PATHOPHYSIOLOGY OF NEPHROTIC SYNDROME

ETIOLOGIES:
PRIMARY:
Infection: Pyelonephritis
Glomerulopnephritis

IgG Level Falls

Altered Immunity

Monitor Intake and

CHON excreted in urine

PROTEINURIA

Stimulates Production of lipoprotein in liver (attempt

Reduced serum albumin level

HYPOALBUMINEMIA

Imbalanced nutrition: Less than body requirements

related to dietary restrictions as evidenced by a
decreased in food and fluid intake

decrease colloidal osmotic pressure in capillary

Decrease GFR

Activates Renin-Angiotensin
System

DIET: high Protein and Low Sodium

Decrease fluid gradient pressure changes /

HYPOVOLEMIA

Production of Antidiuretic Hormone Decrease renal blood flow

Increase hydrostatic pressure

Diuretics

Fluid level accumulates in interstitial spaces and body cavities

Hypertension

Antihypertensive Drugs
Adrenal Secretion of Aldosterone
Monitor BP

Knowledge deficit regarding condition, prognosis,

treatment, self-care, and discharge needs related to
lack of exposure

Foamy Urine

to make for lost protein)

Output

about the disease entity

Steroids

Increase permeability to [plasma CHON / leak of Albumin

HYPERLIPEDEMIA

triglyceride level

Decrease Urine Output

Lack of knowledge of the mother

Hepatitis
Malaria
Cyanotic Heart Disease
Tuberculosis
Infected Vedntriculojugular shunts
Stings/Venoms

Endothelial lining and basement membranes damaged (Renal Glomeruli Damage)

Increase serum cholesterol and

Risk for infection related to depression of

immunologic defenses

Risk for decreased cardiac output related to fluid

deficit

SECONDARY:
Systemic Lupus Erythematosus
Diabetes Mellitus
Allergic Responses
Sickle Cell Anemia
Anaphylactoid Purpura
Renal Vein Throimbosis
Drug Toxicity: TRIMETHADIONE

Impaired skin integrity

related to the
Vasoconstriction
presence of edema as
evidenced by
reddened or taut skin
Increase absorption of Sodium and
or actual breaks in the
water in distal tubules
skin

EDEMA

Abdomen
Eyes

Ascites

Clots Form
Blood flow slows
Clotting Problem Arise

Weigh Daily and dietary

restrictions

Excess fluid volume related to compromised renal

perfusion as evidenced by decreased urine output
and edema
Acute pain related to presence
of edema as evidence by
complaints of pain, and wincing
on movement

Decrease blood flow to kidneys

End Stage Renal Failure

Weight Gain

Periorbital Edema

Scrotum

Increase RBC and Platelet

Albumin IV Transfusion

Dialysis

LEGENDS:
Classical Signs
Physiology changes
Clinical Manifestations
Treatment or Nursing
Interventions
Nursing Diagnoses