Académique Documents
Professionnel Documents
Culture Documents
E number range
Subranges
Description
100109 yellows
110119 oranges
120129 reds
100199 (full list)
130139 blues & violets
Colours
140149 greens
150159 browns & blacks
160199 gold and others
200209 sorbates
210219 benzoates
220229 sulphites
230239 phenols & formates (methanoates)
200299 (full list)
240259 nitrates
Preservatives
260269 acetates (ethanoates)
270279 lactates
280289 propionates (propanoates)
290299 others
300305 ascorbates (vitamin C)
306309 Tocopherol (vitamin E)
310319 gallates & erythorbates
320329 lactates
300399 (full list)
Antioxidants & acidity
330339 citrates & tartrates
regulators
340349 phosphates
350359 malates & adipates
360369 succinates & fumarates
370399 others
400409 alginates
410419 natural gums
420429 other natural agents
430439 polyoxyethene compounds
400499 (full list)
Thickeners, stabilisers & 440449 natural emulsifiers
emulsifiers
450459 phosphates
460469 cellulose compounds
470489 fatty acids & compounds
490499 others
500599 (full list)
500509 mineral acids & bases
pH regulators & anti-caking 510519 chlorides & sulphates
agents
520529 sulphates & hydroxides
530549 alkali metal compounds
550559 silicates
570579
580599
620629
630639
640649
700713
900909
910919
920929
930949
950969
990999
waxes
synthetic glazes
improving agents
packaging gases
sweeteners
foaming agents
New chemicals that do not fall into standard
11001599
classification schemes
NB: Not all examples of a class fall into the given numeric range. Moreover, many
chemicals, particularly in the E400499 range, have a variety of purposes.
E100E199 (colours)
Code Name(s)
Colour
Yellow-orange
E101
Status
Approved in the EU.[9]
Approved in the US.[10]
Approved in the EU.[9]
Approved in the US.[10]
Code Name(s)
E101a Riboflavin-5'-Phosphate
Colour
Yellow-orange
Lemon yellow
E103 Alkannin[11]
Red-brown
Status
Approved in the EU.[9]
Approved in the EU.[9]
Approved in the US.[10]
E110
Yellow
Yellow
Yellow
Yellow-orange
Dark red
Red to maroon
Dark red
Red
Red
E126 Ponceau 6R
Red
Red
E128 Red 2G
E129 Allura Red AC (FD&C Red 40)
Red
Red
Code Name(s)
Colour
Green
Green
Sea green
Brown
Brown
Brown
E150d
E151
E152
E153
Brown
Black
Black
Black
Green
Status
Banned in Switzerland[citation
needed]
. Undergoing a
voluntary phase out in the
UK. Approved in the US.[10]
Brown
Code Name(s)
Colour
yellow
Ethyl ester of beta-apo-8'-carotenic Orange-red to
E160f
acid (C 30)
yellow
Golden-yellow
E161a Flavoxanthin
and brownish
Orange-red to
E161b Lutein
yellow
E161c Cryptoxanthin
Orange-red
E161d Rubixanthin
Orange-red
E161e Violaxanthin
Orange
E161f Rhodoxanthin
Purple
E161g Canthaxanthin
Violet
E161h Zeaxanthin
E161i Citranaxanthin
E161j Astaxanthin
Orange-red
Deep violet
Red
Red
E163
E164
E170
E171
E172
E173
E174
E175
E180
E181
E182
Status
Approved in the US.[10]
Approved in the EU.[9]
pH
dependent(Red,
Anthocyanins
Approved in the EU.[9]
green and purple
ranges)
Saffron
Orange-red[colour?] Approved in the US.[10]
Calcium carbonate, Chalk
White
Approved in the EU.[9]
Approved in the EU.[9]
Titanium dioxide
White
Approved in the US.[10]
Iron oxides and iron hydroxides
Brown
Approved in the EU.[9]
Approved in the US for
sausage casings.[10]
Aluminium
Silver to grey
Approved in the EU.[9]
Silver
Silver
Approved in the EU.[9]
Gold
Gold
Approved in the EU.[9]
Pigment Rubine, Lithol Rubine BK Red
Approved in the EU.[9]
Tannin
Brown
Orcein, Orchil
Purple
E200E299 (preservatives)
Code
E200
E201
E202
E203
E209
E210
E211
E212
E213
Name(s)
Sorbic acid
Sodium sorbate
Potassium sorbate
Calcium sorbate
Heptyl p-hydroxybenzoate
Benzoic acid
Sodium benzoate
Potassium benzoate
Calcium benzoate
Ethylparaben (ethyl paraE214
hydroxybenzoate)
Sodium ethyl paraE215
hydroxybenzoate
E216 Propylparaben (propyl para-
Purpose
preservative
preservative
preservative
preservative
preservative
preservative
preservative
preservative
preservative
Status
Approved in the EU.[9]
preservative
preservative
preservative
Code Name(s)
hydroxybenzoate)
Sodium propyl paraE217
hydroxybenzoate
Methylparaben (methyl paraE218
hydroxybenzoate)
Sodium methyl paraE219
hydroxybenzoate
E220 Sulphur dioxide
E221 Sodium sulphite
Sodium bisulphite (sodium
E222
hydrogen sulphite)
E223 Sodium metabisulphite
E224 Potassium metabisulphite
E225 Potassium sulphite
E226 Calcium sulphite
Calcium hydrogen sulphite
E227
(preservative)
E228 Potassium hydrogen sulphite
E230 Biphenyl, diphenyl
E231 Orthophenyl phenol
E232 Sodium orthophenyl phenol
E233 Thiabendazole
E234 Nisin
E235 Natamycin, Pimaracin
E236 Formic acid
E237 Sodium formate
E238 Calcium formate
Hexamine (hexamethylene
E239
tetramine)
E240 Formaldehyde
E242 Dimethyl dicarbonate
E249 Potassium nitrite
E250 Sodium nitrite
E251 Sodium nitrate (Chile saltpeter)
E252 Potassium nitrate (Saltpetre)
E260 Acetic acid (preservative)
E261 Potassium acetate (preservative)
E262 Sodium acetates (i) Sodium acetate
(ii) Sodium diacetate (sodium
hydrogen acetate)
E263 Calcium acetate (preservative)
E264 Ammonium acetate
Purpose
Status
preservative
preservative
preservative
preservative
preservative
preservative
preservative
preservative
preservative
preservative
firming agent
preservative
preservative
preservative
preservative
preservative
preservative
preservative
preservative
preservative
preservative
preservative
preservative
preservative
preservative
preservative
preservative
preservative
acidity regulator
acidity regulator
preservative,
acidity regulator
Code
E265
E266
E270
E280
E281
E282
E283
E284
E285
E290
E296
E297
Name(s)
Dehydroacetic acid
Sodium dehydroacetate
Lactic acid (preservative)
Propionic acid
Sodium propionate
Calcium propionate
Potassium propionate
Boric acid
Sodium tetraborate (borax)
Carbon dioxide
Malic acid (acid)
Fumaric acid
Purpose
preservative
preservative
antioxidant
preservative
preservative
preservative
preservative
preservative
preservative
acidity regulator
acidity regulator
acidity regulator
Status
Name(s)
Ascorbic acid (Vitamin C)
Sodium ascorbate
Calcium ascorbate
Potassium ascorbate
Fatty acid esters of ascorbic acid
(Ascorbyl palmitate)
Ascorbyl stearate
Tocopherols (natural)
Alpha-tocopherol (synthetic)
Gamma-tocopherol (synthetic)
Delta-tocopherol (synthetic)
Propyl gallate
Octyl gallate
Dodecyl gallate
Ethyl gallate
Guaiac resin
Erythorbic acid
Sodium erythorbate
Erythorbin acid
Purpose
antioxidant
antioxidant
antioxidant
antioxidant
Status
Approved in the EU.[19]
Approved in the EU.[19]
Approved in the EU.[19]
antioxidant
antioxidant
antioxidant
antioxidant
antioxidant
antioxidant
antioxidant
antioxidant
antioxidant
antioxidant
antioxidant
antioxidant
antioxidant
antioxidant
Code
E318
E319
E320
E321
E322
E323
E324
E325
E326
E327
E328
E329
Name(s)
Sodium erythorbin
tert-Butylhydroquinone (TBHQ)
Butylated hydroxyanisole (BHA)
Butylated hydroxytoluene (BHT)
Lecithin
Anoxomer
Ethoxyquin
Sodium lactate
Potassium lactate (antioxidant)
Calcium lactate
Ammonium lactate
Magnesium lactate
Purpose
antioxidant
antioxidant
antioxidant
antioxidant
emulsifier
antioxidant
antioxidant
acidity regulator
acidity regulator
acidity regulator
acidity regulator
acidity regulator
acid, acidity
regulator
Status
Approved in the EU.[19]
Approved in the EU.[19]
Approved in the EU.[19]
Approved in the EU.[20]
antioxidant
anti-caking
agent, firming
agent
Code Name(s)
Tricalcium phosphate
Ammonium phosphates: (i)
E342 monoammonium phosphate (ii)
diammonium phosphate
Magnesium phosphates (i)
E343 monomagnesium phosphate (ii)
Dimagnesium phosphate
E344 Lecitin citrate
E345 Magnesium citrate
E349 Ammonium malate
Sodium malates (i) Sodium malate
E350
(ii) Sodium hydrogen malate
E351 Potassium malate
E352 Calcium malates (i) Calcium
malate (ii) Calcium hydrogen
malate
E353 Metatartaric acid
E354 Calcium tartrate
E355 Adipic acid
E356 Sodium adipate
E357 Potassium adipate
E359 Ammonium adipate
E363 Succinic acid
E365 Sodium fumarate
E366 Potassium fumarate
E367 Calcium fumarate
E368 Ammonium fumarate
E370 1,4-Heptonolactone
E380 Triammonium citrate
E381 Ammonium ferric citrate
E383 Calcium glycerylphosphate
E384 Isopropyl citrate
E385 Calcium disodium ethylene
diamine tetraacetate, (Calcium
disodium EDTA)
Disodium ethylene diamine
E386
tetraacetate (Disodium EDTA)
E387 Oxystearin
E388 Thiodipropionic acid
Purpose
Status
sequestrant
stabiliser
Code
E389
E390
E391
E392
Name(s)
Dilauryl thiodipropionate
Distearyl thiodipropionate
Phytic acid
Extracts of rosemary
Purpose
Status
Approved in 2010[21]
Status
Approved in the EU.[20]
Approved in the EU.[20]
Approved in the EU.[20]
Approved in the EU.[20]
Approved in the EU.[20]
Approved in the EU.[20]
Approved in the EU.[20]
Approved in the EU.[20]
Approved in the EU.[20]
Code Name(s)
E413 Tragacanth (thickener) (stabiliser)
Acacia gum (gum arabic)
E414
(thickener) (stabiliser)
E415 Xanthan gum (thickener)
E416 Karaya gum (thickener) (stabiliser)
E417 Tara gum (thickener)
E418 Gellan gum (thickener) (stabiliser)
E419 Gum ghatti (thickener) (stabiliser)
Sorbitol (i) Sorbitol (ii) Sorbitol
E420
syrup (emulsifier) (sweetener)
E421 Mannitol (anti-caking agent)
E422 Glycerol (emulsifier)
E424 Curdlan
E425
Purpose
emulsifier
Status
Approved in the EU.[20]
emulsifier
stabiliser
emulsifier
stabiliser
emulsifier
emulsifier
humectant
sweetener
sweetener
emulsifier
emulsifier
emulsifier
emulsifier
emulsifier
emulsifier
gelling agent
emulsifier
emulsifier
emulsifier
emulsifier
Code Name(s)
diphosphate (iii) Tetrasodium
diphosphate (iv) Dipotassium
diphosphate (v) Tetrapotassium
diphosphate (vi) Dicalcium
diphosphate (vii) Calcium
dihydrogen diphosphate
Triphosphates (i) Sodium
triphosphate (pentasodium
E451
triphosphate) (ii) Pentapotassium
triphosphate
Polyphosphates (i) Sodium
polyphosphates (ii) Potassium
polyphosphates (iii) Sodium
E452
calcium polyphosphate (iv)
Calcium polyphosphates (v)
Ammonium polyphosphate
E459 Beta-cyclodextrin
Cellulose (i) Microcrystalline
E460
cellulose (ii) Powdered cellulose
E461 Methyl cellulose
E462 Ethyl cellulose
E463 Hydroxypropyl cellulose
Hypromellose (hydroxypropyl
E464
methylcellulose)
E465 Ethyl methyl cellulose
Carboxymethyl cellulose, Sodium
E466
carboxy methyl cellulose
E467 Ethyl hydroxyethyl cellulose
E468
Status
emulsifier
emulsifier
emulsifier
emulsifier
emulsifier
emulsifier
emulsifier
emulsifier
emulsifier
emulsifier
Enzymically hydrolysed
carboxymethylcellulose
Sodium, potassium and calcium
E470a
salts of fatty acids (emulsifier)
Magnesium salts of fatty acids
E470b
(emulsifier)
E471 Mono- and diglycerides of fatty
acids (glyceryl monostearate,
glyceryl distearate)
E469
Purpose
emulsifier
Code Name(s)
Purpose
Acetic acid esters of mono- and
E472a
emulsifier
diglycerides of fatty acids
Lactic acid esters of mono- and
E472b
emulsifier
diglycerides of fatty acids
Citric acid esters of mono- and
E472c
emulsifier
diglycerides of fatty acids
Tartaric acid esters of mono- and
E472d
emulsifier
diglycerides of fatty acids
Mono- and diacetyl tartaric acid
E472e esters of mono- and diglycerides of emulsifier
fatty acids
Mixed acetic and tartaric acid
E472f esters of mono- and diglycerides of emulsifier
fatty acids
E472g Succinylated monoglycerides
emulsifier
E473 Sucrose esters of fatty acids
emulsifier
E474 Sucroglycerides
emulsifier
E475 Polyglycerol esters of fatty acids emulsifier
E476 Polyglycerol polyricinoleate
emulsifier
Propane-1,2-diol esters of fatty
E477 acids, propylene glycol esters of
emulsifier
fatty acids
Lactylated fatty acid esters of
E478
emulsifier
glycerol and propane-1
Thermally oxidized soya bean oil
E479b interacted with mono- and
emulsifier
diglycerides of fatty acids
E480 Dioctyl sodium sulphosuccinate
emulsifier
E481 Sodium stearoyl-2-lactylate
emulsifier
E482 Calcium stearoyl-2-lactylate
emulsifier
E483 Stearyl tartrate
emulsifier
E484 Stearyl citrate
emulsifier
E485 Sodium stearoyl fumarate
emulsifier
E486 Calcium stearoyl fumarate
emulsifier
E487 Sodium laurylsulphate
emulsifier
Ethoxylated Mono- and DiE488
emulsifier
Glycerides
E489 Methyl glucoside-coconut oil ester emulsifier
E490 Propane-1,2-diol
E491 Sorbitan monostearate
emulsifier
E492 Sorbitan tristearate
emulsifier
E493 Sorbitan monolaurate
emulsifier
Status
Approved in the EU.[20]
Approved in the EU.[20]
Approved in the EU.[20]
Approved in the EU.[20]
Approved in the EU.[20]
Approved in the EU.[20]
Code
E494
E495
E496
Name(s)
Sorbitan monooleate
Sorbitan monopalmitate
Sorbitan trioleate
PolyoxypropyleneE497
polyoxyethylene polymers
Partial polyglycerol esters of
E498 polycondensed fatty acids of castor
oil
Purpose
emulsifier
emulsifier
emulsifier
Status
Approved in the EU.[20]
Approved in the EU.[20]
Status
Approved in the EU.[18]
Code
E520
E521
E522
E523
E524
E525
E526
E527
E528
E529
E530
E535
E536
E537
E538
E539
E540
E541
E542
E543
E544
E545
E550
E551
E552
E553a
E553b
E554
E555
E556
E557
E558
Name(s)
Aluminium sulphate
Aluminium sodium sulphate
Aluminium potassium sulphate
Aluminium ammonium sulphate
Sodium hydroxide
Potassium hydroxide
Calcium hydroxide (acidity
regulator)
Ammonium hydroxide
Magnesium hydroxide
Calcium oxide (acidity regulator)
Magnesium oxide (acidity
regulator)
Sodium ferrocyanide (acidity
regulator)
Potassium ferrocyanide
Ferrous hexacyanomanganate
Calcium ferrocyanide
Sodium thiosulphate
Dicalcium diphosphate (acidity
regulator)
Sodium aluminium phosphate (i)
Acidic (ii) Basic
Bone phosphate (Essentiale
Calcium Phosphate, Tribasic)
Calcium sodium polyphosphate
Calcium polyphosphate
Ammonium polyphosphate
Sodium Silicates (i) Sodium
silicate (ii) Sodium metasilicate
Silicon dioxide (Silica)
Calcium silicate
(i) Magnesium silicate (ii)
Magnesium trisilicate
Talc
Sodium aluminosilicate (sodium
aluminium silicate)
Potassium aluminium silicate
Calcium aluminosilicate (calcium
aluminium silicate)
Zinc silicate
Bentonite
Purpose
firming agent
firming agent
acidity regulator
acidity regulator
acidity regulator
acidity regulator
Status
Approved in the EU.[18]
Approved in the EU.[18]
Approved in the EU.[18]
Approved in the EU.[18]
Approved in the EU.[18]
Approved in the EU.[18]
firming agent
anti-caking agent
emulsifier
emulsifier
emulsifier
anti-caking agent
anti-caking agent Approved in the EU.[18]
anti-caking agent Approved in the EU.[18]
anti-caking agent Approved in the EU.[18]
anti-caking agent Approved in the EU.[18]
anti-caking agent Approved in the EU.[18]
anti-caking agent Approved in the EU.[18]
anti-caking agent Approved in the EU.[18]
anti-caking agent
anti-caking agent Approved in the EU.[18]
Code
E559
E560
E561
E562
E563
E565
E566
E570
E572
E574
E575
E576
E577
E578
E579
E580
E585
E586
E598
E599
Name(s)
Aluminium silicate (Kaolin)
Potassium silicate
Vermiculite
Sepiolite
Sepiolitic clay
Lignosulphonates
Natrolite-phonolite
Stearic acid (Fatty acid)
Magnesium stearate, calcium
stearate (emulsifier)
Gluconic acid
Glucono delta-lactone (acidity
regulator)
Sodium gluconate
Potassium gluconate
Calcium gluconate
Ferrous gluconate
Magnesium gluconate
Ferrous lactate
4-Hexylresorcinol
Synthetic calcium aluminates
Perlite
Purpose
Status
anti-caking agent Approved in the EU.[18]
anti-caking agent
sequestrant
sequestrant
firming agent
food colouring
food colouring
antioxidant
Name(s)
Glutamic acid
Monosodium glutamate (MSG)
Monopotassium glutamate
Calcium diglutamate
Monoammonium glutamate
Magnesium diglutamate
Guanylic acid
Disodium guanylate, sodium
guanylate
Dipotassium guanylate
Calcium guanylate
Inosinic acid
Disodium inosinate
Dipotassium inosinate
Calcium inosinate
Calcium 5'-ribonucleotides
Disodium 5'-ribonucleotides
Maltol
Ethyl maltol
Sodium aspartate
Alanine (DL-)
Glycine and its sodium salt
L-leucine
Lysine hydrochloride
Zinc acetate
Purpose
flavour enhancer
flavour enhancer
flavour enhancer
flavour enhancer
flavour enhancer
flavour enhancer
flavour enhancer
Status
Approved in the EU.[18]
Approved in the EU.[18]
Approved in the EU.[18]
Approved in the EU.[18]
Approved in the EU.[18]
Approved in the EU.[18]
Approved in the EU.[18]
Purpose
Status
anti-foaming
agent
glazing agent
flavour enhancer
glazing agent
glazing agent
glazing agent
glazing agent
glazing agent
glazing agent
glazing agent
glazing agent
glazing agent
Code Name(s)
Benzoyl peroxide (improving
E928
agent)
E929 Acetone peroxide
Calcium peroxide (improving
E930
agent)
E938 Argon
E939 Helium
E940 Dichlorodifluoromethane
E941 Nitrogen (packaging gas)
E942 Nitrous oxide
E943a Butane
E943b Isobutane
E944 Propane
E945 Chloropentafluoroethane
E946 Octafluorocyclobutane
E948 Oxygen
E949 Hydrogen
E950 Acesulfame potassium
E951 Aspartame
Cyclamic acid and its sodium and
E952 calcium salts, also known as
Cyclamate
E953 Isomalt, Isomaltitol
Saccharin and its sodium,
E954
potassium and calcium salts
Sucralose
E955
(Trichlorogalactosucrose)
E956 Alitame
E957 Thaumatin (sweetener)
E958 Glycyrrhizin (sweetener)
Neohesperidine dihydrochalcone
E959
(sweetener)
E960 Steviol glycosides
E961 Neotame
Aspartame-acesulfame salt
E962
(sweetener)
Maltitol (i) Maltitol (ii) Maltitol
E965
syrup (sweetener) (stabiliser)
E966 Lactitol
E967 Xylitol
E968 Erythritol
E999 Quillaia extract
Purpose
Status
bleach
bleach
packaging gas
packaging gas
packaging gas
propellant
propellant
propellant
propellant
propellant
propellant
propellant
packaging gas
packaging gas
sweetener
sweetener
sweetener
sweetener
sweetener
sweetener
sweetener
flavour enhancer Approved in the EU.[22]
flavour enhancer
flavour enhancer Approved in the EU.[22]
sweetener
sweetener
stabiliser
humectant
sweetener
sweetener
humectant
foaming agent
Purpose
Status
emulsifier
emulsifier
stabiliser, flavour
enhancer
stabiliser, flavour
enhancer
Code
E1102
E1103
E1104
E1105
E1200
E1201
E1202
E1203
E1204
E1400
E1401
E1402
E1403
E1404
E1405
E1410
E1411
E1412
E1413
E1414
E1420
E1421
E1422
E1423
E1430
E1440
E1441
Name(s)
Glucose oxidase
Invertase
Lipases
Lysozyme
Purpose
antioxidant
stabiliser
Status
Approved in the EU.[20]
preservative
stabiliser,
thickening agent,
Polydextrose
Approved in the EU.[18]
humectant,
carrier
Polyvinylpyrrolidone
stabiliser
Approved in the EU.[18]
Polyvinylpolypyrrolidone (carrier) stabiliser
Approved in the EU.[18]
Polyvinyl alcohol
Approved in 2010[21]
Pullulan
Approved in the EU.[18]
Dextrin (Dextrins, roasted starch
thickening agent
white and yellow) (stabiliser)
Modified starch ((Acid-treated
thickening agent
starch) stabiliser)
Alkaline modified starch
thickening agent
(stabiliser)
Bleached starch (stabiliser)
thickening agent
Oxidized starch (emulsifier)
thickening agent Approved in the EU.[18]
Enzyme treated starch
Monostarch phosphate (stabiliser) thickening agent Approved in the EU.[18]
Distarch glycerol (thickening
emulsifier
agent)
Distarch phosphate esterified with
sodium trimetasphosphate;
thickening agent Approved in the EU.[18]
esterified with phosphorus
oxychloride (stabiliser)
Phosphated distarch phosphate
thickening agent Approved in the EU.[18]
(stabiliser)
Acetylated distarch phosphate
thickening agent Approved in the EU.[18]
(emulsifier)
Starch acetate esterified with acetic
thickening agent Approved in the EU.[18]
anhydride (stabiliser)
Starch acetate esterified with vinyl
thickening agent
acetate (stabiliser)
Acetylated Distarch Adipate
thickening agent Approved in the EU.[18]
(stabiliser)
Acetylated distarch glycerol
thickening agent
Distarch glycerine (stabiliser)
thickening agent
Hydroxy propyl starch (emulsifier) thickening agent Approved in the EU.[18]
Hydroxy propyl distarch glycerine thickening agent
Code Name(s)
Purpose
(stabiliser)
Hydroxy propyl distarch phosphate
E1442
thickening agent
(stabiliser)
E1443 Hydroxy propyl distarch glycerol
Starch sodium octenyl succinate
E1450
thickening agent
(emulsifier) (stabiliser)
Acetylated oxidised starch
E1451
thickening agent
(emulsifier)
E1452 Starch aluminium octenyl succinate
E1501 Benzylated hydrocarbons
E1502 Butane-1, 3-diol
E1503 Castor oil
resolving agent
E1504 Ethyl acetate
flavour solvent
E1505 Triethyl citrate
foam stabiliser
E1510 Ethanol
E1516 Glyceryl monoacetate
flavour solvent
E1517 Glyceryl diacetate or diacetin
flavour solvent
E1518 Glyceryl triacetate or triacetin
humectant
E1519 Benzyl alcohol
E1520 Propylene glycol
humectant
[24]
E1521 Polyethylene glycol 8000
E1525 Hydroxyethyl cellulose
thickening agent
Status
Approved in the EU.[18]