SCHEMATIC DIAGRAM OF ALCOHOLIC CIRRHOSIS

Predisposing Factors:

Precipitating Factors:
-Alcoholic (long term ingestion
of at least 80g/day of ethanol)

-Heredity
-Metabolic disorders (Iron
overload, Glycogen storage
disease, Wilsons disease)

Female: 20g/day
Male: 40g/day

-Underlying condition
(Hepatitis, fatty liver, liver
tumor, etc.)

-Poor diet
-Diet high in fat/ low in protein

-Females are more prone

than males but reports have
higher cases in males

-Obesity

Highly civilized countries

Increased liver synthesis of triglycerides & fatty acids,

reduction in oxidation of fatty acids, and decreased
release of lipoprotein

Fat accumulation in the parenchymal cells of liver and

distention of cytoplasm with fats

Liver Steatosis/ Fatty

Liver

Hepatocytes degenerate and become infiltrated with

leukocytes and lymphocytes, now called as Mallorys
Bodies or alcoholic hyalin

Mallorys bodies may result to fibrosis of its

surrounding cells and veins

Inflammation of the Liver

(Hepatitis)

Alcoholic hyalin leads to a hardened hyaline by which

necrosis may occur

Progressive hepatocyte destruction leads to early scar

formation and further damage to liver parenchyma

Liver capsule becomes firm and formation of

regenerative nodules happens

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ALCOHOLIC CIRRHOSIS