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chronic diarrhea : a decrease in fecal consistency lasting for four or more weeks.
ETIOLOGY
o Osmotic diarrhea: Carbohydrate malabsorption
o Fatty diarrhea
Malabsorption syndromes :Short bowel syndrome ,Postresection diarrhea
,Small bowel bacterial overgrowth ,Mesenteric ischemia
Maldigestion :Pancreatic exocrine insufficiency ,Inadequate luminal bile acid
o Inflammatory diarrhea
IBD
Infectious diseases (TB, CMV, Amebiasis )
Ischemic colitis ,Radiation colitis
o Secretory diarrhea :
Laxative abuse
Post-cholecystectomy (from bile salts)
Microscopic (lymphocytic) colitis ,Collagenous colitis
Drugs
Disordered motility :Postvagotomy diarrhea ,Diabetic autonomic neuropathy
Hyperthyroidism ,IBS,
Neuroendocrine tumors: Gastrinoma ,VIPoma ,Carcinoid syndrome
Medullary carcinoma of thyroid
Neoplasia: Colon carcinoma, Lymphoma ,Villous adenoma
Addison's disease
Idiopathic secretory diarrhea
Two different types of microscopic colitis have been generally recognized: Lymphocytic
colitis ,Collagenous colitis
The term microscopic colitis implies that the diagnosis is made by histology. Thus,
colonoscopy usually reveals macroscopically normal colonic mucosa although slight edema,
erythema, and friability may be seen.
Diarrhea following cholecystectomy is related to excessive bile acids entering the colon The
increased bile acids in the colon lead to diarrhea (cholerheic diarrhea). Patients often
respond to treatment with bile-acid binding resins such as cholestyramine ..
Secretory diarrhea Secretory diarrhea characteristically continues despite fasting, is
associated with stool volumes >1 liter/day, and occurs day and night in contrast to osmotic
diarrhea
The stool osmotic gap (290 - 2 ({Na+} + {K+}))
An osmotic gap of >125 mOsm/kg suggests an osmotic diarrhea while a gap of <50
mOsm/kg suggests a secretory diarrhea
History
1. Introduce yourself
2. Personal history
3. Chief complaint
4. HOPI
a. Analysis of the complaint
1.
Onset, course, duration
2.
Stool characteristics
Blood >>>>>>
Oil/food particles>>>>>>
White/tan color >>>>
Nocturnal diarrhea >>>
3.
4.
Associated symptoms
Symptoms of the same system:
Mesenteric vascular insufficiency,
Abdominal pain >>
obstruction, irritable bowel syndrome
Excessive flatus >>>
Carbohydrate malabsorption
Fecal incontinence
Family
history
5. Past history:
a. Past Hx of the same coplaint with detail if present
b. DM, HTN ,heart dz, asthma
c. Previous hospital admission
d. Previous surgeries
e. Blood transfusion
6. Drug history:
a. Medication( name ,duration)
b. Drugs and food allergy
c. Herbal medicine
7. Family history:
a. Hx of the same complaint
b. Hx of chronic medical disease
c. Cause of death of first degree relatives if present
8. Systemic review
9. Social history:
a. Marital state
b. House
c. Medical insurance
d. Smoking, alcohol
physical examination
Specific testing .
The history and physical examination may point toward a specific diagnosis for which
testing may be indicated.
As an example, serologic testing for celiac disease
o would be appropriate in patients with risk factors (such as type 1 diabetes mellitus or
a family history of celiac disease) or those with unexplained iron deficiency anemia
or weight loss from fat malabsorption.
o Diarrhea in patients with diabetes may also be due to
visceral autonomic neuropathy, pancreatic exocrine insufficiency, bacterial
overgrowth, or fecal incontinence (which may be confused with diarrhea).
The minimum laboratory evaluation in most patients should include
o CBC and differential,
o erythrocyte sedimentation rate,
o thyroid function tests,
o serum electrolytes,
o total protein and albumin,
o and stool occult blood.
o most patients require some form of endoscopic evaluation and mucosal biopsy
(either sigmoidoscopy, colonoscopy, or sometimes upper endoscopy), depending
upon the clinical setting
o The stool osmotic gap
o stool cultures to exclude chronic infection,
o imaging of the small and large bowel,