Recently Asked MCQs (Part 1- Part 4)

General physio, biophysics, nerve and

muscle
1) Cross bridges in skeletal
muscles are the structural
components of:
A. Actin
B. Myosin
C. Troponin
D. Tropomyosin
2) Function of tropomyosin:
A. Slides on actin
B. Binds myosin
C. Binds Ca++
D. None of the above
3) Rate of firing of axon
depends on:
A. K+ channel
B. Na+ channel opening
C. Refractory period
D. Na+ channel closing
4) In a neuron, RMP is closest to
equilibrium potential for:
A. Na+
B. ClC. K+
D. Ca++
5) The current flow across a
single ion channel can be
measured by:
A. Patch clamp
technique
B. Voltage clamp
technique
C. Multimeter
D. Iontophoresis.
6) Which of the following is a
ligand-gated ion channel?
A. GABAA receptor
B. GABAB receptor
C. Na+ channel in a
nerve membrane
D. Ca++ channel in the
myocardium.
7) All of the following are true
regarding excitationcontraction coupling
EXCEPT:

A. Acetyl choline is
released at the motor
end plate
B. Ca++ is pumped into
the SR for relaxation
C. Activation of Ttubules releases Ca++
from SR
D. Ca++ binds to
tropomyosin and
activates it.
8) Excitation contraction
coupling in cardiac muscle is
mediated by:
A. Sarcoplasmic calcium
B. Extracellular calcium
C. Extracellular sodium
D. Extracellular
potassium
9) Hyponatremia has no effect
on the RMP because:
A. Cell membrane is
impermeable to Na+
B. ECF Na+ is high
C. Intracellular K+ is
high
D. Equilibrium potential
for Na+ is +60.
10) One of the earliest feature of
developing malignant
hyperthermia is:
A. Hypercarbia
B. Tachycardia
C. Muscle rigidity
D. Metabolic acidosis
11) Peripheral nerve can sustain
ischemia upto:
A. 30 min.
B. 6 hr
C. 12 hr
D. 24 hr
12) The first change in a sharp
cut nerve is:
A. Schwann cell
proliferation
B. Degeneration of
myelin sheath
C. Chromatolysis
D. Degeneration of
neurilemma

13) Magnitude of an AP is
increased by:
A. Lower ECF Na+
B. Increased ECF Na+
C. Lower ECF Ca++
D. Increased ECF Ca++
14) Albumin contributes the
maximum to the oncotic
pressure because it has:
A. High mol.wt., low
concentration
B. Low mol.wt., low
concentration
C. High mol.wt, high
concentration
D. Low mol wt, high
concentration
15) If a supramaximal stimulus is
applied to an excitable tissue
like a nerve or a muscle and it
elicits a response, then the
tissue is said to be in
A. Absolute refractory
period
B. Relative refractory
period
C. Latent period
D. None of the above.
16) Fast fatigue fibers are
recruited during walking
A. In the beginning
B. In the end
C. Throughout the
walking process
D. When small neurons
are excited.

A. SA node
activation
B. AV node
activation
C. Atrial
depolarization
D. Ventricular
depolarization
19) The pressure-volume loop
shifts to right in:
A. Mitral stenosis
B. Mitral regurgitation
C. Aortic stenosis
D. Aortic regurgitation
20) The tendency for turbulent
flow to occur is inversely
proportional to:
A. Diameter of the
vessel
B. Velocity of the flow
C. Viscosity of the
blood
D. Density of blood
21) During BP measurement with
sphygmomanometer:
A. Cuff at the level of
heart
B. Sphygmomanometer
at the level of heart
C. Cuff should be at the
level of heart and
sphygmomanometer
at observers eye
level
D. Both cuff and
sphygmomanometer at
the level of heart

Cardiovascular system
17) Heart rate accelerates during
inspiration and decelerates
during expiration. This is
called as:
(A) sinus arrhythmia
(B) Bainbridge reflex
(C) Cushings reflex
(D) Marys law

18) In His-bundle electrogram,

the A deflection indicates:

22) Peripheral vascular resistance

is best indicated by which of
the following measure?
A. Diastolic BP
B. Pulse pressure as it
tells about actual
pressure difference
and blood flow to
aorta
C. Systolic resistance in
aorta as it increases
in its length.

D. Mean arterial
pressure which is
responsible for blood
flow to an organ.
23) Sympathetic stimulation
decreases the blood flow in
A. Cerebral circulation
B. Coronary circulation
C. Renal circulation
D. Skin.
24) Which of the following
statements is correct?
A. Jugular venous
pressure can be
examined on both
sides of neck
B. Blood pressure can
be measured
simultaneously on
both arms.
C. Radial and ulnar
artery cannot be
examined together
D. Carotid pulse should
be palpated on both
sides together.
25) In isometric exercise, all of
the following increase
EXCEPT:
A. Heart rate
B. Cardiac output
C. Mean arterial
pressure
D. Systemic vascular
resistance
26) Which scientific principle is
the basis for thermodilution
method used in measurement
of cardiac output?
A. Poisseuille-Hagen
principle
B. Bernoulllis principle
C. Stewart-Hamilton
principle
D. Universal gas
equation
27) Calculate the peripheral
vascular resistance from the
following: cardiac output =
5.4 L, BP = 90 mm Hg.

A.
B.
C.
D.

1
2
4
6

28) Which of the following

defines the pressure in the
vascular system in the
absence of blood flow?
A. Pulse pressure
B. Critical closing
pressure
C. Mean circulatory
filling pressure
D. Perfusion pressure.
29) The left atrial v wave is
larger than a wave in
comparison to right atrium
because
A. Left side is high
pressure system
B. Left atrium is more
compliant
C. Left atrium is
compressed
posteriorly by
pulmonary veins
D. Right atrial pressure
is transmitted into the
pulmonary
circulation.

Respiratory system
30) Which cells produce
surfactant in conducting parts
of the lung?
A. Goblet cells
B. Brush cells
C. Basal cells
D. Clara cells
31) Oxygen therapy is of very
limited value in all types of
hypoxia EXCEPT:
A. Hypoxic
B. Anemic
C. Stagnant
D. Histotoxic
32) Apex of an upright lung,
compared to base, has:

A. Less negative
intrapleural
pressure
B. High ventilation
C. Larger alveoli
D. Low pH in endcapillary blood
33) Pulmonary surfactant reduces
all the following EXCEPT:
A. Filtration forces
from pulmonary
capillaries
B. Surface tension
C. Transpulmonary
pressure
D. Alveolar radius
34) Heads paradoxical reflex is
due to stimulation of:
A. J-receptors
B. Irritant receptors
of lung
C. Pleural stretch
receptors
D. Diaphragmatic
nerve
35) If PO2 is 60 mm Hg, what is
the Hb saturation?
A. 60%
B. 70%
C. 80%
D. 90%
36) The function of carotid body
is to measure:
A. PO2 in arterial blood
B. PO2 in venous blood
C. CO2 in arterial blood
D. CO2 in venous blood
37) A person is having normal
compliance and increased
airway breathing. Most
economical way of breathing
would be:
A. Rapid & deep
B. Rapid & shallow
C. Slow & deep
D. Slow & shallow
Digestive system

38) Maximum concentration of

K+ is present in:
A. Saliva
B. Gastric juice
C. Pancreatic juice
D. Colonic secretion
39) The most important hormone
that increases gall bladder
contraction after a fatty meal
is:
A. Gastrin
B. Secretin
C. CCK
D. GIP.
Kidney, Body fluids
40) What is the pathology of
edema in nephrotic
syndrome?
A. Reduced plasma
protein
B. Sodium and water
retention
C. Increased venous
pressure
D. Hyperlipidemia
41) One of the following is NOT
a part of countercurrent
mechanism:
A. Collecting duct
B. Thick ascending limb
of loop of Henle
C. Thin ascending limb
of loop of Henle
D. Vasa recta
42) Mechanism of
tubuloglomerular feedback
occurs by:
A. ADH action in
collecting duct
B. Balance between
ascending and
descending loop of
Henle
C. Sensing NaCl in
macula densa
D. Constant solute load
in distal tubule

43) If creatinine clearance of the

patient is 135 mL/min, what
is the GFR?
A. 125
B. 130
C. 135
D. 140

Endocrines, Reproductive system

44) All of the following use
cAMP as a second messenger
EXCEPT:
A. Corticotropin
B. Dopamine
C. Glucagon
D. Thyroxine

D. Both muscle spindle

and Golgi tendon
organ
49) The posterior column of the
spinal cord carries all of the
following sensations
EXCEPT:
A. Proprioception
B. Vibration
C. Touch
D. Pain.
50) Which of the following is
NOT a monoamine
neurotransmitter?
A. Serotonin
B. Glycine
C. GABA
D. Dopamine

CNS, Special senses

45) Voluntary movement of
eyeballs is controlled by:
A. Superior colliculus
B. Frontal eye field
C. Cerebellum
D. Visual cortex
46) Sleep spindles and Kcomplexes are characteristic
of:
A. REM sleep
B. Stage I of nREM
sleep
C. Stage II of nREM
sleep
D. Stage III & IV of
nREM sleep.
47) The receptors for noxious
stimulus are present in which
of the following?
A. Intestine
B. Spleen
C. Liver
D. Mesentery
48) Patellar tendon reflex is due
to stimulation of:
A. Golgi tendon organ
B. Intrafusal dynamic
muscle fiber
C. Static nuclear chain
fiber

51) Vestibulo-ocular reflex is

controlled by:
A. Archicerebellum
B. Floculonodular lobe
C. Neocerebellum
D. Occipital lobe
52) In an encephale isole
preparation, the transection is
made at:
A. First cervical spinal
segment
B. Level of medulla
C. Midpontine level
D. Midcollicular level.
53) Nuclear bag fibers are related
to:
A. Force
B. Length
C. Tone

D. Length and velocity