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Datasheet of Efaproxiral sodium

Description:.
Efaproxiral, a synthetic allosteric modi?er of hemoglobinoxygen binding af?nity, has been shown to bind reversibly to
hemoglobin, stabilizing the deoxyhemoglobin tetramer conformation to reduce its af?nity for oxygen. Efaproxiral plus oxygen
breathing reduces the radiobiological hypoxic fraction of EMT6 tumors from the value of 24% found in both air-breathing and
oxygen-breathing mice to 9% and improves the response of the tumors to radiation. Carboplatin (100 mg/kg) slowes tumor
growth in air-breathing mice, producing a growth delay of 3.3 days. Efaproxiral plus oxygen increases the growth delay to 5.7
days; this is 2.4 days (71%) greater than that for carboplatin alone and 2.1 days (57%) greater than that for carboplatin plus
oxygen breathing. Efaproxiral plus oxygen breathing, therefore, improves the tumor growth delay obtained with 100 mg/kg
carboplatin to or beyond that obtained with the highly toxic dose of 150 mg/kg carboplatin, but does so without increasing the
toxicity beyond that seen with 100 mg/kg carboplatin in air-breathing mice. Efaproxiral significantly increases tumor
oxygenation by 8.4 to 43.4 mmHg within 5 days in C3H mice with RIF-1 tumors, with maximum increases at 22-31 min after
treatment. Efaproxiral plus oxygen plus Radiation produces tumor growth inhibition throughout the treatment duration in C3H
mice with RIF-1 tumors, and inhibition is significantly different from radiation plus oxygen from day 3 to day 5. For the detailed
information of Efaproxiral sodium, the solubility of Efaproxiral sodium in water, the solubility of Efaproxiral sodium in DMSO,
the solubility of Efaproxiral sodium in PBS buffer, the animal experiment (test) of Efaproxiral sodium, the cell expriment (test)
of Efaproxiral sodium, the in vivo, in vitro and clinical trial test of Efaproxiral sodium, the EC50, IC50,and affinity,of
Efaproxiral sodium, Please contact DC Chemicals..

Chemical Information
Catalog

DC7819

Purity of current batch:

>98%

Molecular Weight (MW)

363.38

Molecular Formula

C20H23NO4.Na

CAS No.

170787-99-2

Solubility (25C)

DMSO

Storage

Store at -20C (desiccating conditions).

Handling:
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months.
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in
advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable
for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room
temperature for at least 1 hour.