific jurisdictions
REGION X: AK, ID, OR, WA
To ensure that all TCCs, including those established through this FOA, contribute optimally and effectively
to national minority health and health disparities research efforts, the overall direction and scope of
activities supported by this initiative will be coordinated and monitored by a TCC Program Coordinating
Committee consisting of TCC PDs/PIs and NIMHD program staff. The TCC Program Coordinating
Committee will meet at least annually to assess progress toward program goals and promote information
exchange across regions.
In addition, TCCs established through this initiative are expected to work together to address disparities in
chronic disease prevention through a Multilevel Chronic Disease Prevention (MCDP) Coordinating
Committee comprising the PD(s)/PI(s) of each TCC and NIH program staff. This committee will identify
issues that have broad applicability across participating TCCs, and will establish the following subcommittees, each of which will include at least one NIH project scientist:
Executive Committee, consisting of the chair of the MCDP Coordinating Committee, the TCC
PDs/PIs, the NIH Program Officer(s), to meet quarterly via teleconference.
Research Methodology Committee, consisting of key personnel from each TCC Methodology Core
and NIH program staff and responsible for development of consistent definitions, theoretical
frameworks, key approaches, and analytic methods.
Publications Committee responsible for developing a publications policy approved by the
Coordinating Committee at the beginning of the project period and reviewing all abstracts,
presentations and manuscript submissions by MCDP TCC investigators.
The NIMHD will conduct a Technical Assistance webinar for prospective applicants in August 2015 at a
date and time to be determined. Information about the webinar will be posted on the NIMHD website at
www.nimhd.nih.gov (http://www.nimhd.nih.gov).
Section II. Award Information

Funding Instrument
Cooperative Agreement: A support mechanism used when there will be substantial Federal scientific or
programmatic involvement. Substantial involvement means that, after award, NIH scientific or program
staff will assist, guide, coordinate, or participate in project activities.
Application Types Allowed

New
The OER Glossary (http://grants.nih.gov/grants/guide/url_redirect.htm?id=11116) and the SF424 (R&R)
Application Guide provide details on these application types.
Funds Available and Anticipated Number of Awards

NIMHD intends to commit $5,000,000 in FY 2016 to fund 2-3 awards.
Award Budget
Application budgets are limited to $1,500,000 in direct costs annually, exclusive of consortium indirect
costs.
Award Project Period

The scope of the proposed project should determine the project period. The maximum project period is
5 years.
NIH grants policies as described in the NIH Grants Policy Statement

(http://grants.nih.gov/grants/guide/url_redirect.htm?id=11120) will apply to the applications submitted and
awards made in response to this FOA.
Section III. Eligibility Information

1. Eligible Applicants
Eligible Organizations
Higher Education Institutions
Public/State Controlled Institutions of Higher Education
Private Institutions of Higher Education
The following types of Higher Education Institutions are always encouraged to apply for NIH support as
Public or Private Institutions of Higher Education:
Hispanic-serving Institutions
Historically Black Colleges and Universities (HBCUs)
Tribally Controlled Colleges and Universities (TCCUs)
Alaska Native and Native Hawaiian Serving Institutions
Asian American Native American Pacific Islander Serving Institutions (AANAPISIs)
Nonprofits Other Than Institutions of Higher Education
Nonprofits with 501(c)(3) IRS Status (Other than Institutions of Higher Education)
Nonprofits without 501(c)(3) IRS Status (Other than Institutions of Higher Education)
For-Profit Organizations
Small Businesses
For-Profit Organizations (Other than Small Businesses)
Governments
State Governments
County Governments
City or Township Governments
Special District Governments
Indian/Native American Tribal Governments (Federally Recognized)
Indian/Native American Tribal Governments (Other than Federally Recognized)
U.S. Territory or Possession
Other
Independent School Districts
Public Housing Authorities/Indian Housing Authorities
Native American Tribal Organizations (other than Federally recognized tribal governments)
Faith-based or Community-based Organizations
Regional Organizations
Foreign Institutions
Non-domestic (non-U.S.) Entities (Foreign Institutions) are not eligible to apply.
Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.
Foreign components, as defined in the NIH Grants Policy Statement
(http://grants.nih.gov/grants/guide/url_redirect.htm?id=11118), are allowed.
Required Registrations
Applicant Organizations
Applicant organizations must complete and maintain the following registrations as described in the SF 424
(R&R) Application Guide to be eligible to apply for or receive an award. All registrations must be completed
prior to the application being submitted. Registration can take 6 weeks or more, so applicants should
begin the registration process as soon as possible. The NIH Policy on Late Submission of Grant
Applications (http://grants.nih.gov/grants/guide/notice-files/NOT-OD-11-035.html) states that failure to
complete registrations in advance of a due date is not a valid reason for a late submission.
Dun and Bradstreet Universal Numbering System (DUNS) (http://fedgov.dnb.com/webform) - All
registrations require that applicants be issued a DUNS number. After obtaining a DUNS number,
applicants can begin both SAM and eRA Commons registrations. The same DUNS number must be
used for all registrations, as well as on the grant application.
System for Award Management (SAM) (https://www.sam.gov/portal/public/SAM/) (formerly CCR)
Applicants must complete and maintain an active registration, which requires renewal at least
annually. The renewal process may require as much time as the initial registration. SAM registration
includes the assignment of a Commercial and Government Entity (CAGE) Code for domestic
organizations which have not already been assigned a CAGE Code.
NATO Commercial and Government Entity (NCAGE) Code
(http://grants.nih.gov/grants/guide/url_redirect.htm?id=11176) Foreign organizations must
obtain an NCAGE code (in lieu of a CAGE code) in order to register in SAM.
eRA Commons (http://grants.nih.gov/grants/guide/url_redirect.htm?id=11123) - Applicants must

have an active DUNS number and SAM registration in order to complete the eRA Commons
registration. Organizations can register with the eRA Commons as they are working through their
SAM or Grants.gov registration. eRA Commons requires organizations to identify at least one
Signing Official (SO) and at least one Program Director/Principal Investigator (PD/PI) account in
order to submit an application.
Grants.gov (http://www.grants.gov/applicants/organization_registration.jsp) Applicants must have
an active DUNS number and SAM registration in order to complete the Grants.gov registration.
Program Directors/Principal Investigators (PD(s)/PI(s))
All PD(s)/PI(s) must have an eRA Commons account. PD(s)/PI(s) should work with their organizational
officials to either create a new account or to affiliate their existing account with the applicant organization
in eRA Commons. If the PD/PI is also the organizational Signing Official, they must have two distinct eRA
Commons accounts, one for each role. Obtaining an eRA Commons account can take up to 2 weeks.
Eligible Individuals (Program Director/Principal Investigator)

Any individual(s) with the skills, knowledge, and resources necessary to carry out the proposed research as
the Program Director(s)/Principal Investigator(s) (PD(s)/PI(s)) is invited to work with his/her organization to
develop an application for support. Individuals from underrepresented racial and ethnic groups as well as
individuals with disabilities are always encouraged to apply for NIH support.
For institutions/organizations proposing multiple PDs/PIs, visit the Multiple Program Director/Principal
Investigator Policy and submission details in the Senior/Key Person Profile (Expanded) Component of the
SF424 (R&R) Application Guide.
2. Cost Sharing
This FOA does not require cost sharing as defined in the NIH Grants Policy Statement.
(http://grants.nih.gov/grants/guide/url_redirect.htm?id=11126)
3. Additional Information on Eligibility

Number of Applications
Only one application per organization (normally identified by having a unique DUNS number or NIH IPF
number) is allowed.
The NIH will not accept duplicate or highly overlapping applications under review at the same time. This
means that the NIH will not accept:
A new (A0) application that is submitted before issuance of the summary statement from the review
of an overlapping new (A0) or resubmission (A1) application.
A resubmission (A1) application that is submitted before issuance of the summary statement from
the review of the previous new (A0) application.
An application that has substantial overlap with another application pending appeal of initial peer
review (see NOT-OD-11-101 (http://grants.nih.gov/grants/guide/notice-files/NOT-OD-11-101.html)).
Section IV. Application and Submission Information

1. Requesting an Application Package
Applicants can access the SF424 (R&R) application package associated with this funding opportunity using
the Apply for Grant Electronically button in this FOA or following the directions provided at Grants.gov
(http://grants.nih.gov/grants/guide/url_redirect.htm?id=11127).
Most applicants will use NIHs ASSIST system to prepare and submit applications through Grants.gov to
NIH. Applications prepared and submitted using applicant systems capable of submitting electronic multiproject applications to Grants.gov will also be accepted.
2. Content and Form of Application Submission

It is critical that applicants follow the instructions in the SF424 (R&R) Application Guide
(http://grants.nih.gov/grants/guide/url_redirect.htm?id=12000), including Supplemental Grant Application
Instructions (https://grants.nih.gov/grants/funding/424/SupplementalInstructions.pdf) except where
instructed in this funding opportunity announcement to do otherwise and where instructions in the
Application Guide are directly related to the Grants.gov downloadable forms currently used with most NIH
opportunities. Conformance to the requirements in the Application Guide is required and strictly enforced.
Applications that are out of compliance with these instructions may be delayed or not accepted for review.
For information on Application Submission and Receipt, visit Frequently Asked Questions Application
Guide, Electronic Submission of Grant Applications (http://grants.nih.gov/grants/guide/url_redirect.htm?
id=41137).
Letter of Intent
Although a letter of intent is not required, is not binding, and does not enter into the review of a subsequent
application, the information that it contains allows IC staff to estimate the potential review workload and
plan the review.
By the date listed in Part 1. Overview Information, prospective applicants are asked to submit a letter of
intent that includes the following information:
Descriptive title of proposed activity
Name(s), address(es), and telephone number(s) of the PD(s)/PI(s)
Names of other key personnel
Participating institution(s)
Number and title of this funding opportunity
The letter of intent should be sent to:
Maryline Laude-Sharp, PhD
Telephone: 301-451-9536
Fax: 301-480-4049
Email: mlaudesharp@mail.nih.gov (mailto:mlaudesharp@mail.nih.gov)
Page Limitations
Component Types Available in ASSIST
Research Strategy/Program
Plan Page Limits
Overall
12
Admin Core
12
Core (use for Consortium Core, Methodology
6 (per core)
Core (use for Consortium Core, Methodology

Core, and Dissemination Core)
6 (per core)
Project (use for Intervention Project)
12 (per project)
Additional page limits described in the SF424 Application Guide and the Table of Page Limits
(http://grants.nih.gov/grants/guide/url_redirect.htm?id=11133) must be followed.
Instructions for the Submission of Multi-Component Applications

The following section supplements the instructions found in the SF424 (R&R) Application Guide, and
should be used for preparing a multi-component application.
The application should consist of the following components:
Overall: required
Administrative Core: required
Consortium Core: required
Methodology Core: required
Dissemination Core: required
Intervention Project: required, minimum of two, maximum of three
Overall Component
When preparing your application in ASSIST, use Component Type Overall.
All instructions in the SF424 (R&R) Application Guide must be followed, with the following additional
instructions, as noted.
SF424 (R&R) Cover (Overall)

Complete entire form.
PHS 398 Cover Page Supplement (Overall)

Note: Human Embryonic Stem Cell lines from other components should be repeated in cell line table in
Overall component.
Research & Related Other Project Information (Overall)

Follow standard instructions.
Project/Performance Site Location(s) (Overall)

Enter primary site only.
A summary of Project/Performance Sites in the Overall section of the assembled application image in
eRA Commons compiled from data collected in the other components will be generated upon
submission.
Research & Related Senior/Key Person Profile (Overall)

Include only the Project Director/Principal Investigator (PD/PI) and any multi-PDs/PIs (if applicable to
this FOA) for the entire application.
A summary of Senior/Key Persons followed by their Biographical Sketches in the Overall section of the
assembled application image in eRA Commons will be generated upon submission.
Budget (Overall)
The only budget information included in the Overall component is the Estimated Project Funding
section of the SF424 (R&R) Cover.

A budget summary in the Overall section of the assembled application image in eRA Commons
compiled from detailed budget data collected in the other components will be generated upon
submission.
PHS 398 Research Plan (Overall)

Specific Aims: Describe the overall composition, objectives, specific aims, and expected outcomes of
the proposed TCC. Identify the health disparity population(s) to be included in the proposed projects
and describe the chronic diseases/conditions of focus. Delineate the geographic region to be covered,
including the HHS region(s) where the proposed work will occur.
Research Strategy: Identify and delineate the roles of consortium partners. Provide the scientific
rationale for selecting the partners and the population(s) to be included. Describe how the proposed
TCC structure and activities will facilitate productive collaborations, bringing together people with
expertise in multilevel chronic disease prevention.
Describe steps taken prior to or during the development of the application to gain substantive
community input on (1) identification of research topics of importance to the study population(s), and
(2) identification of relevant contextual factors (e.g., social stratification, community ecological context,
cultural factors, environmental factors, health-related policies, etc.) to be considered alongside
individual risk factors.
Explain how the various TCC activities taken together as a whole will significantly contribute to the
integration of chronic disease prevention interventions taking into account the dynamic interplay
between biological, behavioral, social and environmental health risk and protective factors experienced
across the life course.
Explain how the proposed TCC activities will enhance inclusion of health disparity populations in
chronic disease prevention and health promotion research.
Provide an overview of the proposed collaborative intervention projects and describe plans to promote
synergy among them. Describe the scientific rationale and the process used to select the proposed
intervention projects, as well as plans and procedures to monitor and assess progress on those
projects. It is expected that under-performing projects will be discontinued and replaced by new
projects with greater potential as the program evolves and matures.
Identify collaborating NIMHD-supported investigators in the region (if any) who have expertise in
multilevel chronic disease prevention or other relevant resources that could be leveraged to help
achieve TCC goals and objectives and avoid unnecessary duplication. Describe plans for leveraging
any existing core facilities or other shared research resources that are available to support the
proposed activities.
Describe the applicant organization's commitment and capabilities for regional coordination and
collaboration, particularly with community-based organizations, federal, state and local agencies and
private sector partners. Applicant organizations that currently hold federally-funded center awards
should describe center expertise and resources available to support the proposed TCC activities, as
well as how TCC activities are distinct from those of the existing center(s).
Letters of Support: Provide a letter or memorandum of agreement/understanding (MOA/U) for each
proposed consortium partner organization, signed by an authorized official of that organization,

describing its expectations for the partnership and its roles and responsibilities on the project.
The application should also include a detailed statement from the applicant organization's leadership
describing its commitment to the establishment and maintenance of the proposed center. Support
may include but is not limited to provision of professional release time, support staff, facilities, and
other resources that will contribute to the proposed TCC activities.
Resource Sharing Plan: Individuals are required to comply with the instructions for the Resource
Sharing Plans as provided in the SF424 (R&R) Application Guide.
Appendix: Do not use the Appendix to circumvent page limits. Follow all instructions for the Appendix
as described in the SF424 (R&R) Application Guide.
Administrative Core
When preparing your application in ASSIST, use Component Type Admin Core.
SF424 (R&R) Cover (Administrative Core)

Complete only the following fields:
Applicant Information
Type of Applicant (optional)
Descriptive Title of Applicants Project
Proposed Project Start/Ending Dates
PHS 398 Cover Page Supplement (Administrative Core)

Enter Human Embryonic Stem Cells in each relevant component.
Research & Related Other Project Information (Administrative Core)

Human Subjects: Answer only the Are Human Subjects Involved? and 'Is the Project Exempt from
Federal regulations? questions.
Vertebrate Animals: Answer only the Are Vertebrate Animals Used? question.
Project Narrative: Do not complete. Note: ASSIST screens will show an asterisk for this attachment
indicating it is required. However, eRA systems only enforce this requirement in the Overall component
and applications will not receive an error if omitted in other components.
Project /Performance Site Location(s) (Administrative Core)

List all performance sites that apply to the specific component.
Note: The Project Performance Site form allows up to 300 sites, prior to using additional attachment for
additional entries.
Research & Related Senior/Key Person Profile (Administrative Core)

In the Project Director/Principal Investigator section of the form, use Project Role of Other with
Category of Project Lead and provide a valid eRA Commons ID in the Credential field.
In the additional Senior/Key Profiles section, list Senior/Key persons that are working in the
component.
Include a single Biographical Sketch for each Senior/Key person listed in the application
regardless of the number of components in which they participate. When a Senior/Key person is
listed in multiple components, the Biographical Sketch can be included in any one component.
If more than 100 Senior/Key persons are included in a component, the Additional Senior Key
Person attachments should be used.
Budget (Administrative Core)

Budget forms appropriate for the specific component will be included in the application package.
Note: The R&R Budget form included in many of the component types allows for up to 100 Senior/Key
Persons in section A and 100 Equipment Items in section C prior to using attachments for additional
entries. All other SF424 (R&R) instructions apply.
PHS 398 Research Plan (Administrative Core)

Specific Aims: Describe aims to ensure effective management, coordination and support of the TCC's
chronic disease prevention research program and related consortium activities.
Research Strategy: Describe the TCCs organizational and governance structure and explain the roles
and responsibilities of Administrative Core personnel. Describe the processes to be used to allocate
and prioritize fiscal and other resources, as well as procedures for ensuring timely and effective
communication between TCC consortium participants. Include a management plan that describes the
composition and roles of the Steering Committee, as well as any community advisory boards or other
committees proposed to help manage TCC activities. Do not name potential members of the Steering
Committee in the application.
Describe how the Administrative Core will manage, coordinate and supervise the entire range of
proposed TCC activities, monitor progress on intervention projects, and ensure that component plans
are implemented according to proposed timelines.
Include an evaluation plan to monitor progress on proposed TCC activities. The evaluation plan is
intended to facilitate ongoing TCC project management to ensure successful completion of the stated
aims. Describe how the evaluation will be conducted, logic models for the TCC as a whole and for
each proposed core, principal measures and metrics to be used to assess achievement of short- and
long-term goals, and potential sources of data. The plan should address administrative functioning
(process) as well as scientific accomplishments (outcomes) in the following key areas: translational
activities; scope and impact of research; innovation; collaboration and communication; integration and
synergy; and funds management. Describe key milestones and expected outcomes for each area as
appropriate.
NOTE: Under the cooperative agreement mechanism, NIMHD staff will work with TCC award recipients
to develop complementary evaluation methods and measures addressing the scientific impact of the
TCC program at regional and national levels.
Sharing Plans as provided in the SF424 (R&R) Application Guide.
Planned Enrollment Report (Administrative Core)
Not Applicable
PHS 398 Cumulative Inclusion Enrollment Report (Administrative Core)

Not Applicable
Consortium Core
When preparing your application in ASSIST, use Component Type Core.
SF424 (R&R) Cover (Consortium Core)

PHS 398 Cover Page Supplement (Consortium Core)

Research & Related Other Project Information (Consortium Core)

indicating it is required. However, eRA systems only enforce this requirement in the Overall
component and applications will not receive an error if omitted in other components.
Project /Performance Site Location(s) (Consortium Core)

additional entries.
Research & Related Senior/Key Person Profile (Consortium Core)

component.
Budget (Consortium Core)

PHS 398 Research Plan (Consortium Core)

Specific Aims: Describe the aims and objectives that will be pursued to establish the Core as a
regional focal point for organizing and nurturing productive working relationships with a broad crosssection of community organizations, health disparity populations, health service providers, public
health agencies and other stakeholders with an interest in eliminating health disparities. Describe aims
to ensure effective management, coordination and support of the TCC's multilevel chronic disease
prevention research program and related consortium activities.
Research Strategy: Explain the scientific rationale for including the consortium partners in research
involving the proposed study population(s). Summarize the strengths of the proposed consortium,
including relevant expertise, relationships with the study population(s), and experience participating in
productive regional collaborations and partnerships.
Describe specific opportunities to establish or strengthen associations with federal agencies, state and
local health departments and other relevant agencies with expertise and/or interest in the proposed
research, implementation and dissemination activities. Describe strategies and procedures for
assessing the effectiveness of partnerships on an ongoing basis and resolving disputes or
misunderstandings between partner organizations.
Letters of Support: Letters or memoranda of agreement/understanding signed by authorized
representatives of consortium partner organizations are to be included in the application's Overall
Component and should not be duplicated in the Consortium Core component.
Sharing Plans as provided in the SF424 (R&R) Application Guide
Planned Enrollment Report (Consortium Core)

Not Applicable
PHS 398 Cumulative Inclusion Enrollment Report (Consortium Core)

Not Applicable
Methodology Core
SF424 (R&R) Cover (Methodology Core)

PHS 398 Cover Page Supplement (Methodology Core)

Research & Related Other Project Information (Methodology Core)

indicating it is required. However, eRA systems only enforce this requirement in the
Overall component and applications will not receive an error if omitted in other components.
Project /Performance Site Location(s) (Methodology Core)

additional entries.
Research & Related Senior/Key Person Profile (Methodology Core)

component.
Budget (Methodology Core)

PHS 398 Research Plan (Methodology Core)

Specific Aims: Describe the aims and objectives that will be responsible for development of
consistent definitions, theoretical framework, key approaches, and analytic methods for multilevel
chronic disease prevention.

Research Strategy: Describe the roles and responsibilities of key members involved in this core, as
well as any additional collaboration with regional partners with methodology expertise. Core leadership
should include individuals that are likely to be critical to the research methods and study design.
Expertise on economic evaluation is needed.
Describe a comprehensive needs assessment in the community (including social stratification,
community ecological context, cultural factors, environmental factors, health-related policies, etc.).
Describe how to identify barriers to access and utilization of health promotion or preventive care
services and acquire baseline data on multiple chronic diseases (including clinical data, biomarkers, or
other measureable outcomes as necessary). Multimodal methods should be used to triangulate
findings and identify the underlying mechanisms of disparities.
Describe the theoretical or conceptual model supporting the multilevel chronic disease prevention, as
well as the levels proposed in the intervention and the analytic plan to address its impact on individuallevel and contextual factors, the interaction between them and how they influence each other
dynamically. Describe the capabilities of data collection, integration and analysis. Describe the
scalability and sustainability of the proposed study design to reduce disparities in chronic disease
prevention.
Planned Enrollment Report (Methodology Core)

Not Applicable
PHS 398 Cumulative Inclusion Enrollment Report (Methodology Core)

Not Applicable
Intervention Project
When preparing your application in ASSIST, use Component Type Project.
SF424 (R&R) Cover (Intervention Project)

PHS 398 Cover Page Supplement (Intervention Project)

Research & Related Other Project Information (Intervention Project)

and applications will not receive an error if omitted in other components
Project /Performance Site Location(s) (Intervention Project)

additional entries.
Research & Related Senior/Key Person Profile (Intervention Project)

component.
Budget (Intervention Project)

PHS 398 Research Plan (Intervention Project)

Specific Aims: State concisely the overall goals of the proposed intervention project. Identify the
health disparity population(s) to be included and the chronic disease(s) or condition(s) under study. List
succinctly the specific objectives, e.g., to test a stated hypothesis, create a novel design, solve a
specific problem relating to health disparities, challenge an existing paradigm, address a critical barrier
to progress in the field of chronic disease prevention and health promotion as it relates to health
disparities, or develop new technology.
Research Strategy: For research involving human subjects, describe steps taken prior to and/or
during the development of the application to obtain substantive community input into (1) identification
of research topics of importance to the proposed study population(s), and (2) identification of relevant
contextual factors (e.g., social stratification, community ecological context, cultural factors,
environmental factors, health-related policies, etc.) that mediate the effects of interventions targeting
health disparities populations.

Explain how the proposed collaborations will serve to advance scientific knowledge of the interplay
between biological, behavioral, social and environmental risk and protective factors experienced
across the life course.
Describe the multilevel approach used in the project. Describe in detail all levels proposed to receive
interventions and how the partners are going to support such interventions to reduce health disparities.
Describe what type of prevention, primary or secondary, are adopted. Also describe what chronic
disease/condition is being targeted and what potential clinical and other outcome is anticipated.
Describe the timeline of the proposed multilevel intervention and what resources are already available
to develop and conduct such interventions.
Explain how the project will complement and synergize with other intervention projects included in the
application, and how its successful completion will advance the TCC's overall aims and objectives.
Also address plans for leveraging TCC infrastructure and resources to ensure successful completion of
the project's stated aims.
Applications with foreign components that involve data collection in foreign sites must state how the
proposed activities will help improve minority health or reduce health disparities in the United States.
Applications that do not include this information are non-responsive to the FOA
Planned Enrollment Report (Intervention Project)

When conducting clinical research, follow all instructions for completing Planned Enrollment Reports
PHS 398 Cumulative Inclusion Enrollment Report (Intervention Project)

When conducting clinical research, follow all instructions for completing Cumulative Inclusion
Enrollment Report as described in the SF424 (R&R) Application Guide.
Dissemination Core
SF424 (R&R) Cover (Dissemination Core)

PHS 398 Cover Page Supplement (Dissemination Core)

Research & Related Other Project Information (Dissemination Core)

and applications will not receive an error if omitted in other components.
Project /Performance Site Location(s) (Dissemination Core)

additional entries.
Research & Related Senior/Key Person Profile (Dissemination Core)

component.
Budget (Dissemination Core)

PHS 398 Research Plan (Dissemination Core)

Specific Aims: Describe the aims and objectives that will be pursued to support regional
dissemination of multilevel chronic disease prevention, including new interventions developed through
collaborative intervention projects, in collaboration with relevant communities, service providers, other
partner organizations and policy makers.
Research Strategy: Describe the roles and responsibilities of consortium partners involved in this
core, as well as any additional collaboration with health service providers, public health agencies,
policymakers and other relevant stakeholders. Core leadership should include individuals from
organizations that are likely to be critical to the dissemination process and able to use knowledge
generated through research to make informed decisions about policies, programs and/or practices.
Describe strategies to use research findings to inform policy and to promote diffusion, adoption and
sustainability of effective multilevel interventions in relevant communities within the proposed region.
Address ethical considerations for (1) development and/or utilization of variables and measures in
study populations, and (2) communicating research results to the scientific community and the lay
public. Describe plans to ensure protection of study participants and communities from unintended
harms, including risks associated with stigma.
Describe strategies to keep various stakeholders informed, on an ongoing basis, of needs and capacity
assessments, as well as results from intervention projects. Describe steps to assess the effectiveness
of community- or system-level dissemination of interventions and/or health education efforts.
Planned Enrollment Report (Dissemination Core)

Not Applicable
PHS 398 Cumulative Inclusion Enrollment Report (Dissemination Core)

Not Applicable
3. Submission Dates and Times

See Part I. Section III.1 for information regarding the requirements for obtaining a Dun and Bradstreet
Universal Numbering System (DUNS) Number and for completing and maintaining an active System for
Award Management (SAM) registration. Part I. Overview Information contains information about Key Dates.
Applicants are encouraged to submit applications before the due date to ensure they have time to make
any application corrections that might be necessary for successful submission.
Organizations must submit applications to Grants.gov (http://grants.nih.gov/grants/guide/url_redirect.htm?
id=11128) (the online portal to find and apply for grants across all Federal agencies) using ASSIST or other
electronic submission systems. Applicants must then complete the submission process by tracking the
status of the application in the eRA Commons (http://grants.nih.gov/grants/guide/url_redirect.htm?
id=11123), NIHs electronic system for grants administration.
Applicants are responsible for viewing their application before the due date in the eRA Commons to
ensure accurate and successful submission.
Information on the submission process and a definition of on-time submission are provided in the SF424
(R&R) Application Guide.
4. Intergovernmental Review (E.O. 12372)

This initiative is not subject to intergovernmental review.
(http://grants.nih.gov/grants/guide/url_redirect.htm?id=11142)
5. Funding Restrictions
All NIH awards are subject to the terms and conditions, cost principles, and other considerations described
in the NIH Grants Policy Statement (http://grants.nih.gov/grants/guide/url_redirect.htm?id=11120).
Pre-award costs are allowable only as described in the NIH Grants Policy Statement
6. Other Submission Requirements and Information

Applications must be submitted electronically following the instructions described in the SF424 (R&R)
Application Guide. Paper applications will not be accepted.
For information on how your application will be automatically assembled for review and funding
consideration after submission go to: http://grants.nih.gov/grants/ElectronicReceipt/files/Electronic_Multiproject_Application_Image_Assembly.pdf
(http://grants.nih.gov/grants/ElectronicReceipt/files/Electronic_Multiproject_Application_Image_Assembly.pdf).
Applicants must complete all required registrations before the application due date. Section III.
Eligibility Information contains information about registration.
For assistance with your electronic application or for more information on the electronic submission
process, visit Applying Electronically (http://grants.nih.gov/grants/guide/url_redirect.htm?id=11144). If you
encounter a system issue beyond your control that threatens your ability to complete the submission
process on-time, you must follow the Guidelines for Applicants Experiencing System Issues
(http://grants.nih.gov/grants/ElectronicReceipt/support.htm#guidelines).
Important reminders:
All PD(s)/PI(s) and component Project Leads must include their eRA Commons ID in the Credential
field of the Senior/Key Person Profile Component of the SF424(R&R) Application Package. Failure to
register in the Commons and to include a valid PD/PI Commons ID in the credential field will prevent
the successful submission of an electronic application to NIH.
The applicant organization must ensure that the DUNS number it provides on the application is the
same number used in the organizations profile in the eRA Commons and for the System for Award
Management (SAM). Additional information may be found in the SF424 (R&R) Application Guide.
See more tips (http://grants.nih.gov/grants/guide/url_redirect.htm?id=11146) for avoiding common
errors.
Upon receipt, applications will be evaluated for completeness and compliance with application instructions
by the Center for Scientific Review and responsiveness by NIMHD, NIH. Applications that are incomplete,
non-compliant and/or nonresponsive will not be reviewed.
Post Submission Materials

Applicants are required to follow the instructions for post-submission materials, as described in NOT-OD13-030 (http://grants.nih.gov/grants/guide/notice-files/NOT-OD-13-030.html).
Section V. Application Review Information
1. Criteria
Only the review criteria described below will be considered in the review process. As part of the NIH
mission (http://grants.nih.gov/grants/guide/url_redirect.htm?id=11149), all applications submitted to the
NIH in support of biomedical and behavioral research are evaluated for scientific and technical merit
through the NIH peer review system.
Overall Impact - Overall

Reviewers will provide an overall impact score to reflect their assessment of the likelihood for the center to
exert a sustained, powerful influence on the research field(s) involved, in consideration of the following
review criteria and additional review criteria (as applicable for the center proposed).
Scored Review Criteria - Overall

Reviewers will consider each of the review criteria below in the determination of scientific merit, and give a
separate score for each. An application does not need to be strong in all categories to be judged likely to
have major scientific impact. For example, a project that by its nature is not innovative may be essential to
advance a field.
Significance
Does the project address an important problem or a critical barrier to progress in the field? If the aims
of the project are achieved, how will scientific knowledge, technical capability, and/or clinical practice
be improved? How will successful completion of the aims change the concepts, methods,
technologies, treatments, services, or preventative interventions that drive this field?
How likely is the project to yield new insights into the community-based multilevel intervention to
address reduction of disparities in chronic disease prevention in one or more health disparity
populations?
How and to what extent are the proposed activities likely to enhance inclusion of health disparities
populations in chronic disease prevention research?
Do letters or memoranda of agreement/understanding (MOA/U) from proposed consortium partner
organizations raise confidence that each partner organization is actively engaged and committed to
achieving the project's stated aims?
Investigator(s)
Are the PD(s)/PI(s), collaborators, and other researchers well suited to the project? If Early Stage
Investigators or New Investigators, or in the early stages of independent careers, do they have
appropriate experience and training? If established, have they demonstrated an ongoing record of
accomplishments that have advanced their field(s)? If the project is collaborative or multi-PD/PI , do
the investigators have complementary and integrated expertise; are their leadership approach,
governance and organizational structure appropriate for the project?
Does the proposed team include people with demonstrated expertise in prevention research, multilevel
intervention methodology, population health disparities, big data and novel technology, and the
science of translation, implementation and dissemination? Have the PD(s)/PI(s) demonstrated a history
of productive working relationships as scientific collaborators, both in academic settings and in
consortia that include community-based organizations and other stakeholders? Do the partnerships
match with the resources needed for the specific intervention project?

organizations describe adequate qualifications, roles and responsibilities of senior/key personnel and
other significant contributors at those organizations and raise confidence that their involvement will
facilitate achievement of the stated aims?
Innovation
Does the application challenge and seek to shift current research or clinical practice paradigms by
utilizing novel theoretical concepts, approaches or methodologies, instrumentation, or interventions?
Are the concepts, approaches or methodologies, instrumentation, or interventions novel to one field of
research or novel in a broad sense? Is a refinement, improvement, or new application of theoretical
concepts, approaches or methodologies, instrumentation, or interventions proposed?
Does the application propose an innovative conceptual framework, novel strategies or approaches for
integrating individual and contextual level data such that chronic disease prevention interventions are
appropriately informed by multilevel factors that influence health outcomes?
Approach
Are the overall strategy, methodology, and analyses well-reasoned and appropriate to accomplish the
specific aims of the project? Are potential problems, alternative strategies, and benchmarks for
success presented? If the project is in the early stages of development, will the strategy establish
feasibility and will particularly risky aspects be managed?
If the project involves human subjects and/or NIH-defined clinical research, are the plans to address 1)
the protection of human subjects from research risks, and 2) inclusion (or exclusion) of individuals on
the basis of sex/gender, race, and ethnicity, as well as the inclusion or exclusion of children, justified in
terms of the scientific goals and research strategy proposed?
Taken together as a whole, are the proposed TCC activities likely to promote community-based
multilevel interventions that take into account the dynamic interplay between biological, behavioral,
social and environmental health risk and protective factors experienced across the life course? Are the
research designs creative to capture the complexities of different factors?
Is it likely that the proposed TCC activities are sustainable, scalable, and affordable? Is what is
proposed likely to reduce, eliminate or prevent a disparity, based on the supporting theoretical or
conceptual model?
Is there convincing evidence of substantive community input into the selection of proposed research
topics and the identification of relevant community and/or population-level contextual factors to be
examined alongside individual risk factors?
organizations describe adequate roles and responsibilities of each organization in carrying out the
proposed TCC activities and raise confidence that their involvement will facilitate achievement of the
stated aims?
Environment
Will the scientific environment in which the work will be done contribute to the probability of success?
Are the institutional support, equipment and other physical resources available to the investigators
adequate for the project proposed? Will the project benefit from unique features of the scientific
environment, subject populations, or collaborative arrangements?
Does the applicant organization describe its commitment to the establishment and maintenance of the
proposed center in terms that raise confidence in the prospects for success?
Additional Review Criteria - Overall

As applicable for the project proposed, reviewers will evaluate the following additional items while
determining scientific and technical merit, and in providing an overall impact score, but will not give
separate scores for these items.
Protections for Human Subjects

For research that involves human subjects but does not involve one of the six categories of research
that are exempt under 45 CFR Part 46, the committee will evaluate the justification for involvement of
human subjects and the proposed protections from research risk relating to their participation
according to the following five review criteria: 1) risk to subjects, 2) adequacy of protection against
risks, 3) potential benefits to the subjects and others, 4) importance of the knowledge to be gained,
and 5) data and safety monitoring for clinical trials.
For research that involves human subjects and meets the criteria for one or more of the six categories
of research that are exempt under 45 CFR Part 46, the committee will evaluate: 1) the justification for
the exemption, 2) human subjects involvement and characteristics, and 3) sources of materials. For
additional information on review of the Human Subjects section, please refer to the Guidelines for the
Review of Human Subjects (http://grants.nih.gov/grants/guide/url_redirect.htm?id=11175).
Inclusion of Women, Minorities, and Children

When the proposed project involves human subjects and/or NIH-defined clinical research, the
committee will evaluate the proposed plans for the inclusion (or exclusion) of individuals on the basis of
sex/gender, race, and ethnicity, as well as the inclusion (or exclusion) of children to determine if it is
justified in terms of the scientific goals and research strategy proposed. For additional information on
review of the Inclusion section, please refer to the Guidelines for the Review of Inclusion in Clinical
Research (http://grants.nih.gov/grants/guide/url_redirect.htm?id=11174).
Vertebrate Animals
The committee will evaluate the involvement of live vertebrate animals as part of the scientific
assessment according to the following five points: 1) proposed use of the animals, and species,
strains, ages, sex, and numbers to be used; 2) justifications for the use of animals and for the
appropriateness of the species and numbers proposed; 3) adequacy of veterinary care; 4) procedures
for limiting discomfort, distress, pain and injury to that which is unavoidable in the conduct of
scientifically sound research including the use of analgesic, anesthetic, and tranquilizing drugs and/or
comfortable restraining devices; and 5) methods of euthanasia and reason for selection if not
consistent with the AVMA Guidelines on Euthanasia. For additional information on review of the
Vertebrate Animals section, please refer tothe Worksheet for Review of the Vertebrate Animal Section
Biohazards
Reviewers will assess whether materials or procedures proposed are potentially hazardous to research
personnel and/or the environment, and if needed, determine whether adequate protection is proposed.
Resubmissions
Not Applicable
Renewals
Not Applicable
Revisions
Not Applicable
Additional Review Considerations - Overall

As applicable for the project proposed, reviewers will consider each of the following items, but will not
give scores for these items, and should not consider them in providing an overall impact score.
Applications from Foreign Organizations

Not Applicable
Select Agent Research

Reviewers will assess the information provided in this section of the application, including 1) the Select
Agent(s) to be used in the proposed research, 2) the registration status of all entities where Select
Agent(s) will be used, 3) the procedures that will be used to monitor possession use and transfer of
Select Agent(s), and 4) plans for appropriate biosafety, biocontainment, and security of the Select
Agent(s).
Resource Sharing Plans

Reviewers will comment on whether the following Resource Sharing Plans, or the rationale for not
sharing the following types of resources, are reasonable: 1) Data Sharing Plan
(http://grants.nih.gov/grants/guide/url_redirect.htm?id=11151); 2) Sharing Model Organisms
(http://grants.nih.gov/grants/guide/url_redirect.htm?id=11152); and 3) Genomic Data Sharing Plan .
Budget and Period of Support

Reviewers will consider whether the budget and the requested period of support are fully justified and
reasonable in relation to the proposed research.
Administrative Core
Additional Review Criteria - Administrative Core

determining scientific and technical merit, and in providing an overall impact score for the Administrative
Core, but will not give separate scores for these items.
Are strategies to ensure effective management, coordination and support of the TCC's multilevel
chronic disease prevention program and related consortium activities well described and likely to
succeed? Do the proposed approaches for coordinating and supervising TCC activities raise
confidence that each component's aims will be achieved within the project period?
Is the TCC organizational and governance structure adequately described and appropriate for
supporting the stated aims? Does the management plan adequately describe the composition and
roles of the TCC Steering Committee and any other committees proposed to help manage TCC
activities? Are appropriate resources and processes in place to ensure that TCC-supported research
will be carried out in compliance with applicable federal regulations and policies?
Does the applicant include an evaluation plan with a logic model that incorporates appropriate
performance targets, objectives, and intervention outcomes (including economic evaluation)? Is the
proposed evaluation plan well-conceived and described in sufficient detail to judge its utility for
ongoing project management? Is its execution likely to facilitate successful completion of the TCC's
stated aims?
Consortium Core
Additional Review Criteria - Consortium Core

determining scientific and technical merit, and in providing an overall impact score for the Consortium
Are the aims and objectives of the Core well described as a regional focal point for organizing and
nurturing productive working relationships with community organizations, minority and health disparity
populations, health care provider organizations, for-profit or non-profit organizations and other
stakeholders with an interest in using multilevel chronic disease prevention approaches to improve
health equity? Are the proposed strategies to keep consortium partners and other stakeholders
informed on an ongoing basis of TCC activities adequately described and likely to be effective? Does
the applicant involve more than one community-based organization/American Indian Tribal
Government, either as the applicant or partnering organization?
Are consortium partner organizations and their respective roles and contributions clearly articulated? Is
the scientific rationale for including the consortium partners in research involving the proposed study
population(s) clear and consistent with the overall objectives of the proposed TCC? Do consortium
participants have relevant expertise, working relationships with the study population(s), and experience
participating in productive collaborations and partnerships? Does the Consortium Core leadership
include qualified representatives from consortium partner organizations?
Methodology Core
Additional Review Criteria - Methodology Core

determining scientific and technical merit, and in providing an overall impact score for the Methodology
Is there existing evidence of a high prevalence or incidence of chronic diseases or conditions and lack
of prevention and health promotion interventions or resources in the community identified? Is there
documentation that these communities have a higher prevalence or worse outcomes than other
communities? Does the community include significant representation from one or more US health
disparity populations (Blacks/African Americans, Hispanics/Latinos, American Indians/Alaska Natives,
Asian Americans, Native Hawaiians and Other Pacific Islanders, socioeconomically disadvantaged
populations and rural populations)? Do the proposed interventions involve 500 or more participants
within the community?
Are the theoretical or conceptual models provided supporting the multilevel chronic disease
prevention? Are the levels proposed in the intervention adequate and reasonable? Can the analytic
plan address the impact on different levels and the interaction between them and how they influence
each other dynamically? Can the proposed study design improve the scalability and sustainability of
community-based multilevel intervention?
Does the Core encourage and sustain active participation of investigators and partners to explore new
methodologies or approaches, generate baseline data to support the study design and program
evaluation, and implement promising multilevel interventions in community settings?
Intervention Project
Overall Impact - Intervention Project
Reviewers will provide an overall impact score to reflect their assessment of the likelihood for the project to
exert a sustained, powerful influence on the research field(s) involved, in consideration of the following
review criteria and additional review criteria (as applicable for the project proposed).
Scored Review Criteria - Intervention Project

Reviewers will consider each of the review criteria below in the determination of scientific merit, and give a
separate score for each. An application does not need to be strong in all categories to be judged likely to
have major scientific impact. For example, a project that by its nature is not innovative may be essential to
advance a field.
Significance
Does the project address an important problem or a critical barrier to progress in the field? If the aims
of the project are achieved, how will scientific knowledge, technical capability, and/or clinical practice
be improved? How will successful completion of the aims change the concepts, methods,
technologies, treatments, services, or preventative interventions that drive this field?
Does the application describe steps taken prior to and/or during the development of the application to
obtain substantive community input into (1) identification of research topics of importance to the
proposed study population(s), and (2) identification of relevant contextual factors (e.g., social
stratification, community ecological context, cultural factors, environmental factors, health-related
policies, etc.) that mediate the effects of interventions targeting health disparities populations?
Investigator(s)
Are the PD(s)/PI(s), collaborators, and other researchers well suited to the project? If Early Stage
Investigators or New Investigators, or in the early stages of independent careers, do they have
appropriate experience and training? If established, have they demonstrated an ongoing record of
accomplishments that have advanced their field(s)? If the project is collaborative or multi-PD/PI , do
the investigators have complementary and integrated expertise; are their leadership approach,
governance and organizational structure appropriate for the project?
Does the application explain how the proposed collaborations will serve to advance scientific
knowledge of the interplay between biological, behavioral, social and environmental risk and protective
factors experienced across the life course?
Innovation
Does the application challenge and seek to shift current research or clinical practice paradigms by
utilizing novel theoretical concepts, approaches or methodologies, instrumentation, or interventions?
Are the concepts, approaches or methodologies, instrumentation, or interventions novel to one field of
research or novel in a broad sense? Is a refinement, improvement, or new application of theoretical

concepts, approaches or methodologies, instrumentation, or interventions proposed?
Approach
Are the overall strategy, methodology, and analyses well-reasoned and appropriate to accomplish the
specific aims of the project? Are potential problems, alternative strategies, and benchmarks for
success presented? If the project is in the early stages of development, will the strategy establish
feasibility and will particularly risky aspects be managed?
If the project involves human subjects and/or NIH-defined clinical research, are the plans to address 1)
the protection of human subjects from research risks, and 2) inclusion (or exclusion) of individuals on
the basis of sex/gender, race, and ethnicity, as well as the inclusion or exclusion of children, justified in
terms of the scientific goals and research strategy proposed?
Does the application describe the multilevel approach used in the project, including details on all levels
proposed to receive interventions and how the partners are going to support such interventions to
reduce health disparities? What types of prevention, primary or secondary, are adopted? What chronic
disease/condition is being targeted and what potential clinical and other outcomes are anticipated? Is
the timeline of the proposed multilevel intervention included, and does the application describe
resources already available to develop and conduct such interventions?
Environment
Will the scientific environment in which the work will be done contribute to the probability of success?
Are the institutional support, equipment and other physical resources available to the investigators
adequate for the project proposed? Will the project benefit from unique features of the scientific
environment, subject populations, or collaborative arrangements?
Additional Review Criteria - Intervention Project

determining scientific and technical merit, and in providing an overall impact score for the Intervention
Project, but will not give separate scores for these items.
Complementarity of Intervention Projects

Does the application explain how the project will complement and synergize with other intervention
projects included in the application, and how its successful completion will advance the TCC's overall
aims and objectives?
Protections for Human Subjects

For research that involves human subjects but does not involve one of the six categories of research
that are exempt under 45 CFR Part 46, the committee will evaluate the justification for involvement of
human subjects and the proposed protections from research risk relating to their participation
according to the following five review criteria: 1) risk to subjects, 2) adequacy of protection against
risks, 3) potential benefits to the subjects and others, 4) importance of the knowledge to be gained,
and 5) data and safety monitoring for clinical trials.
For research that involves human subjects and meets the criteria for one or more of the six categories
of research that are exempt under 45 CFR Part 46, the committee will evaluate: 1) the justification for
the exemption, 2) human subjects involvement and characteristics, and 3) sources of materials. For
additional information on review of the Human Subjects section, please refer to the Guidelines for the
Review of Human Subjects (http://grants.nih.gov/grants/guide/url_redirect.htm?id=11175).
Inclusion of Women, Minorities, and Children

When the proposed project involves human subjects and/or NIH-defined clinical research, the
committee will evaluate the proposed plans for the inclusion (or exclusion) of individuals on the basis of
sex/gender, race, and ethnicity, as well as the inclusion (or exclusion) of children to determine if it is
justified in terms of the scientific goals and research strategy proposed. For additional information on
review of the Inclusion section, please refer to the Guidelines for the Review of Inclusion in Clinical
Research (http://grants.nih.gov/grants/guide/url_redirect.htm?id=11174).
Vertebrate Animals
The committee will evaluate the involvement of live vertebrate animals as part of the scientific
assessment according to the following five points: 1) proposed use of the animals, and species,
strains, ages, sex, and numbers to be used; 2) justifications for the use of animals and for the
appropriateness of the species and numbers proposed; 3) adequacy of veterinary care; 4) procedures
for limiting discomfort, distress, pain and injury to that which is unavoidable in the conduct of
scientifically sound research including the use of analgesic, anesthetic, and tranquilizing drugs and/or
comfortable restraining devices; and 5) methods of euthanasia and reason for selection if not
consistent with the AVMA Guidelines on Euthanasia. For additional information on review of the
Vertebrate Animals section, please refer tothe Worksheet for Review of the Vertebrate Animal Section
Biohazards
Reviewers will assess whether materials or procedures proposed are potentially hazardous to research
personnel and/or the environment, and if needed, determine whether adequate protection is proposed.
Resubmissions
Not Applicable
Renewals
Not Applicable
Revisions
Not Applicable
Additional Review Considerations - Intervention Project

As applicable for the project proposed, reviewers will consider each of the following items, but will not give
scores for these items, and should not consider them in providing an overall impact score.
Applications from Foreign Organizations

Not Applicable
Select Agent Research
Reviewers will assess the information provided in this section of the application, including 1) the Select
Agent(s) to be used in the proposed research, 2) the registration status of all entities where Select
Agent(s) will be used, 3) the procedures that will be used to monitor possession use and transfer of
Select Agent(s), and 4) plans for appropriate biosafety, biocontainment, and security of the Select
Agent(s).
Resource Sharing Plans

Reviewers will comment on whether the following Resource Sharing Plans, or the rationale for not
sharing the following types of resources, are reasonable: 1) Data Sharing Plan
(http://grants.nih.gov/grants/guide/url_redirect.htm?id=11151); 2) Sharing Model Organisms
(http://grants.nih.gov/grants/guide/url_redirect.htm?id=11152); and 3) Genomic Data Sharing Plan .
Budget and Period of Support

Reviewers will consider whether the budget and the requested period of support are fully justified and
reasonable in relation to the proposed research.
Dissemination Core
Additional Review Criteria - Dissemination Core

determining scientific and technical merit, and in providing an overall impact score for the Dissemination
Are the proposed activities likely to promote or enhance dissemination of multilevel chronic disease
prevention in collaboration with relevant communities, service providers, other partner organizations
and policy makers? Are steps to assess the effectiveness of dissemination efforts adequately
described and appropriate?
Is there an appropriate plan to dissemination project findings to the community at large (rather than
just community partners)? Does the application adequately address ethical considerations for (1)
development and/or utilization of variables and measures in study populations, and (2) communicating
research results to the scientific community and the lay public? Are plans to ensure protection of
participating communities or groups from unintended harms, including risks associated with stigma,
adequately addressed?
2. Review and Selection Process

Applications will be evaluated for scientific and technical merit by (an) appropriate Scientific Review
Group(s), convened by NIMHD in accordance with NIH peer review policy and procedures
(http://grants.nih.gov/grants/guide/url_redirect.htm?id=11154), using the stated review criteria. Assignment
to a Scientific Review Group will be shown in the eRA Commons.
As part of the scientific peer review, all applications:
May undergo a selection process in which only those applications deemed to have the highest
scientific and technical merit (generally the top half of applications under review) will be discussed
and assigned an overall impact score.
Will receive a written critique.
Appeals (http://grants.nih.gov/grants/guide/notice-files/NOT-OD-11-064.html) of initial peer review will not

be accepted for applications submitted in response to this FOA.
Applications will be assigned to the appropriate NIH Institute or Center. Applications will compete for
available funds with all other recommended applications submitted in response to this FOA. Following
initial peer review, recommended applications will receive a second level of review by the National Advisory
Council on Minority Health and Health Disparities. The following will be considered in making funding
decisions:
Scientific and technical merit of the proposed project as determined by scientific peer review.
Availability of funds.
Relevance of the proposed project to program priorities.
Geographic distribution of award recipients.
3. Anticipated Announcement and Award Dates

After the peer review of the application is completed, the PD/PI will be able to access his or her Summary
Statement (written critique) via the eRA Commons (http://grants.nih.gov/grants/guide/url_redirect.htm?
id=11123).
Information regarding the disposition of applications is available in the NIH Grants Policy Statement
Section VI. Award Administration Information

1. Award Notices
If the application is under consideration for funding, NIH will request "just-in-time" information from the
applicant as described in the NIH Grants Policy Statement
A formal notification in the form of a Notice of Award (NoA) will be provided to the applicant organization
for successful applications. The NoA signed by the grants management officer is the authorizing document
and will be sent via email to the grantees business official.
Awardees must comply with any funding restrictions described in Section IV.5. Funding Restrictions.
Selection of an application for award is not an authorization to begin performance. Any costs incurred
before receipt of the NoA are at the recipient's risk. These costs may be reimbursed only to the extent
considered allowable pre-award costs.
Any application awarded in response to this FOA will be subject to terms and conditions found on the
Award Conditions and Information for NIH Grants (http://grants.nih.gov/grants/guide/url_redirect.htm?
id=11158) website. This includes any recent legislation and policy applicable to awards that is highlighted
on this website.
2. Administrative and National Policy Requirements

All NIH grant and cooperative agreement awards include the NIH Grants Policy Statement
(http://grants.nih.gov/grants/guide/url_redirect.htm?id=11120) as part of the NoA. For these terms of
award, see the NIH Grants Policy Statement Part II: Terms and Conditions of NIH Grant Awards, Subpart A:
General (http://grants.nih.gov/grants/guide/url_redirect.htm?id=11157) and Part II: Terms and Conditions
of NIH Grant Awards, Subpart B: Terms and Conditions for Specific Types of Grants, Grantees, and
Activities (http://grants.nih.gov/grants/guide/url_redirect.htm?id=11159). More information is provided at
Award Conditions and Information for NIH Grants (http://grants.nih.gov/grants/guide/url_redirect.htm?
id=11158).
Cooperative Agreement Terms and Conditions of Award

(http://nih-extramural-intranet.od.nih.gov/d/nih/topics/coop/index.htm)The following special terms of award
are in addition to, and not in lieu of, otherwise applicable U.S. Office of Management and Budget (OMB)
administrative guidelines, U.S. Department of Health and Human Services (DHHS) grant administration
regulations at 45 CFR Part 75, and other HHS, PHS, and NIH grant administration policies.
The administrative and funding instrument used for this program will be the cooperative agreement, an
"assistance" mechanism (rather than an "acquisition" mechanism), in which substantial NIH programmatic
involvement with the award recipients is anticipated during the performance of the activities. Under the
cooperative agreement, the NIH purpose is to support and stimulate the recipients' activities by
involvement in and otherwise working jointly with the award recipients in a partnership role; it is not to
assume direction, prime responsibility, or a dominant role in the activities. Consistent with this concept, the
dominant role and prime responsibility resides with the recipients for the project as a whole, although
specific tasks and activities may be shared among the recipients and the NIH as defined below.
The PD(s)/PI(s) will have the primary responsibility for:
Coordinating project activities technically, scientifically and administratively at the recipient
institution and coordinating project activities at other sites that may be supported by the award.
Defining objectives and approaches; collecting and analyzing data; and publishing results,
interpretations, and conclusions of studies conducted under the terms and conditions of the award.
Ensuring that appropriate Institutional Review Board approvals and certifications for research
involving human subjects for all participating sites, collaborators or partners are obtained.
Selecting external members for and participating in the TCC Consortium Steering Committee.
Organizing an annual face-to-face meeting of the TCC Consortium Steering Committee.
Consulting with NIMHD to ensure compliance with relevant grant policies and regulations.
Participating in the TCC Program Coordinating Committee meetings and other PD/PI meetings
convened by NIMHD.
Recipients will retain custody of and have primary rights to the data and software developed under these
awards, subject to Government rights of access consistent with current DHHS, PHS, and NIH policies.
NIH staff have substantial programmatic involvement that is above and beyond the normal
stewardship role in awards, as described below:
NIMHD will assign a Program Official (see below) and Project Scientist(s) to the TCC award. The Project
Scientist(s) will have substantial scientific involvement during the conduct of this activity, through technical
assistance, advice, and coordination. Project Scientists(s) will:
Review and comment on critical stages in the program implementation;
Assist in the interaction between the recipient and investigators at other institutions to promote
collaborations;
Assist in coordinating access to other resources available through statewide, regional, or national
specialized cores or resources;
Retain the option of recommending termination of support if technical performance or

implementation falls below acceptable standards, or when specific key resources cannot be
effectively implemented in a timely manner;
Retain the option to recommend additional infrastructure support within the constraints of the
approved research and negotiated budget;
Convene meetings/workshops to address emerging areas of high priority.
Additionally, the NIMHD program official will be responsible for the normal scientific and programmatic
stewardship of the award and will be named in the award notice. The Program Official will:
Assist with the NIMHDs monitoring of compliance of award-supported activities;
Evaluate progress by reviews of technical or fiscal reports or by site visits to determine that
performance is consistent with objectives, terms and conditions of the award;
Help ensure that activities proposed for development or implementation do not overlap or duplicate
activities supported by other peer-reviewed funding mechanisms;
Provide assistance in reviewing and commenting on all major transitional changes of TCC activities
prior to implementation to ensure consistency with the goals of this FOA;
Link the approaches developed from the TCC to other NIMHD-supported activities to ensure that
information is shared and utilized on the widest basis possible;
Monitor institutional commitments and resources to help ensure that the TCC receives the maximum
chance of stabilization and success;
Assist with the NIMHDs monitoring of financial oversight of the Program.
Areas of Joint Responsibility include:
Establishing a TCC Steering Committee consisting of: 1) the PD(s)/PI(s); 2) two or more members
representing consortium partner organizations, with at least one representative from a non-research
institution, 3) two external members selected by the PD(s)/PI(s); 4) the NIMHD Program Official; and
5) the NIH Project Scientist(s). Each committee member will have one vote except for the NIH staff
members, who will share one vote. The TCC Steering Committee will convene by telephone as
needed and will meet in person at least once a year.
Identifying and facilitating partnerships with other NIMHD award recipients in the respective regions
with expertise and/or interest in multilevel chronic disease prevention and health disparities or other
relevant resources and expertise that could be leveraged to facilitate achievement of the TCC
Program goals and objectives.
Organizing and participating in the TCC Program Coordinating Committee meetings at least annually
to discuss matters of mutual interest and promote information exchange across regions.
Dispute Resolution:
Any disagreements that may arise in scientific or programmatic matters (within the scope of the award)
between award recipients and the NIH may be brought to Dispute Resolution. A Dispute Resolution Panel
composed of three members will be convened. It will have three members: a designee of the Steering
Committee chosen without NIH staff voting, one NIH designee, and a third designee with expertise in the
relevant area who is chosen by the other two; in the case of individual disagreement, the first member may
be chosen by the individual award recipient. This special dispute resolution procedure does not alter the
recipient's right to appeal an adverse action that is otherwise appealable in accordance with PHS
regulation 42 CFR Part 50, Subpart D and DHHS regulation 45 CFR Part 16.
3. Reporting
When multiple years are involved, awardees will be required to submit the Research Performance Progress
Report (RPPR) (http://grants.nih.gov/grants/rppr/index.htm) annually and financial statements as required
in the NIH Grants Policy Statement. (http://grants.nih.gov/grants/guide/url_redirect.htm?id=11161)
A final progress report, invention statement, and the expenditure data portion of the Federal Financial
Report are required for closeout of an award, as described in the NIH Grants Policy Statement
The Federal Funding Accountability and Transparency Act of 2006 (Transparency Act), includes a
requirement for awardees of Federal grants to report information about first-tier subawards and executive
compensation under Federal assistance awards issued in FY2011 or later. All awardees of applicable NIH
grants and cooperative agreementsare required to report to the Federal Subaward Reporting System
(FSRS) available at www.fsrs.gov (http://grants.nih.gov/grants/guide/url_redirect.htm?id=11170) on all
subawards over $25,000. See the NIH Grants Policy Statement
(http://grants.nih.gov/grants/guide/url_redirect.htm?id=11171) for additional information on this reporting
requirement.
Section VII. Agency Contacts

We encourage inquiries concerning this funding opportunity and welcome the opportunity to answer
questions from potential applicants.
Application Submission Contacts

eRA Commons Help Desk (Questions regarding eRA Commons registration, submitting and tracking an
application, documenting system problems that threaten submission by the due date, post submission
issues)
Finding Help Online:http://grants.nih.gov/support/ (http://grants.nih.gov/support/) (preferred method of
contact)
Telephone: 301-402-7469 or 866-504-9552 (Toll Free)
Grants.gov Customer Support (http://www.grants.gov/contactus/contactus.jsp) (Questions regarding
Grants.gov registration and submission, downloading forms and application packages)
Contact Center Telephone: 800-518-4726
Web ticketing system: https://grants-portal.psc.gov/ContactUs.aspx (https://grantsportal.psc.gov/ContactUs.aspx)
Email: support@grants.gov (mailto:support@grants.gov)
GrantsInfo (Questions regarding application instructions and process, finding NIH grant resources)
Email: GrantsInfo@nih.gov (mailto:GrantsInfo@nih.gov) (preferred method of contact)
Telephone: 301-435-0714
Scientific/Research Contact(s)
Xinzhi Zhang, MD, PhD
National Institute on Minority Health and Health Disparities (NIMHD)
Telephone: 301-594-6136
Email: Xinzhi.Zhang@nih.gov (mailto:Xinzhi.Zhang@nih.gov)
Peer Review Contact(s)
Maryline Laude-Sharp, PhD

Telephone: 301-451-9536
Email: mlaudesharp@mail.nih.gov (mailto:mlaudesharp@mail.nih.gov)
Financial/Grants Management Contact(s)

Priscilla Grant, JD
Telephone: 301-594-8412
Email: grantp@mail.nih.gov (mailto:grantp@mail.nih.gov)
Section VIII. Other Information

Recently issued trans-NIH policy notices (http://grants.nih.gov/grants/guide/url_redirect.htm?id=11163)
may affect your application submission. A full list of policy notices published by NIH is provided in the NIH
Guide for Grants and Contracts (http://grants.nih.gov/grants/guide/url_redirect.htm?id=11164). All awards
are subject to the terms and conditions, cost principles, and other considerations described in the NIH
Grants Policy Statement (http://grants.nih.gov/grants/guide/url_redirect.htm?id=11120).
Authority and Regulations

Awards are made under the authorization of Sections 301 and 405 of the Public Health Service Act as
amended (42 USC 241 and 284) and under Federal Regulations 42 CFR Part 52 and 45 CFR Part 75.
Weekly TOC for this Announcement (/grants/guide/WeeklyIndex.cfm?08-07-15)

NIH Funding Opportunities and Notices (/grants/guide/index.html)
(/grants/oer.htm)
(http://www.hhs.gov/)
Department of Health
and Human Services (HHS)
(http://www.usa.gov/)
NIH... Turning Discovery Into Health
Note: For help accessing PDF, RTF, MS Word, Excel, PowerPoint, Audio or Video files, see Help
Downloading Files (/grants/edocs.htm).

RFA-MD-15-014 - NIMHD Transdisciplinary Collaborative Centers For Health Disparities Research On Chronic Disease Prevention (U54)

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RFA-MD-15-014 - NIMHD Transdisciplinary Collaborative Centers For Health Disparities Research On Chronic Disease Prevention (U54)

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Department of Health and Human Services

Part 1. Overview Information

Components of Participating Organizations

Funding Opportunity Title

NIMHD Transdisciplinary Collaborative Centers for Health Disparities

Funding Opportunity Announcement (FOA) Number

Catalog of Federal Domestic Assistance (CFDA) Number(s)

Funding Opportunity Purpose

Open Date (Earliest Submission Date)

Letter of Intent Due Date(s)

Application Due Date(s)

AIDS Application Due Date(s)

Scientific Merit Review

Advisory Council Review

Earliest Start Date

Due Dates for E.O. 12372

** ELECTRONIC APPLICATION SUBMISSION REQUIRED**

Required Application Instructions

Part 2. Full Text of Announcement

(http://www.hhs.gov/about/regions/). Applicant-defined regions may fall within a single HHS region or

Section II. Award Information

Application Types Allowed

Funds Available and Anticipated Number of Awards

Award Project Period

NIH grants policies as described in the NIH Grants Policy Statement

Section III. Eligibility Information

eRA Commons (http://grants.nih.gov/grants/guide/url_redirect.htm?id=11123) - Applicants must

Eligible Individuals (Program Director/Principal Investigator)

3. Additional Information on Eligibility

Section IV. Application and Submission Information

2. Content and Form of Application Submission

Core (use for Consortium Core, Methodology

Core (use for Consortium Core, Methodology

Project (use for Intervention Project)

Instructions for the Submission of Multi-Component Applications

SF424 (R&R) Cover (Overall)

PHS 398 Cover Page Supplement (Overall)

Research & Related Other Project Information (Overall)

Project/Performance Site Location(s) (Overall)

Research & Related Senior/Key Person Profile (Overall)

section of the SF424 (R&R) Cover.

PHS 398 Research Plan (Overall)

proposed consortium partner organization, signed by an authorized official of that organization,

SF424 (R&R) Cover (Administrative Core)

PHS 398 Cover Page Supplement (Administrative Core)

Research & Related Other Project Information (Administrative Core)

Project /Performance Site Location(s) (Administrative Core)

Research & Related Senior/Key Person Profile (Administrative Core)

Budget (Administrative Core)

PHS 398 Research Plan (Administrative Core)

Planned Enrollment Report (Administrative Core)

PHS 398 Cumulative Inclusion Enrollment Report (Administrative Core)

SF424 (R&R) Cover (Consortium Core)

PHS 398 Cover Page Supplement (Consortium Core)

Research & Related Other Project Information (Consortium Core)

Project /Performance Site Location(s) (Consortium Core)

Research & Related Senior/Key Person Profile (Consortium Core)

Budget (Consortium Core)

PHS 398 Research Plan (Consortium Core)

Planned Enrollment Report (Consortium Core)

PHS 398 Cumulative Inclusion Enrollment Report (Consortium Core)

SF424 (R&R) Cover (Methodology Core)

Complete only the following fields:

ELECTRONIC APPLICATION SUBMISSION REQUIRED