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Product Name
Description
Catalog Number
04-0030
Size
2 mg
Alternate Name
N-(2-(2-(dimethylamino)ethoxy)-4-(1H-pyrazol-4-yl)phenyl)-2,3
dihydrobenzo[b][1,4]dioxine-2-carboxamide
Chemical Formula
C22H24N4O4
Structure
Molecular Weight
408.45
CAS Number
N/A
Purity
Formulation
White powder
Solubility
Quality Control
The purity of ROCK II Inhibitor was determined by HPLC analysis. The accurate
mass was determined by mass spectrometry. Cellular toxicity of ROCK II Inhibitor
was tested on mouse embryonic stem cells.
1.
2.
3.
Feng, Y., Yin, Y., Weiser, A., Griffin, E., Cameron, M.D., Lin, L., Ruiz, C.,
Schurer, S.C., Inoue, T., Rao, P.V., Schroter, T., and Lograsso, P. (2008)
Discovery
of
substituted
4-(pyrazol-4-yl)-phenylbenzodioxane-2carboxamides as potent and highly selective Rho kinase (ROCK-II) inhibitors.
J Med Chem 51: 6642-6645.
Olson, M.F. (2008) Applications for ROCK kinase inhibition. Curr Opin Cell
Biol 20: 242-248.
Watanabe, K., Ueno, M., Kamiya, D., Nishiyama, A., Matsumura, M., Wataya,
T., Takahashi, J.B., Nishikawa, S., Muguruma, K., and Sasai, Y. (2007) A ROCK
inhibitor permits survival of dissociated human embryonic stem cells. Nat
Biotechnol 25: 681-686.