FORMAT TUGAS EBM

Nama: Siti Khodizah S

NPM : 1102014252
Kelompok : B 15

1. SKENARIO:
Seorang bapak dan anaknya mendatangi dokter untuk berkonsultasi
masalah kesehatan keluarganya.sang bapak telah lama mengidap
penyakit jantung. Bahkan belum lama istrinya meninggal karena penyakit
jantung. Ia takut anaknya juga terkena penyakit jantung karena si bapak
mengakui bahwa lingkungan dan gaya hidup keluarganya kurang
sehat.kemudian si bapak meminta saran kepada dokter untuk mencegah
penyakit jantung yang dikhawatirkan menyerang anaknya. Dokter pun
menyarankan untuk mengkonsumsi suplemen makanan yang
mengandung antioksidan.
2. PERTANYAAN KLINIS:
Apakah zat antioksidan dapat mencegah penyakit jantung ?
3. KOMPONEN PICO
Patient/Population/Problem
: seorang anak yang orang tuanya
mempunyai riwayat penyakit jantung
Intervention/Indicator:

: anti oksidan

Comparison/Control

Objective/Outcome

:mencegah penyakit jantung

4. TYPE OF STUDY
Randomized Controllad Trial (RCT)
5. TYPE OF QUESTION
diagnosis
6. KATA KUNCI:
cardiovascular disease and antioxidant
7. PEMILIHAN SITUS:
http://web.a.ebscohost.com/ehost/detail/detail?vid=10&sid=7444a9213e49-42ca-926b-2e1f5d36663e
%40sessionmgr4005&hid=4107&bdata=JnNpdGU9ZWhvc3QtbGl2ZQ%3d
%3d#db=mdc&AN=25392110
8. LIMITASI

Limites: Full Text, Date of Publication: 20140701-20141231, Abstract Available, English Language

9. HASIL PENCARIAN:

1.Cardiovascular diseases: oxidative damage and

antioxidant protection
2.Cardiovascular disease-related parameters and oxidative stress in SHROB rats, a
model for metabolic syndrome
Single-step green synthesis and characterization of gold-conjugated polyphenol
nanoparticles with antioxidantand biological activities
3.Oxidative stress is associated with an increased antioxidant defense in elderly
subjects: a multilevel approach.
4.Impaired vascular endothelial growth factor A and inflammation in patients with
peripheral artery disease.
5.Total polyphenols and antioxidant activity in different species of apples grown in
Georgia.
6.Cardiovascular mortality: how can it be prevented?
7.Effect of redox modulating NRF2 activators on chronic kidney disease.
8.Role of oxidative stress on chronic kidney disease progression.
9..SIRT3 interactions with FOXO3 acetylation, phosphorylation and ubiquitinylation
mediate endothelial cell responses to hypoxia
10.sity lipoprotein cholesterol is characterized by elevated oxidative stress.
11.Indoxyl Sulfate-Induced Activation of (Pro)renin Receptor Promotes Cell
Proliferation and Tissue Factor Expression in Vascular Smooth Muscle Cells.
12.Inverse association between serum bilirubin levels and arterial stiffness in Korean
women with type 2 diabetes.
13.Impact of the Superoxide Dismutase 2 Val16Ala Polymorphism on the Relationship
between Valproic Acid Exposure and Elevation of -Glutamyltransferase in Patients with
Epilepsy: A Population Pharmacokinetic-Pharmacodynamic Analysis
14. Growth differentiation factor-15 (GDF-15) levels are associated with cardiac and
renal injury in patients undergoing coronary artery bypass grafting with
cardiopulmonary bypass.
15. Dual role of endothelial nitric oxide synthase in oxidized LDL-induced, p66Shcmediated oxidative stress in cultured human endothelial cells.
16. Disturbed flow enhances inflammatory signaling and atherogenesis by increasing
thioredoxin-1 level in endothelial cell nuclei.
17. Association of chemerin with oxidative stress, inflammation and classical adipokines
in non-diabetic obese patients.
18. Physiological and pathological functions of NADPH oxidases during myocardial
ischemia-reperfusion.
19.ARTIKEL YANG DIPILIH:

Cardiovascular diseases: oxidative damage and

antioxidant protection