OPKO Health's Competitors in the Biologics Space

Opko Health, Inc.
(NYSE:OPK) > Competitors

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Recently Disclosed Competitors
Competitor's Name
Exchange:Ticker Symbol
Company
Entity
Abzena plc (AIM:ABZA)
AIM:ABZA
OPKO Biologics
Subsidiary/Investment
8.89
Ambrx, Inc.
OPKO Biologics
19.63
Amunix Operating Inc.
OPKO Biologics
Antares Pharma Inc. (NasdaqCM:ATRS)
NasdaqCM:ATRS
OPKO Biologics
29.65
AtriCure, Inc. (NasdaqGM:ATRC)
NasdaqGM:ATRC
OPKO Biologics
111.86
Bacterin International Holdings, Inc.

(OTCPK:BONE)
BIOLASE, Inc. (NasdaqCM:BIOL)
OTCPK:BONE
OPKO Biologics
35.92
NasdaqCM:BIOL
OPKO Biologics
46.7
Cardica Inc. (NasdaqGM:CRDC)
NasdaqGM:CRDC
OPKO Biologics
3.31
Cerus Corporation (NasdaqGM:CERS)
NasdaqGM:CERS
OPKO Biologics
36.24
Cogentix Medical, Inc. (NasdaqCM:CGNT)
NasdaqCM:CGNT
OPKO Biologics
26.53
Conceptus, Inc.
OPKO Biologics
145.41
Cutera, Inc. (NasdaqGS:CUTR)
NasdaqGS:CUTR
OPKO Biologics
81.02
Cytori Therapeutics, Inc. (NasdaqGM:CYTX)
NasdaqGM:CYTX
OPKO Biologics
8.51
D. Medical Industries Ltd. (TASE:DMED)
TASE:DMED
OPKO Biologics
0.09
Fresenius Kabi AG
OPKO Biologics
3,676.63
Palomar Medical Technologies Inc.
OPKO Biologics
84.8
Pluristem Therapeutics, Inc.

(NasdaqCM:PSTI)
Protalix BioTherapeutics, Inc. (AMEX:PLX)
NasdaqCM:PSTI
OPKO Biologics
0.38
AMEX:PLX
OPKO Biologics
12.87
Sequenom Inc. (NasdaqGS:SQNM)
NasdaqGS:SQNM
OPKO Biologics
152.31
STAAR Surgical Company (NasdaqGM:STAA) NasdaqGM:STAA
OPKO Biologics
73.53
Stereotaxis Inc. (NasdaqCM:STXS)
NasdaqCM:STXS
OPKO Biologics
36.19
SurModics, Inc. (NasdaqGS:SRDX)
NasdaqGS:SRDX
OPKO Biologics
58.57
Xenetic Biosciences, Inc. (OTCPK:XBIO)
OTCPK:XBIO
OPKO Biologics
Prior and Not Recently Disclosed Competitors

Competitor's Name
Exchange:Ticker Symbol
Company
Entity
Affymax, Inc. (OTCPK:AFFY)
OTCPK:AFFY
OPKO Biologics
Alnylam Pharmaceuticals, Inc.

(NasdaqGS:ALNY)
NasdaqGS:ALNY
Opko Health, Inc. (NYSE:OPK)
Self
LTM Revenue ($mm)
LTM Revenue ($mm)

0.04
60.82
Amgen Inc. (NasdaqGS:AMGN)
NasdaqGS:AMGN
OPKO Biologics
Aptose Biosciences Inc. (TSX:APS)
TSX:APS
Self
Arrowhead Research Corp.

(NasdaqGS:ARWR)
Bayer Pharma AG
NasdaqGS:ARWR
Self
0.3
Cytochroma Inc.
5,709.33
Benitec Biopharma Limited (ASX:BLT)
ASX:BLT
Acuity Pharmaceuticals, Inc.
1.88
Benitec Biopharma Limited (ASX:BLT)
ASX:BLT
Self
1.88
Biogen Idec Hemophilia Inc.
OPKO Biologics
6.9
Biolex Therapeutics, Inc. (Out of Business)
OPKO Biologics
3.71
Calando Pharmaceuticals, Inc.
Carl Zeiss Meditec AG (XTRA:AFX)
XTRA:AFX
Self
CytRx Corporation (NasdaqCM:CYTR)
NasdaqCM:CYTR
0.1
Daewoong Pharmaceutical Co., Ltd.

(KOSE:A069620)
Flamel Technologies SA (NasdaqGM:FLML)
KOSE:A069620
OPKO Biologics
675.44
NasdaqGM:FLML
OPKO Biologics
42.92
Galena Biopharma, Inc. (NasdaqCM:GALE)
NasdaqCM:GALE
9.9
Galena Biopharma, Inc. (NasdaqCM:GALE)
NasdaqCM:GALE
Self
9.9
Heidelberg Engineering, Inc.
Self
12.4
Human Genome Sciences Inc.
OPKO Biologics
187.02
InspireMD, Inc. (AMEX:NSPR)
AMEX:NSPR
OPKO Biologics
1.81
Intradigm Corporation (Acquired)
Self
Isis Pharmaceuticals, Inc. (NasdaqGS:ISIS)
NasdaqGS:ISIS
Self
248.58
Janssen-Cilag Limited
OPKO Biologics
688.16
Johnson & Johnson (NYSE:JNJ)
NYSE:JNJ
OPKO Biologics
73,590.0
Kyto BioPharma Inc.
eXegenics Inc.
Marina Biotech, Inc. (OTCPK:MRNA)
OTCPK:MRNA
0.5
Marina Biotech, Inc. (OTCPK:MRNA)
OTCPK:MRNA
Self
Marret Resource Corp. (TSX:MAR)
TSX:MAR
Medgenics, Inc. (AMEX:MDGN)
AMEX:MDGN
OPKO Biologics
Merck & Co. Inc. (NYSE:MRK)
NYSE:MRK
41,398.0
Merck & Co. Inc. (NYSE:MRK)
NYSE:MRK
Self
41,398.0
Nautilus Biotech S.A.
OPKO Biologics
Neose Technologies, Inc.
OPKO Biologics
10.39
Novartis AG (SWX:NOVN)
SWX:NOVN
Self
Nucleonics, Inc.
Oldtech, Inc.
170.69
Pharm-Rx Chemical Corporation
Self
0.98
Quark Pharmaceuticals, Inc.
Self
5.2
QuatRx Pharmaceuticals Company
Cytochroma Inc.
Regulus Therapeutics Inc. (NasdaqGM:RGLS) NasdaqGM:RGLS
Self
10.24
Roche Holding AG (SWX:ROG)
Self
55,840.99
SWX:ROG
20,575.0
0.38
1,367.77
0.5
5.91
52,777.0
Roche Holdings, Inc.
OPKO Biologics
Roche Innovation Center Copenhagen A/S
Self
Rosetta Genomics, Ltd. (NasdaqCM:ROSG)
NasdaqCM:ROSG
Self
Schering-Plough Corporation (Acquired)
OPKO Biologics
Silence Therapeutics plc (AIM:SLN)
AIM:SLN
Self
Tacere Therapeutics, Inc.
Self
TearLab Corporation (NasdaqCM:TEAR)
NasdaqCM:TEAR
Tekmira Pharmaceuticals Corporation

(NasdaqCM:TKMR)
Topcon Corporation (TSE:7732)
NasdaqCM:TKMR
Self
15.21
TSE:7732
Self
1,544.47
Vision-Sciences Inc. (Acquired)
OPKO Biologics
17.76
Warner Chilcott plc (Acquired)
Cytochroma Inc.
2,424.0
*denotes proprietary relationship
26,424.0
11.98
1.33
17,887.0
0.03
20.92
LTM Date
Source
Business Description
Sep-30-2014
Abzena plc (AIM:ABZA) - Form Doc
Mar-31-2014
Abzena plc, a life sciences company, provides and licenses various services and technologies in North America, the
United
otherand
European
countries,
and internationally.
The companys
services
andoftechnologies
address
Ambrx,Kingdom,
Inc. discovers
develops
protein therapeutics.
The company
develops
a pipeline
product candidates
Mar-31-2015
InspireMD, Inc. (AMEX:NSPR) 2012 Form 10-KT
Mar-31-2015
Mar-31-2015
Mar-31-2015
Mar-31-2015
Mar-31-2015
Mar-31-2015
Mar-31-2013
Mar-31-2015
Mar-31-2015
Dec-31-2014
Mar-31-2013
Mar-31-2015
Mar-31-2015
Mar-31-2015
Apr-03-2015
Mar-31-2015
Mar-31-2015
LTM Date
that
include
antibody
conjugates
(ADCs),
bi- andtechnology
multi-specific
drug
and long-acting
therapeutic
Amunix
Operating
Inc.drug
develops
a half-life
extension
based
onconjugates,
XTEN, a hydrophilic,
unstructured
polypeptide,
which
can
be
recombinantly
fused
or
chemically
conjugated
to
other
peptides,
proteins,
and
Antares Pharma, Inc. operates as a specialty pharmaceutical company that focuses on developing and small
commercializing
self-administered
parenteral
pharmaceutical
products
and technologies
worldwide.
The
companys
AtriCure, Inc., a medical
device company,
provides
atrial fibrillation
solutions
worldwide. The
company
offers
Isolator
Synergy
ablation
system
and
related
radio
frequency(RF)
ablation
devices,
which
include
clamps
that
are
for
Bacterin International Holdings, Inc. develops, manufactures, and markets biologics products in the Unitedused
States
and
internationally.
The company
offers products
that are
used in various
applications,
enhancing
BIOLASE,
Inc., a medical
device company,
develops,
manufactures,
and markets
laserincluding
systems in
dentistry fusion
and in
medicine
in
the
Unites
States
and
internationally.
It
offers
Waterlase
dental
laser
systems
for
cutting
soft
and
hard
Cardica, Inc. designs, manufactures, and markets automated anastomotic systems for use by cardiac surgeons
to
perform
coronary bypass
surgery
in the United
States and
internationally.
It provides
C-Port
Distal Anastomosis
Cerus Corporation
operates
as a biomedical
products
company
focuses on
developing
and commercializing
the
INTERCEPT
Blood
System
to
enhance
blood
safety.
Its
INTERCEPT
Blood
System
is
based
on its products
proprietary
Cogentix Medical, Inc., a medical device company, designs, develops, manufactures, and markets
for the
urology
market
flexible
endoscopy.
company
offersinvasive
Urgent devices
PC neuromodulation
system
for the
overactive
Conceptus,
Inc.and
designs,
develops,
and The
markets
minimally
for reproductive
medical
applications
primarily
in the
United States,
and
Europe.develops,
It primarily
provides Essure
system,
permanent
birth
Cutera, Inc.,
a medical
device France,
company,
designs,
manufactures,
markets,
andaservices
laser
andcontrol
other
energy
based aesthetics
for practitioners
worldwide.
offers
products based
on platforms,
as xeo, a
Cytori Therapeutics,
Inc.,systems
a biotechnology
company,
developsItcell
therapeutics
for specific
diseasessuch
and medical
conditions.
The
company
primarily
provides
Cytori
Cell
Therapy
consisting
of
a
heterogeneous
population
D. Medical Industries Ltd. does not have significant operations. Previously, it was engaged in the research,of
development,
and sale
of products
for diabetesintreatment
drug delivery.
The company
Fresenius Kabimanufacture,
AG is a healthcare
company
that specializes
lifesavingand
medicines
and technologies
for was
infusion,
transfusion,
and
clinical
nutrition
to
help
critically
and
chronically
ill
patients
worldwide.
It
offers
infusion
Palomar Medical Technologies, Inc., together with its subsidiaries, designs, manufactures, markets, andtherapies,
sells lasers
and
other Therapeutics
light-based products,
and related
disposable
items Ltd.,
and accessories
use in dermatology
and cosmetic
Pluristem
Inc., through
its subsidiary,
Pluristem
operates as for
a bio-therapeutics
company
in Israel.
The
company
focuses
on
the
research,
development,
clinical
trial,
and
manufacture
of
cell
therapeutics
products
Protalix BioTherapeutics, Inc., a biopharmaceutical company, together with its subsidiary, Protalix Ltd., focuses onand
the
development
recombinant
proteins
baseddiagnostics
on its proprietary
Sequenom,
Inc., aand
lifecommercialization
sciences company,ofdevelops
and therapeutic
commercializes
molecular
testingProCellEx
services for
the
women's
health
and
oncology
markets
in
the
United
States
and
internationally.
The
company
provides
molecular
STAAR Surgical Company, together with its subsidiaries, designs, develops, manufactures, and sells
implantable
lenses
for theInc.
eye,
and delivery
systems to
deliver
lenses
intosystems
the eye. and
Theinstruments
company offers
implantable
Stereotaxis,
designs,
manufactures,
and
markets
robotic
for the
treatmentcollamer
of abnormal
heart
rhythms
in
the
United
States
and
internationally.
Its
products
include
Niobe
ES
robotic
system
that enables
SurModics, Inc. provides surface modification and in vitro diagnostic technologies to the healthcare industry.
The
company
operates through
segments,
Medical Device and
In Vitro Diagnostics.
The
Medical Device
segment
Xenetic Biosciences,
Inc., atwo
clinical
stage biopharmaceutical
company,
focuses on the
discovery,
development,
and
planned commercialization of human drug therapies for the treatment of various conditions. Its drug delivery platform
Source
Business Description
Jun-30-2014
Medgenics, Inc. (AMEX:MDGN) - Form Doc
Mar-31-2015
Arrowhead Research Corp. (NasdaqGS:ARWR) 2011 Form

10-K
Affymax, Inc. operates as a biopharmaceutical company in the United States. The company was founded in 2001
and
is based
in Cupertino, Inc.,
California.
Alnylam
Pharmaceuticals,
a biopharmaceutical company, discovers, develops, and commercializes novel
therapeutics based on RNA interference. The companys clinical development programs include Patisiran and
Mar-31-2015
Mar-31-2015
Mar-31-2015

10-K
Dec-31-2007
10-K
QuatRx Pharmaceuticals Company 2006 Form S-1
Dec-31-2014
Marret Resource Corp. (TSX:MAR) - Form Doc
Dec-31-2014

10-K
Medgenics,
Inc. (AMEX:MDGN) - Form Doc
Amgen Inc., a biotechnology company, discovers, develops, manufactures, and delivers human therapeutics
worldwide.
It focusesInc.,
for the
treatment of biotechnology
illness in the areas
of oncology,
hematology,
inflammation,
bone
health,
Aptose Biosciences
a clinical-stage
company,
discovers
and develops
personalized
therapies
addressing
unmet medical
needs in
oncology
in Canada.
leadintractable
clinical program
is APTO-253,
a small
molecule
that
Arrowhead Research
Corporation
develops
novel
drugs toItstreat
diseases
in the United
States.
The
companys
principal
product
candidates
comprise
ARC-520,
an
RNAi-based
therapeutic
that
is
in
Phase
IIa
clinical
Bayer Pharma AG develops drugs and therapeutics for cardiovascular and blood diseases, oncological diseases,
ophthalmology,
and Limited,
women'sa health.
It offers company,
prescription
medicines
fortreatments
cardiovascular
and blood
that
Benitec Biopharma
biotechnology
develops
novel
for chronic
and diseases
life-threatening
conditions
based
on
its
gene
silencing
technology,
DNA-directed
RNA
interference
(ddRNAi).
The
companys
ddRNAi
Benitec Biopharma Limited, a biotechnology company, develops novel treatments for chronic and life-threatening
conditions
on its gene
technology,
DNA-directed
RNA interference
The companys
ddRNAi
Biogen
Idecbased
Hemophilia
Inc. issilencing
a biotechnology
company
that discovers,
develops, (ddRNAi).
and manufactures
biological
products
for
chronic
conditions.
It
helps
people
around
the
world
to
manage
disorders,
including
multiple
sclerosis,
On August 25, 2014, Biolex Therapeutics, Inc. went out of business as per its Chapter 7 liquidation filing under
Jun-30-2007
Dec-31-2003
Mar-31-2015
Opko Health, Inc. (NYSE:OPK) 2010 Form 10-K
Mar-31-2015
Dec-31-2014
Mar-31-2015
Mar-31-2015
CytRx Corporation (NasdaqCM:CYTR) 2008 Form 10-K
The
company
offers various
drugs, including
anti-anemic
agents,
anti-diabetic
agents, anti-histamine
agents, antiFlamel
Technologies
SA, a specialty
pharmaceutical
company,
develops
and commercializes
pharmaceutical
products
based
on
its
proprietary
polymer
based
technology
primarily
in
the
United
States
and
Europe.
The company
Galena Biopharma, Inc., a biopharmaceutical company, focuses on developing and commercializing oncology
Mar-31-2015

10-K
therapeutics
that address
unmet medicalcompany,
needs across
cancer
care. Its commercial
products include
Abstral, a
Galena Biopharma,
Inc., amajor
biopharmaceutical
focuses
on developing
and commercializing
oncology
therapeutics
that
address
major
unmet
medical
needs
across
cancer
care.
Its
commercial
products
include
Heidelberg Engineering, Inc. designs, manufactures, and distributes diagnostic instruments and light-basedAbstral,
medicala
Jun-30-2012
Mar-31-2015
devices
for ophthalmic
applications.
Its products
include tracking laser
tomography;
confocal
scanning
laser products
Human Genome
Sciences,
Inc. operates
as a biopharmaceutical
company
in the United
States.
Its principal
include BENLYSTA
for systemic
erythematosus;
inhalation
anthrax. The
companys midInspireMD,
Inc., a medical
devicelupus
company,
focuses onand
theraxibacumab
developmentfor
and
commercialization
of proprietary

10-K
MicroNet
stent5,
platform
technology
for the treatment
of complex
coronary
and vascular
offers MGuard
As of January
2010, Intradigm
Corporation
was acquired
by Silence
Therapeutics
plc.diseases.
IntradigmItCorporation
operates
as
a
biotechnology
company
that
discovers,
develops,
and
delivers
systematic
ribonucleic
Isis Pharmaceuticals, Inc. engages in the discovery and development of antisense drugs using novelacid
druginterference
discovery
10-K
Mar-29-2015
platform.
The companys
product pharmaceutical
includes the KYNAMRO
is an apo-B
synthesis inhibitor
for
Janssen-Cilag
Limited, a flagship
research-based
company,injection,
developswhich
and markets
pharmaceutical
products.
It
offers
prescription
medicines
for
a
range
of
conditions
in
the
areas
of
gastroenterology;
fungal
infections;
womens
Johnson & Johnson, together with its subsidiaries, researches and develops, manufactures, and sells various
Mar-31-2015
bankruptcy.
Biolex Therapeutics,
Inc. operates
as therapeutics
a biopharmaceutical
company. It offers
Locteron,drug
a controlledCalando Pharmaceuticals,
Inc. provides
targeted
for the development
of nanoparticle
formulations.
Its
products
include
targeted
siRNA
and
small
molecule
therapeutics
for
oncology
applications;
and
CALAA-01,
Carl Zeiss Meditec AG operates as a medical technology company worldwide. It provides various products
and an
services
in the fields
of ophthalmology;
neurosurgery;research
plastic and
spine; ear,
nose, and in
throat
(ENT);
CytRx Corporation
operates
as a biopharmaceutical
andreconstructive;
development company
specializing
oncology.
The
companys
product
candidate
is
aldoxorubicin,
which
is
in
Phase
III
clinical
trial
as
a
therapy
for
patients
with
Daewoong Pharmaceutical Co., Ltd. manufactures and sells prescription drugs in South Korea and internationally.soft
Mar-31-2015
products
in the health
field worldwide. company,
It operatesacquires
in three and
segments:
Consumer,
and Medical
Kyto BioPharma,
Inc., care
a biopharmaceutical
develops
toxic andPharmaceutical,
non-immunosuppressive
proprietary
drugsInc.,
for the
treatment of cancer,
arthritis,
and
proliferatedevelopment,
and autoimmune
The company
Marina Biotech,
a biotechnology
company,
focuses
onother
the discovery,
and diseases.
commercialization
of
Mar-31-2015

10-K
nucleic
acid-based
therapies
to treat orphan
diseases.
therapies
include and
small
interfering RNA, of
Marina Biotech,
Inc.,
a biotechnology
company,
focusesThe
on companys
the discovery,
development,
commercialization
nucleic
acid-based
therapies
to
treat
orphan
diseases.
The
companys
therapies
include
small
Marret Resource Corp. focuses on natural resource lending activities in Canada. The companyinterfering
is involvedRNA,
in
Mar-31-2015
Kyto BioPharma Inc. 2008 Form 10KSB
Mar-31-2015
investing
in public
private
debt
securities
of, andcompany,
making term
loans,inincluding
bridgeand
anddevelopment
mezzanine debt
to
Medgenics,
Inc., a and
clinical
stage
medical
technology
engages
the research
of products
in
the
field
of
biotechnology
and
associated
medical
equipment
in
the
United
States.
It
develops
transduced
Merck & Co., Inc. provides health care solutions worldwide. The company offer therapeutic and preventive agents to
Mar-31-2015

10-K
treat cardiovascular,
type 2 health
diabetes,
nasal
allergy symptoms,
allergic
chronic
C virus,
HIVMerck
& Co., Inc. provides
careasthma,
solutions
worldwide.
The company
offer rhinitis,
therapeutic
andhepatitis
preventive
agents
to
treat
cardiovascular,
type
2
diabetes,
asthma,
nasal
allergy
symptoms,
allergic
rhinitis,
chronic
hepatitis
C
virus,
HIVNautilus Biotech S.A. is a biotechnology company. The company has a pipeline of therapeutic proteins with improved
Sep-30-2008
Mar-31-2015

10-K
profiles.
The companys
include
Belerofon,therapeutic
an injectable
and orally
alpha for use in the
Neose Technologies,
Inc.products
develops
next-generation
proteins.
Theavailable
companyinterferon
offers GlycoPEGylation
technology
that
uses
enzymes
to
attach
PEG
to
carbohydrate
structures
on
proteins.
Its
therapeutic
proteinIts
Novartis AG researches, develops, manufactures, and markets a range of healthcare products worldwide.
Sep-30-2005
Dec-31-2010
Mar-31-2015
Dec-31-2014
Oldtech, Inc. 2005 Form 10-K
Pharmaceuticals
division offers
prescription
medicines
in variousIttherapeutic
areas, such
as oncology,
Nucleonics, Inc. develops
RNAi patented
therapeutics
for viral and
other diseases.
offers NUC-B1000,
a hepatitis
B antiviral
agent.
The
company
also
focuses
on
the
development
of
eiRNA-based
therapeutics
for
chronic
hepatitis
B and
Oldtech, Inc. develops and commercializes therapeutics to treat eye diseases. The company develops and
markets

10-K
Macugen,
is used
in the treatment
age-related
macular
degeneration
or AMD. Oldtech,
Inc. was
Pharm-Rx which
Chemical
Corporation
engagesofinneovascular
marketing and
distribution
of chemicals
in the pharmaceutical
and
dietary
supplement
industries.
The
company
was
founded
in
1991
and
is
based
in
Budd
Lake,
New
Jersey.
Quark Pharmaceuticals, Inc., a clinical-stage pharmaceutical company, engages in the discovery and development of
10-K
novel
RNAi-based
therapeutics.
Its products
include PF-655,
a synthetic
siRNA
to inhibit the licensing,
expression
of
QuatRx
Pharmaceuticals
Company,
a biopharmaceutical
company,
engages
in discovering,
developing,
and
commercializing
compounds
in
the
areas
of
endocrine,
metabolic,
and
cardiovascular
therapeutics.
products
Regulus Therapeutics Inc., a biopharmaceutical company, focuses on the discovery and development ofIts
drugs
that

10-K
10-K
target
the treatment
of various diseases
the Unitedbusinesses
States. It uses
its microRNA
product platform
to
RochemicroRNAs
Holding AGfor
operates
in the pharmaceuticals
andindiagnostics
in Europe,
North America,
and Asia.
It offers pharmaceutical products for anaemia, anticoagulation therapy, bone, cancer, cardiovascular, central nervous
Dec-31-2014
-
Roche Holdings, Inc., through its subsidiaries, engages in the development, manufacture, and marketing of
pharmaceuticals
diagnostics.
The company
operates
in two divisions,
Pharmaceuticals
Diagnostics.
Roche Innovationand
Center
Copenhagen
A/S engages
in developing
RNA-targeted
drugs. Theand
company
throughThe
its
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locked
acid Ltd.
platform
engages
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across
various therapeutic
areas. Roche
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develops
and in
commercializes
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tests and therapeutics.
MicroRNAs
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a
group
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genes
that
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produced
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instructions
encoded
in
DNA.
The
company
offers
As of November 3, 2009, Schering-Plough Corporation was acquired by Merck & Co. Inc. Schering-Plough
Dec-31-2014

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Corporation
discovers,plc,
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manufactures,
and discovers,
sells pharmaceuticals
worldwide.
operates
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segments:
Silence Therapeutics
a biotechnology
company,
develops, and
delivers It
RNA
interference
therapeutics
for
the
treatment
of
serious
diseases
primarily
in
North
America
and
the
Asia/Pacific.
It
has
AtuRNAi,
an
Tacere Therapeutics, Inc. develops therapeutics for the treatment of infectious diseases. The companys therapeutic
Mar-31-2015
10-K
TearLab Corporation (NasdaqCM:TEAR) 2007 Form 10-K
Mar-31-2015
Mar-31-2015

10-K
compound
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anas
RNA
interferencedevice
drug for
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C. ItThe
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founded
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TearLab
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States.
develops
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technologies
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Tekmira Pharmaceuticals Corporation, a biopharmaceutical company, focuses on the research and development of
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Jun-30-2013
RNA
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and provides
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pharmaceutical
partners in
Topcon
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positioning,toand
eye care products
worldwide.
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As of March 31, 2015, Vision-Sciences Inc. was acquired by Uroplasty, Inc., in a reverse merger transaction.
VisionSciences,
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designs,
develops,
manufactures,
and by
markets
endoscopy
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Actavis
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OPKO Health's Competitors in the Biologics Space

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OPKO Health's Competitors in the Biologics Space

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Opko Health, Inc.

(NYSE:OPK) > Competitors

Abzena plc (AIM:ABZA)

Amunix Operating Inc.

Antares Pharma Inc. (NasdaqCM:ATRS)

AtriCure, Inc. (NasdaqGM:ATRC)

Bacterin International Holdings, Inc.

Cardica Inc. (NasdaqGM:CRDC)

Cerus Corporation (NasdaqGM:CERS)

Cogentix Medical, Inc. (NasdaqCM:CGNT)

Cutera, Inc. (NasdaqGS:CUTR)

Cytori Therapeutics, Inc. (NasdaqGM:CYTX)

D. Medical Industries Ltd. (TASE:DMED)

Palomar Medical Technologies Inc.

Pluristem Therapeutics, Inc.

Sequenom Inc. (NasdaqGS:SQNM)

STAAR Surgical Company (NasdaqGM:STAA) NasdaqGM:STAA

Stereotaxis Inc. (NasdaqCM:STXS)

SurModics, Inc. (NasdaqGS:SRDX)

Xenetic Biosciences, Inc. (OTCPK:XBIO)

Prior and Not Recently Disclosed Competitors

Affymax, Inc. (OTCPK:AFFY)

Alnylam Pharmaceuticals, Inc.

Opko Health, Inc. (NYSE:OPK)

LTM Revenue ($mm)

LTM Revenue ($mm)

Amgen Inc. (NasdaqGS:AMGN)

Aptose Biosciences Inc. (TSX:APS)

Opko Health, Inc. (NYSE:OPK)

Arrowhead Research Corp.

Opko Health, Inc. (NYSE:OPK)

Benitec Biopharma Limited (ASX:BLT)

Acuity Pharmaceuticals, Inc.

Benitec Biopharma Limited (ASX:BLT)

Opko Health, Inc. (NYSE:OPK)

Biogen Idec Hemophilia Inc.

Biolex Therapeutics, Inc. (Out of Business)

Calando Pharmaceuticals, Inc.

Acuity Pharmaceuticals, Inc.

Carl Zeiss Meditec AG (XTRA:AFX)

Opko Health, Inc. (NYSE:OPK)

CytRx Corporation (NasdaqCM:CYTR)

Acuity Pharmaceuticals, Inc.

Daewoong Pharmaceutical Co., Ltd.

Galena Biopharma, Inc. (NasdaqCM:GALE)

Acuity Pharmaceuticals, Inc.

Galena Biopharma, Inc. (NasdaqCM:GALE)

Opko Health, Inc. (NYSE:OPK)

Heidelberg Engineering, Inc.

Opko Health, Inc. (NYSE:OPK)

Human Genome Sciences Inc.

InspireMD, Inc. (AMEX:NSPR)

Intradigm Corporation (Acquired)

Opko Health, Inc. (NYSE:OPK)

Isis Pharmaceuticals, Inc. (NasdaqGS:ISIS)

Opko Health, Inc. (NYSE:OPK)

Johnson & Johnson (NYSE:JNJ)

Kyto BioPharma Inc.

Marina Biotech, Inc. (OTCPK:MRNA)

Acuity Pharmaceuticals, Inc.

Marina Biotech, Inc. (OTCPK:MRNA)

Opko Health, Inc. (NYSE:OPK)